World journal of pharmaceutical research, May 1, 2017
Introduction: Cancer treatment involves comprehensive multimodality approaches and sometimes last... more Introduction: Cancer treatment involves comprehensive multimodality approaches and sometimes lasts for several months. Patients' daily agenda, in oncology care units, is long and exhausting. Such agenda may lead to mental, emotional and physical stresses. In Israel, only 14 oncology units exist, including the day-care facilities based in tertiary hospitals. Establishing community based oncological units may serve as good solution for the shortage of facilities by providing more accessible and available care. Objectives: To compare treatment quality between two oncology unit models: A tertiary and a community-based oncology units in Israel, in terms of treatment schedule and chemotherapeutic drug dosage, as well as the patients overall satisfaction and other psychological parameters. Methods: A cross sectional analytic study was conducted with a cohort of 143 patients; 76 treated in a tertiary center and 67 in a community center, using two validated questionnaires (DIC and HADS) and patients' data file. Results: There was no difference between the two models in terms of therapeutic quality (dose density and intensity) and psychological status in terms of depression or anxiety. However, a significant improvement World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 5, 37-51. Research Article ISSN 2277–7105 Article Received on 28 Feb. 2017, Revised on 21 March 2017, Accepted on 09 April 2017 DOI: 10.20959/wjpr20175-8354 *Corresponding Author
ABSTRACT Since 1990, researchers have proposed that genetic variants of dopaminergic genes and ot... more ABSTRACT Since 1990, researchers have proposed that genetic variants of dopaminergic genes and other "reward genes" are important common determinants of Reward Deficiency Syndrome (RDS). RDS refers to the breakdown of a cascade of neurotransmitters in the brain in which one reaction triggers another — the reward cascade — and resultant aberrant conduct. Association studies have amassed strong evidence implicating the D (2) dopamine receptor (DRD2) gene in harmful conditions such as alcoholism, and the DRD2 gene also has been found to be involved in other substance use disorders including cocaine, nicotine, and opioid dependence, as well as obesity. Brain dopamine has been implicated as the so-called ―anti-stress molecule.‖ The present study investigated anti-anxiety effects of Synaptamine Complex [KB220], a dopaminergic activator, in a randomized double-blind placebo controlled study in alcoholics and in polydrug abusers attending an in-patient chemical dependency program. In this randomized double-blind placebo controlled study of 62 alcoholic and polydrug abusers, we utilized skin conductance level (SCL) to evaluate stress responses. Patients receiving Synaptamine Complex [KB220] had a significantly reduced stress response as measured by SCL, compared to patients receiving placebo. Two factor ANOVA yielded significant differences as a function of Time (p<0.001), and Treatment (p<0.025) as well as a Time– by-Treatment interaction (p< 0.01). The results of this study suggest that the Synaptamine Complex™ [KB220] may improve treatment response in an in-patient treatment setting by reducing stress related behaviors and warrants further investigation.
World journal of pharmaceutical research, May 1, 2017
Introduction: Cancer treatment involves comprehensive multimodality approaches and sometimes last... more Introduction: Cancer treatment involves comprehensive multimodality approaches and sometimes lasts for several months. Patients' daily agenda, in oncology care units, is long and exhausting. Such agenda may lead to mental, emotional and physical stresses. In Israel, only 14 oncology units exist, including the day-care facilities based in tertiary hospitals. Establishing community based oncological units may serve as good solution for the shortage of facilities by providing more accessible and available care. Objectives: To compare treatment quality between two oncology unit models: A tertiary and a community-based oncology units in Israel, in terms of treatment schedule and chemotherapeutic drug dosage, as well as the patients overall satisfaction and other psychological parameters. Methods: A cross sectional analytic study was conducted with a cohort of 143 patients; 76 treated in a tertiary center and 67 in a community center, using two validated questionnaires (DIC and HADS) and patients' data file. Results: There was no difference between the two models in terms of therapeutic quality (dose density and intensity) and psychological status in terms of depression or anxiety. However, a significant improvement World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 5, 37-51. Research Article ISSN 2277–7105 Article Received on 28 Feb. 2017, Revised on 21 March 2017, Accepted on 09 April 2017 DOI: 10.20959/wjpr20175-8354 *Corresponding Author
ABSTRACT Since 1990, researchers have proposed that genetic variants of dopaminergic genes and ot... more ABSTRACT Since 1990, researchers have proposed that genetic variants of dopaminergic genes and other "reward genes" are important common determinants of Reward Deficiency Syndrome (RDS). RDS refers to the breakdown of a cascade of neurotransmitters in the brain in which one reaction triggers another — the reward cascade — and resultant aberrant conduct. Association studies have amassed strong evidence implicating the D (2) dopamine receptor (DRD2) gene in harmful conditions such as alcoholism, and the DRD2 gene also has been found to be involved in other substance use disorders including cocaine, nicotine, and opioid dependence, as well as obesity. Brain dopamine has been implicated as the so-called ―anti-stress molecule.‖ The present study investigated anti-anxiety effects of Synaptamine Complex [KB220], a dopaminergic activator, in a randomized double-blind placebo controlled study in alcoholics and in polydrug abusers attending an in-patient chemical dependency program. In this randomized double-blind placebo controlled study of 62 alcoholic and polydrug abusers, we utilized skin conductance level (SCL) to evaluate stress responses. Patients receiving Synaptamine Complex [KB220] had a significantly reduced stress response as measured by SCL, compared to patients receiving placebo. Two factor ANOVA yielded significant differences as a function of Time (p<0.001), and Treatment (p<0.025) as well as a Time– by-Treatment interaction (p< 0.01). The results of this study suggest that the Synaptamine Complex™ [KB220] may improve treatment response in an in-patient treatment setting by reducing stress related behaviors and warrants further investigation.
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