To describe the clinical profiles and results of surgical and non-surgical interventions in a lar... more To describe the clinical profiles and results of surgical and non-surgical interventions in a large cohort of patients with strabismus associated with chronic progressive external ophthalmoplegia (CPEO). A retrospective case note review was conducted of all patients with a clinical diagnosis of CPEO referred to our institution's strabismus department in the United Kingdom between 1990 and 2008. The total number of patients in this series was 28 (12 male, 16 female). The main presenting symptoms were diplopia (14) or cosmetically objectionable strabismus (11). Three had symptoms unrelated to strabismus and were excluded from further analysis. The most common strabismus findings were large angle exotropias (mean 47 prism diopters), half of which had associated vertical deviations. Strabismus management consisted of prisms (3), occlusion (3), botulinum toxin (7), and surgery (8). Two patients were offered surgery but were deemed unfit for general anesthesia, and a further 2 declined surgery or defaulted follow-up. Three had no active treatment for strabismus. The most effective procedure for exotropia was maximal, bilateral lateral rectus recessions (8 mm or 17 mm from the limbus) with medial rectus resections (7 mm) using adjustable sutures. Patients who had less than maximal horizontal muscle surgery were inevitably undercorrected, even in the early postoperative period. Long-term stability of measurements was rarely achieved, with either progressive increase in the angle of exotropia, or with new onset vertical deviations. In selected patients with CPEO and exotropia, maximal bilateral surgery significantly improves ocular alignment and may relieve symptoms of diplopia, but due to the progressive nature of the disease, strabismus often recurs. Toxin can be invaluable in maintaining a satisfactory ocular alignment in patients with residual or progressive exotropias, who have undergone maximal horizontal rectus muscle surgery or multiple previous strabismus procedures.
To describe the demographics, clinical features and management of the largest case series to date... more To describe the demographics, clinical features and management of the largest case series to date on poststreptococcal syndrome uveitis (PSU), a newly recognised immune-mediated response to group A β-haemolytic streptococcus infection. Case notes of all patients presenting to the Red Cross War Memorial Children's Hospital, Cape Town, with serologically confirmed PSU between 2004 and 2010, were retrospectively reviewed. A total of 22 cases were identified. Ages ranged from 4 to 12 years. 64% were black children and 64% were boys. Presenting visual acuities ranged from 6/6 to hand movements (median 6/24). 68% had bilateral disease. All had anterior uveitis (27% with posterior synechiae and 27% with hypopyon). 36% had vitritis and 23% had panuveitis. None had systemic illness or features of other poststreptococcal syndromes such as rheumatic fever, glomerulonephritis or polyarthritis. Anti-streptococcal titres (anti-streptolysin O and/or anti-deoxyribonuclease B) were significantly raised in all cases. Treatment comprised topical steroids and cycloplegic agents. Those with severe posterior segment involvement (41%) were treated with systemic corticosteroids. 55% received a course of oral penicillin. 82% had a single episode of uveitis. Four children had recurrences. Final visual acuities ranged from 6/6 to 6/36 (median 6/6). This case series significantly increases the evidence for PSU currently available in the world literature. The condition can manifest with the full spectrum of ocular inflammation, and most cases respond well to standard uveitis regimens. The role of antibiotic therapy remains unclear and requires further investigation.
To describe the clinical profiles and results of surgical and non-surgical interventions in a lar... more To describe the clinical profiles and results of surgical and non-surgical interventions in a large cohort of patients with strabismus associated with chronic progressive external ophthalmoplegia (CPEO). A retrospective case note review was conducted of all patients with a clinical diagnosis of CPEO referred to our institution's strabismus department in the United Kingdom between 1990 and 2008. The total number of patients in this series was 28 (12 male, 16 female). The main presenting symptoms were diplopia (14) or cosmetically objectionable strabismus (11). Three had symptoms unrelated to strabismus and were excluded from further analysis. The most common strabismus findings were large angle exotropias (mean 47 prism diopters), half of which had associated vertical deviations. Strabismus management consisted of prisms (3), occlusion (3), botulinum toxin (7), and surgery (8). Two patients were offered surgery but were deemed unfit for general anesthesia, and a further 2 declined surgery or defaulted follow-up. Three had no active treatment for strabismus. The most effective procedure for exotropia was maximal, bilateral lateral rectus recessions (8 mm or 17 mm from the limbus) with medial rectus resections (7 mm) using adjustable sutures. Patients who had less than maximal horizontal muscle surgery were inevitably undercorrected, even in the early postoperative period. Long-term stability of measurements was rarely achieved, with either progressive increase in the angle of exotropia, or with new onset vertical deviations. In selected patients with CPEO and exotropia, maximal bilateral surgery significantly improves ocular alignment and may relieve symptoms of diplopia, but due to the progressive nature of the disease, strabismus often recurs. Toxin can be invaluable in maintaining a satisfactory ocular alignment in patients with residual or progressive exotropias, who have undergone maximal horizontal rectus muscle surgery or multiple previous strabismus procedures.
To describe the demographics, clinical features and management of the largest case series to date... more To describe the demographics, clinical features and management of the largest case series to date on poststreptococcal syndrome uveitis (PSU), a newly recognised immune-mediated response to group A β-haemolytic streptococcus infection. Case notes of all patients presenting to the Red Cross War Memorial Children's Hospital, Cape Town, with serologically confirmed PSU between 2004 and 2010, were retrospectively reviewed. A total of 22 cases were identified. Ages ranged from 4 to 12 years. 64% were black children and 64% were boys. Presenting visual acuities ranged from 6/6 to hand movements (median 6/24). 68% had bilateral disease. All had anterior uveitis (27% with posterior synechiae and 27% with hypopyon). 36% had vitritis and 23% had panuveitis. None had systemic illness or features of other poststreptococcal syndromes such as rheumatic fever, glomerulonephritis or polyarthritis. Anti-streptococcal titres (anti-streptolysin O and/or anti-deoxyribonuclease B) were significantly raised in all cases. Treatment comprised topical steroids and cycloplegic agents. Those with severe posterior segment involvement (41%) were treated with systemic corticosteroids. 55% received a course of oral penicillin. 82% had a single episode of uveitis. Four children had recurrences. Final visual acuities ranged from 6/6 to 6/36 (median 6/6). This case series significantly increases the evidence for PSU currently available in the world literature. The condition can manifest with the full spectrum of ocular inflammation, and most cases respond well to standard uveitis regimens. The role of antibiotic therapy remains unclear and requires further investigation.
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