Background. Several existing medications are being repurposed for treatment of COVID-19, includin... more Background. Several existing medications are being repurposed for treatment of COVID-19, including chloroquine and hydroxychloroquine. The use of these medications has been associated with QT prolongation. Their use in patients with COVID-19, magnifies the risk for development of heart arrhythmias. Objective of the study. The aim of this bibliographic research was to perform an analysis of existing clinical reports regarding effects of drugs used in patients with COVID-19 on myocardial repolarization, effects which can be measured on ECG as dispersion of QT interval. Material and Methods. A three‐step approach was employed. Firstly, a search of clinical reports in HINARI and PubMed using key words COVID-19 and QT dispersion was performed. Secondarily, selected articles were limited to the English language and human studies. Finally, full texts of all the selected articles were reviewed in details and points relevant to QT dispersion related to use of drugs were extracted. Results. T...
Department of Internal Medicine, Medical clinic No 3, Discipline of Cardiology Nicolae Testemitsa... more Department of Internal Medicine, Medical clinic No 3, Discipline of Cardiology Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova
This study aims to evaluate patients with limited state of changes in coronary arteries detected ... more This study aims to evaluate patients with limited state of changes in coronary arteries detected by coronary angiography, the dynamics of these changes over the two years, identify the relevant diagnostic criteria, and assess the efficacy of applied treatment by using speckle tracking echocardiography. Peak radial and circumferential strain and SR (systolic, early, and late diastolic strains) were measured based on the short-axis view; peak longitudinal strain and SR were measured from the apical side of fourtwoand three-chamber views. Radial, longitudinal (GLS), circumferential global and regional strains were calculated as an average of measurements. All patients (n − 146) were assigned to normal (control) and CAD groups according to cardiac angiography results. 128 of them were evaluated repeatedly after two years. Depending on angiography findings, LAD (85.83%) stenosis predominate, when subsequently fewer instances of RCA (52.5%) or LCX (40.83%) were observed. Most (about 80%) ...
Contact address: Prof. dr. Ion Popovici Department of Interventional Cardiology, Polivalent Hospi... more Contact address: Prof. dr. Ion Popovici Department of Interventional Cardiology, Polivalent Hospital NOVAMED, 30 Tudor Strisca, Chisinau, Republic of Moldova. npchisinau@gmail.com 1 Department of Interventional Cardiology, Polivalent Hospital NOVAMED, 30 Tudor Strisca, Chisinau, Republic of Moldova Abstract: Premises – Left main coronary artery disease is the highest-risk lesion subset of ischemic heart disease, and has traditionally been an indication for coronary artery bypass grafting. In recent years, many interventional techniques have been proposed for the treatment of such lesions. Implantation of self-apposing stents is one of them. These stents have a conical shape and open cells, which allows us to restore the bifurcation of left main and achieve anatomy close to the physiological. Material and methods – Thirty-three patients with left main bifurcation lesions treated with self-apposing coronary, nitinol, sirolimus-eluting stent using stent with balloon technique were enro...
Background. Several existing medications are being repurposed for treatment of COVID-19, includin... more Background. Several existing medications are being repurposed for treatment of COVID-19, including chloroquine and hydroxychloroquine. The use of these medications has been associated with QT prolongation. Their use in patients with COVID-19, magnifies the risk for development of heart arrhythmias. Objective of the study. The aim of this bibliographic research was to perform an analysis of existing clinical reports regarding effects of drugs used in patients with COVID-19 on myocardial repolarization, effects which can be measured on ECG as dispersion of QT interval. Material and Methods. A three‐step approach was employed. Firstly, a search of clinical reports in HINARI and PubMed using key words COVID-19 and QT dispersion was performed. Secondarily, selected articles were limited to the English language and human studies. Finally, full texts of all the selected articles were reviewed in details and points relevant to QT dispersion related to use of drugs were extracted. Results. T...
Department of Internal Medicine, Medical clinic No 3, Discipline of Cardiology Nicolae Testemitsa... more Department of Internal Medicine, Medical clinic No 3, Discipline of Cardiology Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova
This study aims to evaluate patients with limited state of changes in coronary arteries detected ... more This study aims to evaluate patients with limited state of changes in coronary arteries detected by coronary angiography, the dynamics of these changes over the two years, identify the relevant diagnostic criteria, and assess the efficacy of applied treatment by using speckle tracking echocardiography. Peak radial and circumferential strain and SR (systolic, early, and late diastolic strains) were measured based on the short-axis view; peak longitudinal strain and SR were measured from the apical side of fourtwoand three-chamber views. Radial, longitudinal (GLS), circumferential global and regional strains were calculated as an average of measurements. All patients (n − 146) were assigned to normal (control) and CAD groups according to cardiac angiography results. 128 of them were evaluated repeatedly after two years. Depending on angiography findings, LAD (85.83%) stenosis predominate, when subsequently fewer instances of RCA (52.5%) or LCX (40.83%) were observed. Most (about 80%) ...
Contact address: Prof. dr. Ion Popovici Department of Interventional Cardiology, Polivalent Hospi... more Contact address: Prof. dr. Ion Popovici Department of Interventional Cardiology, Polivalent Hospital NOVAMED, 30 Tudor Strisca, Chisinau, Republic of Moldova. npchisinau@gmail.com 1 Department of Interventional Cardiology, Polivalent Hospital NOVAMED, 30 Tudor Strisca, Chisinau, Republic of Moldova Abstract: Premises – Left main coronary artery disease is the highest-risk lesion subset of ischemic heart disease, and has traditionally been an indication for coronary artery bypass grafting. In recent years, many interventional techniques have been proposed for the treatment of such lesions. Implantation of self-apposing stents is one of them. These stents have a conical shape and open cells, which allows us to restore the bifurcation of left main and achieve anatomy close to the physiological. Material and methods – Thirty-three patients with left main bifurcation lesions treated with self-apposing coronary, nitinol, sirolimus-eluting stent using stent with balloon technique were enro...
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