Akut faz yanitinin olcumu, hastaliklarin tani ve takibinde bize yardimci olmaktadir. Bu olcumler ... more Akut faz yanitinin olcumu, hastaliklarin tani ve takibinde bize yardimci olmaktadir. Bu olcumler icinde de Eritrosit Sedimentasyon Hizi (ESH) yaygin olarak kullanilan bir tetkikdir. ESH’yi eritrositlerdeki rulo olusumu ya da kume olusumu belirler ve bu olusumlari etkileyen baslica faktorler fibrinojen, α2, β ve γ globundir. Ayrica; eritrositlerle plazma arasindaki oran, plazma vizkozitesi, sedimantasyon tupu ile ilgili durumlar, kullanilan antikoagulan ve oda isisi da ESH’yi etkiler. ESH; gebelik, menstruasyon ve yaslilik gibi fizyolojik durumlarda yukselebilecegi gibi, patolojik bircok durumda da yukselebilir. ESH tipki nabiz ve vucut isisi gibi genel bilgi verir; ciddi hastaliklarin cogunda yukselir, ancak normalde kalabilir. Bu derlemede ESH’nin tanimi, olcum metodlari, etkileyen faktorleri ve klinikte kullanimi hakkinda pratik basvuru kaynagi sunmak amaclanmistir
Although paracetamol and diclofenac sodium are most commonly used drugs and considered as safe, t... more Although paracetamol and diclofenac sodium are most commonly used drugs and considered as safe, they are also frequently become a current issue with complications in therapeutic doses or overdose situations. Both drugs can cause bleeding disorders as a result of platelet dysfunction and can be presented as an atypical clinical situation such as subconjunctival hemorrhage. In these presented cases, the subconjunctival hemorrhage seen after ingestion of paracetamol and diclofenac sodium in toxic doses for the purpose of suicide, is considered as related with the bleeding disorder that is associated with drug side effect. For these patients who do not have any known co-morbidities, the reasons that can cause subconjunctival hemorrhage other than drugs such as trauma, infections, thrombocytopenia, malignant blood disorders, septicemia, hypertension, severe cough are excluded. Although hepatic and renal toxicities are commonly known side effects that are related with high doses of these ...
Woodhouse-Sakati Syndrome (WSS) is a rare autosomal recessive syndrome characterized by sensorine... more Woodhouse-Sakati Syndrome (WSS) is a rare autosomal recessive syndrome characterized by sensorineural hearing loss, ECG ST-T changes, partial alopecia, hypogonadism, diabetes, and moderate mental retardation. A 23-year-old male patient was admitted to our hospital with complaints of purpura and petechial rashes. His platelet count was 3.04 x 109/L and the peripheral blood smear was compatible with this count. No atypical cell was observed. He had mild mental retardation. He had hearing loss since childhood. Physical examination showed widespread petechiae and purpura on bilateral lower extremities. Significant growth retardation was detected and male pattern hair growth was less. In genital examination, bilateral testicles were small; penis length was 1 cm and it was 4 cm when elongated. T negativity was present in precordial derivations of ECG. He was diagnosed Immune thrombocytopenic purpura (ITP) and WSS according to these findings. In addition to ITP treatment with steroids, the...
Measuring acute phase response helps us diagnose and follow up diseases. Erythrocytes Sedimentati... more Measuring acute phase response helps us diagnose and follow up diseases. Erythrocytes Sedimentation Rate (ESR) among those measurements is a biochemical method which is commonly used. Roll formation or clustering of erythrocytes determines of sedimentation rate, and main factors affecting those events are fibrinogen, α2, β and γ globins. Moreover, some conditions such as ratio between plasma and erythrocytes, plasma viscosity, tube used for measuring in sedimentation rate, room temperature and anti-coagulant agent used affect Erythrocyte sedimentation rate measurement. It can be elevated in several pathological conditions as well as in pregnancy, senility and menstruation. ESH gives general idea or information as pulse and body temperature do; it is elevated in several severe diseases, it can be course in normal levels. In this review, it was aimed to present its use of clinical practice, definition, measurement methods, and factors affecting ESH.
Kaya, Ertugrul/0000-0003-0081-682XWOS: 000330151200043Aims: To determine the effects of diabetes ... more Kaya, Ertugrul/0000-0003-0081-682XWOS: 000330151200043Aims: To determine the effects of diabetes mellitus (DM) treatment regimens on malignancy. Methods: Six hundred fifty-five DM patients were enrolled. Patients receiving diabetes therapies for at least one year were retrospectively assessed with physical examination, detailed medical, habits, demographic characteristics and laboratory tests, and divided into two groups according to the diabetes treatment type (using oral agent or insulin and using metformin or not). Insulin users were grouped according to insulin regimens (intensive, basal and mixed) and to the insulin type (glargine, detemir, human insulin, biphasic analogue). Cancer cases were identified at the first visit. Results: Among 655 DM patients 13 (2%) were Type 1 DM, 642 (98%) were Type 2 DM; 379 (58%) were female, 276 (42%) were male. Thirty-sir cancers and 76 benign tumors were observed. Patients with and without a cancer were compared for diabetes treatment regimen...
Kaya, Ertugrul/0000-0003-0081-682XWOS: 000330151200043Aims: To determine the effects of diabetes ... more Kaya, Ertugrul/0000-0003-0081-682XWOS: 000330151200043Aims: To determine the effects of diabetes mellitus (DM) treatment regimens on malignancy. Methods: Six hundred fifty-five DM patients were enrolled. Patients receiving diabetes therapies for at least one year were retrospectively assessed with physical examination, detailed medical, habits, demographic characteristics and laboratory tests, and divided into two groups according to the diabetes treatment type (using oral agent or insulin and using metformin or not). Insulin users were grouped according to insulin regimens (intensive, basal and mixed) and to the insulin type (glargine, detemir, human insulin, biphasic analogue). Cancer cases were identified at the first visit. Results: Among 655 DM patients 13 (2%) were Type 1 DM, 642 (98%) were Type 2 DM; 379 (58%) were female, 276 (42%) were male. Thirty-sir cancers and 76 benign tumors were observed. Patients with and without a cancer were compared for diabetes treatment regimen...
Amaç: Behçet hastalığı (BH)’nın doğal seyri sırasında ya da kullanılan ilaçlara bağlı olarak oste... more Amaç: Behçet hastalığı (BH)’nın doğal seyri sırasında ya da kullanılan ilaçlara bağlı olarak osteoporoz gelişebilir. Çalışmanın amacı BH’nda osteoprotegerin ve tümor nekroz faktör (TNF-?) düzeyleri ve bunlar arasındaki korelasyonu araştırmaktır. Gereç ve yöntem: Çalışmaya, hasta grubu ve kontrol grubu olarak iki grup alındı. TNF-?, osteoprotegerin, osteokalsin, sedimantasyon, CRP, idrar kreatin ve deoksipridinolin düzeyleri ile beraber kemik mineral dansitometrisi (KMD) ölçüldü ve iki grup karşılaştırıldı. Bulgular: Çalışma grubuna 41 hasta, kontrol grubuna 36 hasta alındı. Çalışma ve kontrol grubunun yaş ortalaması sırasıyla 42.2611.64 ve 41.6670.99 bulundu. Vücut kitle indeksi yönünden iki grup arasında fark bulunmadı. TNF-? (p0.001), deokspiridinolin (p0.001) ve osteokalsin (p0.041) düzeyleri kontrol grubundan önemli oranda yüksek bulundu. Osteoprotogerin düzeyi hasta grubunda düşüktü ancak anlamlı düzeyde değildi (p0.05). İdrar deoxypyridinoline/ idrar kreatinin oranı hasta grub...
Amaç: Behçet hastalığı (BH)’nın doğal seyri sırasında ya da kullanılan ilaçlara bağlı olarak oste... more Amaç: Behçet hastalığı (BH)’nın doğal seyri sırasında ya da kullanılan ilaçlara bağlı olarak osteoporoz gelişebilir. Çalışmanın amacı BH’nda osteoprotegerin ve tümor nekroz faktör (TNF-?) düzeyleri ve bunlar arasındaki korelasyonu araştırmaktır. Gereç ve yöntem: Çalışmaya, hasta grubu ve kontrol grubu olarak iki grup alındı. TNF-?, osteoprotegerin, osteokalsin, sedimantasyon, CRP, idrar kreatin ve deoksipridinolin düzeyleri ile beraber kemik mineral dansitometrisi (KMD) ölçüldü ve iki grup karşılaştırıldı. Bulgular: Çalışma grubuna 41 hasta, kontrol grubuna 36 hasta alındı. Çalışma ve kontrol grubunun yaş ortalaması sırasıyla 42.2611.64 ve 41.6670.99 bulundu. Vücut kitle indeksi yönünden iki grup arasında fark bulunmadı. TNF-? (p0.001), deokspiridinolin (p0.001) ve osteokalsin (p0.041) düzeyleri kontrol grubundan önemli oranda yüksek bulundu. Osteoprotogerin düzeyi hasta grubunda düşüktü ancak anlamlı düzeyde değildi (p0.05). İdrar deoxypyridinoline/ idrar kreatinin oranı hasta grub...
Although paracetamol and diclofenac sodium are most commonly used drugs and considered as safe, t... more Although paracetamol and diclofenac sodium are most commonly used drugs and considered as safe, they are also frequently become a current issue with complications in therapeutic doses or overdose situations. Both drugs can cause bleeding disorders as a result of platelet dysfunction and can be presented as an atypical clinical situation such as subconjunctival hemorrhage. In these presented cases, the subconjunctival hemorrhage seen after ingestion of paracetamol and diclofenac sodium in toxic doses for the purpose of suicide, is considered as related with the bleeding disorder that is associated with drug side effect. For these patients who do not have any known co-morbidities, the reasons that can cause subconjunctival hemorrhage other than drugs such as trauma, infections, thrombocytopenia, malignant blood disorders, septicemia, hypertension, severe cough are excluded. Although hepatic and renal toxicities are commonly known side effects that are related with high doses of these drugs, in our cases there were not any impairment of hepatic or renal function tests other than compensated metabolic acidosis. In this report, the relationship of parasetamol and diclofenac sodium with bleeding disorders is discussed over two cases which presented as subconjunctival hemorrhage.
Herediter anjioödem hepatositler tarafından üretilen C1 esteraz inhibitör eksikliği veya disfonks... more Herediter anjioödem hepatositler tarafından üretilen C1 esteraz inhibitör eksikliği veya disfonksiyonundan kaynaklanan, nadir rastlanılan, potansiyel olarak yaşamı tehdit edici bir hastalıktır. Subkutan veya submukozal bölgede tekrarlayan anjioödem ataklarıyla karakterizedir. Herediter anjioödemde nadir olarak görülen larenks ödemi ani hava yolu obstruksiyonuna neden olup ölümle sonuçlanabilir. Burada trakeostomi açılmasını gerektirecek kadar şiddetli larenks ödemi gelişen herediter anjioödemli bir erkek olgu sunulmaktadır.Hereditary angioedema is a rare and potentially life-threatening disease resulting from deficiency or disfunction of C1 esterase inhibitor which is produced by hepatocytes. It is characterized by recurrent angioedema attacks at subcutaneous or submucosal region. Larynx edema could be seen rarely in hereditary angioedema and may result in death by causing sudden air way obstruction. Herein, we present a male hereditary angioedema case with laryngeal edema which is severe enough to require tracheostomy
A pancreatic pseudocyst is a localized fluid collection wit-hin or adjacent to the pancreas, encl... more A pancreatic pseudocyst is a localized fluid collection wit-hin or adjacent to the pancreas, enclosed by a non-epit-helized wall. Pseudocysts account for about 75 % or mo-re of the cystic lesions of the pancreas (1). Pancreatitis, trauma and obstructive neoplasms are the common cau-ses. Pancreatic pseudocysts often arise as a complication of acute or chronic pancreatitis. The prevalence of pan-creatic pseudocysts in acute pancreatitis has been repor-ted to range from 6%-18.5%, while the prevalence of pancreatic pseudocysts in chronic pancreatitis ranges from 20%-40 % (2,3). A 52-year-old man with a diagnosis of acute pancreatitis was referred to our clinic with diffuse abdominal and back pain. His relatives recalled that he had suffered an acute pancreatitis attack three weeks before. He did not
OBJECTIVE The mean platelet volume (MPV) can be used as an indicator of platelet activation. Howe... more OBJECTIVE The mean platelet volume (MPV) can be used as an indicator of platelet activation. However, it has been shown that the platelet/lymphocyte ratio (PLR) can provide useful predictive information about inflammation and aggregation pathways. The neutrophil/lymphocyte ratio (NLR) may also be helpful as a marker of systemic or local inflammation. The main objective of this study evaluated to unselected critically ill patients the relationship of initial MPV, NLR, and PLR with mortality, length of hospitalization, and the risk of developing nosocomial infections in ICU patients. PATIENTS AND METHODS In this retrospective study, we evaluated consecutive patients at our tertiary nine-bed ICU. One hundred seventy-three patients who were followed up during a 1-year period were included. RESULTS MPV levels were found to be higher in patients who died in the hospital (p = 0.05). In addition, there was a significant positive correlation between expected mortality rate and MPV among non-...
Knowledge about the inhibition of centrally located angiotensin-I (AT-I) receptors by highly lipo... more Knowledge about the inhibition of centrally located angiotensin-I (AT-I) receptors by highly lipophilic AT-I receptor blockers and its' effect are limited with experimental studies. Thus, we aimed to investigate the effect of Telmisartan on Inter-dialytic weight gain (IDWG) % and echocardiographic measurements in anuric hemodialysis (HD) patients. A total of forty-one anuric HD patients with ≥ 6 months maintenance on HD were included in this prospective, randomized and self-controlled study. Four weeks prior the study, angiotensin converting enzyme blockers and AT-I receptor blocker drugs were stopped. Patients were assessed three times during the study protocol. These are baseline, three months later (without Telmisartan period) and three months after Telmisartan therapy. IDWG % was significantly decreased in the period of with Telmisartan compared to period without Telmisartan (5.6 ± 1.0% vs 5.3 ± 1.0%, p = 0.03). After the administration of Telmisartan left ventricule end-dia...
Akut faz yanitinin olcumu, hastaliklarin tani ve takibinde bize yardimci olmaktadir. Bu olcumler ... more Akut faz yanitinin olcumu, hastaliklarin tani ve takibinde bize yardimci olmaktadir. Bu olcumler icinde de Eritrosit Sedimentasyon Hizi (ESH) yaygin olarak kullanilan bir tetkikdir. ESH’yi eritrositlerdeki rulo olusumu ya da kume olusumu belirler ve bu olusumlari etkileyen baslica faktorler fibrinojen, α2, β ve γ globundir. Ayrica; eritrositlerle plazma arasindaki oran, plazma vizkozitesi, sedimantasyon tupu ile ilgili durumlar, kullanilan antikoagulan ve oda isisi da ESH’yi etkiler. ESH; gebelik, menstruasyon ve yaslilik gibi fizyolojik durumlarda yukselebilecegi gibi, patolojik bircok durumda da yukselebilir. ESH tipki nabiz ve vucut isisi gibi genel bilgi verir; ciddi hastaliklarin cogunda yukselir, ancak normalde kalabilir. Bu derlemede ESH’nin tanimi, olcum metodlari, etkileyen faktorleri ve klinikte kullanimi hakkinda pratik basvuru kaynagi sunmak amaclanmistir
Although paracetamol and diclofenac sodium are most commonly used drugs and considered as safe, t... more Although paracetamol and diclofenac sodium are most commonly used drugs and considered as safe, they are also frequently become a current issue with complications in therapeutic doses or overdose situations. Both drugs can cause bleeding disorders as a result of platelet dysfunction and can be presented as an atypical clinical situation such as subconjunctival hemorrhage. In these presented cases, the subconjunctival hemorrhage seen after ingestion of paracetamol and diclofenac sodium in toxic doses for the purpose of suicide, is considered as related with the bleeding disorder that is associated with drug side effect. For these patients who do not have any known co-morbidities, the reasons that can cause subconjunctival hemorrhage other than drugs such as trauma, infections, thrombocytopenia, malignant blood disorders, septicemia, hypertension, severe cough are excluded. Although hepatic and renal toxicities are commonly known side effects that are related with high doses of these ...
Woodhouse-Sakati Syndrome (WSS) is a rare autosomal recessive syndrome characterized by sensorine... more Woodhouse-Sakati Syndrome (WSS) is a rare autosomal recessive syndrome characterized by sensorineural hearing loss, ECG ST-T changes, partial alopecia, hypogonadism, diabetes, and moderate mental retardation. A 23-year-old male patient was admitted to our hospital with complaints of purpura and petechial rashes. His platelet count was 3.04 x 109/L and the peripheral blood smear was compatible with this count. No atypical cell was observed. He had mild mental retardation. He had hearing loss since childhood. Physical examination showed widespread petechiae and purpura on bilateral lower extremities. Significant growth retardation was detected and male pattern hair growth was less. In genital examination, bilateral testicles were small; penis length was 1 cm and it was 4 cm when elongated. T negativity was present in precordial derivations of ECG. He was diagnosed Immune thrombocytopenic purpura (ITP) and WSS according to these findings. In addition to ITP treatment with steroids, the...
Measuring acute phase response helps us diagnose and follow up diseases. Erythrocytes Sedimentati... more Measuring acute phase response helps us diagnose and follow up diseases. Erythrocytes Sedimentation Rate (ESR) among those measurements is a biochemical method which is commonly used. Roll formation or clustering of erythrocytes determines of sedimentation rate, and main factors affecting those events are fibrinogen, α2, β and γ globins. Moreover, some conditions such as ratio between plasma and erythrocytes, plasma viscosity, tube used for measuring in sedimentation rate, room temperature and anti-coagulant agent used affect Erythrocyte sedimentation rate measurement. It can be elevated in several pathological conditions as well as in pregnancy, senility and menstruation. ESH gives general idea or information as pulse and body temperature do; it is elevated in several severe diseases, it can be course in normal levels. In this review, it was aimed to present its use of clinical practice, definition, measurement methods, and factors affecting ESH.
Kaya, Ertugrul/0000-0003-0081-682XWOS: 000330151200043Aims: To determine the effects of diabetes ... more Kaya, Ertugrul/0000-0003-0081-682XWOS: 000330151200043Aims: To determine the effects of diabetes mellitus (DM) treatment regimens on malignancy. Methods: Six hundred fifty-five DM patients were enrolled. Patients receiving diabetes therapies for at least one year were retrospectively assessed with physical examination, detailed medical, habits, demographic characteristics and laboratory tests, and divided into two groups according to the diabetes treatment type (using oral agent or insulin and using metformin or not). Insulin users were grouped according to insulin regimens (intensive, basal and mixed) and to the insulin type (glargine, detemir, human insulin, biphasic analogue). Cancer cases were identified at the first visit. Results: Among 655 DM patients 13 (2%) were Type 1 DM, 642 (98%) were Type 2 DM; 379 (58%) were female, 276 (42%) were male. Thirty-sir cancers and 76 benign tumors were observed. Patients with and without a cancer were compared for diabetes treatment regimen...
Kaya, Ertugrul/0000-0003-0081-682XWOS: 000330151200043Aims: To determine the effects of diabetes ... more Kaya, Ertugrul/0000-0003-0081-682XWOS: 000330151200043Aims: To determine the effects of diabetes mellitus (DM) treatment regimens on malignancy. Methods: Six hundred fifty-five DM patients were enrolled. Patients receiving diabetes therapies for at least one year were retrospectively assessed with physical examination, detailed medical, habits, demographic characteristics and laboratory tests, and divided into two groups according to the diabetes treatment type (using oral agent or insulin and using metformin or not). Insulin users were grouped according to insulin regimens (intensive, basal and mixed) and to the insulin type (glargine, detemir, human insulin, biphasic analogue). Cancer cases were identified at the first visit. Results: Among 655 DM patients 13 (2%) were Type 1 DM, 642 (98%) were Type 2 DM; 379 (58%) were female, 276 (42%) were male. Thirty-sir cancers and 76 benign tumors were observed. Patients with and without a cancer were compared for diabetes treatment regimen...
Amaç: Behçet hastalığı (BH)’nın doğal seyri sırasında ya da kullanılan ilaçlara bağlı olarak oste... more Amaç: Behçet hastalığı (BH)’nın doğal seyri sırasında ya da kullanılan ilaçlara bağlı olarak osteoporoz gelişebilir. Çalışmanın amacı BH’nda osteoprotegerin ve tümor nekroz faktör (TNF-?) düzeyleri ve bunlar arasındaki korelasyonu araştırmaktır. Gereç ve yöntem: Çalışmaya, hasta grubu ve kontrol grubu olarak iki grup alındı. TNF-?, osteoprotegerin, osteokalsin, sedimantasyon, CRP, idrar kreatin ve deoksipridinolin düzeyleri ile beraber kemik mineral dansitometrisi (KMD) ölçüldü ve iki grup karşılaştırıldı. Bulgular: Çalışma grubuna 41 hasta, kontrol grubuna 36 hasta alındı. Çalışma ve kontrol grubunun yaş ortalaması sırasıyla 42.2611.64 ve 41.6670.99 bulundu. Vücut kitle indeksi yönünden iki grup arasında fark bulunmadı. TNF-? (p0.001), deokspiridinolin (p0.001) ve osteokalsin (p0.041) düzeyleri kontrol grubundan önemli oranda yüksek bulundu. Osteoprotogerin düzeyi hasta grubunda düşüktü ancak anlamlı düzeyde değildi (p0.05). İdrar deoxypyridinoline/ idrar kreatinin oranı hasta grub...
Amaç: Behçet hastalığı (BH)’nın doğal seyri sırasında ya da kullanılan ilaçlara bağlı olarak oste... more Amaç: Behçet hastalığı (BH)’nın doğal seyri sırasında ya da kullanılan ilaçlara bağlı olarak osteoporoz gelişebilir. Çalışmanın amacı BH’nda osteoprotegerin ve tümor nekroz faktör (TNF-?) düzeyleri ve bunlar arasındaki korelasyonu araştırmaktır. Gereç ve yöntem: Çalışmaya, hasta grubu ve kontrol grubu olarak iki grup alındı. TNF-?, osteoprotegerin, osteokalsin, sedimantasyon, CRP, idrar kreatin ve deoksipridinolin düzeyleri ile beraber kemik mineral dansitometrisi (KMD) ölçüldü ve iki grup karşılaştırıldı. Bulgular: Çalışma grubuna 41 hasta, kontrol grubuna 36 hasta alındı. Çalışma ve kontrol grubunun yaş ortalaması sırasıyla 42.2611.64 ve 41.6670.99 bulundu. Vücut kitle indeksi yönünden iki grup arasında fark bulunmadı. TNF-? (p0.001), deokspiridinolin (p0.001) ve osteokalsin (p0.041) düzeyleri kontrol grubundan önemli oranda yüksek bulundu. Osteoprotogerin düzeyi hasta grubunda düşüktü ancak anlamlı düzeyde değildi (p0.05). İdrar deoxypyridinoline/ idrar kreatinin oranı hasta grub...
Although paracetamol and diclofenac sodium are most commonly used drugs and considered as safe, t... more Although paracetamol and diclofenac sodium are most commonly used drugs and considered as safe, they are also frequently become a current issue with complications in therapeutic doses or overdose situations. Both drugs can cause bleeding disorders as a result of platelet dysfunction and can be presented as an atypical clinical situation such as subconjunctival hemorrhage. In these presented cases, the subconjunctival hemorrhage seen after ingestion of paracetamol and diclofenac sodium in toxic doses for the purpose of suicide, is considered as related with the bleeding disorder that is associated with drug side effect. For these patients who do not have any known co-morbidities, the reasons that can cause subconjunctival hemorrhage other than drugs such as trauma, infections, thrombocytopenia, malignant blood disorders, septicemia, hypertension, severe cough are excluded. Although hepatic and renal toxicities are commonly known side effects that are related with high doses of these drugs, in our cases there were not any impairment of hepatic or renal function tests other than compensated metabolic acidosis. In this report, the relationship of parasetamol and diclofenac sodium with bleeding disorders is discussed over two cases which presented as subconjunctival hemorrhage.
Herediter anjioödem hepatositler tarafından üretilen C1 esteraz inhibitör eksikliği veya disfonks... more Herediter anjioödem hepatositler tarafından üretilen C1 esteraz inhibitör eksikliği veya disfonksiyonundan kaynaklanan, nadir rastlanılan, potansiyel olarak yaşamı tehdit edici bir hastalıktır. Subkutan veya submukozal bölgede tekrarlayan anjioödem ataklarıyla karakterizedir. Herediter anjioödemde nadir olarak görülen larenks ödemi ani hava yolu obstruksiyonuna neden olup ölümle sonuçlanabilir. Burada trakeostomi açılmasını gerektirecek kadar şiddetli larenks ödemi gelişen herediter anjioödemli bir erkek olgu sunulmaktadır.Hereditary angioedema is a rare and potentially life-threatening disease resulting from deficiency or disfunction of C1 esterase inhibitor which is produced by hepatocytes. It is characterized by recurrent angioedema attacks at subcutaneous or submucosal region. Larynx edema could be seen rarely in hereditary angioedema and may result in death by causing sudden air way obstruction. Herein, we present a male hereditary angioedema case with laryngeal edema which is severe enough to require tracheostomy
A pancreatic pseudocyst is a localized fluid collection wit-hin or adjacent to the pancreas, encl... more A pancreatic pseudocyst is a localized fluid collection wit-hin or adjacent to the pancreas, enclosed by a non-epit-helized wall. Pseudocysts account for about 75 % or mo-re of the cystic lesions of the pancreas (1). Pancreatitis, trauma and obstructive neoplasms are the common cau-ses. Pancreatic pseudocysts often arise as a complication of acute or chronic pancreatitis. The prevalence of pan-creatic pseudocysts in acute pancreatitis has been repor-ted to range from 6%-18.5%, while the prevalence of pancreatic pseudocysts in chronic pancreatitis ranges from 20%-40 % (2,3). A 52-year-old man with a diagnosis of acute pancreatitis was referred to our clinic with diffuse abdominal and back pain. His relatives recalled that he had suffered an acute pancreatitis attack three weeks before. He did not
OBJECTIVE The mean platelet volume (MPV) can be used as an indicator of platelet activation. Howe... more OBJECTIVE The mean platelet volume (MPV) can be used as an indicator of platelet activation. However, it has been shown that the platelet/lymphocyte ratio (PLR) can provide useful predictive information about inflammation and aggregation pathways. The neutrophil/lymphocyte ratio (NLR) may also be helpful as a marker of systemic or local inflammation. The main objective of this study evaluated to unselected critically ill patients the relationship of initial MPV, NLR, and PLR with mortality, length of hospitalization, and the risk of developing nosocomial infections in ICU patients. PATIENTS AND METHODS In this retrospective study, we evaluated consecutive patients at our tertiary nine-bed ICU. One hundred seventy-three patients who were followed up during a 1-year period were included. RESULTS MPV levels were found to be higher in patients who died in the hospital (p = 0.05). In addition, there was a significant positive correlation between expected mortality rate and MPV among non-...
Knowledge about the inhibition of centrally located angiotensin-I (AT-I) receptors by highly lipo... more Knowledge about the inhibition of centrally located angiotensin-I (AT-I) receptors by highly lipophilic AT-I receptor blockers and its' effect are limited with experimental studies. Thus, we aimed to investigate the effect of Telmisartan on Inter-dialytic weight gain (IDWG) % and echocardiographic measurements in anuric hemodialysis (HD) patients. A total of forty-one anuric HD patients with ≥ 6 months maintenance on HD were included in this prospective, randomized and self-controlled study. Four weeks prior the study, angiotensin converting enzyme blockers and AT-I receptor blocker drugs were stopped. Patients were assessed three times during the study protocol. These are baseline, three months later (without Telmisartan period) and three months after Telmisartan therapy. IDWG % was significantly decreased in the period of with Telmisartan compared to period without Telmisartan (5.6 ± 1.0% vs 5.3 ± 1.0%, p = 0.03). After the administration of Telmisartan left ventricule end-dia...
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