Journal of Pharmaceutical and Biomedical Analysis, 2010
The use of 2,5-dimethyl-1H-pyrrole-3,4-dicarbaldehyde as a precolumn derivatization reagent for H... more The use of 2,5-dimethyl-1H-pyrrole-3,4-dicarbaldehyde as a precolumn derivatization reagent for HPLC analysis of amino acids is proposed. The compound reacts under mild conditions (10min at ambient temperature) with primary amino groups. The derivatization conditions to obtain quantitative reaction were optimised by considering different parameters (temperature, pH and reagent concentration) using l-Val as the model compound. The synthesized l-Val derivative was characterized by (1)H NMR and UV. The derivatives of 19 amino acids were separated by reversed-phase HPLC and detected at lambda=320nm. The method was applied successfully to the qualitative and quantitative analysis of commercial polyamino acid preparations.
Collection of Czechoslovak Chemical Communications, 1991
A series of 5-haloimidazo[2,1-b]thiazoles, related to 5-bromo-6-phenylimidazo[2,1-b]thiazole XIII... more A series of 5-haloimidazo[2,1-b]thiazoles, related to 5-bromo-6-phenylimidazo[2,1-b]thiazole XIII,was prepared and tested for their herbicidal activity against seven species of plants.
Starting from the potent inhibitory effect of the previously described 2-methyl-6-(2-thienyl) imi... more Starting from the potent inhibitory effect of the previously described 2-methyl-6-(2-thienyl) imidazo [2, 1-b] thiazole on mitochondrial complex I, we prepared a series of derivatives in order to study the effect of a different substitution at the positions 2, 5 and 6. The replacement of the thienyl group at position 6 with a phenyl group does not modify the biological behaviour of the lead compound, whereas the shift of the methyl group from position 2 to position 5 yields a compound devoid of inhibitory effects. In both the 6-thienyl ...
Journal of Pharmaceutical and Biomedical Analysis, 2010
The use of 2,5-dimethyl-1H-pyrrole-3,4-dicarbaldehyde as a precolumn derivatization reagent for H... more The use of 2,5-dimethyl-1H-pyrrole-3,4-dicarbaldehyde as a precolumn derivatization reagent for HPLC analysis of amino acids is proposed. The compound reacts under mild conditions (10min at ambient temperature) with primary amino groups. The derivatization conditions to obtain quantitative reaction were optimised by considering different parameters (temperature, pH and reagent concentration) using l-Val as the model compound. The synthesized l-Val derivative was characterized by (1)H NMR and UV. The derivatives of 19 amino acids were separated by reversed-phase HPLC and detected at lambda=320nm. The method was applied successfully to the qualitative and quantitative analysis of commercial polyamino acid preparations.
Collection of Czechoslovak Chemical Communications, 1991
A series of 5-haloimidazo[2,1-b]thiazoles, related to 5-bromo-6-phenylimidazo[2,1-b]thiazole XIII... more A series of 5-haloimidazo[2,1-b]thiazoles, related to 5-bromo-6-phenylimidazo[2,1-b]thiazole XIII,was prepared and tested for their herbicidal activity against seven species of plants.
Starting from the potent inhibitory effect of the previously described 2-methyl-6-(2-thienyl) imi... more Starting from the potent inhibitory effect of the previously described 2-methyl-6-(2-thienyl) imidazo [2, 1-b] thiazole on mitochondrial complex I, we prepared a series of derivatives in order to study the effect of a different substitution at the positions 2, 5 and 6. The replacement of the thienyl group at position 6 with a phenyl group does not modify the biological behaviour of the lead compound, whereas the shift of the methyl group from position 2 to position 5 yields a compound devoid of inhibitory effects. In both the 6-thienyl ...
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