Clostridium difficile infection (CDI) is a toxin-mediated disease. Oncology patients are at incre... more Clostridium difficile infection (CDI) is a toxin-mediated disease. Oncology patients are at increased risk for developing CDI. Diagnosis of CDI by PCR has led to misclassification of some C. difficile carriers as CDI cases. We determined if an optimized C. difficile PCR cycle threshold value (CT) could reliably predict presence of free toxin, and in turn improve the utility of PCR in detecting clinically relevant CDI in oncology patients. 183 consecutive patients positive for C. difficile by the Xpert C. difficile were additionally tested using the cell culture cytotoxicity neutralization assay (CYT) and enzyme immunoassays (EIA). CT values at diagnosis and relevant clinical information were recorded. Receiver operating characteristic (ROC) curve was used to assess predictive validity and to find optimal CT for CYT positive cases. Severity of CDI was assessed by blinded charts review. Using CYT as the reference, ROC-derived Youden cut-off CT of 28.0 predicted 77% cytotoxin positive ...
Archivos De Bronconeumologia Organo Oficial De La Sociedad Espanola De Neumologia Y Cirugia Toracica Separ Y La Asociacion Latinoamericana De Torax, 2003
Downloadable! Marketing literature suggests that consumer perceptions of corporate social respons... more Downloadable! Marketing literature suggests that consumer perceptions of corporate social responsibility's actions and programs could improve the image and the reputation of the firms. However, little is known about the issue. Hence to find it out, drawing from recent theoretical ...
Clostridium difficile infection (CDI) is a toxin-mediated disease. Oncology patients are at incre... more Clostridium difficile infection (CDI) is a toxin-mediated disease. Oncology patients are at increased risk for developing CDI. Diagnosis of CDI by PCR has led to misclassification of some C. difficile carriers as CDI cases. We determined if an optimized C. difficile PCR cycle threshold value (CT) could reliably predict presence of free toxin, and in turn improve the utility of PCR in detecting clinically relevant CDI in oncology patients. 183 consecutive patients positive for C. difficile by the Xpert C. difficile were additionally tested using the cell culture cytotoxicity neutralization assay (CYT) and enzyme immunoassays (EIA). CT values at diagnosis and relevant clinical information were recorded. Receiver operating characteristic (ROC) curve was used to assess predictive validity and to find optimal CT for CYT positive cases. Severity of CDI was assessed by blinded charts review. Using CYT as the reference, ROC-derived Youden cut-off CT of 28.0 predicted 77% cytotoxin positive ...
Archivos De Bronconeumologia Organo Oficial De La Sociedad Espanola De Neumologia Y Cirugia Toracica Separ Y La Asociacion Latinoamericana De Torax, 2003
Downloadable! Marketing literature suggests that consumer perceptions of corporate social respons... more Downloadable! Marketing literature suggests that consumer perceptions of corporate social responsibility's actions and programs could improve the image and the reputation of the firms. However, little is known about the issue. Hence to find it out, drawing from recent theoretical ...
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