Acute lymphoblastic leukemia (ALL) is the most common type of leukemia affecting children under t... more Acute lymphoblastic leukemia (ALL) is the most common type of leukemia affecting children under the age of 15 years old in Malaysia. Chemotherapy is the primary treatment for cancer, which involves the intake of chemotherapeutic drugs to kill cancer cells. Glucocorticoids such as dexamethasone are chemotherapeutic agents used in the treatment of ALL. Although dexamethasone is highly effective, it is also associated with adverse effects such as bone fractures and organ toxicity. Therefore, there is a need to develop a new anticancer drug which milder side effects and better efficacy. Organometallic compounds such as organotin have a high potential to be developed as an antineoplastic agent and show high specificity towards cancer cells compared to normal cells. This study is done to evaluate the cytotoxic effects of diphenyltin(IV) diisopropyl dithiocarbamate (DPDT) against leukemic cells CCL-119 using the Trypan Blue exclusion (TBE) method at the intervals of 24, 48 and 72 h. Dexame...
This study has been done to determine the isotherm and kinetic adsorption of boron on activated c... more This study has been done to determine the isotherm and kinetic adsorption of boron on activated carbon that been modified with curcumin. In this study, the maximum boron removal was obtained at pH 5.6 and the optimum contact time was 120 minutes. The comparison of boron removal percentage and adsorption isotherms between activated carbon modified with curcumin and activated carbon without curcumin also been studied. The percentage of boron removal by activated carbon modified with curcumin is 53.3% ...
Australian Journal of Basic and Applied Sciences, 2011
Abstract: Tamarindus indica (tamarind), Garcinia atroviridis, and Curcuma longa (turmeric) are wi... more Abstract: Tamarindus indica (tamarind), Garcinia atroviridis, and Curcuma longa (turmeric) are widely used in food preparation. This study was conducted to determine the aluminium leachability in acidic food flavors Tamarindus indica and Garcinia atroviridis and tumeric powder. The results showed that aluminium contents were increased accordingly to the dosage of these acidic food flavors. The results showed that aluminium leaching was higher in solutions without Curcuma longa compare to the present of Curcuma longa. The effect ...
... Robert C. Brown, MRC Toxicology Unit, University of Leices-ter, Leicester, United Kingdom Der... more ... Robert C. Brown, MRC Toxicology Unit, University of Leices-ter, Leicester, United Kingdom Derrick R. Crump, Building Research Establishment, Garston, Watford, United Kingdom MichalKrzyzanowski, WHO European Centre for Environ-ment and Health, Bilthoven Division ...
Ternary complexes of Cu(II) with acetylacetone and various salicylic acids (viz., salicylic, 5-ch... more Ternary complexes of Cu(II) with acetylacetone and various salicylic acids (viz., salicylic, 5-chloro-, 3,5-dibromo-, 3,5-dinitro-, thio-, and acetyl-salicylic acids) were synthesised in pure state and these complexes were characterised by elemental analysis, conductivity, IR data and optical absorption. The antibacterial and antifungal activity studies on these complexes revealed that the ternary complexes are better toxic agents than the binary complexes
The renovation of a building will certainly affect the quality of air in the vicinity of where as... more The renovation of a building will certainly affect the quality of air in the vicinity of where associated activities were undertaken, this includes the quality of air inside the building. Indoor air pollutants such as particulate matter, heavy metals, and fine fibers are likely to be emitted during renovation work. This study was conducted to determine the concentration of heavy metals, asbestos and suspended particulates in the Biology Building, at the Universiti Kebangsaan, Malaysia (UKM). Renovation activities were carried out widely in the laboratories which were located in this building. A low-volume sampler was used to collect suspended particulate matter of a diameter size less than 10 μm (PM10) and an air sampling pump, fitted with a cellulose ester membrane filter, were used for asbestos sampling. Dust was collected using a small brush and scope. The concentration of heavy metals was determined through the use of inductively coupled plasma–mass spectroscopy and the fibers w...
Synthesis and Reactivity in Inorganic Metal-organic and Nano-metal Chemistry, 2012
Some triphenyltin and dibutyltin thiobiurets of the type Ph3SnL and Bu2SnL2 [where LH = 1,5 diphe... more Some triphenyltin and dibutyltin thiobiurets of the type Ph3SnL and Bu2SnL2 [where LH = 1,5 diphenyl-2-thiobiuret (PPTBH), 1-(4-ethoxyphenyl)-5-phenyl-2-thiobiuret (EtOPPTBH) or 1-naphthyl-5-phenyl-2-thiobiuret (naph PTBH)], have been synthesized and characterized by elemental analysis and various physico-chemical techniques. Molar conductance measurements show the non-ionic behavior of the complexes. FAB mass spectra exhibit their monomeric nature.H and CNMR spectra support the proposed stoichiometry of
Acta Crystallographica Section E Structure Reports Online, 2014
In the title compound, C12H15FN2O2S, the molecule adopts acisconfiguration of the fluorobenzoyl g... more In the title compound, C12H15FN2O2S, the molecule adopts acisconfiguration of the fluorobenzoyl group with respect to the thiono group about their C—N bond. The dihedral angle between the fluorobenzoyl group and the thiourea N2CS fragment is 69.60 (11)°. An intramolecular N—H...O hydrogen bond occurs. In the crystal, molecules form chains along theb-axis directionviaO—H...S and C—H...O hydrogen bonds.
Acute lymphoblastic leukemia (ALL) is the most common type of leukemia affecting children under t... more Acute lymphoblastic leukemia (ALL) is the most common type of leukemia affecting children under the age of 15 years old in Malaysia. Chemotherapy is the primary treatment for cancer, which involves the intake of chemotherapeutic drugs to kill cancer cells. Glucocorticoids such as dexamethasone are chemotherapeutic agents used in the treatment of ALL. Although dexamethasone is highly effective, it is also associated with adverse effects such as bone fractures and organ toxicity. Therefore, there is a need to develop a new anticancer drug which milder side effects and better efficacy. Organometallic compounds such as organotin have a high potential to be developed as an antineoplastic agent and show high specificity towards cancer cells compared to normal cells. This study is done to evaluate the cytotoxic effects of diphenyltin(IV) diisopropyl dithiocarbamate (DPDT) against leukemic cells CCL-119 using the Trypan Blue exclusion (TBE) method at the intervals of 24, 48 and 72 h. Dexame...
This study has been done to determine the isotherm and kinetic adsorption of boron on activated c... more This study has been done to determine the isotherm and kinetic adsorption of boron on activated carbon that been modified with curcumin. In this study, the maximum boron removal was obtained at pH 5.6 and the optimum contact time was 120 minutes. The comparison of boron removal percentage and adsorption isotherms between activated carbon modified with curcumin and activated carbon without curcumin also been studied. The percentage of boron removal by activated carbon modified with curcumin is 53.3% ...
Australian Journal of Basic and Applied Sciences, 2011
Abstract: Tamarindus indica (tamarind), Garcinia atroviridis, and Curcuma longa (turmeric) are wi... more Abstract: Tamarindus indica (tamarind), Garcinia atroviridis, and Curcuma longa (turmeric) are widely used in food preparation. This study was conducted to determine the aluminium leachability in acidic food flavors Tamarindus indica and Garcinia atroviridis and tumeric powder. The results showed that aluminium contents were increased accordingly to the dosage of these acidic food flavors. The results showed that aluminium leaching was higher in solutions without Curcuma longa compare to the present of Curcuma longa. The effect ...
... Robert C. Brown, MRC Toxicology Unit, University of Leices-ter, Leicester, United Kingdom Der... more ... Robert C. Brown, MRC Toxicology Unit, University of Leices-ter, Leicester, United Kingdom Derrick R. Crump, Building Research Establishment, Garston, Watford, United Kingdom MichalKrzyzanowski, WHO European Centre for Environ-ment and Health, Bilthoven Division ...
Ternary complexes of Cu(II) with acetylacetone and various salicylic acids (viz., salicylic, 5-ch... more Ternary complexes of Cu(II) with acetylacetone and various salicylic acids (viz., salicylic, 5-chloro-, 3,5-dibromo-, 3,5-dinitro-, thio-, and acetyl-salicylic acids) were synthesised in pure state and these complexes were characterised by elemental analysis, conductivity, IR data and optical absorption. The antibacterial and antifungal activity studies on these complexes revealed that the ternary complexes are better toxic agents than the binary complexes
The renovation of a building will certainly affect the quality of air in the vicinity of where as... more The renovation of a building will certainly affect the quality of air in the vicinity of where associated activities were undertaken, this includes the quality of air inside the building. Indoor air pollutants such as particulate matter, heavy metals, and fine fibers are likely to be emitted during renovation work. This study was conducted to determine the concentration of heavy metals, asbestos and suspended particulates in the Biology Building, at the Universiti Kebangsaan, Malaysia (UKM). Renovation activities were carried out widely in the laboratories which were located in this building. A low-volume sampler was used to collect suspended particulate matter of a diameter size less than 10 μm (PM10) and an air sampling pump, fitted with a cellulose ester membrane filter, were used for asbestos sampling. Dust was collected using a small brush and scope. The concentration of heavy metals was determined through the use of inductively coupled plasma–mass spectroscopy and the fibers w...
Synthesis and Reactivity in Inorganic Metal-organic and Nano-metal Chemistry, 2012
Some triphenyltin and dibutyltin thiobiurets of the type Ph3SnL and Bu2SnL2 [where LH = 1,5 diphe... more Some triphenyltin and dibutyltin thiobiurets of the type Ph3SnL and Bu2SnL2 [where LH = 1,5 diphenyl-2-thiobiuret (PPTBH), 1-(4-ethoxyphenyl)-5-phenyl-2-thiobiuret (EtOPPTBH) or 1-naphthyl-5-phenyl-2-thiobiuret (naph PTBH)], have been synthesized and characterized by elemental analysis and various physico-chemical techniques. Molar conductance measurements show the non-ionic behavior of the complexes. FAB mass spectra exhibit their monomeric nature.H and CNMR spectra support the proposed stoichiometry of
Acta Crystallographica Section E Structure Reports Online, 2014
In the title compound, C12H15FN2O2S, the molecule adopts acisconfiguration of the fluorobenzoyl g... more In the title compound, C12H15FN2O2S, the molecule adopts acisconfiguration of the fluorobenzoyl group with respect to the thiono group about their C—N bond. The dihedral angle between the fluorobenzoyl group and the thiourea N2CS fragment is 69.60 (11)°. An intramolecular N—H...O hydrogen bond occurs. In the crystal, molecules form chains along theb-axis directionviaO—H...S and C—H...O hydrogen bonds.
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