Periodontal disease is caused by specific pathogens which results in inflammation of the tooth-su... more Periodontal disease is caused by specific pathogens which results in inflammation of the tooth-supporting structures and subsequently causes the continued breakdown of alveolar bone and periodontal ligament. Licorice (Glycyrrhiza glabra) is a perennial herb with substantial medicinal value. Licorice extract is derived from dried, unpeeled stolons and roots of Glycyrrhiza uralensis and G. glabra. The bioactive ingredients in licorice extract such as glycyrrhizin, licoricidin, glabridin, licochalcone A, and licorisoflavan A have anti-inflammatory, antimicrobial, and anti-adherence effects that are beneficial against periodontal disease. Since periodontal disease has a complex etiology that includes the host response and microorganisms, licorice phytochemicals offer a therapeutic advantage due to their dual functionality. The aim of this review was to enumerate the bioactive compounds present in herbal licorice extract and to elucidate the beneficial effects of licorice and its derivat...
The efficacy and effectiveness of electric toothbrushes in comparison to manual toothbrushes lead... more The efficacy and effectiveness of electric toothbrushes in comparison to manual toothbrushes lead to superior full-mouth and interproximal plaque removal and reduction of gingivitis, periodontitis and dental caries. Additionally, the use of an irrigator has been shown to improve the overall oral health. The aim of this study was to design and develop a utility model for the combined effect of the oral irrigator and tooth brush for maintaining oral health. The design of the modified toothbrushing unit comprises of an electric toothbrush and an oral irrigator. This was achieved by removing the electric toothbrush head to place a drill in the centre of the brush head for the insertion of irrigator head. The irrigator which was attached to a 50 ml water container with a detachable irrigator head powered by a 12 V external battery source was used to pump the water. The outcome was that a multifunctional working model combining the electric tooth brush and oral irrigator is designed succe...
In the literature, the periodontal tissue reaction to dissimilar occlusal stress has been describ... more In the literature, the periodontal tissue reaction to dissimilar occlusal stress has been described, including clinical and histologic changes caused by stresses in periodontal structures. With respect to occlusal forces, periodontal assembly demonstrates varying adaptive capacity from individual to individual and period to period within the same individual. Unfortunately, these occlusal stresses are yet to be quantified. As a result, determining the effect of normal occlusal force on periodontal elements in various angulations is of interest. Based on CBCT images, one FEA of the maxillary First molar was created, consisting of tooth pulp, periodontal ligament (PDL), and alveolar bone; the effect of normal occlusal force on the pdl in alternate angulations was assessed. Occlusion will occur at three contact areas representing the centric occlusion contact points, each of which will share a 150 N force. The analysis was performed for four force inclinations (0, 22.5°, 45°, and 90°). ...
Background- N-terminal-pro-brain natriuretic peptide (NT-proBNP) is an inactive hormone which is ... more Background- N-terminal-pro-brain natriuretic peptide (NT-proBNP) is an inactive hormone which is seen during inflammation and is a known biomarker of cardiovascular disease (CVD). Evidence suggests that periodontitis has a bidirectional relationship with CVD and NTProBNP has a potential role in periodontal disease. However, there is no evidence on the impact of Non-surgical periodontal therapy (NSPT) on the levels of NTProBNP in GCF and serum in patients with chronic periodontitis. Hence, the aim of this study was to compare the levels of NT-proBNP in GCF and serum in patients with Chronic generalized periodontitis before and after NSPT after 6 weeks. Methods: An interventional study was carried out in which GCF and serum samples was collected in 19 patients with chronic generalized periodontitis prior and post NSPT 45 days and the cumulative or reduction in values of NTProBNP in both parameters; GCF and serum was assessed. All subjects underwent nonsurgical periodontal therapy (NSP...
Objectives The use of herbal dentifrices has grown exponentially over the years. They are categor... more Objectives The use of herbal dentifrices has grown exponentially over the years. They are categorically referred to as ethnomedicines. Various agents have been tried with contradicting findings based on phytopharmacological analysis. Miswak is one agent which has been used over the years. A novel Moringa oleifera-based dentifrice has shown promising results in terms of its cytotoxicity, biocompatibility, and as a potent anti-inflammatory agent. Therefore, the present study aims to compare the efficacy of two commercially available miswak- and moringa-based herbal dentifrices on the reduction of plaque and gingivitis scores. Materials and Methods This randomized clinical crossover study included 20 subjects with mild to moderate gingivitis. The study was conducted over a total examination period of 20 days with a wash-out period of 2 weeks between the use of both the toothpastes. The plaque index and gingival index of the study subjects were recorded at the designated time intervals ...
Introduction: Retrograde peri-imp lantitis is a rare condition that involves the apical area of t... more Introduction: Retrograde peri-imp lantitis is a rare condition that involves the apical area of the imp lant causing extensive bone loss and exposure of imp lant.
Photodiagnosis and photodynamic therapy, Jan 24, 2018
Oral lichen planus is relatively chronic inflammatory, immune mediated mucocutaneous disorder of ... more Oral lichen planus is relatively chronic inflammatory, immune mediated mucocutaneous disorder of uncertain etiology. Psychologic stress has been found to be main contributing factor in onset and progression of lesions. Few erosive OLP patients are refractory to available therapies, even corticosteroids, and report remarkable side effects. Advent of photodynamic therapy (PDT) has proved it to be effective and safe alternative treatment of abnormal or neoplastic cells. Due to limited literature on application of this method for treatment of refractory erosive OLP, we present series of 10 cases of bilateral erosive LP treated by 5 -Aminolevulinic acid mediated PDT. Outcome of our clinical cases showed remarkable improvement in lesions with reduction in Reticulation, Erythema, Ulceration (REU) score ( from 5 to 3) and burning sensation as recorded by Visual Analogue Scale (Pretreatment VAS ranged from 5-8, posttreatment VAS was 0-1), thus PDT could be used as a complementary treatment m...
Neurofibroma is an uncommon benign tumor of the oral cavity derived from the cells that constitut... more Neurofibroma is an uncommon benign tumor of the oral cavity derived from the cells that constitute the nerve sheath neurofibromatosis type 1 (NF1), also known as von Recklinghausen's disease, is the most common type of neurofibromatosis and accounts for about 90% of all cases. It is one of the most frequent human genetic diseases, with the prevalence of one case in 3,000 births. Neurofibroma is seen either as a solitary lesion or as part of the generalized syndrome of neurofibromatosis. The solitary form does not differ from the disseminated form or the multiple form of the disease, except that systemic and hereditary factors present in the disseminated form are absent in the solitary type. Oral cavity involvement by a solitary and peripheral plexiform neurofibroma in patients with no other signs of neurofibromatosis is uncommon. The expressivity of NF1 is extremely variable, with manifestations ranging from mild lesions to several complications and functional impairment. Oral manifestations can be found in almost 72% of NF1 patients. This is a case report of a 40-year-old lady with a history of multiple faint rounded densities in the skin, chest pain occasionally since 8 months and breathlessness since 1 year and swelling of the right side of the angle of the mandible with limited mouth opening.
Periodontal diseases produce physical and chemical alterations in the root cementum. Various topi... more Periodontal diseases produce physical and chemical alterations in the root cementum. Various topical applications as root conditioning agents have been recommended as an adjunct to mechanical root surface debridement to remove smear layer, endotoxins and to expose collagen fibers on dentin surface. The objectives were to compare dentin surface changes following applications of tetracyclines and citric acid to the instrumented root surface of periodontally involved human teeth under scanning electron microscope.The study group comprised of 80 dentin samples, which were prepared from periodontally-compromised teeth, planned for extraction. Diseased surfaces were root planed. The teeth were sectioned and solutions of tetracycline HCl, minocycline, doxycycline and citric acid were applied to the surfaces with cotton pellets for 5minutes.The root surface samples were then examined by scanning electron microscope.Removal of smear layer in all the four groups was near total except a few areas. All four groups showed slight difference in mean number of total dentinal tubules. Minocycline and doxycycline showed no significant difference. The proportion of patent dentinal tubules was (74%) in tetracycline HCl group compared to minocycline (48.3%), doxycycline 42%), citric acid (52%), showing the differences statistically significant. Tetracycline group showed higher number of patent tubules when compared to minocycline, doxycycline and the difference was statistically significant.Results of this study suggest that tetracycline is the best current tetracycline form for root surface conditioning as measured by its ability to affect both dentin smear layer removal and tubule exposure.
Periodontal disease is caused by specific pathogens which results in inflammation of the tooth-su... more Periodontal disease is caused by specific pathogens which results in inflammation of the tooth-supporting structures and subsequently causes the continued breakdown of alveolar bone and periodontal ligament. Licorice (Glycyrrhiza glabra) is a perennial herb with substantial medicinal value. Licorice extract is derived from dried, unpeeled stolons and roots of Glycyrrhiza uralensis and G. glabra. The bioactive ingredients in licorice extract such as glycyrrhizin, licoricidin, glabridin, licochalcone A, and licorisoflavan A have anti-inflammatory, antimicrobial, and anti-adherence effects that are beneficial against periodontal disease. Since periodontal disease has a complex etiology that includes the host response and microorganisms, licorice phytochemicals offer a therapeutic advantage due to their dual functionality. The aim of this review was to enumerate the bioactive compounds present in herbal licorice extract and to elucidate the beneficial effects of licorice and its derivat...
The efficacy and effectiveness of electric toothbrushes in comparison to manual toothbrushes lead... more The efficacy and effectiveness of electric toothbrushes in comparison to manual toothbrushes lead to superior full-mouth and interproximal plaque removal and reduction of gingivitis, periodontitis and dental caries. Additionally, the use of an irrigator has been shown to improve the overall oral health. The aim of this study was to design and develop a utility model for the combined effect of the oral irrigator and tooth brush for maintaining oral health. The design of the modified toothbrushing unit comprises of an electric toothbrush and an oral irrigator. This was achieved by removing the electric toothbrush head to place a drill in the centre of the brush head for the insertion of irrigator head. The irrigator which was attached to a 50 ml water container with a detachable irrigator head powered by a 12 V external battery source was used to pump the water. The outcome was that a multifunctional working model combining the electric tooth brush and oral irrigator is designed succe...
In the literature, the periodontal tissue reaction to dissimilar occlusal stress has been describ... more In the literature, the periodontal tissue reaction to dissimilar occlusal stress has been described, including clinical and histologic changes caused by stresses in periodontal structures. With respect to occlusal forces, periodontal assembly demonstrates varying adaptive capacity from individual to individual and period to period within the same individual. Unfortunately, these occlusal stresses are yet to be quantified. As a result, determining the effect of normal occlusal force on periodontal elements in various angulations is of interest. Based on CBCT images, one FEA of the maxillary First molar was created, consisting of tooth pulp, periodontal ligament (PDL), and alveolar bone; the effect of normal occlusal force on the pdl in alternate angulations was assessed. Occlusion will occur at three contact areas representing the centric occlusion contact points, each of which will share a 150 N force. The analysis was performed for four force inclinations (0, 22.5°, 45°, and 90°). ...
Background- N-terminal-pro-brain natriuretic peptide (NT-proBNP) is an inactive hormone which is ... more Background- N-terminal-pro-brain natriuretic peptide (NT-proBNP) is an inactive hormone which is seen during inflammation and is a known biomarker of cardiovascular disease (CVD). Evidence suggests that periodontitis has a bidirectional relationship with CVD and NTProBNP has a potential role in periodontal disease. However, there is no evidence on the impact of Non-surgical periodontal therapy (NSPT) on the levels of NTProBNP in GCF and serum in patients with chronic periodontitis. Hence, the aim of this study was to compare the levels of NT-proBNP in GCF and serum in patients with Chronic generalized periodontitis before and after NSPT after 6 weeks. Methods: An interventional study was carried out in which GCF and serum samples was collected in 19 patients with chronic generalized periodontitis prior and post NSPT 45 days and the cumulative or reduction in values of NTProBNP in both parameters; GCF and serum was assessed. All subjects underwent nonsurgical periodontal therapy (NSP...
Objectives The use of herbal dentifrices has grown exponentially over the years. They are categor... more Objectives The use of herbal dentifrices has grown exponentially over the years. They are categorically referred to as ethnomedicines. Various agents have been tried with contradicting findings based on phytopharmacological analysis. Miswak is one agent which has been used over the years. A novel Moringa oleifera-based dentifrice has shown promising results in terms of its cytotoxicity, biocompatibility, and as a potent anti-inflammatory agent. Therefore, the present study aims to compare the efficacy of two commercially available miswak- and moringa-based herbal dentifrices on the reduction of plaque and gingivitis scores. Materials and Methods This randomized clinical crossover study included 20 subjects with mild to moderate gingivitis. The study was conducted over a total examination period of 20 days with a wash-out period of 2 weeks between the use of both the toothpastes. The plaque index and gingival index of the study subjects were recorded at the designated time intervals ...
Introduction: Retrograde peri-imp lantitis is a rare condition that involves the apical area of t... more Introduction: Retrograde peri-imp lantitis is a rare condition that involves the apical area of the imp lant causing extensive bone loss and exposure of imp lant.
Photodiagnosis and photodynamic therapy, Jan 24, 2018
Oral lichen planus is relatively chronic inflammatory, immune mediated mucocutaneous disorder of ... more Oral lichen planus is relatively chronic inflammatory, immune mediated mucocutaneous disorder of uncertain etiology. Psychologic stress has been found to be main contributing factor in onset and progression of lesions. Few erosive OLP patients are refractory to available therapies, even corticosteroids, and report remarkable side effects. Advent of photodynamic therapy (PDT) has proved it to be effective and safe alternative treatment of abnormal or neoplastic cells. Due to limited literature on application of this method for treatment of refractory erosive OLP, we present series of 10 cases of bilateral erosive LP treated by 5 -Aminolevulinic acid mediated PDT. Outcome of our clinical cases showed remarkable improvement in lesions with reduction in Reticulation, Erythema, Ulceration (REU) score ( from 5 to 3) and burning sensation as recorded by Visual Analogue Scale (Pretreatment VAS ranged from 5-8, posttreatment VAS was 0-1), thus PDT could be used as a complementary treatment m...
Neurofibroma is an uncommon benign tumor of the oral cavity derived from the cells that constitut... more Neurofibroma is an uncommon benign tumor of the oral cavity derived from the cells that constitute the nerve sheath neurofibromatosis type 1 (NF1), also known as von Recklinghausen's disease, is the most common type of neurofibromatosis and accounts for about 90% of all cases. It is one of the most frequent human genetic diseases, with the prevalence of one case in 3,000 births. Neurofibroma is seen either as a solitary lesion or as part of the generalized syndrome of neurofibromatosis. The solitary form does not differ from the disseminated form or the multiple form of the disease, except that systemic and hereditary factors present in the disseminated form are absent in the solitary type. Oral cavity involvement by a solitary and peripheral plexiform neurofibroma in patients with no other signs of neurofibromatosis is uncommon. The expressivity of NF1 is extremely variable, with manifestations ranging from mild lesions to several complications and functional impairment. Oral manifestations can be found in almost 72% of NF1 patients. This is a case report of a 40-year-old lady with a history of multiple faint rounded densities in the skin, chest pain occasionally since 8 months and breathlessness since 1 year and swelling of the right side of the angle of the mandible with limited mouth opening.
Periodontal diseases produce physical and chemical alterations in the root cementum. Various topi... more Periodontal diseases produce physical and chemical alterations in the root cementum. Various topical applications as root conditioning agents have been recommended as an adjunct to mechanical root surface debridement to remove smear layer, endotoxins and to expose collagen fibers on dentin surface. The objectives were to compare dentin surface changes following applications of tetracyclines and citric acid to the instrumented root surface of periodontally involved human teeth under scanning electron microscope.The study group comprised of 80 dentin samples, which were prepared from periodontally-compromised teeth, planned for extraction. Diseased surfaces were root planed. The teeth were sectioned and solutions of tetracycline HCl, minocycline, doxycycline and citric acid were applied to the surfaces with cotton pellets for 5minutes.The root surface samples were then examined by scanning electron microscope.Removal of smear layer in all the four groups was near total except a few areas. All four groups showed slight difference in mean number of total dentinal tubules. Minocycline and doxycycline showed no significant difference. The proportion of patent dentinal tubules was (74%) in tetracycline HCl group compared to minocycline (48.3%), doxycycline 42%), citric acid (52%), showing the differences statistically significant. Tetracycline group showed higher number of patent tubules when compared to minocycline, doxycycline and the difference was statistically significant.Results of this study suggest that tetracycline is the best current tetracycline form for root surface conditioning as measured by its ability to affect both dentin smear layer removal and tubule exposure.
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Papers by Bhavya Shetty