I am an oncologic radiologist specializing in the application of MRI techniques. My primary area of expertise lies within the realm of prostate cancer. I am recognized for my contribution to the introduction of PI-RADS and am currently deeply involved in the process of seeking approval from the European Medicines Agency (EMA) for nano-MRI. This innovative technique employs ultrasmall iron oxide particles (USPIO, specifically Ferrotran) as a contrast agent to facilitate the visualization of macrophages in small lymph nodes, allowing for the detection of 1.5 mm lymph node metastases and the identification of inflammatory processes, including brain degeneration and vulnerable plaques. Additionally, I am actively committed to ongoing research endeavors focused on the development of nano-batteries for the targeted eradication of cancer cells.
The diagnosis of cancer by FDG PET-CT is often inaccurate owing to subjectivity of interpretation... more The diagnosis of cancer by FDG PET-CT is often inaccurate owing to subjectivity of interpretation. We compared the accuracy of a novel normalized (standardized) method of interpretation with conventional non-normalized SUV. Patients (n = 393) with various malignancies were studied with FDG PET/CT to determine the presence or absence of cancer. Target lesions were assessed by two methods: (1) conventional SUVmax (conSUVmax) and (2) a novel method that combined multiple factors to optimize SUV (optSUVmax), including the patient’s normal liver SUVmax, a liver constant (k) derived from a review of the literature, and use of site-specific thresholds for malignancy. The two methods were compared to pathology findings in 154 patients being evaluated for mediastinal and/or hilar lymph node (MHLNs) metastases, 143 evaluated for extra-thoracic lymph node (ETLNs) metastases, and 96 evaluated for liver metastases. OptSUVmax was superior to conSUVmax for all patient groups. For MHLNs, sensitivit...
Additional file 4: Figure S4. Positive controls for antibody validation. Validation of NY-ESO-1, ... more Additional file 4: Figure S4. Positive controls for antibody validation. Validation of NY-ESO-1, MAGE-C2 and MUC1 antibodies for immunohistochemistry in positive control tissue (testicular or tonsil tissue).
Medical Imaging 2007: Computer-Aided Diagnosis, 2007
A system for automatic detection of pelvic lymph nodes is developed by incorporating complementar... more A system for automatic detection of pelvic lymph nodes is developed by incorporating complementary information extracted from multiple MR sequences. A single MR sequence lacks sufficient diagnostic information for lymph node localization and staging. Correct diagnosis often requires input from multiple complementary sequences which makes manual detection of lymph nodes very labor intensive. Small lymph nodes are often missed even
Summary Using a macrophage, specific MR-contrast agent and high resolution MR imaging allows the ... more Summary Using a macrophage, specific MR-contrast agent and high resolution MR imaging allows the detection of small and otherwise undetectable lymph node metastases in patients with cancer. This has an important clinical impactions, as the diagnosis will be more precise and less invasive to obtain. Subsequently this will reduce morbidity and health care costs. However, solid knowledge of sequence parameters and planes; lymph node anatomy; appearance of normal and abnormal nodes; and other pitfalls is essential when using this technique. A very important role for education by expert radiologists, MR-manufacturers, and contrast agent companies is therefore also required.
Imaging plays a vital role in the management of patients with cancer. Not only is it important fo... more Imaging plays a vital role in the management of patients with cancer. Not only is it important for diagnosis, indicating sites of abnormality, and guiding biopsies, but it is also crucial in assessing disease extent and thereby determining treatment. In this review, conventional imaging techniques such as ultrasound, computed tomography, magnetic resonance imaging, and [18F]fluorodeoxyglucose–positron emission tomography are described, with attention to their mechanisms of action, and their strengths and weaknesses in diagnosis and staging of tumors. New developments are addressed and radiation safety issues are highlighted. In addition, we describe current and expected future uses of imaging techniques in oncology. Given that each technique has its inherent strengths and weaknesses, the combination of the methods will result in improved diagnosis, staging, and treatment prediction and monitoring.
We have previously shown that the dense vascular network in mouse brain allows for growth of huma... more We have previously shown that the dense vascular network in mouse brain allows for growth of human melanoma xenografts (Mel57) by co‐option of preexisting vessels. Overexpression of recombinant vascular endothelial growth factor‐A (VEGF‐A) by such xenografts induced functional and morphologic alterations of preexisting vessels. We now describe the effects of VEGF‐A expression on visualization of these brain tumors in mice by magnetic resonance imaging (MRI), using gadolinium diethylenetriaminepenta‐acetic acid (Gd‐DTPA) and ultra small paramagnetic iron oxide particles (USPIO) as contrast agents. Brain lesions derived from (mock‐transfected) Mel57 cells were undetectable in MRI after Gd‐DTPA injection. However, the majority of such lesions became visible after injection of USPIO, due to the lower vascular density in the lesions as compared to the surrounding parenchyma. In contrast, VEGF‐A‐expressing lesions were visualized using Gd‐DTPA‐enhanced MRI by a rapid circumferential enhan...
The diagnosis of cancer by FDG PET-CT is often inaccurate owing to subjectivity of interpretation... more The diagnosis of cancer by FDG PET-CT is often inaccurate owing to subjectivity of interpretation. We compared the accuracy of a novel normalized (standardized) method of interpretation with conventional non-normalized SUV. Patients (n = 393) with various malignancies were studied with FDG PET/CT to determine the presence or absence of cancer. Target lesions were assessed by two methods: (1) conventional SUVmax (conSUVmax) and (2) a novel method that combined multiple factors to optimize SUV (optSUVmax), including the patient’s normal liver SUVmax, a liver constant (k) derived from a review of the literature, and use of site-specific thresholds for malignancy. The two methods were compared to pathology findings in 154 patients being evaluated for mediastinal and/or hilar lymph node (MHLNs) metastases, 143 evaluated for extra-thoracic lymph node (ETLNs) metastases, and 96 evaluated for liver metastases. OptSUVmax was superior to conSUVmax for all patient groups. For MHLNs, sensitivit...
Additional file 4: Figure S4. Positive controls for antibody validation. Validation of NY-ESO-1, ... more Additional file 4: Figure S4. Positive controls for antibody validation. Validation of NY-ESO-1, MAGE-C2 and MUC1 antibodies for immunohistochemistry in positive control tissue (testicular or tonsil tissue).
Medical Imaging 2007: Computer-Aided Diagnosis, 2007
A system for automatic detection of pelvic lymph nodes is developed by incorporating complementar... more A system for automatic detection of pelvic lymph nodes is developed by incorporating complementary information extracted from multiple MR sequences. A single MR sequence lacks sufficient diagnostic information for lymph node localization and staging. Correct diagnosis often requires input from multiple complementary sequences which makes manual detection of lymph nodes very labor intensive. Small lymph nodes are often missed even
Summary Using a macrophage, specific MR-contrast agent and high resolution MR imaging allows the ... more Summary Using a macrophage, specific MR-contrast agent and high resolution MR imaging allows the detection of small and otherwise undetectable lymph node metastases in patients with cancer. This has an important clinical impactions, as the diagnosis will be more precise and less invasive to obtain. Subsequently this will reduce morbidity and health care costs. However, solid knowledge of sequence parameters and planes; lymph node anatomy; appearance of normal and abnormal nodes; and other pitfalls is essential when using this technique. A very important role for education by expert radiologists, MR-manufacturers, and contrast agent companies is therefore also required.
Imaging plays a vital role in the management of patients with cancer. Not only is it important fo... more Imaging plays a vital role in the management of patients with cancer. Not only is it important for diagnosis, indicating sites of abnormality, and guiding biopsies, but it is also crucial in assessing disease extent and thereby determining treatment. In this review, conventional imaging techniques such as ultrasound, computed tomography, magnetic resonance imaging, and [18F]fluorodeoxyglucose–positron emission tomography are described, with attention to their mechanisms of action, and their strengths and weaknesses in diagnosis and staging of tumors. New developments are addressed and radiation safety issues are highlighted. In addition, we describe current and expected future uses of imaging techniques in oncology. Given that each technique has its inherent strengths and weaknesses, the combination of the methods will result in improved diagnosis, staging, and treatment prediction and monitoring.
We have previously shown that the dense vascular network in mouse brain allows for growth of huma... more We have previously shown that the dense vascular network in mouse brain allows for growth of human melanoma xenografts (Mel57) by co‐option of preexisting vessels. Overexpression of recombinant vascular endothelial growth factor‐A (VEGF‐A) by such xenografts induced functional and morphologic alterations of preexisting vessels. We now describe the effects of VEGF‐A expression on visualization of these brain tumors in mice by magnetic resonance imaging (MRI), using gadolinium diethylenetriaminepenta‐acetic acid (Gd‐DTPA) and ultra small paramagnetic iron oxide particles (USPIO) as contrast agents. Brain lesions derived from (mock‐transfected) Mel57 cells were undetectable in MRI after Gd‐DTPA injection. However, the majority of such lesions became visible after injection of USPIO, due to the lower vascular density in the lesions as compared to the surrounding parenchyma. In contrast, VEGF‐A‐expressing lesions were visualized using Gd‐DTPA‐enhanced MRI by a rapid circumferential enhan...
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