Colorectal cancer (CRC) is the second-leading cause of cancer death, with a worldwide incidence r... more Colorectal cancer (CRC) is the second-leading cause of cancer death, with a worldwide incidence rate constantly increasing; thus, new strategies for its prevention or treatment are needed. Here, we describe the adjuvant effect of the polyphenol-enriched fractions of cinnamon, from cinnamon bark and buds, when co-administered with a potent anticancer drug, cetuximab, used for CRC therapy. The co-administration significantly reduces the cetuximab dose required for the antiproliferative activity against colorectal cancer cell line E705, which is sensitive to EGFR-targeted therapy. The anticancer activity of these cinnamon-derived fractions, whose major components (as assessed by UPLC–HRMS analysis) are procyanidins and other flavonoids, strictly correlates with their ability to induce apoptosis in cancer cell lines through ERK activation and the mitochondrial membrane potential impairment. Due to the severe side effects of cetuximab administration, our results suggest the use of nutrac...
Metabolite library built from NMR spectra for metabolomic analysis of leaves' hydroalcholic e... more Metabolite library built from NMR spectra for metabolomic analysis of leaves' hydroalcholic extract (80% MeOH) from wild mountain Mentha longifolia, using the Simple Mixture Analysis (SMA) tool implemented in MestreNova 14.1 software.
A panel of new potential Ras ligands was generated by decorating a tricyclic levoglucosenone-deri... more A panel of new potential Ras ligands was generated by decorating a tricyclic levoglucosenone-derived scaffold with aromatic moieties. Some members of the panel show in vitro inhibitory activity toward the nucleotide exchange process on Ras and are toxic to some human cancer cell lines.
There is a pressing need to identify biomarkers that are useful to monitor effects of expensive t... more There is a pressing need to identify biomarkers that are useful to monitor effects of expensive treatments such as i.v. alpha-1-antitrypsin (AAT) augmentation. We applied Nuclear Magnetic Resonance (NMR) spectroscopy to single , blinded samples of exhaled breath condensate (EBC) from 11 patients with moderate to severe emphysema and PiZZ- AAT deficiency and 11 spouse healthy controls. The spectral metabolomics profiles showed the presence of 20 to 25 metabolites such as propionic acid, acetate, butyrate, benzoate, butanediol, fatty acid, alanine, acetone, acetoin, ethanol, lactate and methanol which were common to both groups. However, the difference in the level of metabolites (4 to 300 fold, p PLS-DA analysis: 2D scores plot between the selected PCs.
Colorectal cancer (CRC) is the second-leading cause of cancer death, with a worldwide incidence r... more Colorectal cancer (CRC) is the second-leading cause of cancer death, with a worldwide incidence rate constantly increasing; thus, new strategies for its prevention or treatment are needed. Here, we describe the adjuvant effect of the polyphenol-enriched fractions of cinnamon, from cinnamon bark and buds, when co-administered with a potent anticancer drug, cetuximab, used for CRC therapy. The co-administration significantly reduces the cetuximab dose required for the antiproliferative activity against colorectal cancer cell line E705, which is sensitive to EGFR-targeted therapy. The anticancer activity of these cinnamon-derived fractions, whose major components (as assessed by UPLC–HRMS analysis) are procyanidins and other flavonoids, strictly correlates with their ability to induce apoptosis in cancer cell lines through ERK activation and the mitochondrial membrane potential impairment. Due to the severe side effects of cetuximab administration, our results suggest the use of nutrac...
Metabolite library built from NMR spectra for metabolomic analysis of leaves' hydroalcholic e... more Metabolite library built from NMR spectra for metabolomic analysis of leaves' hydroalcholic extract (80% MeOH) from wild mountain Mentha longifolia, using the Simple Mixture Analysis (SMA) tool implemented in MestreNova 14.1 software.
A panel of new potential Ras ligands was generated by decorating a tricyclic levoglucosenone-deri... more A panel of new potential Ras ligands was generated by decorating a tricyclic levoglucosenone-derived scaffold with aromatic moieties. Some members of the panel show in vitro inhibitory activity toward the nucleotide exchange process on Ras and are toxic to some human cancer cell lines.
There is a pressing need to identify biomarkers that are useful to monitor effects of expensive t... more There is a pressing need to identify biomarkers that are useful to monitor effects of expensive treatments such as i.v. alpha-1-antitrypsin (AAT) augmentation. We applied Nuclear Magnetic Resonance (NMR) spectroscopy to single , blinded samples of exhaled breath condensate (EBC) from 11 patients with moderate to severe emphysema and PiZZ- AAT deficiency and 11 spouse healthy controls. The spectral metabolomics profiles showed the presence of 20 to 25 metabolites such as propionic acid, acetate, butyrate, benzoate, butanediol, fatty acid, alanine, acetone, acetoin, ethanol, lactate and methanol which were common to both groups. However, the difference in the level of metabolites (4 to 300 fold, p PLS-DA analysis: 2D scores plot between the selected PCs.
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Papers by Cristina Airoldi