Retinol is lipid soluble vitamin widely used during pregnancy as a food supplement.The study has ... more Retinol is lipid soluble vitamin widely used during pregnancy as a food supplement.The study has been conducted in Animal House/Faculty of Sciences/University of Kufa between December 2021 and February 2022, fifteen female Albino Rats are used. The present study has been intended to show the histolopathologiacl effects of retinol on blastocyst implantation in female Albino Rats. The females Rats are randomly divided into three main groups, comprising five rats for each group. The control group is given orally injection of physiological normal saline and the second and third group are given orally injection of retinol doses ten, twenty μcg/kg/day respectively for seven days from the first day to the end of experimental allocated for each female.The rats are sacrificed in 7 th (dpc) to study the implantation of embryos in decidual tissues. Retinol doses ten, twenty μcg/kg/day caused macroscopic malformations in embryos of female rats compare to control group. The histopathlogical stu...
Vitamin A is lipid soluble vitamin widely used during pregnancy as a food supplement. The study h... more Vitamin A is lipid soluble vitamin widely used during pregnancy as a food supplement. The study has been conducted in Animal House/Faculty of Sciences/University of Kufa between December 2021 and February 2022, thirty female Albino Rats are used. The present study has been intended to show the teratogenic effects of Vitamin A on embryos in female Albino Rats. The females Rats are randomly divided into four main groups,The first and second control groups are given orally injection of physiological normal saline and the third group 15th (dpc) are given orally injection of vitamin A doses ten, twenty μcg/kg/day respectively for fifteen days from the first day to the end of experimental allocated for each female. The fouth group 20 th (dpc) are given orally injection of vitamin A doses ten, twenty μcg/kg/day respectively for tewnty days from the first day to the end of experimental allocated for each female. The rats are sacrificed in 15,20 th (dpc) to study the teratogenic effects on e...
Ginger (Zingiber officinalis) is one of the frequently used spices in the world and medicinal pla... more Ginger (Zingiber officinalis) is one of the frequently used spices in the world and medicinal plant, which has been used all over the world. This study was designed to investigate the role of aqueous ginger extract to inhibit the genotoxicity of methotrexate (MTX) in female albino mice by using these parameters: mitotic index (MI), chromosome aberrations (CA) and micronuclei formation (MNPCE) in somatic cells (bone marrow). The cytological protection of aqueous ginger extract (AGE) was performed at doses (25, 50) mg \ kg against MTX effects (0.5) mg/kg for three weeks exposure. The results revealed the high inhibitory effects of MTX for cell division in addition to induction of chromosome aberration with micronuclei formation, the absence of cytotoxicity for AGE at tested doses, and the inhibitory efficiency of AGE against the toxicity and mutagenicity of MTX, specially at the dose 50 mg\kg. From the results we can concluded that the AGE has a promising role in the protection of som...
Breast Cancer occurs as a result of mutations, or abnormal changes, in the genes responsible for ... more Breast Cancer occurs as a result of mutations, or abnormal changes, in the genes responsible for regulating the growth of cells and keeping them healthy. Cells that have been mutated gain the ability to keep dividing without control or order, producing more cells and forming a tumor.This study is designed to investigate the hormonal and histopathological changes that take place in breast cancer cells in patients who undergone surgery for breast tumour removal in Al sader hospital at Al najaf governate between the period of January 2012 and December 2013.The study examines the role of hormone Estrogen and progesterone in breast cancer patients to outline the involvement of such hormones and study their impact on cellular changes in breast cells. Furthermore the study investigates the histological changes that take place in breast cancer cells in patients suffering from breast cancer in Al najaf governate. A total of 60 female participants ageing between 30-90 years have been identifi...
s The study was conducted on 60 patients and 30 healthy as control group to determine the influen... more s The study was conducted on 60 patients and 30 healthy as control group to determine the influences of infected with Giardia lamblia on levels of p-selectin, ferritin and IL-5, patient infected with G. lamblia in compared with healthy group. Who have visited Al-Sadder medical city and Al-Hakeem Hospital in AlNajaf AL-Ashraf Province during the period from October, 2015 till March 2016. Diagnosis infection with this parasite by using the wet amount microscope for stool from patients. The results showed significant increase (P<0.05) in p-selectin and IL-5 in G. lamblia infection patients in compared to control group. Whereas the results showed a significant decrease (P<0.05) in serum concentration of ferritin in G. lamblia infection patients in compared to control group. Key word: Giardia lamblia, P-selectin, ferritin, IL-5 INTRODUCTION Giardia lamblia is a pathogenic protozoan that colonizes in the small intestine of humans which attachment strongly to the host intestine and c...
This study amid to evaluated of some biomarker such as Lactferrin, ferritin and iron in male infe... more This study amid to evaluated of some biomarker such as Lactferrin, ferritin and iron in male infected with Giardia lamblia in compared with control group. From 30 healthy male and 60 out patients stool samples were collected and diagnosis this parasite by using the wet amount microscope who have visited Al-Sadder teaching and Al-Hakeem Hospital in AlNajaf Province during the period from August till march 2015. also serum sample collected from the same patients and control to estimated the Lactferrin, iron and ferritin. Results of study recorded significant decrease (P<0.05) in Lactferrin, iron and ferritin in G. lamblia infection patients in compared to control group.
The present study was conducted on 60 patients and 30 healthy persons (17 male and 13 female) to ... more The present study was conducted on 60 patients and 30 healthy persons (17 male and 13 female) to determine the effects of scabies disease in some immunological biomarkers it was IL-8, IL-5 and IgE levels. The results of the current study showed a significantly elevated (P<0.05) in level of IL-8, in patients infested with Sarcoptes scabiei parasite in 356.047 ± 0.201pg /ml in compared to the control group 240.815 ± 0.081pg /ml, also serum concentration of IL-5 was significantly increased (P<0.05) in Sarcoptes scabiei infection patients which were 42.128 ±0.415pg /ml in compared to the control group 14.512 ± 0.021pg /ml, whereas the level of IgE in patients was 401.654 ±0.618pg /ml)in compared to the control group 179.092 ± 0.109ng /ml. The current study concluded that the infection with Sarcoptes scabiei was affected in some immunological biomarkers of human represent by IL8, IL-5 and IgE. Key word: Scabies, IgE, IL-5, IL-8, Sarcoptes scabie
The current study included forty Iraqi female patients suffered from breast carcinoma were age ... more The current study included forty Iraqi female patients suffered from breast carcinoma were age varied from 34-75 years old, diagnosed through the period from 19 January 2019 to 7 April 2021. In present study used paraffin-embedded of female breast carcinoma sections have been confirmed histological diagnosis such as tumor size, differentiation degree and types of invasive breast cancers after reviewing all slides by specialist pathologists from different centers in AL-Najaf province. Cross sectional study of immunohistochemical expression of biomarker protein P53 (P53) positive and negative females with invasive breast cancers that have been conducted in Middle Euphrates Unit for Cancer Researches / University of Kufa . The highest percentage of P53 over expression was (12.5%) at age (50-59), while the lowest percentage found in age less than 40 years. The results obtained from the present study showed that there was significant difference (p<0.05) between P53 overexpression...
One of the most world anti parasitic and antibacterial compound used is Metronidazole (MTZ),all D... more One of the most world anti parasitic and antibacterial compound used is Metronidazole (MTZ),all Drugtoxicity must be acceptable to relief patients and should cause less harm to human than infection itself.MTZ is potentially genotoxic to humans due to the following facts: it is a proven toxogenic to human cellsas well as wide range of side effects including chromosomal aberration and reproductive toxicity. The studyis designed to assess the cytotoxic and reproductive toxicity effects of two dose of MTZ (250 mg/kg b.wtgroup and 500 mg/kg b.wt group) orally by gavage for 30 days and compared with control group (givennormal saline) and then examine chromosomes from bone marrow cells and testicular gametogenic activityof adult male albino rats.Evident toxicity of both treatments of MTZ groups on chromosomal aberration (fragment, deletion and ringchromosome),with increased number of polyploid cells which were significantly increased (P< 0.05) by doseand time compared with control group...
The study was designed to conducted sixty out patients and thirty healthy people to investigate t... more The study was designed to conducted sixty out patients and thirty healthy people to investigate the impact of Giardia lamblia infection on serum levels of lactoferrin, prostaglandin E2, iron and ferritin in patients infected with this intestinal parasite in compared with healthy group, Who've visited Al-Sadder medical city and Al-Hakeem Hospital in AlNajaf province all through the duration from October 2016 until April 2017. The results displayed significant increase (P<0.05) in levels of prostaglandin E2. While decrease in levels of lactoferrin, iron and ferritin in patients infected with G. lamblia in compared to control group.
Follistatin (FST) is glycoprotein, otherwise called activin restricting protein, is an endogenous... more Follistatin (FST) is glycoprotein, otherwise called activin restricting protein, is an endogenously created protein that ties activin A with high fondness and restrains its bioactivity. The essential capacity of FST is the authoritative and bioneutralization of individuals from the TGF-β superfamily and activin A specifically. FST advances adipogenic separation of begetter cells. FST has been embroiled in aggravation and renovating, any adjustment in the level of FST, which might be a determinant of the seriousness of irritation, or tissue phenotypic change. Atherosclerosis is a dynamical procedure that rises up out of the interchange between lipid digestion, irritation and inborn insusceptibility. The blood vessel area of atherosclerosis makes it strategically and morally hard to think about in vivo. To enhance our comprehension of the infection, we should discover elective approaches to research its movement. The points of this investigation; we need to know the connection between...
Retinol is lipid soluble vitamin widely used during pregnancy as a food supplement.The study has ... more Retinol is lipid soluble vitamin widely used during pregnancy as a food supplement.The study has been conducted in Animal House/Faculty of Sciences/University of Kufa between December 2021 and February 2022, fifteen female Albino Rats are used. The present study has been intended to show the histolopathologiacl effects of retinol on blastocyst implantation in female Albino Rats. The females Rats are randomly divided into three main groups, comprising five rats for each group. The control group is given orally injection of physiological normal saline and the second and third group are given orally injection of retinol doses ten, twenty μcg/kg/day respectively for seven days from the first day to the end of experimental allocated for each female.The rats are sacrificed in 7 th (dpc) to study the implantation of embryos in decidual tissues. Retinol doses ten, twenty μcg/kg/day caused macroscopic malformations in embryos of female rats compare to control group. The histopathlogical stu...
Vitamin A is lipid soluble vitamin widely used during pregnancy as a food supplement. The study h... more Vitamin A is lipid soluble vitamin widely used during pregnancy as a food supplement. The study has been conducted in Animal House/Faculty of Sciences/University of Kufa between December 2021 and February 2022, thirty female Albino Rats are used. The present study has been intended to show the teratogenic effects of Vitamin A on embryos in female Albino Rats. The females Rats are randomly divided into four main groups,The first and second control groups are given orally injection of physiological normal saline and the third group 15th (dpc) are given orally injection of vitamin A doses ten, twenty μcg/kg/day respectively for fifteen days from the first day to the end of experimental allocated for each female. The fouth group 20 th (dpc) are given orally injection of vitamin A doses ten, twenty μcg/kg/day respectively for tewnty days from the first day to the end of experimental allocated for each female. The rats are sacrificed in 15,20 th (dpc) to study the teratogenic effects on e...
Ginger (Zingiber officinalis) is one of the frequently used spices in the world and medicinal pla... more Ginger (Zingiber officinalis) is one of the frequently used spices in the world and medicinal plant, which has been used all over the world. This study was designed to investigate the role of aqueous ginger extract to inhibit the genotoxicity of methotrexate (MTX) in female albino mice by using these parameters: mitotic index (MI), chromosome aberrations (CA) and micronuclei formation (MNPCE) in somatic cells (bone marrow). The cytological protection of aqueous ginger extract (AGE) was performed at doses (25, 50) mg \ kg against MTX effects (0.5) mg/kg for three weeks exposure. The results revealed the high inhibitory effects of MTX for cell division in addition to induction of chromosome aberration with micronuclei formation, the absence of cytotoxicity for AGE at tested doses, and the inhibitory efficiency of AGE against the toxicity and mutagenicity of MTX, specially at the dose 50 mg\kg. From the results we can concluded that the AGE has a promising role in the protection of som...
Breast Cancer occurs as a result of mutations, or abnormal changes, in the genes responsible for ... more Breast Cancer occurs as a result of mutations, or abnormal changes, in the genes responsible for regulating the growth of cells and keeping them healthy. Cells that have been mutated gain the ability to keep dividing without control or order, producing more cells and forming a tumor.This study is designed to investigate the hormonal and histopathological changes that take place in breast cancer cells in patients who undergone surgery for breast tumour removal in Al sader hospital at Al najaf governate between the period of January 2012 and December 2013.The study examines the role of hormone Estrogen and progesterone in breast cancer patients to outline the involvement of such hormones and study their impact on cellular changes in breast cells. Furthermore the study investigates the histological changes that take place in breast cancer cells in patients suffering from breast cancer in Al najaf governate. A total of 60 female participants ageing between 30-90 years have been identifi...
s The study was conducted on 60 patients and 30 healthy as control group to determine the influen... more s The study was conducted on 60 patients and 30 healthy as control group to determine the influences of infected with Giardia lamblia on levels of p-selectin, ferritin and IL-5, patient infected with G. lamblia in compared with healthy group. Who have visited Al-Sadder medical city and Al-Hakeem Hospital in AlNajaf AL-Ashraf Province during the period from October, 2015 till March 2016. Diagnosis infection with this parasite by using the wet amount microscope for stool from patients. The results showed significant increase (P<0.05) in p-selectin and IL-5 in G. lamblia infection patients in compared to control group. Whereas the results showed a significant decrease (P<0.05) in serum concentration of ferritin in G. lamblia infection patients in compared to control group. Key word: Giardia lamblia, P-selectin, ferritin, IL-5 INTRODUCTION Giardia lamblia is a pathogenic protozoan that colonizes in the small intestine of humans which attachment strongly to the host intestine and c...
This study amid to evaluated of some biomarker such as Lactferrin, ferritin and iron in male infe... more This study amid to evaluated of some biomarker such as Lactferrin, ferritin and iron in male infected with Giardia lamblia in compared with control group. From 30 healthy male and 60 out patients stool samples were collected and diagnosis this parasite by using the wet amount microscope who have visited Al-Sadder teaching and Al-Hakeem Hospital in AlNajaf Province during the period from August till march 2015. also serum sample collected from the same patients and control to estimated the Lactferrin, iron and ferritin. Results of study recorded significant decrease (P<0.05) in Lactferrin, iron and ferritin in G. lamblia infection patients in compared to control group.
The present study was conducted on 60 patients and 30 healthy persons (17 male and 13 female) to ... more The present study was conducted on 60 patients and 30 healthy persons (17 male and 13 female) to determine the effects of scabies disease in some immunological biomarkers it was IL-8, IL-5 and IgE levels. The results of the current study showed a significantly elevated (P<0.05) in level of IL-8, in patients infested with Sarcoptes scabiei parasite in 356.047 ± 0.201pg /ml in compared to the control group 240.815 ± 0.081pg /ml, also serum concentration of IL-5 was significantly increased (P<0.05) in Sarcoptes scabiei infection patients which were 42.128 ±0.415pg /ml in compared to the control group 14.512 ± 0.021pg /ml, whereas the level of IgE in patients was 401.654 ±0.618pg /ml)in compared to the control group 179.092 ± 0.109ng /ml. The current study concluded that the infection with Sarcoptes scabiei was affected in some immunological biomarkers of human represent by IL8, IL-5 and IgE. Key word: Scabies, IgE, IL-5, IL-8, Sarcoptes scabie
The current study included forty Iraqi female patients suffered from breast carcinoma were age ... more The current study included forty Iraqi female patients suffered from breast carcinoma were age varied from 34-75 years old, diagnosed through the period from 19 January 2019 to 7 April 2021. In present study used paraffin-embedded of female breast carcinoma sections have been confirmed histological diagnosis such as tumor size, differentiation degree and types of invasive breast cancers after reviewing all slides by specialist pathologists from different centers in AL-Najaf province. Cross sectional study of immunohistochemical expression of biomarker protein P53 (P53) positive and negative females with invasive breast cancers that have been conducted in Middle Euphrates Unit for Cancer Researches / University of Kufa . The highest percentage of P53 over expression was (12.5%) at age (50-59), while the lowest percentage found in age less than 40 years. The results obtained from the present study showed that there was significant difference (p<0.05) between P53 overexpression...
One of the most world anti parasitic and antibacterial compound used is Metronidazole (MTZ),all D... more One of the most world anti parasitic and antibacterial compound used is Metronidazole (MTZ),all Drugtoxicity must be acceptable to relief patients and should cause less harm to human than infection itself.MTZ is potentially genotoxic to humans due to the following facts: it is a proven toxogenic to human cellsas well as wide range of side effects including chromosomal aberration and reproductive toxicity. The studyis designed to assess the cytotoxic and reproductive toxicity effects of two dose of MTZ (250 mg/kg b.wtgroup and 500 mg/kg b.wt group) orally by gavage for 30 days and compared with control group (givennormal saline) and then examine chromosomes from bone marrow cells and testicular gametogenic activityof adult male albino rats.Evident toxicity of both treatments of MTZ groups on chromosomal aberration (fragment, deletion and ringchromosome),with increased number of polyploid cells which were significantly increased (P< 0.05) by doseand time compared with control group...
The study was designed to conducted sixty out patients and thirty healthy people to investigate t... more The study was designed to conducted sixty out patients and thirty healthy people to investigate the impact of Giardia lamblia infection on serum levels of lactoferrin, prostaglandin E2, iron and ferritin in patients infected with this intestinal parasite in compared with healthy group, Who've visited Al-Sadder medical city and Al-Hakeem Hospital in AlNajaf province all through the duration from October 2016 until April 2017. The results displayed significant increase (P<0.05) in levels of prostaglandin E2. While decrease in levels of lactoferrin, iron and ferritin in patients infected with G. lamblia in compared to control group.
Follistatin (FST) is glycoprotein, otherwise called activin restricting protein, is an endogenous... more Follistatin (FST) is glycoprotein, otherwise called activin restricting protein, is an endogenously created protein that ties activin A with high fondness and restrains its bioactivity. The essential capacity of FST is the authoritative and bioneutralization of individuals from the TGF-β superfamily and activin A specifically. FST advances adipogenic separation of begetter cells. FST has been embroiled in aggravation and renovating, any adjustment in the level of FST, which might be a determinant of the seriousness of irritation, or tissue phenotypic change. Atherosclerosis is a dynamical procedure that rises up out of the interchange between lipid digestion, irritation and inborn insusceptibility. The blood vessel area of atherosclerosis makes it strategically and morally hard to think about in vivo. To enhance our comprehension of the infection, we should discover elective approaches to research its movement. The points of this investigation; we need to know the connection between...
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