The Journal of Maternal-Fetal & Neonatal Medicine, 2019
Abstract Aim Despite the increasing trend in delayed childbirth and the known associated complica... more Abstract Aim Despite the increasing trend in delayed childbirth and the known associated complications in advancing maternal age, limited information exists regarding outcomes in very advanced maternal age by delivery type. This study aims to evaluate maternal and neonatal outcomes in women age 40 or more undergoing cesarean delivery or trial of labor after cesarean delivery. Materials and methods We performed a secondary analysis of the Cesarean Section Registry Maternal-Fetal Medicine Units (MFMU) Network data, which was a prospective study of women undergoing repeat cesarean delivery or trial of labor after cesarean delivery from 1 January 1999 to 31 December 2002. Women age 40 years or more at the time of delivery were compared to the control group of women less than 40 years of age. Results There were 67,389 cases identified that met inclusion criteria. 2,436 (3.6%) were age ≥40 years old, and 65,403 (97.05%) were <40 at delivery. The >40 group had a higher rate of PRBC transfusion (aRR 1.75; 95% CI 1.20–2.56), maternal ICU admission (aRR 2.02; 1.41–2.89), bowel injury (aRR 3.65; 1.43–9.31), placenta accreta (aRR 1.92; 1.09–3.38) and classical uterine incision (aRR 1.59; 1.43–9.31) compared to the control group. Maternal death rates were similar in both groups (p = .30). Conclusion Women aged 40 or more undergoing repeat cesarean delivery or trial of labor after cesarean delivery are more likely to have maternal complications including intraoperative transfusion, maternal ICU admission, abnormal placentation and surgical complications in comparison to women under age 40.
1. J Reprod Med. 2006 Sep;51(9):725-8. Arrhythmogenic right ventricular dysplasia in pregnancy: a... more 1. J Reprod Med. 2006 Sep;51(9):725-8. Arrhythmogenic right ventricular dysplasia in pregnancy: a case report. Lee LC, Bathgate SL, Macri CJ. Department of Obstetrics and Gynecology, George Washington University School ...
BACKGROUND Arrhythmogenic right ventricular dysplasia (ARVD) is characterized by progressive fibr... more BACKGROUND Arrhythmogenic right ventricular dysplasia (ARVD) is characterized by progressive fibrous or fibrofatty tissue replacement of the right ventricular myocardium. Interspersed adipocytes and fibrous tissue may provide foci for arrhythmias. The clinical spectrum of ARVD may include asymptomatic premature ventricular complexes to ventricular tachycardia and sudden death. There is currently little information about ARVD in pregnancy. CASE A 29-year-old primigravida, diagnosed with ARVD 1 year prior to pregnancy, underwent a full-term, uncomplicated pregnancy and delivery while maintained on acebutolol and an implanted cardioverter defibrillator. Her infant was born without an apparent cardiac anomaly or heart rate abnormality. CONCLUSION Successful management of pregnancy complicated by ARVD can be accomplished with an implanted cardioverter defibrillator and an antiarrhythmic agent. Such patients should be managed with close monitoring during pregnancy for signs and symptoms o...
Les procedes de la presente inveniton metnent en evidence que l'adrenomedulline (AM) est expr... more Les procedes de la presente inveniton metnent en evidence que l'adrenomedulline (AM) est exprimee dans des lignees cellulaires cancereuses humaines d'origine et de fonctions diverses sous forme d'un facteur de croissance autocrine universel entrainant une proliferation neoplasique. La presente invention concerne de peptides et anticorps d'AM utilises dans des compositions therapeutiques, pharmacologiques et physiologiques. La presente invention concerne de plus des procedees de diagnostic, de traitement et de prevention de maladies, ces procedees mettant en oeuvre des compositions comprenant les peptides et anticorps d'AM. Les procedes de la presente invention s'appliquent egalement a des modeles experimentaux destines a etre utilises dans l'identification du role de l'AM en physiologie pancreatique. Les procedes relatifs aux ilots pancreatiques isoles chez le rat ont mis en evidence que l'AM inhibe la secretion de l'insuline de maniere propor...
Background Genetic screening and testing has only recently become an accessible assessment for ge... more Background Genetic screening and testing has only recently become an accessible assessment for genetic risk. Unfortunately, these technologies have been underutilized in minority populations despite their usefulness for predicting diseases like sickle cell disease (SCD), often found in African American and Black and Hispanic populations. We surveyed prenatal patients to understand current choices, beliefs and experiences surrounding genetic screening and testing, specifically for sickle cell disease. Methods In this cross-sectional survey, we collected information from 322 women during prenatal visits from July 2019 through May 2021. Responses to questions about pregnancy screening and testing practices were analyzed for trends to identify barriers to care and education about testing and screening for sickle cell disease. Patients were asked to rate whether they agree or disagree with statements regarding sickle cell health behaviors. We used χ2 tests to compare categorical variable...
Adrenomedullin Alfredo Martinez and Frank Cuttitta (Eds.) 1OS Press and Ohmsha, 1998 Adrenomedull... more Adrenomedullin Alfredo Martinez and Frank Cuttitta (Eds.) 1OS Press and Ohmsha, 1998 Adrenomedullin Is Widely Expressed throughout Normal and Abnormal Reproductive Tissues of Women Evidence for Cyclic Regulation Charles Macri, 1 Davonne Loup, 1 Michael McHale, 1 Robyn ...
Lichen sclerosus (LS) is a chronic inflammatory skin disorder with unknown pathogenesis. The aber... more Lichen sclerosus (LS) is a chronic inflammatory skin disorder with unknown pathogenesis. The aberrant expression of microRNAs (miRNAs) is considered to exert a crucial role in LS. We used the next-generation sequencing technology (RNASeq) for miRNA profiling and Ingenuity Pathway Analysis (IPA) for molecular network analysis. We performed qRT-PCR, miRNA transfection and Matrigel assays for functional studies. We identified a total of 170 differentially expressed miRNAs between female LS and matched adjacent normal tissue using RNASeq, with 119 upregulated and 51 downregulated. Bioinformatics analysis revealed molecular networks that may shed light on the pathogenesis of LS. We verified the expression of a set of miRNAs that are related to autoimmunity, such as upregulated miR-326, miR-142-5p, miR-155 and downregulated miR-664a-3p and miR-181a-3p in LS tissue compared to the matched adjacent normal tissue. The differentially expressed miRNAs were also verified in blood samples from L...
The Journal of Maternal-Fetal & Neonatal Medicine, 2019
Abstract Aim Despite the increasing trend in delayed childbirth and the known associated complica... more Abstract Aim Despite the increasing trend in delayed childbirth and the known associated complications in advancing maternal age, limited information exists regarding outcomes in very advanced maternal age by delivery type. This study aims to evaluate maternal and neonatal outcomes in women age 40 or more undergoing cesarean delivery or trial of labor after cesarean delivery. Materials and methods We performed a secondary analysis of the Cesarean Section Registry Maternal-Fetal Medicine Units (MFMU) Network data, which was a prospective study of women undergoing repeat cesarean delivery or trial of labor after cesarean delivery from 1 January 1999 to 31 December 2002. Women age 40 years or more at the time of delivery were compared to the control group of women less than 40 years of age. Results There were 67,389 cases identified that met inclusion criteria. 2,436 (3.6%) were age ≥40 years old, and 65,403 (97.05%) were <40 at delivery. The >40 group had a higher rate of PRBC transfusion (aRR 1.75; 95% CI 1.20–2.56), maternal ICU admission (aRR 2.02; 1.41–2.89), bowel injury (aRR 3.65; 1.43–9.31), placenta accreta (aRR 1.92; 1.09–3.38) and classical uterine incision (aRR 1.59; 1.43–9.31) compared to the control group. Maternal death rates were similar in both groups (p = .30). Conclusion Women aged 40 or more undergoing repeat cesarean delivery or trial of labor after cesarean delivery are more likely to have maternal complications including intraoperative transfusion, maternal ICU admission, abnormal placentation and surgical complications in comparison to women under age 40.
1. J Reprod Med. 2006 Sep;51(9):725-8. Arrhythmogenic right ventricular dysplasia in pregnancy: a... more 1. J Reprod Med. 2006 Sep;51(9):725-8. Arrhythmogenic right ventricular dysplasia in pregnancy: a case report. Lee LC, Bathgate SL, Macri CJ. Department of Obstetrics and Gynecology, George Washington University School ...
BACKGROUND Arrhythmogenic right ventricular dysplasia (ARVD) is characterized by progressive fibr... more BACKGROUND Arrhythmogenic right ventricular dysplasia (ARVD) is characterized by progressive fibrous or fibrofatty tissue replacement of the right ventricular myocardium. Interspersed adipocytes and fibrous tissue may provide foci for arrhythmias. The clinical spectrum of ARVD may include asymptomatic premature ventricular complexes to ventricular tachycardia and sudden death. There is currently little information about ARVD in pregnancy. CASE A 29-year-old primigravida, diagnosed with ARVD 1 year prior to pregnancy, underwent a full-term, uncomplicated pregnancy and delivery while maintained on acebutolol and an implanted cardioverter defibrillator. Her infant was born without an apparent cardiac anomaly or heart rate abnormality. CONCLUSION Successful management of pregnancy complicated by ARVD can be accomplished with an implanted cardioverter defibrillator and an antiarrhythmic agent. Such patients should be managed with close monitoring during pregnancy for signs and symptoms o...
Les procedes de la presente inveniton metnent en evidence que l'adrenomedulline (AM) est expr... more Les procedes de la presente inveniton metnent en evidence que l'adrenomedulline (AM) est exprimee dans des lignees cellulaires cancereuses humaines d'origine et de fonctions diverses sous forme d'un facteur de croissance autocrine universel entrainant une proliferation neoplasique. La presente invention concerne de peptides et anticorps d'AM utilises dans des compositions therapeutiques, pharmacologiques et physiologiques. La presente invention concerne de plus des procedees de diagnostic, de traitement et de prevention de maladies, ces procedees mettant en oeuvre des compositions comprenant les peptides et anticorps d'AM. Les procedes de la presente invention s'appliquent egalement a des modeles experimentaux destines a etre utilises dans l'identification du role de l'AM en physiologie pancreatique. Les procedes relatifs aux ilots pancreatiques isoles chez le rat ont mis en evidence que l'AM inhibe la secretion de l'insuline de maniere propor...
Background Genetic screening and testing has only recently become an accessible assessment for ge... more Background Genetic screening and testing has only recently become an accessible assessment for genetic risk. Unfortunately, these technologies have been underutilized in minority populations despite their usefulness for predicting diseases like sickle cell disease (SCD), often found in African American and Black and Hispanic populations. We surveyed prenatal patients to understand current choices, beliefs and experiences surrounding genetic screening and testing, specifically for sickle cell disease. Methods In this cross-sectional survey, we collected information from 322 women during prenatal visits from July 2019 through May 2021. Responses to questions about pregnancy screening and testing practices were analyzed for trends to identify barriers to care and education about testing and screening for sickle cell disease. Patients were asked to rate whether they agree or disagree with statements regarding sickle cell health behaviors. We used χ2 tests to compare categorical variable...
Adrenomedullin Alfredo Martinez and Frank Cuttitta (Eds.) 1OS Press and Ohmsha, 1998 Adrenomedull... more Adrenomedullin Alfredo Martinez and Frank Cuttitta (Eds.) 1OS Press and Ohmsha, 1998 Adrenomedullin Is Widely Expressed throughout Normal and Abnormal Reproductive Tissues of Women Evidence for Cyclic Regulation Charles Macri, 1 Davonne Loup, 1 Michael McHale, 1 Robyn ...
Lichen sclerosus (LS) is a chronic inflammatory skin disorder with unknown pathogenesis. The aber... more Lichen sclerosus (LS) is a chronic inflammatory skin disorder with unknown pathogenesis. The aberrant expression of microRNAs (miRNAs) is considered to exert a crucial role in LS. We used the next-generation sequencing technology (RNASeq) for miRNA profiling and Ingenuity Pathway Analysis (IPA) for molecular network analysis. We performed qRT-PCR, miRNA transfection and Matrigel assays for functional studies. We identified a total of 170 differentially expressed miRNAs between female LS and matched adjacent normal tissue using RNASeq, with 119 upregulated and 51 downregulated. Bioinformatics analysis revealed molecular networks that may shed light on the pathogenesis of LS. We verified the expression of a set of miRNAs that are related to autoimmunity, such as upregulated miR-326, miR-142-5p, miR-155 and downregulated miR-664a-3p and miR-181a-3p in LS tissue compared to the matched adjacent normal tissue. The differentially expressed miRNAs were also verified in blood samples from L...
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Papers by Charles Macri