h i g h l i g h t s New formamidine ligands were synthesized and characterized. Their mixed oxala... more h i g h l i g h t s New formamidine ligands were synthesized and characterized. Their mixed oxalate Pd(II) complexes were also synthesized and characterized. The structures are geometrically optimized and the computed vibrations and transition are compared with the experimental. The cytotoxicity of the ligands and complexes were tested with promising IC 50 values. g r a p h i c a l a b s t r a c t A series of new ternary palladium(II) complexes of the type [Pd(L 1-4)ox]ÁxH 2 O where L = formamidine ligands and ox = oxalate, were synthesized and characterized by elemental analyses, magnetic susceptibility , UV-Vis, infrared (IR) and mass spectroscopy and thermal analysis. The spectroscopic data indicated that the formamidine ligands act as bidentate N2 donors and the oxalate as O2 ligand. Complex (1) HOMO-Molecular Orbitals Complex (1) LUMO-Molecular Orbitals-0.2346 a.u-0.133 a.u HOMO LUMO E=0.101 a b s t r a c t A series of new ternary palladium(II) complexes of the type [Pd(L 1-4)ox]ÁxH 2 O where L = formamidine ligands and ox = oxalate, were synthesized and characterized by elemental analyses, magnetic susceptibility , UV-Vis, infrared (IR) and mass spectroscopy and thermal analysis. The spectroscopic data indicated that the formamidine ligands act as bidentate N2 donors and the oxalate as O2 ligand. The complexes (1-4) are diamagnetic and the optimization of their structures indicated that the geometry is distorted square planer with O-Pd-O and N-Pd-N bond angles ranged 82.70-83.87°and 88.21-95.02°; respectively which is acceptable for the heteroleptic complexes. The dipole moment of the complexes (13.97-18.77 Debye) indicating that the complexes are more polarized than the ligands (1.93-4.96 Debye). The complexes are thermally stable as shown from their relatively higher overall activation energies (441-688 kJ mol À1). The ligands and the complexes are proved to have good cytotoxicity with IC 50 (lM) in the range of (0.011-0.168) against MCF-7, (0.012-0.150) against HCT-116, (0.042-0.094) against PC-3 and (0.006-0.222) against HepG-2 cell lines, which open the field for further application as antitumor compounds.
Mo(VI), and Mo(IV) complexes with two Schiff base ligands derived from salicylic acid hydrazide w... more Mo(VI), and Mo(IV) complexes with two Schiff base ligands derived from salicylic acid hydrazide with 4-dimethylaminobenzaldehyde and 4-Nitrobenzaldehyde have been prepared and characterized by several techniques: infrared and electronic spectra, magnetic susceptibility, molar conductance measurements, and the metal content in complexes are estimated by gravimetric analysis. Based on this study square pyramidal structure for Mo(IV) complexes and octahedral structure for the Mo(VI) complexes are proposed. The biological activity of these are studied against two strain gram +ve bacteria (Staphalococcus auras, P.aeruginosa) and two strain gram-ve bacteria (E.coli, Enterococcus) and yeast Candida albicans to assess their inhibiting potential. The results show the two ligands are inactive against Staphalococcus auras and they have moderate activity against the rest microbactrial organisms, the antimicrobial screening show that complex [MoO (Lb)2] exhibit the most activity against the two types of bacteria and the complex [MoO (La)2] exhibit the most activity against the yeast Candida albicans.
Mn(II), Mn(III), and Mn (IV) complexes with two Schiff base ligands derived from salicylic acid h... more Mn(II), Mn(III), and Mn (IV) complexes with two Schiff base ligands derived from salicylic acid hydrazide with 4-dimethylaminobenzaldehyde and 4-Nitrobenzaldehyde have been prepared and characterized by several techniques, including, infrared and electronic spectra, magnetic measurements, molar conductance measurements, and the metal content in complexes were estimated by gravimetric analysis. Based on these studies square pyramidal structure for Mn (III) complexes and octahedral structure for the Mn (II) and Mn (IV) complexes were proposed. The antimicrobial activity against two Strain Gram +ve bacteria (Staphalococcus auras, Enterococcus) and two Strain Gram-ve bacteria (E.coli, P.aeruginosa) and yeast Candida albicans to assess their inhibiting potential, the results showed all ligands and their complexes inactive against Staphalococcus auras and they have moderate activity against the rest microorganisms.
h i g h l i g h t s New formamidine ligands were synthesized and characterized. Their mixed oxala... more h i g h l i g h t s New formamidine ligands were synthesized and characterized. Their mixed oxalate Pd(II) complexes were also synthesized and characterized. The structures are geometrically optimized and the computed vibrations and transition are compared with the experimental. The cytotoxicity of the ligands and complexes were tested with promising IC 50 values. g r a p h i c a l a b s t r a c t A series of new ternary palladium(II) complexes of the type [Pd(L 1-4)ox]ÁxH 2 O where L = formamidine ligands and ox = oxalate, were synthesized and characterized by elemental analyses, magnetic susceptibility , UV-Vis, infrared (IR) and mass spectroscopy and thermal analysis. The spectroscopic data indicated that the formamidine ligands act as bidentate N2 donors and the oxalate as O2 ligand. Complex (1) HOMO-Molecular Orbitals Complex (1) LUMO-Molecular Orbitals-0.2346 a.u-0.133 a.u HOMO LUMO E=0.101 a b s t r a c t A series of new ternary palladium(II) complexes of the type [Pd(L 1-4)ox]ÁxH 2 O where L = formamidine ligands and ox = oxalate, were synthesized and characterized by elemental analyses, magnetic susceptibility , UV-Vis, infrared (IR) and mass spectroscopy and thermal analysis. The spectroscopic data indicated that the formamidine ligands act as bidentate N2 donors and the oxalate as O2 ligand. The complexes (1-4) are diamagnetic and the optimization of their structures indicated that the geometry is distorted square planer with O-Pd-O and N-Pd-N bond angles ranged 82.70-83.87°and 88.21-95.02°; respectively which is acceptable for the heteroleptic complexes. The dipole moment of the complexes (13.97-18.77 Debye) indicating that the complexes are more polarized than the ligands (1.93-4.96 Debye). The complexes are thermally stable as shown from their relatively higher overall activation energies (441-688 kJ mol À1). The ligands and the complexes are proved to have good cytotoxicity with IC 50 (lM) in the range of (0.011-0.168) against MCF-7, (0.012-0.150) against HCT-116, (0.042-0.094) against PC-3 and (0.006-0.222) against HepG-2 cell lines, which open the field for further application as antitumor compounds.
Mo(VI), and Mo(IV) complexes with two Schiff base ligands derived from salicylic acid hydrazide w... more Mo(VI), and Mo(IV) complexes with two Schiff base ligands derived from salicylic acid hydrazide with 4-dimethylaminobenzaldehyde and 4-Nitrobenzaldehyde have been prepared and characterized by several techniques: infrared and electronic spectra, magnetic susceptibility, molar conductance measurements, and the metal content in complexes are estimated by gravimetric analysis. Based on this study square pyramidal structure for Mo(IV) complexes and octahedral structure for the Mo(VI) complexes are proposed. The biological activity of these are studied against two strain gram +ve bacteria (Staphalococcus auras, P.aeruginosa) and two strain gram-ve bacteria (E.coli, Enterococcus) and yeast Candida albicans to assess their inhibiting potential. The results show the two ligands are inactive against Staphalococcus auras and they have moderate activity against the rest microbactrial organisms, the antimicrobial screening show that complex [MoO (Lb)2] exhibit the most activity against the two types of bacteria and the complex [MoO (La)2] exhibit the most activity against the yeast Candida albicans.
Mn(II), Mn(III), and Mn (IV) complexes with two Schiff base ligands derived from salicylic acid h... more Mn(II), Mn(III), and Mn (IV) complexes with two Schiff base ligands derived from salicylic acid hydrazide with 4-dimethylaminobenzaldehyde and 4-Nitrobenzaldehyde have been prepared and characterized by several techniques, including, infrared and electronic spectra, magnetic measurements, molar conductance measurements, and the metal content in complexes were estimated by gravimetric analysis. Based on these studies square pyramidal structure for Mn (III) complexes and octahedral structure for the Mn (II) and Mn (IV) complexes were proposed. The antimicrobial activity against two Strain Gram +ve bacteria (Staphalococcus auras, Enterococcus) and two Strain Gram-ve bacteria (E.coli, P.aeruginosa) and yeast Candida albicans to assess their inhibiting potential, the results showed all ligands and their complexes inactive against Staphalococcus auras and they have moderate activity against the rest microorganisms.
Uploads
Papers by Othman I B R A H I M Alajrawy