In the last few years inflammation has been potentially linked to atherosclerosis. This review ga... more In the last few years inflammation has been potentially linked to atherosclerosis. This review gathers information on the effect of diet on coronary heart disease, through an inflammatory pathway. Different methodological approaches to study diet were highlighted: single nutrients and/or foods and dietary patterns, and the relations between them and inflammatory markers were extensively described. Together, findings suggest that inflammation could be a potential pathway by which diet can modulate the coronary risk. However, research is still in progress and many scientific questions have not yet feasible answers. Most of the cohort studies providing dietary evaluations were conducted in the U.S, but the higher food diversity and wide ranges in dietary exposure frequently observed in European populations could provide novel and interesting insights into this filed. The use of different methodological approaches to study diet in a same population, and further providing straight compar...
Clinical nutrition (Edinburgh, Scotland), Jan 2, 2016
A possible relationship between children's dietary intake and certain aspects of eating behav... more A possible relationship between children's dietary intake and certain aspects of eating behaviours has been documented, but most studies are cross-sectional and do not consider the complexity of the diet. The aim of this study was to quantify the association between dietary patterns established at 4 years old and appetite-related eating behaviours identified at 7 years old. Participants are children from the Generation XXI population-based birth cohort. Trained interviewers collected data at birth, 4 and 7 years old on socio-demographics, health and lifestyles, and anthropometrics. At 4 years old, diet was assessed by a Food Frequency Questionnaire and three dietary patterns were identified by Latent Class Analysis: 'Healthier', 'Snacking' and 'Energy Dense Foods' (EDF). A Portuguese version of the original Children's Eating Behaviour Questionnaire (CEBQ) was self-completed by mothers at 7 year-old. This version has previously shown good psychometric ...
The time of eating has been considered to have an important role in weight regulation. However, i... more The time of eating has been considered to have an important role in weight regulation. However, it is unknown if there are specific daily patterns of energy and macronutrient distribution that could be more beneficial for metabolic outcomes, especially obesity. This study aimed to assess the effect of time-of-day energy and macronutrient intake at 4 y of age on the weight status at 7 y of age. The study sample included 1961 children from the population-based birth cohort Generation XXI, with data on 3-day food diaries at 4 y and body mass index (BMI) z-scores at 7 y. Dietary patterns based on the collected data were obtained for the distribution of energy and macronutrients across eating occasions. Having a relatively higher energy intake at lunch and supper (OR = 1.19, 95% CI = 1.05 to 1.34) or at mid-afternoon (OR = 1.18, 95% CI = 1.05 to 1.34) at 4 y was associated with higher odds of becoming overweight/obese at 7 y. A relatively higher intake of fat at lunch was positively asso...
Identifying the underlying child-eating behaviours that contribute to weight differences across g... more Identifying the underlying child-eating behaviours that contribute to weight differences across growth has been a constant challenge. This report reviews the various literature approaches for assessing appetite regulation. In doing so, it attempts to understand how appetite control develops and determines the eating habits in early childhood, and its effects on children's weight status. The interaction between homeostatic and hedonic mechanisms largely explains the appetite regulation process. Homeostatic mechanisms are mediated by the biological need to maintain the body's energy reserves, increasing the motivation to eat. On the contrary, the hedonic mechanisms are mediated by food reward, increasing the craving for high-palatable foods and triggering the release of dopamine and serotonin. There are many biological methods (plasma measurements of hormones, like leptin, ghrelin and insulin) and behavioural evaluation methods of appetite. The Children's Eating Behaviour ...
European journal of clinical nutrition, Jan 11, 2018
There is scarce evidence of how certain eating behaviours compromise the compliance with dietary ... more There is scarce evidence of how certain eating behaviours compromise the compliance with dietary guidelines and weight status in school-aged children. This study aims to evaluate the association of children's problematic eating behaviours with food quality and body mass index at 7 years of age. Participants were children aged 7 years old from a population-based cohort study from Porto, Portugal-Generation XXI. Children's quantity and speed of ingestion, food refusal at the table and food rewards requesting were evaluated by caregiver's perception. Food consumption was evaluated by a food frequency questionnaire and compared with age-appropriate guidelines. Children's weight status was assessed by objective measurements and parent's perceptions. Associations were estimated by logistic regressions (odds ratio (OR), 95% confidence intervals (95% CI)) adjusted for maternal age, education, smoking during pregnancy, birth type, child's sex, weight-for-gestational a...
The aim of this study was to compare the accuracy of body fat patterns and single measures in ass... more The aim of this study was to compare the accuracy of body fat patterns and single measures in assessing body fat and to clarify the use of indices based on waist circumference as measures of adiposity in children. This study included 2,531 7-year-old children from the Generation XXI birth cohort (Porto, Portugal). Anthropometrics were obtained by trained personnel and whole-body dual-energy x-ray absorptiometry (DXA) scans were performed. Principal component analysis identified two body fat patterns. Pattern 1 (BMI, fat mass index from tetra-polar bioelectric impedance, and waist-to-height ratio) showed strong correlations with DXA fat mass index (r = 0.85; P < 0.001), and pattern 2 (waist-to-hip, waist-to-thigh, and waist-to-weight ratios) showed moderate correlations with DXA central fat (r = 0.35; P < 0.001). Compared with single measures, body fat patterns showed similar correlations with DXA-derived measures. Compared with single anthropometric indices, body fat patterns ...
The assessment of food consumption data using harmonized methodologies at the European level is f... more The assessment of food consumption data using harmonized methodologies at the European level is fundamental to support the development of public policies. Portugal is one of the countries with the most outdated information on individual food consumption. The objective of this study was to describe the design and methodology of the National Food, Nutrition and Physical Activity Survey, 2015-2016, developed to collect national and regional data on dietary habits, physical activity (PA), and nutritional status, in a representative sample of the Portuguese general population (3 months-84 years). Participants were selected by multistage sampling, using the National Heath Registry as the sampling frame. Data collection, during 12 months, was harmonized according to European guidelines (EU-MENU, European Food Safety Authority [EFSA]). Computer-assisted personal interviewing (CAPI) was performed on a specific electronic platform synchronized with nutritional composition data and considering...
Research on the influence of early eating habits on eating behaviours related to appetite using a... more Research on the influence of early eating habits on eating behaviours related to appetite using a prospective approach is scarce, especially in children. The aim of this study was to explore the relationship between changes in diet variety from 4 to 7 years of age and appetitive traits measured at 7 years of age. Participants are from the population-based birth cohort Generation XXI (2005-2006). The present analysis included 4537 children with complete data on a food frequency questionnaire (FFQ) at both ages, and on the Children's Eating Behaviour Questionnaire at 7y. A healthy diet variety index (HDVI) was calculated at both ages using data from the FFQ. To assess tracking of diet variety, tertiles of HDVI scores were calculated and then re-categorized as 'maintain: low', 'maintain: high', 'increase' and 'decrease'. Although the HDVI score decreased from 4 to 7y (p < .001), it showed a high stability, a positive predictive value, and a fair a...
Not only healthy growth but also childhood obesity partly originate from early life. The current ... more Not only healthy growth but also childhood obesity partly originate from early life. The current work aimed to examine the association of feeding practices during infancy with growth and adiposity indices in preschool children from four European countries and in UK schoolchildren and adolescents. Existing data from four European birth cohorts (ALSPAC-UK, EDEN-France, EuroPrevall-Greece and Generation XXI-Portugal) were used. Anthropometrics and body composition indices were collected. Parallel multivariate regression analyses were performed to examine the research hypothesis. Overall, the analyses showed that breastfeeding and timing of complementary feeding were not consistently associated with height z-score, overweight/obesity, and body fat mass in children or adolescents. However, breastfeeding duration for less than 6 months was associated with lower height z-scores in 5-year-old French children (P < 0.001) but with higher height z-scores in 4-year-old UK children (P = 0.006...
The present study aimed to evaluate the association of 4-year-old children's dietary patterns... more The present study aimed to evaluate the association of 4-year-old children's dietary patterns with adiposity at 7 years, according to child's sex, using a conceptual model. Prospective cohort study. Diet was assessed using an FFQ. Age- and sex-specific BMI standard deviation scores (Z-scores) were defined according to the WHO. Fat mass percentage (FM%), fat mass index (FMI) and waist-to-height ratio (WHtR) were also considered, converted into Z-scores using sex-specific means and standard deviations of the current sample. Dietary patterns were identified by latent class analysis and their association with adiposity was estimated by linear regression models. Population-based birth cohort Generation XXI (Porto, Portugal, 2005-2006). Children (n 3473) evaluated at both 4 and 7 years of age. Three dietary patterns were identified: high in energy-dense foods (EDF); low in foods typically consumed at main meals and intermediate in snacks (Snacking); and higher in vegetables and fi...
International journal of epidemiology, Oct 27, 2017
It has been suggested that prenatal exposure to n-3 long-chain fatty acids protects against asthm... more It has been suggested that prenatal exposure to n-3 long-chain fatty acids protects against asthma and other allergy-related diseases later in childhood. The extent to which fish intake in pregnancy protects against child asthma and rhinitis symptoms remains unclear. We aimed to assess whether fish and seafood consumption in pregnancy is associated with childhood wheeze, asthma and allergic rhinitis. We pooled individual data from 60 774 mother-child pairs participating in 18 European and US birth cohort studies. Information on wheeze, asthma and allergic rhinitis prevalence was collected using validated questionnaires. The time periods of interest were: infancy (0-2 years), preschool age (3-4 years), and school age (5-8 years). We used multivariable generalized models to assess associations of fish and seafood (other than fish) consumption during pregnancy with child respiratory outcomes in cohort-specific analyses, with subsequent random-effects meta-analyses. The median fish cons...
In the last few years inflammation has been potentially linked to atherosclerosis. This review ga... more In the last few years inflammation has been potentially linked to atherosclerosis. This review gathers information on the effect of diet on coronary heart disease, through an inflammatory pathway. Different methodological approaches to study diet were highlighted: single nutrients and/or foods and dietary patterns, and the relations between them and inflammatory markers were extensively described. Together, findings suggest that inflammation could be a potential pathway by which diet can modulate the coronary risk. However, research is still in progress and many scientific questions have not yet feasible answers. Most of the cohort studies providing dietary evaluations were conducted in the U.S, but the higher food diversity and wide ranges in dietary exposure frequently observed in European populations could provide novel and interesting insights into this filed. The use of different methodological approaches to study diet in a same population, and further providing straight compar...
Clinical nutrition (Edinburgh, Scotland), Jan 2, 2016
A possible relationship between children's dietary intake and certain aspects of eating behav... more A possible relationship between children's dietary intake and certain aspects of eating behaviours has been documented, but most studies are cross-sectional and do not consider the complexity of the diet. The aim of this study was to quantify the association between dietary patterns established at 4 years old and appetite-related eating behaviours identified at 7 years old. Participants are children from the Generation XXI population-based birth cohort. Trained interviewers collected data at birth, 4 and 7 years old on socio-demographics, health and lifestyles, and anthropometrics. At 4 years old, diet was assessed by a Food Frequency Questionnaire and three dietary patterns were identified by Latent Class Analysis: 'Healthier', 'Snacking' and 'Energy Dense Foods' (EDF). A Portuguese version of the original Children's Eating Behaviour Questionnaire (CEBQ) was self-completed by mothers at 7 year-old. This version has previously shown good psychometric ...
The time of eating has been considered to have an important role in weight regulation. However, i... more The time of eating has been considered to have an important role in weight regulation. However, it is unknown if there are specific daily patterns of energy and macronutrient distribution that could be more beneficial for metabolic outcomes, especially obesity. This study aimed to assess the effect of time-of-day energy and macronutrient intake at 4 y of age on the weight status at 7 y of age. The study sample included 1961 children from the population-based birth cohort Generation XXI, with data on 3-day food diaries at 4 y and body mass index (BMI) z-scores at 7 y. Dietary patterns based on the collected data were obtained for the distribution of energy and macronutrients across eating occasions. Having a relatively higher energy intake at lunch and supper (OR = 1.19, 95% CI = 1.05 to 1.34) or at mid-afternoon (OR = 1.18, 95% CI = 1.05 to 1.34) at 4 y was associated with higher odds of becoming overweight/obese at 7 y. A relatively higher intake of fat at lunch was positively asso...
Identifying the underlying child-eating behaviours that contribute to weight differences across g... more Identifying the underlying child-eating behaviours that contribute to weight differences across growth has been a constant challenge. This report reviews the various literature approaches for assessing appetite regulation. In doing so, it attempts to understand how appetite control develops and determines the eating habits in early childhood, and its effects on children's weight status. The interaction between homeostatic and hedonic mechanisms largely explains the appetite regulation process. Homeostatic mechanisms are mediated by the biological need to maintain the body's energy reserves, increasing the motivation to eat. On the contrary, the hedonic mechanisms are mediated by food reward, increasing the craving for high-palatable foods and triggering the release of dopamine and serotonin. There are many biological methods (plasma measurements of hormones, like leptin, ghrelin and insulin) and behavioural evaluation methods of appetite. The Children's Eating Behaviour ...
European journal of clinical nutrition, Jan 11, 2018
There is scarce evidence of how certain eating behaviours compromise the compliance with dietary ... more There is scarce evidence of how certain eating behaviours compromise the compliance with dietary guidelines and weight status in school-aged children. This study aims to evaluate the association of children's problematic eating behaviours with food quality and body mass index at 7 years of age. Participants were children aged 7 years old from a population-based cohort study from Porto, Portugal-Generation XXI. Children's quantity and speed of ingestion, food refusal at the table and food rewards requesting were evaluated by caregiver's perception. Food consumption was evaluated by a food frequency questionnaire and compared with age-appropriate guidelines. Children's weight status was assessed by objective measurements and parent's perceptions. Associations were estimated by logistic regressions (odds ratio (OR), 95% confidence intervals (95% CI)) adjusted for maternal age, education, smoking during pregnancy, birth type, child's sex, weight-for-gestational a...
The aim of this study was to compare the accuracy of body fat patterns and single measures in ass... more The aim of this study was to compare the accuracy of body fat patterns and single measures in assessing body fat and to clarify the use of indices based on waist circumference as measures of adiposity in children. This study included 2,531 7-year-old children from the Generation XXI birth cohort (Porto, Portugal). Anthropometrics were obtained by trained personnel and whole-body dual-energy x-ray absorptiometry (DXA) scans were performed. Principal component analysis identified two body fat patterns. Pattern 1 (BMI, fat mass index from tetra-polar bioelectric impedance, and waist-to-height ratio) showed strong correlations with DXA fat mass index (r = 0.85; P < 0.001), and pattern 2 (waist-to-hip, waist-to-thigh, and waist-to-weight ratios) showed moderate correlations with DXA central fat (r = 0.35; P < 0.001). Compared with single measures, body fat patterns showed similar correlations with DXA-derived measures. Compared with single anthropometric indices, body fat patterns ...
The assessment of food consumption data using harmonized methodologies at the European level is f... more The assessment of food consumption data using harmonized methodologies at the European level is fundamental to support the development of public policies. Portugal is one of the countries with the most outdated information on individual food consumption. The objective of this study was to describe the design and methodology of the National Food, Nutrition and Physical Activity Survey, 2015-2016, developed to collect national and regional data on dietary habits, physical activity (PA), and nutritional status, in a representative sample of the Portuguese general population (3 months-84 years). Participants were selected by multistage sampling, using the National Heath Registry as the sampling frame. Data collection, during 12 months, was harmonized according to European guidelines (EU-MENU, European Food Safety Authority [EFSA]). Computer-assisted personal interviewing (CAPI) was performed on a specific electronic platform synchronized with nutritional composition data and considering...
Research on the influence of early eating habits on eating behaviours related to appetite using a... more Research on the influence of early eating habits on eating behaviours related to appetite using a prospective approach is scarce, especially in children. The aim of this study was to explore the relationship between changes in diet variety from 4 to 7 years of age and appetitive traits measured at 7 years of age. Participants are from the population-based birth cohort Generation XXI (2005-2006). The present analysis included 4537 children with complete data on a food frequency questionnaire (FFQ) at both ages, and on the Children's Eating Behaviour Questionnaire at 7y. A healthy diet variety index (HDVI) was calculated at both ages using data from the FFQ. To assess tracking of diet variety, tertiles of HDVI scores were calculated and then re-categorized as 'maintain: low', 'maintain: high', 'increase' and 'decrease'. Although the HDVI score decreased from 4 to 7y (p < .001), it showed a high stability, a positive predictive value, and a fair a...
Not only healthy growth but also childhood obesity partly originate from early life. The current ... more Not only healthy growth but also childhood obesity partly originate from early life. The current work aimed to examine the association of feeding practices during infancy with growth and adiposity indices in preschool children from four European countries and in UK schoolchildren and adolescents. Existing data from four European birth cohorts (ALSPAC-UK, EDEN-France, EuroPrevall-Greece and Generation XXI-Portugal) were used. Anthropometrics and body composition indices were collected. Parallel multivariate regression analyses were performed to examine the research hypothesis. Overall, the analyses showed that breastfeeding and timing of complementary feeding were not consistently associated with height z-score, overweight/obesity, and body fat mass in children or adolescents. However, breastfeeding duration for less than 6 months was associated with lower height z-scores in 5-year-old French children (P < 0.001) but with higher height z-scores in 4-year-old UK children (P = 0.006...
The present study aimed to evaluate the association of 4-year-old children's dietary patterns... more The present study aimed to evaluate the association of 4-year-old children's dietary patterns with adiposity at 7 years, according to child's sex, using a conceptual model. Prospective cohort study. Diet was assessed using an FFQ. Age- and sex-specific BMI standard deviation scores (Z-scores) were defined according to the WHO. Fat mass percentage (FM%), fat mass index (FMI) and waist-to-height ratio (WHtR) were also considered, converted into Z-scores using sex-specific means and standard deviations of the current sample. Dietary patterns were identified by latent class analysis and their association with adiposity was estimated by linear regression models. Population-based birth cohort Generation XXI (Porto, Portugal, 2005-2006). Children (n 3473) evaluated at both 4 and 7 years of age. Three dietary patterns were identified: high in energy-dense foods (EDF); low in foods typically consumed at main meals and intermediate in snacks (Snacking); and higher in vegetables and fi...
International journal of epidemiology, Oct 27, 2017
It has been suggested that prenatal exposure to n-3 long-chain fatty acids protects against asthm... more It has been suggested that prenatal exposure to n-3 long-chain fatty acids protects against asthma and other allergy-related diseases later in childhood. The extent to which fish intake in pregnancy protects against child asthma and rhinitis symptoms remains unclear. We aimed to assess whether fish and seafood consumption in pregnancy is associated with childhood wheeze, asthma and allergic rhinitis. We pooled individual data from 60 774 mother-child pairs participating in 18 European and US birth cohort studies. Information on wheeze, asthma and allergic rhinitis prevalence was collected using validated questionnaires. The time periods of interest were: infancy (0-2 years), preschool age (3-4 years), and school age (5-8 years). We used multivariable generalized models to assess associations of fish and seafood (other than fish) consumption during pregnancy with child respiratory outcomes in cohort-specific analyses, with subsequent random-effects meta-analyses. The median fish cons...
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