Journal of Pharmaceutical and Biomedical Analysis, Apr 1, 1996
The stability of zorubicin (ZOR) in admixtures for continuous intravenous infusion was studied. Z... more The stability of zorubicin (ZOR) in admixtures for continuous intravenous infusion was studied. ZOR was reconstituted and diluted to 600 micrograms ml-1 for simulated infusion and to 250 and 1000 micrograms ml-1 for storage in poly(vinyl chloride) (PVC) bags containing 5% dextrose injection or 0.9% sodium chloride injection (0.9% NaCl). Bags were then stored at refrigerated temperature (4 degrees C) and in the dark for 24 h. ZOR concentrations in each admixture were tested by stability-indicating high-performance liquid chromatographic (HPLC) assay with ultraviolet detection. No substantial loss of ZOR was observed during simulated infusions (n = 4) using PVC infusion bags and administration sets over a 1 h infusion. The drug stored at 4 degrees C in the dark in PVC bags showed that it is highly unstable at 250 micrograms ml-1 in 0.9% NaCl injection and in 5% dextrose injection. On the other hand, under the same storage conditions, at 1000 micrograms ml-1, ZOR is more stable in 0.9% NaCl injection (6 h) than in 5% dextrose (4 h). The reported superior stability of the 1000 micrograms ml-1 in 0.9% NaCl can be explained, at least in part, by the difference in pH. Changes in pH, particularly a decrease, seem to affect adversely the stability of ZOR. In fact, ZOR is rapidly converted into daunorubicin, the dominant degradation product, which is more cardiotoxic than the parent drug. Therefore, several precautions must be observed when the commercial product (Rubidazone) is prepared and reconstituted in i.v. fluids and containers.
WSEAS TRANSACTIONS ON INFORMATION SCIENCE AND APPLICATIONS
Chronic respiratory diseases constitute a prognostic severity factor for some respiratory illness... more Chronic respiratory diseases constitute a prognostic severity factor for some respiratory illnesses. A case in point is pneumonia, a lung infection, whose effective management requires highly accurate diagnosis and precise treatment. Categorizing pneumonia as positive or negative does go through a process of classifying chest radiography images. This task plays a crucial role in medical diagnostics as it facilitates the detection of pneumonia and helps in making timely treatment decisions. Deep learning has shown remarkable effectiveness in various medical imaging applications, including the recognition and categorization of pneumonia in chest radiography images. The main aim of this research is to compare the efficacy of two convolutional neural network models for classifying pneumonia in chest radiography images. The first model was directly trained on the original images, achieving a training accuracy of 0.9266, whereas the second model was trained on images transformed using wav...
2020 International Conference on Electrical and Information Technologies (ICEIT), 2020
There is various architecture of convolutional neural network (CNN) based on deep learning method... more There is various architecture of convolutional neural network (CNN) based on deep learning methods and techniques applied to modern computer vision tasks. However, models based on CNNs are used in image segmentation such as LeNet, FCN, AlexNet, VGGNet, GoogLeNet, and ResNet. In this paper we present the application of Deep CNN based model for Image Segmentation, especially to detect the Optic Disc from retina images. We use the Indian Diabetic Retinopathy Image Dataset (IDRiD), we also implement the model with keras in python. A brief description of model, training with data augmentation, validation and predictions is given, at the end we compare the result with an existing labeled data. Finally, an overview is given of future works of usage of the convolutional neural network for image segmentation problems in medical imaging context and the challenges involved therein.
The stability and compatibility of 5-fluorouracil (5-FU) in admixtures for continuous intravenous... more The stability and compatibility of 5-fluorouracil (5-FU) in admixtures for continuous intravenous infusion using PVC bags and administration sets were studied. 5-fluorouracil was reconstituted and diluted to 1.8 mg/ml for infusion in polyvinyl chloride and glass containers, and to 1 mg/ml to 16 mg/ml for storage in polyvinyl chloride bags containing 5 per cent dextrose or 0.9 per cent sodium chloride injections. Admixtures were stored at +4 degrees C and with protection from light, for 7 days. Analyses were performed by HPLC. No significant drug loss was observed during simulated infusions using PVC infusion bags and administration sets vs glass bottles and administration sets, over an infusion period used in hospitals (24 h). The solution stored at +4 degrees C with protection from light in PVC bags showed that at 1 mg/ml to 16 mg/ml, 5-fluorouracil was stable at least for 7 days in 0.9 per cent sodium chloride and 5 per cent dextrose.
International Journal of Online and Biomedical Engineering (iJOE)
Computer-aided diagnosis has the potential to replace or at least support medical personnel in th... more Computer-aided diagnosis has the potential to replace or at least support medical personnel in their everyday responsibilities such as diagnosis, therapy, and surgery. In the area of ophthalmology, artificial intelligence approaches have been incorporated in the diagnosis of the most frequent ocular disorders, such as choroidal neovascularization (CNV), diabetic macular oedema (DMO), and DRUSEN; these illnesses pose a significant risk of vision loss. Optical coherence tomography (OCT) is an imaging technology used to diagnose the aforementioned eye disorders. It enables ophthalmologists to see the back of the eye and take various slices of the retina. The goal of this research is to automate the diagnosis of retinopathy, which includes CNV, DME, and DRUSEN. The approach employed is a deep learning-based, and transfer learning technique, applying to a public dataset of OCT pictures and two pertained neural network models VGG16 and InceptionV3, which are trained on the big database &q...
WSEAS TRANSACTIONS ON INFORMATION SCIENCE AND APPLICATIONS
We identify obstructive sleep apnea as the most common respiratory issue associated with sleep. F... more We identify obstructive sleep apnea as the most common respiratory issue associated with sleep. Frequent breathing disruptions characterize sleep apnea during sleep due to an obstruction in the upper airway. This illness, if left untreated, can lead to significant health problems. This article outlines a sound approach for detecting sleep apnea and tracking it in an automated and intelligent manner. The method entails an automated identification of OSA based on the sound signal during breathing and a cardio-respiratory signals analysis for more efficient results. The suggested approach is put to the test under a variety of scenarios to verify its efficacy and dependability. The benefits and drawbacks of the suggested algorithm are mentioned further down.
... pump (r f. VIP II), opaque PVC infusion sets (r f. Perfecran 781547) for protec-tion from lig... more ... pump (r f. VIP II), opaque PVC infusion sets (r f. Perfecran 781547) for protec-tion from light obtained from Fandre Laborato-ries ... Benvenuto, JA, Anderson, RW, Kerkof, K., Smith, RG and Loo, TL, Stability and compatibility of antitumor agents in glass and plastic containers. Am. ...
Methods and Findings in Experimental and Clinical Pharmacology, 2000
This study was carried out in healthy volunteers in order to examine the influence of changes in ... more This study was carried out in healthy volunteers in order to examine the influence of changes in eating and rest/activity rhythms during Ramadan on the pharmacokinetics of valproic acid (VPA; Depakine). A single oral dose of 800 mg was administered to the first group of subjects (n = 7) at 8:00 PM and to the second group (n = 5) at 5:00 AM. Each group was submitted to three treatment phases: the first was carried out 3 weeks prior to Ramadan (PR), the second one at the end of the first week of Ramadan (R1) and the last at the end of the third week of Ramadan (R3). The plasma kinetics of VPA were determined for each treatment schedule throughout the 50 h following drug intake. During Ramadan, a significant decrease was observed in the Cmax (56.22 +/- 5.32 mg/l in PR vs. 48.35 +/- 5.07 mg/l in R3; p < 0.05) and in the AUC(0.50 h) (1429.92 +/- 284.23 in PR vs. 1090.26 +/- 277.73 mg.h/l in R3; p < 0.05) for the 8:00 PM intake. For the 5:00 AM intake, a significant decrease was observed in the t1/2 (12.15 +/- 1.45 h in PR vs. 9.55 +/- 1.97 h in R3; p < 0.05) and AUC(0.50 h) values (1241.29 +/- 239.01 mg.h/l in PR vs. 1019.21 +/- 256.86 mg.h/l in R3; p < 0.05). These parameters showed a significant decrease at the end of the third week of Ramadan (R3), compared to the control period (PR).
Journal of Clinical Pharmacy and Therapeutics, 1994
The availability and compatibility of drugs from solutions infused via PVC infusion bags through ... more The availability and compatibility of drugs from solutions infused via PVC infusion bags through PVC administration sets have been examined. No significant drug loss was observed during simulated infusions using PVC infusion bags and administration sets over time periods used in hospitals (cisplatin, 2 h; carboplatin, 1 h). The stability of carboplatin was studied in 5% dextrose. In 0.9% NaCl, we observed that carboplatin could be converted to cisplatin in the presence of chloride ions. With cisplatin, no significant difference was found between infusion solutions (5% dextrose or 0.9% NaCl). The stability of cisplatin (5% dextrose or 0.9% NaCl) and carboplatin (5% dextrose) was also studied in PVC bags after storage in the dark at room temperature. The results show that the drugs were stable over the 9-day storage period studied.
BackgroundDuring Ramadan, many patients with diabetes, renal, cardiovascular, gastrointestinal di... more BackgroundDuring Ramadan, many patients with diabetes, renal, cardiovascular, gastrointestinal diseases, headaches, and epilepsy choose to fast even against their doctor's advice. The impact of this intermittent fasting on health and disease could be different in men and women. The aim of this study was to determine the effect of sex as a factor in diseases outcomes of patients who opt to fast during Ramadan.Main BodyThe articles included in this study reported data on six diseases: diabetes, renal, cardiovascular, gastrointestinal diseases, headaches, and epilepsy. A systematic search was performed on PubMed and Scopus for observational and clinical studies mentioning Ramadan, diabetes, renal, cardiovascular, gastrointestinal diseases, headaches, and epilepsy in both men and women. Data was extracted by two independent reviewers using a standardized data-collection form. From 381 original articles, 38 studies were selected, including 25,023 patients of which 44.4% were women. S...
Envenomation by Moroccan vipers (Cerastes cerastes Cc and Macrovipera mauretanica Mm) has caused ... more Envenomation by Moroccan vipers (Cerastes cerastes Cc and Macrovipera mauretanica Mm) has caused signi ficant morbidity and mortality. In Morocco, both vipers we re increasingly identified as a dangerous and commo n source of envenomation. The antivenom production in Morocc o against poisonous snakes encounters a number of difficulties; unfortunately, there is still no monospecific Moroccan antivenom to date. This study aim s to assess the feasibility of monospecific Cc and Mm antivenom pro duction F(ab’)2 prepared under the same immunization protocols in rabbits. SDS-PAGE analysis of both typ es of antivenoms showed similar serum protein profi les. C.cerastes venom elicited satisfactory titers of an ti-Cc F(ab’) 2 after immunization as compared to M.mauretanica venom. Both antivenoms, isolated with ammonium sulf ate precipitation method, were effective in neutral izing the venom lethality (potency = 49.75 and 39.07 LD 50 per ml for anti-Cc and anti-Mm respectively) as we ll as its ...
Journal of Pharmaceutical and Biomedical Analysis, Apr 1, 1996
The stability of zorubicin (ZOR) in admixtures for continuous intravenous infusion was studied. Z... more The stability of zorubicin (ZOR) in admixtures for continuous intravenous infusion was studied. ZOR was reconstituted and diluted to 600 micrograms ml-1 for simulated infusion and to 250 and 1000 micrograms ml-1 for storage in poly(vinyl chloride) (PVC) bags containing 5% dextrose injection or 0.9% sodium chloride injection (0.9% NaCl). Bags were then stored at refrigerated temperature (4 degrees C) and in the dark for 24 h. ZOR concentrations in each admixture were tested by stability-indicating high-performance liquid chromatographic (HPLC) assay with ultraviolet detection. No substantial loss of ZOR was observed during simulated infusions (n = 4) using PVC infusion bags and administration sets over a 1 h infusion. The drug stored at 4 degrees C in the dark in PVC bags showed that it is highly unstable at 250 micrograms ml-1 in 0.9% NaCl injection and in 5% dextrose injection. On the other hand, under the same storage conditions, at 1000 micrograms ml-1, ZOR is more stable in 0.9% NaCl injection (6 h) than in 5% dextrose (4 h). The reported superior stability of the 1000 micrograms ml-1 in 0.9% NaCl can be explained, at least in part, by the difference in pH. Changes in pH, particularly a decrease, seem to affect adversely the stability of ZOR. In fact, ZOR is rapidly converted into daunorubicin, the dominant degradation product, which is more cardiotoxic than the parent drug. Therefore, several precautions must be observed when the commercial product (Rubidazone) is prepared and reconstituted in i.v. fluids and containers.
WSEAS TRANSACTIONS ON INFORMATION SCIENCE AND APPLICATIONS
Chronic respiratory diseases constitute a prognostic severity factor for some respiratory illness... more Chronic respiratory diseases constitute a prognostic severity factor for some respiratory illnesses. A case in point is pneumonia, a lung infection, whose effective management requires highly accurate diagnosis and precise treatment. Categorizing pneumonia as positive or negative does go through a process of classifying chest radiography images. This task plays a crucial role in medical diagnostics as it facilitates the detection of pneumonia and helps in making timely treatment decisions. Deep learning has shown remarkable effectiveness in various medical imaging applications, including the recognition and categorization of pneumonia in chest radiography images. The main aim of this research is to compare the efficacy of two convolutional neural network models for classifying pneumonia in chest radiography images. The first model was directly trained on the original images, achieving a training accuracy of 0.9266, whereas the second model was trained on images transformed using wav...
2020 International Conference on Electrical and Information Technologies (ICEIT), 2020
There is various architecture of convolutional neural network (CNN) based on deep learning method... more There is various architecture of convolutional neural network (CNN) based on deep learning methods and techniques applied to modern computer vision tasks. However, models based on CNNs are used in image segmentation such as LeNet, FCN, AlexNet, VGGNet, GoogLeNet, and ResNet. In this paper we present the application of Deep CNN based model for Image Segmentation, especially to detect the Optic Disc from retina images. We use the Indian Diabetic Retinopathy Image Dataset (IDRiD), we also implement the model with keras in python. A brief description of model, training with data augmentation, validation and predictions is given, at the end we compare the result with an existing labeled data. Finally, an overview is given of future works of usage of the convolutional neural network for image segmentation problems in medical imaging context and the challenges involved therein.
The stability and compatibility of 5-fluorouracil (5-FU) in admixtures for continuous intravenous... more The stability and compatibility of 5-fluorouracil (5-FU) in admixtures for continuous intravenous infusion using PVC bags and administration sets were studied. 5-fluorouracil was reconstituted and diluted to 1.8 mg/ml for infusion in polyvinyl chloride and glass containers, and to 1 mg/ml to 16 mg/ml for storage in polyvinyl chloride bags containing 5 per cent dextrose or 0.9 per cent sodium chloride injections. Admixtures were stored at +4 degrees C and with protection from light, for 7 days. Analyses were performed by HPLC. No significant drug loss was observed during simulated infusions using PVC infusion bags and administration sets vs glass bottles and administration sets, over an infusion period used in hospitals (24 h). The solution stored at +4 degrees C with protection from light in PVC bags showed that at 1 mg/ml to 16 mg/ml, 5-fluorouracil was stable at least for 7 days in 0.9 per cent sodium chloride and 5 per cent dextrose.
International Journal of Online and Biomedical Engineering (iJOE)
Computer-aided diagnosis has the potential to replace or at least support medical personnel in th... more Computer-aided diagnosis has the potential to replace or at least support medical personnel in their everyday responsibilities such as diagnosis, therapy, and surgery. In the area of ophthalmology, artificial intelligence approaches have been incorporated in the diagnosis of the most frequent ocular disorders, such as choroidal neovascularization (CNV), diabetic macular oedema (DMO), and DRUSEN; these illnesses pose a significant risk of vision loss. Optical coherence tomography (OCT) is an imaging technology used to diagnose the aforementioned eye disorders. It enables ophthalmologists to see the back of the eye and take various slices of the retina. The goal of this research is to automate the diagnosis of retinopathy, which includes CNV, DME, and DRUSEN. The approach employed is a deep learning-based, and transfer learning technique, applying to a public dataset of OCT pictures and two pertained neural network models VGG16 and InceptionV3, which are trained on the big database &q...
WSEAS TRANSACTIONS ON INFORMATION SCIENCE AND APPLICATIONS
We identify obstructive sleep apnea as the most common respiratory issue associated with sleep. F... more We identify obstructive sleep apnea as the most common respiratory issue associated with sleep. Frequent breathing disruptions characterize sleep apnea during sleep due to an obstruction in the upper airway. This illness, if left untreated, can lead to significant health problems. This article outlines a sound approach for detecting sleep apnea and tracking it in an automated and intelligent manner. The method entails an automated identification of OSA based on the sound signal during breathing and a cardio-respiratory signals analysis for more efficient results. The suggested approach is put to the test under a variety of scenarios to verify its efficacy and dependability. The benefits and drawbacks of the suggested algorithm are mentioned further down.
... pump (r f. VIP II), opaque PVC infusion sets (r f. Perfecran 781547) for protec-tion from lig... more ... pump (r f. VIP II), opaque PVC infusion sets (r f. Perfecran 781547) for protec-tion from light obtained from Fandre Laborato-ries ... Benvenuto, JA, Anderson, RW, Kerkof, K., Smith, RG and Loo, TL, Stability and compatibility of antitumor agents in glass and plastic containers. Am. ...
Methods and Findings in Experimental and Clinical Pharmacology, 2000
This study was carried out in healthy volunteers in order to examine the influence of changes in ... more This study was carried out in healthy volunteers in order to examine the influence of changes in eating and rest/activity rhythms during Ramadan on the pharmacokinetics of valproic acid (VPA; Depakine). A single oral dose of 800 mg was administered to the first group of subjects (n = 7) at 8:00 PM and to the second group (n = 5) at 5:00 AM. Each group was submitted to three treatment phases: the first was carried out 3 weeks prior to Ramadan (PR), the second one at the end of the first week of Ramadan (R1) and the last at the end of the third week of Ramadan (R3). The plasma kinetics of VPA were determined for each treatment schedule throughout the 50 h following drug intake. During Ramadan, a significant decrease was observed in the Cmax (56.22 +/- 5.32 mg/l in PR vs. 48.35 +/- 5.07 mg/l in R3; p < 0.05) and in the AUC(0.50 h) (1429.92 +/- 284.23 in PR vs. 1090.26 +/- 277.73 mg.h/l in R3; p < 0.05) for the 8:00 PM intake. For the 5:00 AM intake, a significant decrease was observed in the t1/2 (12.15 +/- 1.45 h in PR vs. 9.55 +/- 1.97 h in R3; p < 0.05) and AUC(0.50 h) values (1241.29 +/- 239.01 mg.h/l in PR vs. 1019.21 +/- 256.86 mg.h/l in R3; p < 0.05). These parameters showed a significant decrease at the end of the third week of Ramadan (R3), compared to the control period (PR).
Journal of Clinical Pharmacy and Therapeutics, 1994
The availability and compatibility of drugs from solutions infused via PVC infusion bags through ... more The availability and compatibility of drugs from solutions infused via PVC infusion bags through PVC administration sets have been examined. No significant drug loss was observed during simulated infusions using PVC infusion bags and administration sets over time periods used in hospitals (cisplatin, 2 h; carboplatin, 1 h). The stability of carboplatin was studied in 5% dextrose. In 0.9% NaCl, we observed that carboplatin could be converted to cisplatin in the presence of chloride ions. With cisplatin, no significant difference was found between infusion solutions (5% dextrose or 0.9% NaCl). The stability of cisplatin (5% dextrose or 0.9% NaCl) and carboplatin (5% dextrose) was also studied in PVC bags after storage in the dark at room temperature. The results show that the drugs were stable over the 9-day storage period studied.
BackgroundDuring Ramadan, many patients with diabetes, renal, cardiovascular, gastrointestinal di... more BackgroundDuring Ramadan, many patients with diabetes, renal, cardiovascular, gastrointestinal diseases, headaches, and epilepsy choose to fast even against their doctor's advice. The impact of this intermittent fasting on health and disease could be different in men and women. The aim of this study was to determine the effect of sex as a factor in diseases outcomes of patients who opt to fast during Ramadan.Main BodyThe articles included in this study reported data on six diseases: diabetes, renal, cardiovascular, gastrointestinal diseases, headaches, and epilepsy. A systematic search was performed on PubMed and Scopus for observational and clinical studies mentioning Ramadan, diabetes, renal, cardiovascular, gastrointestinal diseases, headaches, and epilepsy in both men and women. Data was extracted by two independent reviewers using a standardized data-collection form. From 381 original articles, 38 studies were selected, including 25,023 patients of which 44.4% were women. S...
Envenomation by Moroccan vipers (Cerastes cerastes Cc and Macrovipera mauretanica Mm) has caused ... more Envenomation by Moroccan vipers (Cerastes cerastes Cc and Macrovipera mauretanica Mm) has caused signi ficant morbidity and mortality. In Morocco, both vipers we re increasingly identified as a dangerous and commo n source of envenomation. The antivenom production in Morocc o against poisonous snakes encounters a number of difficulties; unfortunately, there is still no monospecific Moroccan antivenom to date. This study aim s to assess the feasibility of monospecific Cc and Mm antivenom pro duction F(ab’)2 prepared under the same immunization protocols in rabbits. SDS-PAGE analysis of both typ es of antivenoms showed similar serum protein profi les. C.cerastes venom elicited satisfactory titers of an ti-Cc F(ab’) 2 after immunization as compared to M.mauretanica venom. Both antivenoms, isolated with ammonium sulf ate precipitation method, were effective in neutral izing the venom lethality (potency = 49.75 and 39.07 LD 50 per ml for anti-Cc and anti-Mm respectively) as we ll as its ...
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Papers by Brahim Benaji