This preliminary feasibility study is based on the availability of the CERN LEP2 superconducting ... more This preliminary feasibility study is based on the availability of the CERN LEP2 superconducting RF system after LEP de-commissioning. The option that is explored is to use this system as part of a high energy H- linac injecting at 2 GeV into the CERN PS, with the aim of reliably providing at its output twice the presently foreseen transverse beam
As the pre-injector of the LHC injector chain, the proton linac at CERN is required to provide a ... more As the pre-injector of the LHC injector chain, the proton linac at CERN is required to provide a high-intensity (180mA) beam to the Proton Synchrotron Booster. The results of measurements at this intensity will be presented. Furthermore, the linac is now equipped with bunch shape monitors from INR, Moscow, which have allowed the comparison of the Alvarez tank RF settings
The original 1973 design specification of the CERN 50 MeV Proton Linac was for a 150 mA beam but ... more The original 1973 design specification of the CERN 50 MeV Proton Linac was for a 150 mA beam but this intensity was rarely used. Preliminary tests for the high brightness beam required for LHC indicated that 170 mA could be produced for short pulses (30 micro sec). Since then further optimisation has enabled the 170 mA to be delivered reliably,
A proposal was made at the end of 1996 to use the large inventory of RF hardware available after ... more A proposal was made at the end of 1996 to use the large inventory of RF hardware available after the decommissioning of LEP-2 for the construction of a 2 GeV Superconducting Proton Linac (SPL) to inject directly into the PS [1.1]. The brightness of the beam in the PS at low energy would double, helping the injector complex to satisfy
The ion injector chain for the LHC has to be adapted and modified to reach the design beam parame... more The ion injector chain for the LHC has to be adapted and modified to reach the design beam parameters. Up to now an ECR4 delivered the ion beam for the SPS fixed target physics programme. This source will be replaced by a higher intensity source to produce the Pb27+ ion current required to fill the Low Energy Ion Ring (LEIR).
This study evaluated responses of the systemic endocrine stress (cortisol) and growth (IGF-I, GH)... more This study evaluated responses of the systemic endocrine stress (cortisol) and growth (IGF-I, GH) axes, as well as those of inflammatory mediators (prostaglandin E2 [PGE2] and tumor necrosis factor alpha [TNFalpha]), to active infection with Salmonella typhimurium. Eighteen crossbred barrows were penned individually with ad libitum access to feed and water. After an acclimation period, jugular catheters were placed in all animals. Control pigs received sterile broth orally (CON, n = 7), whereas the treated pigs (S.TYP, n = 11) received 3 x 10(9) cfu of S. typhimurium orally. Plasma was collected at 6-h intervals from -48 to 120 h. Body weights, feed intake, and rectal temperatures also were monitored. Rectal temperatures were elevated in S.TYP pigs (P < .01) relative to CON pigs by 12 h, peaked at 42 h (P < .001), and remained elevated throughout the remainder of the study. Feed intake was reduced maximally in S.TYP pigs at 48 h (P < .001) and remained reduced through 120 h...
The objective of this research was to provide an integrated look at systemic adrenal, somatotropi... more The objective of this research was to provide an integrated look at systemic adrenal, somatotropic, and immune responses of growing pigs to challenge with lipopolysaccharide (LPS). Weaned pigs were challenged intraperitoneally with 100 microg/kg BW of LPS or sterile saline, and rectal temperature and blood data were collected for 72 h. Daily feed intake also was monitored. Plasma was analyzed for concentrations of cortisol, tumor necrosis factor alpha (TNFalpha), the acute phase protein haptoglobin, growth hormone (GH), insulin-like growth factor I (IGF-I), and prostaglandin E2 (PGE2). As expected, LPS decreased feed intake, stimulated a febrile response, and activated the hypothalamic-pituitary-adrenal (HPA) axis as demonstrated by increased cortisol levels. Cortisol reached maximum elevation 2 h after treatment (P < .001) and remained elevated through 12 h (P < .001). Circulating TNFalpha was increased by LPS at 2 and 4 h after treatment (P < .001), and an apparent (not s...
OBJECTIVES--To compare the pullout properties of 3.5-mm AO/ASIF self-tapping screws (STS) to corr... more OBJECTIVES--To compare the pullout properties of 3.5-mm AO/ASIF self-tapping screws (STS) to corresponding standard cortex screws (CS) in a uniform synthetic test material and in canine femoral bone. The influence of screw-insertion technique, test material, and test-material thickness were also assessed. STUDY DESIGN--In vitro experimental study. SAMPLE POPULATION--Two independent studies: a uniform synthetic test material and paired femurs from mature dogs. METHODS-Mechanical testing was performed in accordance with standards established by the American Society for Testing and Materials for determination of axial pullout strength of medical bone screws. Completely inserted STS, completely inserted CS, and incompletely inserted STS were tested in 3 groups of 10 test specimens each in 4.96-mm and 6.8-mm thick sheets of synthetic material. In the bone study, group 1 consisted of 24 completely inserted STS compared with 24 completely inserted CS, and group 2 consisted of 24 incompletely inserted STS versus 24 completely inserted CS. Comparisons were made between paired femurs at corresponding insertion sites. Pullout data were normalized, thereby eliminating the effect of test-material thickness on pullout properties. Mean values were compared using 2-way ANOVA. Statistical significance was set at P &lt;.05. RESULTS--In both the 4.96-mm and 6.8-mm synthetic material, pullout testing of the completely inserted STS demonstrated significantly greater yield strength and ultimate strength than completely inserted CS. There was no significant difference between incompletely inserted STS and completely inserted STS. The 6.8-mm test material significantly increased yield strength and ultimate strength for all test groups compared with the 4.96-mm test material. In canine bone, there was no significant difference in yield strength of completely inserted STS and completely inserted CS. Yield strength of completely inserted STS and completely inserted CS were significantly greater than incompletely inserted STS. CONCLUSIONS--Pullout properties of completely inserted STS were significantly greater than corresponding CS in a uniform test material. In canine bone, the pullout strength of STS and CS were not different. Incomplete STS insertion resulted in an 18% reduction in holding power as compared with completely inserted CS and STS in canine bone. CLINICAL RELEVANCE--The length of STS used in canine bone should be such that the cutting flutes extend beyond the trans cortex to maximize pullout strength.
To optimise the heavy ion injector for the LHC, a good knowledge of the parameters of the ECR4 io... more To optimise the heavy ion injector for the LHC, a good knowledge of the parameters of the ECR4 ion source and the beam transport in the Low Energy Beam Transport (LEBT) for a lead ion beam is necessary. Results of the emittance measurements of the full beam (O + Pb) leaving the source using a scanning slit and profile monitor will be presented. Furthermore, the emittance of a single charge state after the source has been measured using a solenoid scan coupled to a guillotine and spectrometer. The results for last year’s operation for the SPS fixed target physics with indium will also be presented.
The GTS-LHC ion source, designed and build by CEA Grenoble, was installed and commissioned at CER... more The GTS-LHC ion source, designed and build by CEA Grenoble, was installed and commissioned at CERN in 2005. Since than the source has delivered oxygen and lead ion beams (O4+ and Pb27+ from the source, Pb54+ from the linac) for the commissioning of the Low Energy Ion Ring (LEIR). Results of this operation and attempts to improve the source performance and reliability, and the linac performance will be presented in this paper.
This preliminary feasibility study is based on the availability of the CERN LEP2 superconducting ... more This preliminary feasibility study is based on the availability of the CERN LEP2 superconducting RF system after LEP de-commissioning. The option that is explored is to use this system as part of a high energy H- linac injecting at 2 GeV into the CERN PS, with the aim of reliably providing at its output twice the presently foreseen transverse beam
As the pre-injector of the LHC injector chain, the proton linac at CERN is required to provide a ... more As the pre-injector of the LHC injector chain, the proton linac at CERN is required to provide a high-intensity (180mA) beam to the Proton Synchrotron Booster. The results of measurements at this intensity will be presented. Furthermore, the linac is now equipped with bunch shape monitors from INR, Moscow, which have allowed the comparison of the Alvarez tank RF settings
The original 1973 design specification of the CERN 50 MeV Proton Linac was for a 150 mA beam but ... more The original 1973 design specification of the CERN 50 MeV Proton Linac was for a 150 mA beam but this intensity was rarely used. Preliminary tests for the high brightness beam required for LHC indicated that 170 mA could be produced for short pulses (30 micro sec). Since then further optimisation has enabled the 170 mA to be delivered reliably,
A proposal was made at the end of 1996 to use the large inventory of RF hardware available after ... more A proposal was made at the end of 1996 to use the large inventory of RF hardware available after the decommissioning of LEP-2 for the construction of a 2 GeV Superconducting Proton Linac (SPL) to inject directly into the PS [1.1]. The brightness of the beam in the PS at low energy would double, helping the injector complex to satisfy
The ion injector chain for the LHC has to be adapted and modified to reach the design beam parame... more The ion injector chain for the LHC has to be adapted and modified to reach the design beam parameters. Up to now an ECR4 delivered the ion beam for the SPS fixed target physics programme. This source will be replaced by a higher intensity source to produce the Pb27+ ion current required to fill the Low Energy Ion Ring (LEIR).
This study evaluated responses of the systemic endocrine stress (cortisol) and growth (IGF-I, GH)... more This study evaluated responses of the systemic endocrine stress (cortisol) and growth (IGF-I, GH) axes, as well as those of inflammatory mediators (prostaglandin E2 [PGE2] and tumor necrosis factor alpha [TNFalpha]), to active infection with Salmonella typhimurium. Eighteen crossbred barrows were penned individually with ad libitum access to feed and water. After an acclimation period, jugular catheters were placed in all animals. Control pigs received sterile broth orally (CON, n = 7), whereas the treated pigs (S.TYP, n = 11) received 3 x 10(9) cfu of S. typhimurium orally. Plasma was collected at 6-h intervals from -48 to 120 h. Body weights, feed intake, and rectal temperatures also were monitored. Rectal temperatures were elevated in S.TYP pigs (P < .01) relative to CON pigs by 12 h, peaked at 42 h (P < .001), and remained elevated throughout the remainder of the study. Feed intake was reduced maximally in S.TYP pigs at 48 h (P < .001) and remained reduced through 120 h...
The objective of this research was to provide an integrated look at systemic adrenal, somatotropi... more The objective of this research was to provide an integrated look at systemic adrenal, somatotropic, and immune responses of growing pigs to challenge with lipopolysaccharide (LPS). Weaned pigs were challenged intraperitoneally with 100 microg/kg BW of LPS or sterile saline, and rectal temperature and blood data were collected for 72 h. Daily feed intake also was monitored. Plasma was analyzed for concentrations of cortisol, tumor necrosis factor alpha (TNFalpha), the acute phase protein haptoglobin, growth hormone (GH), insulin-like growth factor I (IGF-I), and prostaglandin E2 (PGE2). As expected, LPS decreased feed intake, stimulated a febrile response, and activated the hypothalamic-pituitary-adrenal (HPA) axis as demonstrated by increased cortisol levels. Cortisol reached maximum elevation 2 h after treatment (P < .001) and remained elevated through 12 h (P < .001). Circulating TNFalpha was increased by LPS at 2 and 4 h after treatment (P < .001), and an apparent (not s...
OBJECTIVES--To compare the pullout properties of 3.5-mm AO/ASIF self-tapping screws (STS) to corr... more OBJECTIVES--To compare the pullout properties of 3.5-mm AO/ASIF self-tapping screws (STS) to corresponding standard cortex screws (CS) in a uniform synthetic test material and in canine femoral bone. The influence of screw-insertion technique, test material, and test-material thickness were also assessed. STUDY DESIGN--In vitro experimental study. SAMPLE POPULATION--Two independent studies: a uniform synthetic test material and paired femurs from mature dogs. METHODS-Mechanical testing was performed in accordance with standards established by the American Society for Testing and Materials for determination of axial pullout strength of medical bone screws. Completely inserted STS, completely inserted CS, and incompletely inserted STS were tested in 3 groups of 10 test specimens each in 4.96-mm and 6.8-mm thick sheets of synthetic material. In the bone study, group 1 consisted of 24 completely inserted STS compared with 24 completely inserted CS, and group 2 consisted of 24 incompletely inserted STS versus 24 completely inserted CS. Comparisons were made between paired femurs at corresponding insertion sites. Pullout data were normalized, thereby eliminating the effect of test-material thickness on pullout properties. Mean values were compared using 2-way ANOVA. Statistical significance was set at P &lt;.05. RESULTS--In both the 4.96-mm and 6.8-mm synthetic material, pullout testing of the completely inserted STS demonstrated significantly greater yield strength and ultimate strength than completely inserted CS. There was no significant difference between incompletely inserted STS and completely inserted STS. The 6.8-mm test material significantly increased yield strength and ultimate strength for all test groups compared with the 4.96-mm test material. In canine bone, there was no significant difference in yield strength of completely inserted STS and completely inserted CS. Yield strength of completely inserted STS and completely inserted CS were significantly greater than incompletely inserted STS. CONCLUSIONS--Pullout properties of completely inserted STS were significantly greater than corresponding CS in a uniform test material. In canine bone, the pullout strength of STS and CS were not different. Incomplete STS insertion resulted in an 18% reduction in holding power as compared with completely inserted CS and STS in canine bone. CLINICAL RELEVANCE--The length of STS used in canine bone should be such that the cutting flutes extend beyond the trans cortex to maximize pullout strength.
To optimise the heavy ion injector for the LHC, a good knowledge of the parameters of the ECR4 io... more To optimise the heavy ion injector for the LHC, a good knowledge of the parameters of the ECR4 ion source and the beam transport in the Low Energy Beam Transport (LEBT) for a lead ion beam is necessary. Results of the emittance measurements of the full beam (O + Pb) leaving the source using a scanning slit and profile monitor will be presented. Furthermore, the emittance of a single charge state after the source has been measured using a solenoid scan coupled to a guillotine and spectrometer. The results for last year’s operation for the SPS fixed target physics with indium will also be presented.
The GTS-LHC ion source, designed and build by CEA Grenoble, was installed and commissioned at CER... more The GTS-LHC ion source, designed and build by CEA Grenoble, was installed and commissioned at CERN in 2005. Since than the source has delivered oxygen and lead ion beams (O4+ and Pb27+ from the source, Pb54+ from the linac) for the commissioning of the Low Energy Ion Ring (LEIR). Results of this operation and attempts to improve the source performance and reliability, and the linac performance will be presented in this paper.
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Papers by Carol Hill