Aim: Cardiovascular events are associated with increased mortality in patients with autosomal dom... more Aim: Cardiovascular events are associated with increased mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Urotensin II (UT II) is the most potent vasoconstrictor peptide. The aim of the study was to investigate the relationship between UT II and arterial stiffness (AS) and atherosclerosis in ADPKD patients. Material and Methods: 55 ADPKD patients with a mean age of 50±14.4 years. The presence of AS was determined with brachial-ankle pulse wave velocity (baPWV) and the presence of atherosclerosis was determined with carotid artery intima-media thickness (CA-IMT). Plasma UT II levels were determined by enzyme-linked immunosorbent assay. Results: Mean log10 UT II was 0.92±0.16 ng/mL. 12 (10.9%) patients had LVH. Mean baPWV and CA-IMT were 7.65±1.5 m/sec and 0.63±0.13 mm, respectively. Log10 UT II (p=0.009), baPWV (p < 0.001) and CA-IMT (p=0.001) were high in patients compared to healthy individuals. There was an independent relationship between log10 UT II and creatinine (p=0.044) and spot urine protein-creatinine ratio (UPCR) (p=0.026) in multiple regression analysis. There was no relationship between log10 UT II and baPWV and CA-IMT. Conclusion: High plasma UT II levels were observed in ADPKD patients compared to healthy individuals. There was a relationship between UT II and kidney dysfunction and proteinuria. There was no relationship between UT II and AS and atherosclerosis.
Background and aim Data on NOAC discontinuation patterns in Turkey are lacking. We conducted a su... more Background and aim Data on NOAC discontinuation patterns in Turkey are lacking. We conducted a subgroup analysis in ASPECT-NOAC study to determine anticoagulant discontinuation pattern in AF patients with recently initiated NOAC therapy. Methods ASPECT-NOAC was a national, multicenter, 12-month observational study conducted in 34 outpatient cardiology clinics of state, university, private, and research hospitals covering all geographic regions of Turkey. Adult AF patients who were under NOAC therapy for less than four months were enrolled. Patients who discontinued using their NOACs were recorded at the end of 12 months. A comparative analysis of patients with discontinuation of medication was conducted. Results This study included 991 non-valvular AF patients. NOAC continuation data were available for 854 patients. During study follow-up, 74 patients (8.7%) discontinued their NOAC medication. Mean age of these patients was 67.1±11.3 years old and 38 patients (51.4%) were female. Mo...
Aim: Cardiovascular events are associated with increased mortality in patients with autosomal dom... more Aim: Cardiovascular events are associated with increased mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Urotensin II (UT II) is the most potent vasoconstrictor peptide. The aim of the study was to investigate the relationship between UT II and arterial stiffness (AS) and atherosclerosis in ADPKD patients. Material and Methods: 55 ADPKD patients with a mean age of 50±14.4 years. The presence of AS was determined with brachial-ankle pulse wave velocity (baPWV) and the presence of atherosclerosis was determined with carotid artery intima-media thickness (CA-IMT). Plasma UT II levels were determined by enzyme-linked immunosorbent assay. Results: Mean log10 UT II was 0.92±0.16 ng/mL. 12 (10.9%) patients had LVH. Mean baPWV and CA-IMT were 7.65±1.5 m/sec and 0.63±0.13 mm, respectively. Log10 UT II (p=0.009), baPWV (p < 0.001) and CA-IMT (p=0.001) were high in patients compared to healthy individuals. There was an independent relationship between log10 UT II and creatinine (p=0.044) and spot urine protein-creatinine ratio (UPCR) (p=0.026) in multiple regression analysis. There was no relationship between log10 UT II and baPWV and CA-IMT. Conclusion: High plasma UT II levels were observed in ADPKD patients compared to healthy individuals. There was a relationship between UT II and kidney dysfunction and proteinuria. There was no relationship between UT II and AS and atherosclerosis.
Background and aim Data on NOAC discontinuation patterns in Turkey are lacking. We conducted a su... more Background and aim Data on NOAC discontinuation patterns in Turkey are lacking. We conducted a subgroup analysis in ASPECT-NOAC study to determine anticoagulant discontinuation pattern in AF patients with recently initiated NOAC therapy. Methods ASPECT-NOAC was a national, multicenter, 12-month observational study conducted in 34 outpatient cardiology clinics of state, university, private, and research hospitals covering all geographic regions of Turkey. Adult AF patients who were under NOAC therapy for less than four months were enrolled. Patients who discontinued using their NOACs were recorded at the end of 12 months. A comparative analysis of patients with discontinuation of medication was conducted. Results This study included 991 non-valvular AF patients. NOAC continuation data were available for 854 patients. During study follow-up, 74 patients (8.7%) discontinued their NOAC medication. Mean age of these patients was 67.1±11.3 years old and 38 patients (51.4%) were female. Mo...
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