The aim of the study was to compare the safety profiles (prevalence of both local and systemic si... more The aim of the study was to compare the safety profiles (prevalence of both local and systemic side effects) of COVID-19 vaccines (Pfizer–BioNTech, Moderna, Oxford–AstraZeneca) among healthcare workers (doctors, nurses, and pharmacists) administered with a first and a second dose of the vaccines. Another goal of the research was to evaluate potential demographic and clinical risk factors for the frequency and intensity of side effects. A post-marketing, cross-sectional survey-based study was carried out on a sample of 971 respondents (323 doctors, 324 nurses, and 324 pharmacists), all more than 18 years old, who have taken two doses of the following SARS-CoV-2 vaccines: BNT162b2 (Pfizer–BioNTech) (group 1), mRNA-1273 (Moderna) (group 2), and ChAdOx1 nCoV-19 (Oxford–AstraZeneca) (group 3). A validated, self-administered questionnaire was developed and delivered online to the target population group of healthcare workers. The survey was conducted during the third wave of the COVID-19 ...
The studies aimed to determine the antidepressant efficacy of single and chronic administration o... more The studies aimed to determine the antidepressant efficacy of single and chronic administration of dapoxetine alone and vortioxetine alone, as well as in the combination of these drugs. An additional objective of the study was to measure the effect of the active substances on the corticosterone level in chronically stressed animals. The study was conducted on male Wistar rats using non‑stressed and stressed groups (chronic restraint stress). The experiment comprised both forced swimming test (immobility time test) and corticosterone level measurement using Corticosterone ELISA Kit. The obtained results confirm the antidepressant efficacy of used drugs upon both single and chronic administration and potential efficacy of these drugs administered in combination with stressed rats. Corticosterone level analysis, meanwhile, showed stress relieving properties of the study drugs, which reduced the animal stress hormone level, whether administered separately or in combination. Dapoxetine a...
Katedra i Zakład Farmakoekonomiki i Farmacji Społecznej, Uniwersytet Medyczny im. Karola Marcinko... more Katedra i Zakład Farmakoekonomiki i Farmacji Społecznej, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu PRACA ORYGINALNA STRESZCZENIE Wstęp. Cukrzyca jest poważną chorobą dietozależną, w której sposobem leczenia jest prawidłowo dobrana dieta, wysiłek fi zyczny oraz stosowanie odpowiedniej farma-koterapii. W związku z dużą zachorowalnością istnieje konieczność ciągłego badania pacjentów, udoskonalania już istniejących metod diagnostycznych oraz poszukiwa-nia nowych metod leczenia. Prewencja cukrzycy jest zatem istotnym problemem przy zmiennym trybie życia oraz żywienia diabetyków. Cel. Celem pracy było zbadanie stanu wiedzy osób ze zdiagnozowaną cukrzycą na temat związany z profi laktyką i leczeniem cukrzycy. Materiał i metody. W celu dokonania oceny poziomu świadomości pacjentów na temat profi laktyki i leczenia choroby, przeprowadzono ankietę wśród 107 pacjentów ze zdiagnozowaną postacią choroby. Wyniki. Wyniki badań wskazują, iż pacjenci nie posiadają wystarczającej wi...
In adolescents, arterial hypertension (AH) is diagnosed much more frequently than previously thou... more In adolescents, arterial hypertension (AH) is diagnosed much more frequently than previously thought--it affects 3.2% of the population aged 11-18. In Poland, at present, there are no cost analyses of treatment arterial hypertension among adolescents. The aim of the conducted studies was to analyze direct medical and non-medical costs in the time horizon of one calendar year (2010) of AH treatment in adolescents in Poland. A retrospective study from the societal perspective was based on data from 480 patients medical history cards obtained from the archives of the hospital. From this group, according to the criteria for inclusion in the study, a research group was selected consisting of 36 patients aged 16-18 years, with a diagnosed and treated hypertension. Analysis covered direct medical costs (costs of pharmacotherapy, doctors' visits and laboratory tests, hospitalization) and direct non-medical costs (cost of transport to the outpatient clinic). Average annual cost of hypert...
International Journal of Environmental Research and Public Health
The SARS-CoV-2 virus pandemic has exerted enormous impacts on individuals’ lifestyle, economics a... more The SARS-CoV-2 virus pandemic has exerted enormous impacts on individuals’ lifestyle, economics and social life. The aim of the study was to assess the impact of the COVID-19 pandemic on health-promoting behaviors of a sample of the Polish population, including dietary supplementation, physical activity, eating habits, and the implementation of preventive vaccinations. Within the scope of a survey, data was collected from 1101 adult respondents residing in Poland (862 women and 239 men). An anonymous questionnaire prepared based on the scientific literature was used as a research tool. The survey was conducted during the second wave of COVID-19 using the CAWI (Computer—Assisted Web Interview) method by disseminating the questionnaire using selected social media. We found that, during the COVID-19 pandemic, the respondents were more likely to maintain healthy eating habits and use dietary supplementation; however, the majority engaged in physical activity less frequently and had a se...
Background There is a need to investigate how adopting different strategies for treating obesity ... more Background There is a need to investigate how adopting different strategies for treating obesity in different countries in the European Union affects the psychological well-being of patients. Aims The aim of this study was to perform a comparative evaluation of psychiatric symptoms (depression, anxiety and stress) in patients undergoing bariatric surgery versus patients receiving conservative treatment for morbid obesity in Poland and Germany. Method A multicentre international prospective cohort study with 155 patients who underwent bariatric surgery and 409 patients who received conservative weight reduction treatment. Evaluation of the psychiatric symptoms was carried out for each patient at baseline and after 12 months of active treatment using a standardised Depression Anxiety Stress Scale questionnaire (DASS-21) questionnaire. Results After 12 months of active treatment, the level of psychiatric symptoms (depression, anxiety and stress) significantly decreased in both groups o...
i Zakład Toksykologii, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu PRACA ORYGINALN... more i Zakład Toksykologii, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu PRACA ORYGINALNA STRESZCZENIE Wstęp. Medyczne bazy danych (MBD) to zbiór informacji, który w swoim założeniu ma ułatwić dostęp do rzetelnych danych medycznych zgodnie z Evidence Based Medicine (EBM). Prawidłowo przygotowana baza przyjmuje różne formy, od prostych baz danych pacjentów po bazy semantyczne, ukierunkowane na dane jednostki cho-robowe (zw. bazy referencyjne), pozwalające na zoptymalizowanie pracy całego personelu medycznego. Ośrodki medyczne starają się prowadzić MBD w wersji kompu-terowej, które zawierają m.in. dane z podstawowego i poszerzonego wywiadu, przebieg i czas leczenia, wyniki badań ambulatoryjno-laboratoryjnych. Bazy te znacząco wspomagają proces diagnostyczny i wybór metody leczenia, np. schizofrenii, która stanowi obecnie w Europie prawie połowę osób leczonych na choroby psychiczne. Dla podjęcia prawidłowej terapii niezbędna jest pełna informacja pochodząca z jednej strony z b...
Stroke is a major cause of morbidity in industrialized countries, representing 8% of total deaths... more Stroke is a major cause of morbidity in industrialized countries, representing 8% of total deaths across Europe in 2017. It is also a very costly disorder, frequently caused by atrial fibrillation. We aimed to calculate the cost of stroke hospitalization in 2018 in Poznań (Poland). We also intended to present patients with the first AF diagnosis at the time of stroke. The study was conducted from January 2019 to July 2020. Data were obtained from hospital records and from the hospital accounting department. Out of 164 patients included in the study, 41 had AF and in 18 cases AF was first diagnosed at the time of stroke. The cost of hospitalization in Poznań was EUR 139,257.21 (x¯= EUR 849.13). Among those with concomitant AF, the general cost of inpatient care was EUR 33,859.18 (x¯= EUR 825.83). Considering those who had AF first diagnosed during hospitalization the cost was EUR 16,248.97 (x¯= EUR 906.24). Stroke is associated with high costs of inpatient care, which turned out to b...
Background Scientific references lack sufficient amount of data on analyses of the reasons for ho... more Background Scientific references lack sufficient amount of data on analyses of the reasons for hospital admissions or assessment of efficacy of arterial hypertension treatment at hospitals. Objectives The aim of the study was to evaluate the efficacy of antihypertensive drug therapy on the blood pressure control among hospitalized hypertensive patients. Methodology. A cross-sectional retrospective study consisted of 204 patients aged 18–65 years admitted to the hospital due to hypertension between January 2018 and December 2018. The study was based on analysis of electronic records, obtained from the medical database of the selected healthcare facility. Results As a result of the treatment applied at the hospital, 65.19% of the patients achieved the desired degree of blood pressure normalization (≤130/80 mmHg). Vast majority of the patients during their stay at the ward would receive three or more hypertensive drugs (63.73%). The most frequently prescribed antihypertensive drug comb...
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2021
Purpose The study aimed to compare the metabolic effects of an intensive dose of metformin alone ... more Purpose The study aimed to compare the metabolic effects of an intensive dose of metformin alone among non-adherence patients with type 2 diabetes versus in combination with insulin among adherence patients. Methods The prospective cohort study was carried out on a sample of 140 patients above 18 years old, divided into two groups. The first group (n=70) was recommended metformin monotherapy in an intensive dose of 2–3 g/day, whereas the second group (n=70) was prescribed metformin (1–2g/day) in combination with insulin. FPG, HbA1c, BMI, blood pressure, TC, TG, HDL-C, LDL-C, creatinine, and eGFR were measured for each patient at baseline and after a follow-up of 6 months of active treatment. Results After six months of active treatment using monotherapy with an intensive dose of metformin, only 11.43% of patients achieved the target levels of HBA1c below 7%. In the group of patients treated using a combination of metformin with insulin, after six months of active treatment, 45.72% a...
Background The major goals of pharmaceutical care (PC) are to improve the patient’s quality of li... more Background The major goals of pharmaceutical care (PC) are to improve the patient’s quality of life and ensure safety of pharmacotherapy. Inclusion of a pharmacist in the multidisciplinary team caring for the patient and integration of state-of-the-art pharmaceutical services with medical care and nursing are some of the most important challenges that the health care system in Poland is facing. Objectives To evaluate the pharmacists attitudes towards practice in, and knowledge of PC in Poland and to identify the barriers in PC provision. Methods The study was designed as a multicenter study, conducted among Polish pharmacists. Random sampling technique was employed to select the study group. Face-to-face questionnaire method was used to interview the pharmacists, upon obtaining their prior verbal consent to participate in the study. The study was conducted between January 2017 and September 2019. Results Only 15% of the pharmacists have ever attended a training on PC. 72% believed P...
Introduction. Multiple sclerosis (MS) is an autoimmune disease characterized by the presence of d... more Introduction. Multiple sclerosis (MS) is an autoimmune disease characterized by the presence of demyelinating lesions in the brain and the spinal cord. Treatment of MS is based on three strategies: preventing disease progression, mitigating the consequences of symptom relapse, eliminating symptoms. It should be noted that the selection of appropriate therapy should be guided by such factors as: the classifi cation of disease progression by EDSS, the type of MS, symptoms, patient’s opinion. Aim. Aim of this study was to estimate the knowledge of the term and standards of EBM among physicians dealing with patients with multiple sclerosis as well as the degree of use of EBM standards in medical practice. Material and methods. A method of surveying with a specially prepared questionnaire was used in the study. Results. Study demonstrated that the term EBM is relatively common among physicians dealing with multiple sclerosis, but the knowledge of EBM standards is mostly general. Principl...
Cystic fibrosis (CF) is a rare disease. Its prevalence in Poland is around 1 : 5000, and adult pa... more Cystic fibrosis (CF) is a rare disease. Its prevalence in Poland is around 1 : 5000, and adult patients comprise as little as 32% of all patients suffering from this disease. CF treatment is based on a properly selected and effective pharmacotherapy. The aim of this study was to understand the regimen of pharmacotherapy in adult CF population in Poland, and to calculate the costs of drugs used in this group of patients. The researchers conducted a retrospective study. Following an analysis of the patientsí medical documentation, 46 adult patients were included in the study group. Data were sourced from case history forms, doctorsí order sheets and medical treatment records made by physicians. Total pharmacotherapy cost in 2013 amounted to EUR 467876.66 giving EUR 10171.23 (± 2818.39) per patient. The most popular group of drugs used by CF patients was mucolytic drugs, with the estimated cost of EUR 382054.21. Only 14 patients were treated with antibiotics. The total cost of using an...
Wstep Nadciśnienie tetnicze jest jedną z najbardziej rozpowszechnionych chorob cywilizacyjnych na... more Wstep Nadciśnienie tetnicze jest jedną z najbardziej rozpowszechnionych chorob cywilizacyjnych na świecie. Niewlaściwy styl zycia wspolczesnych spoleczenstw (dieta bogatotluszczowa, mala aktywnośc fizyczna, naduzywanie alkoholu, wzrost spozycia soli i palenie tytoniu) jest glowną przyczyną rozwoju nadciśnienia tetniącego. W Polsce na nadciśnienie choruje 29% doroslej populacji. Wyniki ogolnopolskiego badania NATPOL PLUS wskazują, ze 62% badanych przyjmuje leki hipotensyjne systematycznie, 19% czyni to nieregularnie, a az 19% nie podjelo proponowanego leczenia. Analiza kosztow terapii nadciśnienia tetniczego dostarcza informacji na temat wielkości obciązenia systemu ochrony zdrowia kosztami leczenia związanymi z danym schorzeniem. Celem badania byla analiza kosztow bezpośrednich stosowanej farmakoterapii, badan laboratoryjnych i diagnostycznych oraz kosztow związanych z zakupem aparatury pomocniczej pacjenta z rozpoznanym nadciśnieniem tetniczym, ktory byl monitorowany w jednej z wie...
The aim of the study was to compare the safety profiles (prevalence of both local and systemic si... more The aim of the study was to compare the safety profiles (prevalence of both local and systemic side effects) of COVID-19 vaccines (Pfizer–BioNTech, Moderna, Oxford–AstraZeneca) among healthcare workers (doctors, nurses, and pharmacists) administered with a first and a second dose of the vaccines. Another goal of the research was to evaluate potential demographic and clinical risk factors for the frequency and intensity of side effects. A post-marketing, cross-sectional survey-based study was carried out on a sample of 971 respondents (323 doctors, 324 nurses, and 324 pharmacists), all more than 18 years old, who have taken two doses of the following SARS-CoV-2 vaccines: BNT162b2 (Pfizer–BioNTech) (group 1), mRNA-1273 (Moderna) (group 2), and ChAdOx1 nCoV-19 (Oxford–AstraZeneca) (group 3). A validated, self-administered questionnaire was developed and delivered online to the target population group of healthcare workers. The survey was conducted during the third wave of the COVID-19 ...
The studies aimed to determine the antidepressant efficacy of single and chronic administration o... more The studies aimed to determine the antidepressant efficacy of single and chronic administration of dapoxetine alone and vortioxetine alone, as well as in the combination of these drugs. An additional objective of the study was to measure the effect of the active substances on the corticosterone level in chronically stressed animals. The study was conducted on male Wistar rats using non‑stressed and stressed groups (chronic restraint stress). The experiment comprised both forced swimming test (immobility time test) and corticosterone level measurement using Corticosterone ELISA Kit. The obtained results confirm the antidepressant efficacy of used drugs upon both single and chronic administration and potential efficacy of these drugs administered in combination with stressed rats. Corticosterone level analysis, meanwhile, showed stress relieving properties of the study drugs, which reduced the animal stress hormone level, whether administered separately or in combination. Dapoxetine a...
Katedra i Zakład Farmakoekonomiki i Farmacji Społecznej, Uniwersytet Medyczny im. Karola Marcinko... more Katedra i Zakład Farmakoekonomiki i Farmacji Społecznej, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu PRACA ORYGINALNA STRESZCZENIE Wstęp. Cukrzyca jest poważną chorobą dietozależną, w której sposobem leczenia jest prawidłowo dobrana dieta, wysiłek fi zyczny oraz stosowanie odpowiedniej farma-koterapii. W związku z dużą zachorowalnością istnieje konieczność ciągłego badania pacjentów, udoskonalania już istniejących metod diagnostycznych oraz poszukiwa-nia nowych metod leczenia. Prewencja cukrzycy jest zatem istotnym problemem przy zmiennym trybie życia oraz żywienia diabetyków. Cel. Celem pracy było zbadanie stanu wiedzy osób ze zdiagnozowaną cukrzycą na temat związany z profi laktyką i leczeniem cukrzycy. Materiał i metody. W celu dokonania oceny poziomu świadomości pacjentów na temat profi laktyki i leczenia choroby, przeprowadzono ankietę wśród 107 pacjentów ze zdiagnozowaną postacią choroby. Wyniki. Wyniki badań wskazują, iż pacjenci nie posiadają wystarczającej wi...
In adolescents, arterial hypertension (AH) is diagnosed much more frequently than previously thou... more In adolescents, arterial hypertension (AH) is diagnosed much more frequently than previously thought--it affects 3.2% of the population aged 11-18. In Poland, at present, there are no cost analyses of treatment arterial hypertension among adolescents. The aim of the conducted studies was to analyze direct medical and non-medical costs in the time horizon of one calendar year (2010) of AH treatment in adolescents in Poland. A retrospective study from the societal perspective was based on data from 480 patients medical history cards obtained from the archives of the hospital. From this group, according to the criteria for inclusion in the study, a research group was selected consisting of 36 patients aged 16-18 years, with a diagnosed and treated hypertension. Analysis covered direct medical costs (costs of pharmacotherapy, doctors' visits and laboratory tests, hospitalization) and direct non-medical costs (cost of transport to the outpatient clinic). Average annual cost of hypert...
International Journal of Environmental Research and Public Health
The SARS-CoV-2 virus pandemic has exerted enormous impacts on individuals’ lifestyle, economics a... more The SARS-CoV-2 virus pandemic has exerted enormous impacts on individuals’ lifestyle, economics and social life. The aim of the study was to assess the impact of the COVID-19 pandemic on health-promoting behaviors of a sample of the Polish population, including dietary supplementation, physical activity, eating habits, and the implementation of preventive vaccinations. Within the scope of a survey, data was collected from 1101 adult respondents residing in Poland (862 women and 239 men). An anonymous questionnaire prepared based on the scientific literature was used as a research tool. The survey was conducted during the second wave of COVID-19 using the CAWI (Computer—Assisted Web Interview) method by disseminating the questionnaire using selected social media. We found that, during the COVID-19 pandemic, the respondents were more likely to maintain healthy eating habits and use dietary supplementation; however, the majority engaged in physical activity less frequently and had a se...
Background There is a need to investigate how adopting different strategies for treating obesity ... more Background There is a need to investigate how adopting different strategies for treating obesity in different countries in the European Union affects the psychological well-being of patients. Aims The aim of this study was to perform a comparative evaluation of psychiatric symptoms (depression, anxiety and stress) in patients undergoing bariatric surgery versus patients receiving conservative treatment for morbid obesity in Poland and Germany. Method A multicentre international prospective cohort study with 155 patients who underwent bariatric surgery and 409 patients who received conservative weight reduction treatment. Evaluation of the psychiatric symptoms was carried out for each patient at baseline and after 12 months of active treatment using a standardised Depression Anxiety Stress Scale questionnaire (DASS-21) questionnaire. Results After 12 months of active treatment, the level of psychiatric symptoms (depression, anxiety and stress) significantly decreased in both groups o...
i Zakład Toksykologii, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu PRACA ORYGINALN... more i Zakład Toksykologii, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu PRACA ORYGINALNA STRESZCZENIE Wstęp. Medyczne bazy danych (MBD) to zbiór informacji, który w swoim założeniu ma ułatwić dostęp do rzetelnych danych medycznych zgodnie z Evidence Based Medicine (EBM). Prawidłowo przygotowana baza przyjmuje różne formy, od prostych baz danych pacjentów po bazy semantyczne, ukierunkowane na dane jednostki cho-robowe (zw. bazy referencyjne), pozwalające na zoptymalizowanie pracy całego personelu medycznego. Ośrodki medyczne starają się prowadzić MBD w wersji kompu-terowej, które zawierają m.in. dane z podstawowego i poszerzonego wywiadu, przebieg i czas leczenia, wyniki badań ambulatoryjno-laboratoryjnych. Bazy te znacząco wspomagają proces diagnostyczny i wybór metody leczenia, np. schizofrenii, która stanowi obecnie w Europie prawie połowę osób leczonych na choroby psychiczne. Dla podjęcia prawidłowej terapii niezbędna jest pełna informacja pochodząca z jednej strony z b...
Stroke is a major cause of morbidity in industrialized countries, representing 8% of total deaths... more Stroke is a major cause of morbidity in industrialized countries, representing 8% of total deaths across Europe in 2017. It is also a very costly disorder, frequently caused by atrial fibrillation. We aimed to calculate the cost of stroke hospitalization in 2018 in Poznań (Poland). We also intended to present patients with the first AF diagnosis at the time of stroke. The study was conducted from January 2019 to July 2020. Data were obtained from hospital records and from the hospital accounting department. Out of 164 patients included in the study, 41 had AF and in 18 cases AF was first diagnosed at the time of stroke. The cost of hospitalization in Poznań was EUR 139,257.21 (x¯= EUR 849.13). Among those with concomitant AF, the general cost of inpatient care was EUR 33,859.18 (x¯= EUR 825.83). Considering those who had AF first diagnosed during hospitalization the cost was EUR 16,248.97 (x¯= EUR 906.24). Stroke is associated with high costs of inpatient care, which turned out to b...
Background Scientific references lack sufficient amount of data on analyses of the reasons for ho... more Background Scientific references lack sufficient amount of data on analyses of the reasons for hospital admissions or assessment of efficacy of arterial hypertension treatment at hospitals. Objectives The aim of the study was to evaluate the efficacy of antihypertensive drug therapy on the blood pressure control among hospitalized hypertensive patients. Methodology. A cross-sectional retrospective study consisted of 204 patients aged 18–65 years admitted to the hospital due to hypertension between January 2018 and December 2018. The study was based on analysis of electronic records, obtained from the medical database of the selected healthcare facility. Results As a result of the treatment applied at the hospital, 65.19% of the patients achieved the desired degree of blood pressure normalization (≤130/80 mmHg). Vast majority of the patients during their stay at the ward would receive three or more hypertensive drugs (63.73%). The most frequently prescribed antihypertensive drug comb...
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2021
Purpose The study aimed to compare the metabolic effects of an intensive dose of metformin alone ... more Purpose The study aimed to compare the metabolic effects of an intensive dose of metformin alone among non-adherence patients with type 2 diabetes versus in combination with insulin among adherence patients. Methods The prospective cohort study was carried out on a sample of 140 patients above 18 years old, divided into two groups. The first group (n=70) was recommended metformin monotherapy in an intensive dose of 2–3 g/day, whereas the second group (n=70) was prescribed metformin (1–2g/day) in combination with insulin. FPG, HbA1c, BMI, blood pressure, TC, TG, HDL-C, LDL-C, creatinine, and eGFR were measured for each patient at baseline and after a follow-up of 6 months of active treatment. Results After six months of active treatment using monotherapy with an intensive dose of metformin, only 11.43% of patients achieved the target levels of HBA1c below 7%. In the group of patients treated using a combination of metformin with insulin, after six months of active treatment, 45.72% a...
Background The major goals of pharmaceutical care (PC) are to improve the patient’s quality of li... more Background The major goals of pharmaceutical care (PC) are to improve the patient’s quality of life and ensure safety of pharmacotherapy. Inclusion of a pharmacist in the multidisciplinary team caring for the patient and integration of state-of-the-art pharmaceutical services with medical care and nursing are some of the most important challenges that the health care system in Poland is facing. Objectives To evaluate the pharmacists attitudes towards practice in, and knowledge of PC in Poland and to identify the barriers in PC provision. Methods The study was designed as a multicenter study, conducted among Polish pharmacists. Random sampling technique was employed to select the study group. Face-to-face questionnaire method was used to interview the pharmacists, upon obtaining their prior verbal consent to participate in the study. The study was conducted between January 2017 and September 2019. Results Only 15% of the pharmacists have ever attended a training on PC. 72% believed P...
Introduction. Multiple sclerosis (MS) is an autoimmune disease characterized by the presence of d... more Introduction. Multiple sclerosis (MS) is an autoimmune disease characterized by the presence of demyelinating lesions in the brain and the spinal cord. Treatment of MS is based on three strategies: preventing disease progression, mitigating the consequences of symptom relapse, eliminating symptoms. It should be noted that the selection of appropriate therapy should be guided by such factors as: the classifi cation of disease progression by EDSS, the type of MS, symptoms, patient’s opinion. Aim. Aim of this study was to estimate the knowledge of the term and standards of EBM among physicians dealing with patients with multiple sclerosis as well as the degree of use of EBM standards in medical practice. Material and methods. A method of surveying with a specially prepared questionnaire was used in the study. Results. Study demonstrated that the term EBM is relatively common among physicians dealing with multiple sclerosis, but the knowledge of EBM standards is mostly general. Principl...
Cystic fibrosis (CF) is a rare disease. Its prevalence in Poland is around 1 : 5000, and adult pa... more Cystic fibrosis (CF) is a rare disease. Its prevalence in Poland is around 1 : 5000, and adult patients comprise as little as 32% of all patients suffering from this disease. CF treatment is based on a properly selected and effective pharmacotherapy. The aim of this study was to understand the regimen of pharmacotherapy in adult CF population in Poland, and to calculate the costs of drugs used in this group of patients. The researchers conducted a retrospective study. Following an analysis of the patientsí medical documentation, 46 adult patients were included in the study group. Data were sourced from case history forms, doctorsí order sheets and medical treatment records made by physicians. Total pharmacotherapy cost in 2013 amounted to EUR 467876.66 giving EUR 10171.23 (± 2818.39) per patient. The most popular group of drugs used by CF patients was mucolytic drugs, with the estimated cost of EUR 382054.21. Only 14 patients were treated with antibiotics. The total cost of using an...
Wstep Nadciśnienie tetnicze jest jedną z najbardziej rozpowszechnionych chorob cywilizacyjnych na... more Wstep Nadciśnienie tetnicze jest jedną z najbardziej rozpowszechnionych chorob cywilizacyjnych na świecie. Niewlaściwy styl zycia wspolczesnych spoleczenstw (dieta bogatotluszczowa, mala aktywnośc fizyczna, naduzywanie alkoholu, wzrost spozycia soli i palenie tytoniu) jest glowną przyczyną rozwoju nadciśnienia tetniącego. W Polsce na nadciśnienie choruje 29% doroslej populacji. Wyniki ogolnopolskiego badania NATPOL PLUS wskazują, ze 62% badanych przyjmuje leki hipotensyjne systematycznie, 19% czyni to nieregularnie, a az 19% nie podjelo proponowanego leczenia. Analiza kosztow terapii nadciśnienia tetniczego dostarcza informacji na temat wielkości obciązenia systemu ochrony zdrowia kosztami leczenia związanymi z danym schorzeniem. Celem badania byla analiza kosztow bezpośrednich stosowanej farmakoterapii, badan laboratoryjnych i diagnostycznych oraz kosztow związanych z zakupem aparatury pomocniczej pacjenta z rozpoznanym nadciśnieniem tetniczym, ktory byl monitorowany w jednej z wie...
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