The Journal of Allergy and Clinical Immunology: In Practice, Feb 1, 2022
BACKGROUND Allergic sensitization increases the risk of and asthma and allergic rhinitis, but the... more BACKGROUND Allergic sensitization increases the risk of and asthma and allergic rhinitis, but the impact of age at onset of sensitization is less studied. OBJECTIVE To examine the cumulative incidence of asthma and rhinitis up to age 19 years in relation to age at onset of sensitization to airborne allergens. METHOD All children in grade one and two (median age 8 years) in two municipalities in Northern Sweden were invited to skin prick tests and a questionnaire about allergic diseases, and 88% participated. At ages 12 and 19 years the protocol was repeated, and n=1510 individuals participated in all three examinations. Specific IgE was collected in a random sample at age 19, n=770. Onset of sensitization was defined; ≤8 years, 8-12 years, 12-19 years, and never sensitized. Adjusted Poisson regression was utilized to calculate risk ratios. RESULTS At age 19, those sensitized ≤8 year had the highest risk of asthma (RR 4.68 (95%CI 3.14-6.97)) and rhinitis (RR 22.3 (95%CI 13.3-37.6)), and 84% had developed either asthma or rhinitis. The combination of sensitization ≤8 year and family history of allergic diseases rendered high risks for asthma (RR 10.6 (6.71-16.7)) and rhinitis (RR 36.3 (18.9-69.7). Individuals sensitized ≤8 year showed significantly highest level of sensitization, as judged by number of positive skin tests and titers of specific IgE. CONCLUSION The majority of individuals with sensitization ≤8 years developed asthma or rhinitis before young adulthood. The high level of sensitization in early sensitized contribute to the high incidence of allergic airway conditions.
Background: Double-blind, placebo-controlled food challenges are the gold standard for diagnosing... more Background: Double-blind, placebo-controlled food challenges are the gold standard for diagnosing the clinical relevance of a suspected food allergy. Hitherto there are no descriptions on how adol ...
Sensitization to animal allergen components in relation to asthma among young adults in Northern ... more Sensitization to animal allergen components in relation to asthma among young adults in Northern Sweden
Animal sensitization is a major determinant of asthma in children. Component-resolved studies of ... more Animal sensitization is a major determinant of asthma in children. Component-resolved studies of unselected pediatric populations are lacking. The aim was to describe sensitization to animal components and the association with asthma and rhinitis in animal-sensitized schoolchildren. A random sample of 696 children (11-12 years) from a Swedish population-based cohort was tested for sensitization to cat, dog, and horse dander using ImmunoCAP. Sera from animal-sensitized children were further analyzed by microarray including three allergen components from cat, four from dog, and two from horse. The parents completed an expanded ISAAC questionnaire. Of 259 animal-sensitized children (≥0.1 kUA /l), 51% were sensitized to all three, 23% to two, and 25% to one species. Current asthma and asthma symptoms following contact with cats were associated with co-sensitization to Fel d 1 and Fel d 4. This association was seen already at moderate-level sensitization (1-15 ISU) to Fel d 4, at which level most children were sensitized to Fel d 1, as well. In dog-sensitized children, the majority was sensitized to more than one dog component, and co-sensitization to Can f 5 and Can f 1/f 2 conferred the greatest risk for asthma. Sensitization to the highly cross-reactive serum albumins was uncommon and not associated with asthma. Among schoolchildren in northern Sweden, where mite allergy is uncommon, furry animals were the primary perennial sensitizers. Asthma was associated with higher levels of component sensitization, and sensitization to more than one component from the same animal conferred the greatest risk.
Furry animal sensitisation to allergen components and asthma diagnosis in a child cohort from nor... more Furry animal sensitisation to allergen components and asthma diagnosis in a child cohort from northern Sweden
Background During several decades the prevalence of atopic dermatitis (AD) has increased and now ... more Background During several decades the prevalence of atopic dermatitis (AD) has increased and now affects about one fifth of all children in high-income countries. While the increase continues in lower income countries, the AD prevalence might have reached a plateau in high-income countries. Objectives The aim of this study was to investigate trends in prevalence of AD and atopic comorbidity among schoolchildren in Sweden. Methods The study population consisted of three cohorts of children in Norrbotten, Sweden, from 1996 (n=3430), 2006 (n=2585), and 2017 (n=2785), median age 8 years. A questionnaire was used, including questions from the ISAAC protocol, identical in all three cohorts. Trends in prevalence of AD was estimated, as well as trends in atopic comorbidity. Prevalence was estimated both according to the ISAAC definition of AD, and by adding reported diagnosis by a physician (D-AD). Results The prevalence of AD decreased in the last decade, from 22.8 % (1996) and 21,3 % (200...
The Journal of Allergy and Clinical Immunology: In Practice, Feb 1, 2022
BACKGROUND Allergic sensitization increases the risk of and asthma and allergic rhinitis, but the... more BACKGROUND Allergic sensitization increases the risk of and asthma and allergic rhinitis, but the impact of age at onset of sensitization is less studied. OBJECTIVE To examine the cumulative incidence of asthma and rhinitis up to age 19 years in relation to age at onset of sensitization to airborne allergens. METHOD All children in grade one and two (median age 8 years) in two municipalities in Northern Sweden were invited to skin prick tests and a questionnaire about allergic diseases, and 88% participated. At ages 12 and 19 years the protocol was repeated, and n=1510 individuals participated in all three examinations. Specific IgE was collected in a random sample at age 19, n=770. Onset of sensitization was defined; ≤8 years, 8-12 years, 12-19 years, and never sensitized. Adjusted Poisson regression was utilized to calculate risk ratios. RESULTS At age 19, those sensitized ≤8 year had the highest risk of asthma (RR 4.68 (95%CI 3.14-6.97)) and rhinitis (RR 22.3 (95%CI 13.3-37.6)), and 84% had developed either asthma or rhinitis. The combination of sensitization ≤8 year and family history of allergic diseases rendered high risks for asthma (RR 10.6 (6.71-16.7)) and rhinitis (RR 36.3 (18.9-69.7). Individuals sensitized ≤8 year showed significantly highest level of sensitization, as judged by number of positive skin tests and titers of specific IgE. CONCLUSION The majority of individuals with sensitization ≤8 years developed asthma or rhinitis before young adulthood. The high level of sensitization in early sensitized contribute to the high incidence of allergic airway conditions.
Background: Double-blind, placebo-controlled food challenges are the gold standard for diagnosing... more Background: Double-blind, placebo-controlled food challenges are the gold standard for diagnosing the clinical relevance of a suspected food allergy. Hitherto there are no descriptions on how adol ...
Sensitization to animal allergen components in relation to asthma among young adults in Northern ... more Sensitization to animal allergen components in relation to asthma among young adults in Northern Sweden
Animal sensitization is a major determinant of asthma in children. Component-resolved studies of ... more Animal sensitization is a major determinant of asthma in children. Component-resolved studies of unselected pediatric populations are lacking. The aim was to describe sensitization to animal components and the association with asthma and rhinitis in animal-sensitized schoolchildren. A random sample of 696 children (11-12 years) from a Swedish population-based cohort was tested for sensitization to cat, dog, and horse dander using ImmunoCAP. Sera from animal-sensitized children were further analyzed by microarray including three allergen components from cat, four from dog, and two from horse. The parents completed an expanded ISAAC questionnaire. Of 259 animal-sensitized children (≥0.1 kUA /l), 51% were sensitized to all three, 23% to two, and 25% to one species. Current asthma and asthma symptoms following contact with cats were associated with co-sensitization to Fel d 1 and Fel d 4. This association was seen already at moderate-level sensitization (1-15 ISU) to Fel d 4, at which level most children were sensitized to Fel d 1, as well. In dog-sensitized children, the majority was sensitized to more than one dog component, and co-sensitization to Can f 5 and Can f 1/f 2 conferred the greatest risk for asthma. Sensitization to the highly cross-reactive serum albumins was uncommon and not associated with asthma. Among schoolchildren in northern Sweden, where mite allergy is uncommon, furry animals were the primary perennial sensitizers. Asthma was associated with higher levels of component sensitization, and sensitization to more than one component from the same animal conferred the greatest risk.
Furry animal sensitisation to allergen components and asthma diagnosis in a child cohort from nor... more Furry animal sensitisation to allergen components and asthma diagnosis in a child cohort from northern Sweden
Background During several decades the prevalence of atopic dermatitis (AD) has increased and now ... more Background During several decades the prevalence of atopic dermatitis (AD) has increased and now affects about one fifth of all children in high-income countries. While the increase continues in lower income countries, the AD prevalence might have reached a plateau in high-income countries. Objectives The aim of this study was to investigate trends in prevalence of AD and atopic comorbidity among schoolchildren in Sweden. Methods The study population consisted of three cohorts of children in Norrbotten, Sweden, from 1996 (n=3430), 2006 (n=2585), and 2017 (n=2785), median age 8 years. A questionnaire was used, including questions from the ISAAC protocol, identical in all three cohorts. Trends in prevalence of AD was estimated, as well as trends in atopic comorbidity. Prevalence was estimated both according to the ISAAC definition of AD, and by adding reported diagnosis by a physician (D-AD). Results The prevalence of AD decreased in the last decade, from 22.8 % (1996) and 21,3 % (200...
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Papers by Anna Winberg