Objectives.To investigate haemostatic markers (especially fibrinolysis), inflammatory parameters ... more Objectives.To investigate haemostatic markers (especially fibrinolysis), inflammatory parameters and lipids in patients with stable angina pectoris. Special attention was paid to differences between male and female patients, and to the reactivity to exercise or the diurnal variation of certain parameters. Subjects. Eight hundred and nine patients (31% females) and a matched healthy control group (n = 50). Results. The patients had signs of disturbed fibrinolysis, with elevated plasma levels of tissue plasminogen activator (tPA) antigen and plasminogen activator inhibitor (PAI‐1) activity at rest, and attenuated responses of tPA antigen and activity to exercise. Elevated levels of fibrinogen, white blood cell counts and orosomucoid were found, suggesting increased inflammatory activity, as well as a more disturbed lipid profile (higher triglycerides and lower HDL cholesterol levels) than among controls. Female patients had higher HDL cholesterol and lower triglyceride levels than male patients, but higher platelet counts and signs of enhanced platelet activity (β‐thromboglobulin excretion). In addition, female patients had lower white blood cell counts, suggesting lesser inflammatory activity. Conclusions. Patients with stable angina pectoris have signs of markedly disturbed fibrinolysis both at rest and in response to exercise, as well as signs of enhanced inflammatory activity and dyslipidemia. The observed sex differences suggest that male patients with stable angina pectoris may have a more lipid‐related disease, whereas it may be more dependent on platelet function in females.
Eating behavior and food‐related decision making are among the most complex of the motivated beha... more Eating behavior and food‐related decision making are among the most complex of the motivated behaviors, and understanding the neurobiology of eating behavior, and its developmental dynamics, is critical to advancing the nutritional sciences and public health. Recent advances from both human and animal studies are revealing that individual capacity to make health‐promoting food decisions varies based on biological and physiological variation in the signaling pathways that regulate the homeostatic, hedonic, and executive functions; past developmental exposures and current life‐stage; the food environment; and complications of chronic disease that reinforce the obese state. Eating rate drives increased calorie intake and represents an important opportunity to lower rates of food consumption and energy intake through product reformulation. Understanding human eating behaviors and nutrition in the context of neuroscience can strengthen the evidence base from which dietary guidelines are derived and can inform policies, practices, and educational programs in a way that increases the likelihood they are adopted and effective for reducing rates of obesity and other diet‐related chronic disease.
Different plasma lipoprotein fractions in physiological concentrations have opposite effects on t... more Different plasma lipoprotein fractions in physiological concentrations have opposite effects on the phagocytosis and migration of human neutrophilic granulocytes. Preincubation for half an hour with very low density lipoproteins decreased the phagocytosis as well as the chemotactic and random migrations of the cells, while preincubation with high density lipoproteins increased the same functions. No effects were seen with low density lipoproteins. It is suggested that disturbances in plasma lipoprotein pattern may affect the function of phagocytes.
Objectives.To investigate haemostatic markers (especially fibrinolysis), inflammatory parameters ... more Objectives.To investigate haemostatic markers (especially fibrinolysis), inflammatory parameters and lipids in patients with stable angina pectoris. Special attention was paid to differences between male and female patients, and to the reactivity to exercise or the diurnal variation of certain parameters. Subjects. Eight hundred and nine patients (31% females) and a matched healthy control group (n = 50). Results. The patients had signs of disturbed fibrinolysis, with elevated plasma levels of tissue plasminogen activator (tPA) antigen and plasminogen activator inhibitor (PAI‐1) activity at rest, and attenuated responses of tPA antigen and activity to exercise. Elevated levels of fibrinogen, white blood cell counts and orosomucoid were found, suggesting increased inflammatory activity, as well as a more disturbed lipid profile (higher triglycerides and lower HDL cholesterol levels) than among controls. Female patients had higher HDL cholesterol and lower triglyceride levels than male patients, but higher platelet counts and signs of enhanced platelet activity (β‐thromboglobulin excretion). In addition, female patients had lower white blood cell counts, suggesting lesser inflammatory activity. Conclusions. Patients with stable angina pectoris have signs of markedly disturbed fibrinolysis both at rest and in response to exercise, as well as signs of enhanced inflammatory activity and dyslipidemia. The observed sex differences suggest that male patients with stable angina pectoris may have a more lipid‐related disease, whereas it may be more dependent on platelet function in females.
Eating behavior and food‐related decision making are among the most complex of the motivated beha... more Eating behavior and food‐related decision making are among the most complex of the motivated behaviors, and understanding the neurobiology of eating behavior, and its developmental dynamics, is critical to advancing the nutritional sciences and public health. Recent advances from both human and animal studies are revealing that individual capacity to make health‐promoting food decisions varies based on biological and physiological variation in the signaling pathways that regulate the homeostatic, hedonic, and executive functions; past developmental exposures and current life‐stage; the food environment; and complications of chronic disease that reinforce the obese state. Eating rate drives increased calorie intake and represents an important opportunity to lower rates of food consumption and energy intake through product reformulation. Understanding human eating behaviors and nutrition in the context of neuroscience can strengthen the evidence base from which dietary guidelines are derived and can inform policies, practices, and educational programs in a way that increases the likelihood they are adopted and effective for reducing rates of obesity and other diet‐related chronic disease.
Different plasma lipoprotein fractions in physiological concentrations have opposite effects on t... more Different plasma lipoprotein fractions in physiological concentrations have opposite effects on the phagocytosis and migration of human neutrophilic granulocytes. Preincubation for half an hour with very low density lipoproteins decreased the phagocytosis as well as the chemotactic and random migrations of the cells, while preincubation with high density lipoproteins increased the same functions. No effects were seen with low density lipoproteins. It is suggested that disturbances in plasma lipoprotein pattern may affect the function of phagocytes.
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