Pelawan merah (Tristaniopsis merguensis) merupakan tanaman yang banyak ditemukan di pulau Bangka.... more Pelawan merah (Tristaniopsis merguensis) merupakan tanaman yang banyak ditemukan di pulau Bangka. Bagian dari tanaman pelawan seperti akar, batang, dan daunnya banyak dimanfaatkan oleh masyarakat secara turun-temurun sebagai bahan obat untuk berbagai penyakit, salah satunya adalah diare. Daun pelawan merah mengandung metabolit sekunder seperti alkaloid, tanin, dan saponin yang dikenal sebagai zat aktif yang berkhasiat sebagai antidiare. Penelitian ini bertujuan untuk mendapatkan informasi dan data ilmiah mengenai efektivitas antidiare dari infusa daun pelawan merah (Tristaniopsis merguensis) dengan menggunakan metode proteksi intestinal dan transit intestinal. Penelitian ini juga dilakukan untuk menentukan konsentrasi efektif yang memberikan efek antidiare terbaik pada mencit. Penelitian ini menggunakan 25 ekor mencit yang dibagi menjadi lima kelompok yaitu kontrol negatif, kontrol positif, dan tiga kelompok perlakuan yang diberi infusa daun pelawan merah dengan konsentrasi 50%, 75%...
Dates (Phoenix dactylifera) are considered as a well-known fruit consumed by many people in vario... more Dates (Phoenix dactylifera) are considered as a well-known fruit consumed by many people in various countries. This study aimed to examine potential effects of dates as a hepatoprotective agent in mice. This study was conducted at the Iratco Group’s eLRosa Laboratory Research Facility, Indonesia, starting from June 2022 to July 2022. Mice from ddY strain were randomly divided into 5 groups (n=5 per group) of positive and negative control groups, and treatment groups 1, 2, and 3. The negative control group as the normal baseline did not receive acetaminophen and date extract. In treatment groups, 30 µL/30 gr BW, 60 µL/30 gr BW, and 100 µL/30 gr BW extract was given per oral to Treatment Group 1, Group 2, and Group 3, respectively for 20 days. On day 21, all treatment groups were induced with 300mg/KgBW acetaminophen for 3 days via the intraperitoneal route. Blood tests were performed on day 24 to measure the serum transaminase level as the parameter of liver damage. The lowest leve...
Jurnal Kedokteran Hewan - Indonesian Journal of Veterinary Sciences
The purpose of this study was to examine the efficacy of a herbal combination of avocado, mung be... more The purpose of this study was to examine the efficacy of a herbal combination of avocado, mung bean sprouts, and holy basil (Jamu ATOKE) in optimizing the reproductive health of adult female rats. Eighteen female Sprague Dawley rats aged 9-10 weeks old weighing around 180-250 g, and had not been pregnant previously were equally and randomly divided into 3 groups: one control group and two treatment groups (n= 6 rats per group). The treatment groups received Jamu ATOKE with a concentration of 2.5 and 5%, respectively. Jamu ATOKE was added to the drinking water and consumed by the rats for 30 days prior to pregnancy. Reproductivity (pregnancy success, estrogen and progesterone hormone concentrations), and health performance (body weight gain, food, and water consumption, motor activity, red blood cell (RBC) count, white blood cell (WBC) count and differentials, SGPT, SGOT, ureum, and creatinine) of rats were observed. The results showed that groups receiving the Jamu ATOKE had better ...
AULIA ANDI MUSTIKA. Potention of Zingiber officinale, Kaempferia galanga, Curcuma xanthorriza and... more AULIA ANDI MUSTIKA. Potention of Zingiber officinale, Kaempferia galanga, Curcuma xanthorriza and Andrographis paniculata as anti Mycoplasma gallisepticum and Eschericia coli Agents of Complex Chronic Respiratory Diseases. Under supervision of MIN RAHMINIWATI, SOERIPTO and UNANG PATRIANA Zingiber officinale Rosc, Kaempferia galanga, Curcuma xanthorrhiza roxb and Andrographis paniculata nees are medicinal plants that have been used widely for traditional treatment for human in Indonesia. The herbs have also been used for treatment in animals but they have not been proven scientifically. The advantages of using herbs for treatment compared to antibiotics are the herbs have less resistances, low toxicity and no residual component produce in the body organs. Complex chronic respiratory disease (CCRD) of chickens was known to be infectious and causes high economic losses against poultry industries. The main agent of the disease is Mycoplasma gallisepticum (M. gallisepticum) and complicat...
Penelitian ini dilakukan untuk mengeksplorasi khasiat fitofarmaka lokal Indonesia yaitu kemangi s... more Penelitian ini dilakukan untuk mengeksplorasi khasiat fitofarmaka lokal Indonesia yaitu kemangi sebagai antifertilitas dalam meningkatkan kesehatan dan keamanan tikus betina. Sebanyak 15 ekor tikus betina galur Sprague-Dawley (umur 8 minggu, bobot badan 220-230 g) dibagi acak ke dalam 3 perlakuan dan 5 ulangan, yaitu: kontrol (K0); kemangi 1% (K1); dan kemangi 5% (K5) dalam bentuk maserasi yang ditambahkan ke dalam air minum. Pemberian jamu dilakukan selama 20 hari dimulai pada fase diestrus. Parameter profil darah yang diamati adalah gambaran darah merah (jumlah butir darah merah, hematokrit, dan hemoglobin) dan diferensial darah putih (limfosit, monosit, neutrofil, eosinofil, basofil). Parameter keamanan diamati dengan melihat fungsi organ hati (SGPT, SGOT) dan ginjal (ureum, kreatinin). Hasil menunjukkan bahwa profil darah dan pengamatan fungsi hati dan ginjal pada kelompok tikus betina yang diberi kemangi tidak terdapat perbedaan nyata (P>0.05) dengan kelompok kontrol. Pember...
DOAJ (DOAJ: Directory of Open Access Journals), 2016
Betle and ginger juice extracts have been reported to have antibacterial activity against E. coli... more Betle and ginger juice extracts have been reported to have antibacterial activity against E. coliand M. gallisepticum. However, fractionation analysis showed the have differences in their antibacterialpotency which appeared to be associated with the nature of the solvent polarity. This study wasconducted to obtain information about antibacterial activity of Piper betles and gingers extract againstE. coli and M. gallisepticum. Three types of betle, P. betle, P. betle var nigra, P. crocatum, wereexamined for their antibacterial activity using disc method and three types of ginger, Zingiber officinale,Z. officinale Linn var rubrum, and Z. majus rumph which were extracted by soxhletation using ethanol30%, 60% and 90% as well as distestillation for three and five hours. Piper betle and P. crocatumconsistently have antibacterial effect against E. coli whereas Z. officinale consistently has antibacterialeffect against M. gallisepticum, either extracted by distillation or soxhletation. Piper betle is potentialyield of distillate and extract that has the highest antibacterial activity against E. coli, and M.gallisepticum with inhibitory zone were 9.76 mm and 22 mm respectively.
Kanker masih menjadi salah satu penyebab kematian di dunia. Salah satu alternatif metode untuk me... more Kanker masih menjadi salah satu penyebab kematian di dunia. Salah satu alternatif metode untuk mengobati kanker adalah dengan obat herbal yang mempunyai khasiat sebagai antikanker. Penelitian ini bertujuan untuk manganalisis efek sitotoksik esktrak Capsium annuum pada sel WiDr. Kemampuan sitotoksik ekstrak Capsium annuum diuji secara in vitro pada sel WiDr menggunakan metode MTT tetrazolium reduction assay. Hasil uji MTT menunjukkan bahwa ekstrak Capsicum annuum menghambat proliferasi sel WiDr seiring dengan peningkatan konsentrasi (400, 800, dan 1600 ppm), dengan persentase penghambatan sel tertinggi diperoleh pada konsentrasi 800 ppm dari setiap kelompok terapi 24, 48, dan 72 jam. Nilai inhibitory concentration 50 (IC50) terendah dihasilkan oleh kelompok waktu terapi 48 jam, yaitu 651,18 ppm. Nilai IC50 ekstrak Capsicum annuum untuk sel WiDr memiliki nilai yang tinggi yang menunjukkan belum efektif sebagai obat antikanker. Penelitian lebih lanjut dibutuhkan untuk mendapatkan dosi...
Background: Skin is a layer of tissue from body that covers and protects the body from the danger... more Background: Skin is a layer of tissue from body that covers and protects the body from the danger that comes from outside and the environment. Skin is very susceptible to trauma, which is a cut wound. Objective: The purpose of the study was to determine the effectiveness of the mixture from sea cucumber and turmeric extract in cream dosage on rat’s cut wounds. Methods: This study used 15 white rats which were given a cut and the treatments of mixed cream with the different concentrations. The treatments were given by to dab the mixed cream on the wound area each day. The wound healing was observed on days 1, 7, 14 and 21, then the researchers gave scores on those wounds. The researcher measured the wound healing through the acceleration parameters of wound closure and inflammation reduction. Results: The results of this study showed that the rats wound completely closed on all area treatments and also showed that the healing time is faster than those who did not receive treatment. ...
Pelawan merah (Tristaniopsis merguensis) merupakan tanaman yang banyak ditemukan di pulau Bangka.... more Pelawan merah (Tristaniopsis merguensis) merupakan tanaman yang banyak ditemukan di pulau Bangka. Bagian dari tanaman pelawan seperti akar, batang, dan daunnya banyak dimanfaatkan oleh masyarakat secara turun-temurun sebagai bahan obat untuk berbagai penyakit, salah satunya adalah diare. Daun pelawan merah mengandung metabolit sekunder seperti alkaloid, tanin, dan saponin yang dikenal sebagai zat aktif yang berkhasiat sebagai antidiare. Penelitian ini bertujuan untuk mendapatkan informasi dan data ilmiah mengenai efektivitas antidiare dari infusa daun pelawan merah (Tristaniopsis merguensis) dengan menggunakan metode proteksi intestinal dan transit intestinal. Penelitian ini juga dilakukan untuk menentukan konsentrasi efektif yang memberikan efek antidiare terbaik pada mencit. Penelitian ini menggunakan 25 ekor mencit yang dibagi menjadi lima kelompok yaitu kontrol negatif, kontrol positif, dan tiga kelompok perlakuan yang diberi infusa daun pelawan merah dengan konsentrasi 50%, 75%...
Dates (Phoenix dactylifera) are considered as a well-known fruit consumed by many people in vario... more Dates (Phoenix dactylifera) are considered as a well-known fruit consumed by many people in various countries. This study aimed to examine potential effects of dates as a hepatoprotective agent in mice. This study was conducted at the Iratco Group’s eLRosa Laboratory Research Facility, Indonesia, starting from June 2022 to July 2022. Mice from ddY strain were randomly divided into 5 groups (n=5 per group) of positive and negative control groups, and treatment groups 1, 2, and 3. The negative control group as the normal baseline did not receive acetaminophen and date extract. In treatment groups, 30 µL/30 gr BW, 60 µL/30 gr BW, and 100 µL/30 gr BW extract was given per oral to Treatment Group 1, Group 2, and Group 3, respectively for 20 days. On day 21, all treatment groups were induced with 300mg/KgBW acetaminophen for 3 days via the intraperitoneal route. Blood tests were performed on day 24 to measure the serum transaminase level as the parameter of liver damage. The lowest leve...
Jurnal Kedokteran Hewan - Indonesian Journal of Veterinary Sciences
The purpose of this study was to examine the efficacy of a herbal combination of avocado, mung be... more The purpose of this study was to examine the efficacy of a herbal combination of avocado, mung bean sprouts, and holy basil (Jamu ATOKE) in optimizing the reproductive health of adult female rats. Eighteen female Sprague Dawley rats aged 9-10 weeks old weighing around 180-250 g, and had not been pregnant previously were equally and randomly divided into 3 groups: one control group and two treatment groups (n= 6 rats per group). The treatment groups received Jamu ATOKE with a concentration of 2.5 and 5%, respectively. Jamu ATOKE was added to the drinking water and consumed by the rats for 30 days prior to pregnancy. Reproductivity (pregnancy success, estrogen and progesterone hormone concentrations), and health performance (body weight gain, food, and water consumption, motor activity, red blood cell (RBC) count, white blood cell (WBC) count and differentials, SGPT, SGOT, ureum, and creatinine) of rats were observed. The results showed that groups receiving the Jamu ATOKE had better ...
AULIA ANDI MUSTIKA. Potention of Zingiber officinale, Kaempferia galanga, Curcuma xanthorriza and... more AULIA ANDI MUSTIKA. Potention of Zingiber officinale, Kaempferia galanga, Curcuma xanthorriza and Andrographis paniculata as anti Mycoplasma gallisepticum and Eschericia coli Agents of Complex Chronic Respiratory Diseases. Under supervision of MIN RAHMINIWATI, SOERIPTO and UNANG PATRIANA Zingiber officinale Rosc, Kaempferia galanga, Curcuma xanthorrhiza roxb and Andrographis paniculata nees are medicinal plants that have been used widely for traditional treatment for human in Indonesia. The herbs have also been used for treatment in animals but they have not been proven scientifically. The advantages of using herbs for treatment compared to antibiotics are the herbs have less resistances, low toxicity and no residual component produce in the body organs. Complex chronic respiratory disease (CCRD) of chickens was known to be infectious and causes high economic losses against poultry industries. The main agent of the disease is Mycoplasma gallisepticum (M. gallisepticum) and complicat...
Penelitian ini dilakukan untuk mengeksplorasi khasiat fitofarmaka lokal Indonesia yaitu kemangi s... more Penelitian ini dilakukan untuk mengeksplorasi khasiat fitofarmaka lokal Indonesia yaitu kemangi sebagai antifertilitas dalam meningkatkan kesehatan dan keamanan tikus betina. Sebanyak 15 ekor tikus betina galur Sprague-Dawley (umur 8 minggu, bobot badan 220-230 g) dibagi acak ke dalam 3 perlakuan dan 5 ulangan, yaitu: kontrol (K0); kemangi 1% (K1); dan kemangi 5% (K5) dalam bentuk maserasi yang ditambahkan ke dalam air minum. Pemberian jamu dilakukan selama 20 hari dimulai pada fase diestrus. Parameter profil darah yang diamati adalah gambaran darah merah (jumlah butir darah merah, hematokrit, dan hemoglobin) dan diferensial darah putih (limfosit, monosit, neutrofil, eosinofil, basofil). Parameter keamanan diamati dengan melihat fungsi organ hati (SGPT, SGOT) dan ginjal (ureum, kreatinin). Hasil menunjukkan bahwa profil darah dan pengamatan fungsi hati dan ginjal pada kelompok tikus betina yang diberi kemangi tidak terdapat perbedaan nyata (P>0.05) dengan kelompok kontrol. Pember...
DOAJ (DOAJ: Directory of Open Access Journals), 2016
Betle and ginger juice extracts have been reported to have antibacterial activity against E. coli... more Betle and ginger juice extracts have been reported to have antibacterial activity against E. coliand M. gallisepticum. However, fractionation analysis showed the have differences in their antibacterialpotency which appeared to be associated with the nature of the solvent polarity. This study wasconducted to obtain information about antibacterial activity of Piper betles and gingers extract againstE. coli and M. gallisepticum. Three types of betle, P. betle, P. betle var nigra, P. crocatum, wereexamined for their antibacterial activity using disc method and three types of ginger, Zingiber officinale,Z. officinale Linn var rubrum, and Z. majus rumph which were extracted by soxhletation using ethanol30%, 60% and 90% as well as distestillation for three and five hours. Piper betle and P. crocatumconsistently have antibacterial effect against E. coli whereas Z. officinale consistently has antibacterialeffect against M. gallisepticum, either extracted by distillation or soxhletation. Piper betle is potentialyield of distillate and extract that has the highest antibacterial activity against E. coli, and M.gallisepticum with inhibitory zone were 9.76 mm and 22 mm respectively.
Kanker masih menjadi salah satu penyebab kematian di dunia. Salah satu alternatif metode untuk me... more Kanker masih menjadi salah satu penyebab kematian di dunia. Salah satu alternatif metode untuk mengobati kanker adalah dengan obat herbal yang mempunyai khasiat sebagai antikanker. Penelitian ini bertujuan untuk manganalisis efek sitotoksik esktrak Capsium annuum pada sel WiDr. Kemampuan sitotoksik ekstrak Capsium annuum diuji secara in vitro pada sel WiDr menggunakan metode MTT tetrazolium reduction assay. Hasil uji MTT menunjukkan bahwa ekstrak Capsicum annuum menghambat proliferasi sel WiDr seiring dengan peningkatan konsentrasi (400, 800, dan 1600 ppm), dengan persentase penghambatan sel tertinggi diperoleh pada konsentrasi 800 ppm dari setiap kelompok terapi 24, 48, dan 72 jam. Nilai inhibitory concentration 50 (IC50) terendah dihasilkan oleh kelompok waktu terapi 48 jam, yaitu 651,18 ppm. Nilai IC50 ekstrak Capsicum annuum untuk sel WiDr memiliki nilai yang tinggi yang menunjukkan belum efektif sebagai obat antikanker. Penelitian lebih lanjut dibutuhkan untuk mendapatkan dosi...
Background: Skin is a layer of tissue from body that covers and protects the body from the danger... more Background: Skin is a layer of tissue from body that covers and protects the body from the danger that comes from outside and the environment. Skin is very susceptible to trauma, which is a cut wound. Objective: The purpose of the study was to determine the effectiveness of the mixture from sea cucumber and turmeric extract in cream dosage on rat’s cut wounds. Methods: This study used 15 white rats which were given a cut and the treatments of mixed cream with the different concentrations. The treatments were given by to dab the mixed cream on the wound area each day. The wound healing was observed on days 1, 7, 14 and 21, then the researchers gave scores on those wounds. The researcher measured the wound healing through the acceleration parameters of wound closure and inflammation reduction. Results: The results of this study showed that the rats wound completely closed on all area treatments and also showed that the healing time is faster than those who did not receive treatment. ...
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