dObra[s] – revista da Associação Brasileira de Estudos de Pesquisas em Moda
This technical paper will assess new technological advances that could change the way we buy clot... more This technical paper will assess new technological advances that could change the way we buy clothes, exploring existing solutions that are still commonly confused with each other: Smart fitting rooms (SFR), interactive mirrors (IM), Virtual Reality (VR), and Augmented Reality (AR). The methodological approach based on an exploratory research will start with a literature review on SFR and IM, comparing the main differences between these two technologies and addressing their unsuccessful attempts in retail. Our research will also assess daily technologies, which could possibly improve the customer’s experience with online shopping, as well as customers with reduced mobility. With smart gadgets in every corner, consumers are more difficult to convince with innovative products. We will propose future possibilities for fashion retail, where results will be presented as a first approach, in hopes of creating innovative solutions for the future. Moreover, sustainable implications related ...
Abstract Rheology is a branch of physics which signifies the flow or deformation of fluids on app... more Abstract Rheology is a branch of physics which signifies the flow or deformation of fluids on application of stress. Rheological features have imperative implications in diverse applications across all industries concerning food products, pharmaceutical products, polymer science, bio-printing, paints, textiles, plastics, metals, geology, concrete material, etc. In pharmaceutical products, rheology measurements govern the formulation, process, and material control factors such as blending, mixing, draining, pouring, spraying, injecting, spreading, dose uniformity, physical stability, etc. These features are of utmost importance as they directly influence the quality and stability of the pharmaceutical product. Numerous mathematical explanations have been defined by scientists to describe the relationship between viscosity of matter and other parameters. Rheology modifiers are typically incorporated in these systems to offer the anticipated flow features. This chapter describes the basis and theoretical consideration of this along with an overview of variables affecting the rheological properties of the formulations quoting various research-based case studies. This chapter also provides an overview on viscometers and rheometers, which are an integral part of rheology, as they offer measurements of simple flow to characterization of deformation behavior. Finally, the chapter also provides understanding on the applications of rheology, i.e., its contribution to the material science, geophysics, physiology, food rheology, concrete rheology, filled polymer rheology, pharmaceuticals, and an overview of dilation rheology as medical diagnostics.
Abstract A typical product lifecycle stage is fraught with challenges right from the inception, i... more Abstract A typical product lifecycle stage is fraught with challenges right from the inception, i.e., early drug discovery/lead optimization to product development. Challenge includes optimization of operation process, i.e., procurement and supply of bulk materials as well as production span to develop a final commercial product. The putative reasons attributed to failure to translation of product from conception to commercialization may include but not limited to subtherapeutic efficacy, toxicity issues, commercial viability, unforeseen operational issues, and so on. Together, these issues may culminate into failures of phase-II and phase-III clinical trials. Hence, to minimize all these formulation and delivery issues during the later stages of product development and registration, there is always a need for preformulation studies before the development stage. Preformulation studies are designed to provide insights of the essential physicochemical attributes of a new chemical entity, drug-excipient compatibility, to determine kinetic rate profile of the drug and the stability indicating assay method. However, the relation between preformulation and pharmacokinetics is also needed to be understood to utilize this concept in a better way. Apart from the general information on preformulation (importance, parameters, technologies, etc.), the chapter also covers a few recent case studies on the role of preformulation in development of dosage forms such as hydrogels, liposomes, and vaccines.
This exploratory article seeks to analyse how fashion, as a theme with a strong aesthetic and art... more This exploratory article seeks to analyse how fashion, as a theme with a strong aesthetic and artistic component, has been worked on by podcasting. We start from the idea that today social media represent an essential field for the communication of brands in the fashion industry, mainly due to its visual component and because it is in these spaces that influencers are found, key players in current dissemination strategies. Considering these new forms of communication and knowing the growth that podcasts have registered, we explore the potential that this medium can have in connecting with consumers. Based on a selection of fifteen fashion podcasts, we analyse the extent to which podcasting has been a territory for promoting the fashion industry.
Abstract Nanoscale engineering in tissue engineered scaffolds is gaining recognition as it mimics... more Abstract Nanoscale engineering in tissue engineered scaffolds is gaining recognition as it mimics the topographical features of the biological tissues. The most crucial elements in tissue engineering impacting cell-surface interactions, roughness and topography of the scaffold surface are the materials chemistry and scaffold architecture i.e. pore size and pore volume. Numerous literatures document the impact of the methods in introducing these nanoscale features on 2D flat surfaces, as well as nanostructuring the surface of 3D scaffolds. In this context, this book chapter will provide indepth review of the diverse techniques that have been used to fabricate nanoscale topography in both 2D surfaces and 3D scaffolds. Besides this, the review also discusses the techniques used to generate components that self-assemble into 3D scaffolds via postprocessing. To name a few, the techniques will include lithography and printing based methodologies, polymer de-mixing, chemical etching, solvent casting, electrospinning, electrospraying, thermally induced phase separation, nanoparticle based techniques.
Poster: "ECR 2018 / C-2988 / TI-RADS 2017 comparison with other thyroid nodule evaluation gu... more Poster: "ECR 2018 / C-2988 / TI-RADS 2017 comparison with other thyroid nodule evaluation guidelines – One system to rule them all?" by: "J. Abrantes1, C. Fernandes2, J. Granadeiro3; 1 Barreiro/PT, 2Barreiro/PT, 3Oeiras/PT"
Abstract The intensive efforts undertaken to get effective drugs have resulted in the generation ... more Abstract The intensive efforts undertaken to get effective drugs have resulted in the generation of candidates with unfavorable properties, i.e., greater lipophilicity, high molecular weight resulting in poor aqueous solubility. It was reported that more than 40% of the drugs discovered belong to the Biopharmaceutics Classification System Class II and IV drugs, i.e., have low aqueous solubility, poor dissolution, and low bioavailability. Thus, it can be stated that drug solubility and bioavailability enhancement approaches are the important challenges in facing the pharmaceutical scientists. In this chapter, we have discussed many methods to uplift the drug solubility which includes pH modification, crystal structure manipulation which includes polymorphs, salt formation, cocrystal, complexation, crystal structure disruption (amorphization), supersaturated solutions, prodrug strategies, size reduction, and excipient-based solubilization which includes cosolvency, polymer as excipient, surfactant as excipient, lipid, and cyclodextrin. Overall, this chapter provides the summary of the strategies which may be used to report the challenges of low solubility during drug discovery.
The patient presented with recurrent epigastric pain and recent onset jaundice, with laboratory f... more The patient presented with recurrent epigastric pain and recent onset jaundice, with laboratory findings showing anemia (10.5 g/dL) and increased bilirubin levels (3.40 mg/dL).
Abstract The systemic absorption of a drug from its site of application is one of the major consi... more Abstract The systemic absorption of a drug from its site of application is one of the major considerations for the successful drug product design. Absorption site plays a crucial role in the success of drug delivery as well as its therapeutic effect at the anticipated site. Numerous diffusion pathways (viz, facilitated and carrier-mediated transportation) help drug molecules to get absorbed into the systemic circulation. However, the physiology of the human cell membrane usually prevents the entry of such drug molecules and acts as a barrier in their absorption process. Physiological barriers have been categorized into two part, i.e., mucosal and nonmucosal barriers. On the other hand, first pass metabolism, disease conditions, and food habits of the patient are also responsible for the difference in the absorption pattern of drugs. Therefore, it is always challenging for the formulation scientists to overcome these physiological constraints and develop a versatile drug formulation that can suit all cadre of patients. At the time of dosage form development, a scientist has to consider all the physicochemical, physiological, and pharmaceutical factors to come up with a clinically successful product. This chapter focuses on various physiological constraints that pose major barriers during the absorption of drugs in the body. This chapter also expounds on strategies that can be employed to overcome such barriers by modifying product characteristics such as mucoadhesive property, solubilization, enhancement of permeation, and uptake facilitator.
An amendment to this paper has been published and can be accessed via a link at the top of the pa... more An amendment to this paper has been published and can be accessed via a link at the top of the paper.
A 34-year-old multipara presented 72 hours postpartum with acute right-sided abdominal pain. The ... more A 34-year-old multipara presented 72 hours postpartum with acute right-sided abdominal pain. The investigation revealed mild leucocytosis with positive D-dimer and elevated C reactive protein. Abdominal ultrasound and abdominopelvic CT demonstrated an enlarged right ovarian vein with endoluminal thrombus, representing postpartum ovarian vein thrombosis. The patient became asymptomatic 48 hours after starting broad-spectrum antibiotic treatment and anticoagulant therapy. She completed the treatment in ambulatory regimen and control abdominopelvic CT imaging was performed and revealed a duplicated right ovarian vein and a small residual subacute thrombus in the lumen of the distal right ovarian vein. The patient remained asymptomatic in the clinical follow-up.
In this study, a lauroyl grafted hydrophobic glycolipid derivative of alginate has been successfu... more In this study, a lauroyl grafted hydrophobic glycolipid derivative of alginate has been successfully synthesized and characterized. This glycolipid has been incorporated into Psyllium husk gel-alginate composite films and compared with the films containing only Psyllim husk gel and Psyllim husk gel-alginate for its mechanical and physicochemical properties. Additionally, the composite film has also been evaluated for protein adsorption and antimicrobial property to verify its utility in biomedical applications. The results showed that the composite films have enhanced physicochemical and mechanical properties. The film produced better swelling characteristic and lower protein adsorption property indicating the usefulness of the film in wound care dressing, particularly for low suppurating wounds. Incorporation of the synthesised glycolipid derivative also imparts antimicrobial activity to the composite film. Therefore, the developed film is capable of sustaining the microbial contam...
Multifunctional Nanocarriers for Contemporary Healthcare Applications
Nanocomposites are a class of materials in which one or more phases with nanoscale dimensions are... more Nanocomposites are a class of materials in which one or more phases with nanoscale dimensions are embedded in a metal, ceramic, or polymer matrix. The properties of nanocomposites depend on matrix, loading, degree of dispersion, size, shape, and orientation of the nanoscale phase and interaction between the matrix and the nanoscale phase. Nanocomposites are generally prepared using direct melt intercalation. The formation of nanocomposite is ascertained by XRD pattern, FTIR spectra, electron microscopy, and thermal analysis like DSC and TGA. Nanocomposites have properties of nanoparticles, multifunctional capabilities, chemical functionalization, huge interphase zone. Novel nanomaterials offer a new chemotherapeutic route for cancer treatment by combining cell imaging and hyperthermia in a synergistic way. In spite of toxicity and safety concerns, multifunctional nanocomposite still interest the researchers because of emergence of versatile properties, better understanding of diseas...
dObra[s] – revista da Associação Brasileira de Estudos de Pesquisas em Moda
This technical paper will assess new technological advances that could change the way we buy clot... more This technical paper will assess new technological advances that could change the way we buy clothes, exploring existing solutions that are still commonly confused with each other: Smart fitting rooms (SFR), interactive mirrors (IM), Virtual Reality (VR), and Augmented Reality (AR). The methodological approach based on an exploratory research will start with a literature review on SFR and IM, comparing the main differences between these two technologies and addressing their unsuccessful attempts in retail. Our research will also assess daily technologies, which could possibly improve the customer’s experience with online shopping, as well as customers with reduced mobility. With smart gadgets in every corner, consumers are more difficult to convince with innovative products. We will propose future possibilities for fashion retail, where results will be presented as a first approach, in hopes of creating innovative solutions for the future. Moreover, sustainable implications related ...
Abstract Rheology is a branch of physics which signifies the flow or deformation of fluids on app... more Abstract Rheology is a branch of physics which signifies the flow or deformation of fluids on application of stress. Rheological features have imperative implications in diverse applications across all industries concerning food products, pharmaceutical products, polymer science, bio-printing, paints, textiles, plastics, metals, geology, concrete material, etc. In pharmaceutical products, rheology measurements govern the formulation, process, and material control factors such as blending, mixing, draining, pouring, spraying, injecting, spreading, dose uniformity, physical stability, etc. These features are of utmost importance as they directly influence the quality and stability of the pharmaceutical product. Numerous mathematical explanations have been defined by scientists to describe the relationship between viscosity of matter and other parameters. Rheology modifiers are typically incorporated in these systems to offer the anticipated flow features. This chapter describes the basis and theoretical consideration of this along with an overview of variables affecting the rheological properties of the formulations quoting various research-based case studies. This chapter also provides an overview on viscometers and rheometers, which are an integral part of rheology, as they offer measurements of simple flow to characterization of deformation behavior. Finally, the chapter also provides understanding on the applications of rheology, i.e., its contribution to the material science, geophysics, physiology, food rheology, concrete rheology, filled polymer rheology, pharmaceuticals, and an overview of dilation rheology as medical diagnostics.
Abstract A typical product lifecycle stage is fraught with challenges right from the inception, i... more Abstract A typical product lifecycle stage is fraught with challenges right from the inception, i.e., early drug discovery/lead optimization to product development. Challenge includes optimization of operation process, i.e., procurement and supply of bulk materials as well as production span to develop a final commercial product. The putative reasons attributed to failure to translation of product from conception to commercialization may include but not limited to subtherapeutic efficacy, toxicity issues, commercial viability, unforeseen operational issues, and so on. Together, these issues may culminate into failures of phase-II and phase-III clinical trials. Hence, to minimize all these formulation and delivery issues during the later stages of product development and registration, there is always a need for preformulation studies before the development stage. Preformulation studies are designed to provide insights of the essential physicochemical attributes of a new chemical entity, drug-excipient compatibility, to determine kinetic rate profile of the drug and the stability indicating assay method. However, the relation between preformulation and pharmacokinetics is also needed to be understood to utilize this concept in a better way. Apart from the general information on preformulation (importance, parameters, technologies, etc.), the chapter also covers a few recent case studies on the role of preformulation in development of dosage forms such as hydrogels, liposomes, and vaccines.
This exploratory article seeks to analyse how fashion, as a theme with a strong aesthetic and art... more This exploratory article seeks to analyse how fashion, as a theme with a strong aesthetic and artistic component, has been worked on by podcasting. We start from the idea that today social media represent an essential field for the communication of brands in the fashion industry, mainly due to its visual component and because it is in these spaces that influencers are found, key players in current dissemination strategies. Considering these new forms of communication and knowing the growth that podcasts have registered, we explore the potential that this medium can have in connecting with consumers. Based on a selection of fifteen fashion podcasts, we analyse the extent to which podcasting has been a territory for promoting the fashion industry.
Abstract Nanoscale engineering in tissue engineered scaffolds is gaining recognition as it mimics... more Abstract Nanoscale engineering in tissue engineered scaffolds is gaining recognition as it mimics the topographical features of the biological tissues. The most crucial elements in tissue engineering impacting cell-surface interactions, roughness and topography of the scaffold surface are the materials chemistry and scaffold architecture i.e. pore size and pore volume. Numerous literatures document the impact of the methods in introducing these nanoscale features on 2D flat surfaces, as well as nanostructuring the surface of 3D scaffolds. In this context, this book chapter will provide indepth review of the diverse techniques that have been used to fabricate nanoscale topography in both 2D surfaces and 3D scaffolds. Besides this, the review also discusses the techniques used to generate components that self-assemble into 3D scaffolds via postprocessing. To name a few, the techniques will include lithography and printing based methodologies, polymer de-mixing, chemical etching, solvent casting, electrospinning, electrospraying, thermally induced phase separation, nanoparticle based techniques.
Poster: "ECR 2018 / C-2988 / TI-RADS 2017 comparison with other thyroid nodule evaluation gu... more Poster: "ECR 2018 / C-2988 / TI-RADS 2017 comparison with other thyroid nodule evaluation guidelines – One system to rule them all?" by: "J. Abrantes1, C. Fernandes2, J. Granadeiro3; 1 Barreiro/PT, 2Barreiro/PT, 3Oeiras/PT"
Abstract The intensive efforts undertaken to get effective drugs have resulted in the generation ... more Abstract The intensive efforts undertaken to get effective drugs have resulted in the generation of candidates with unfavorable properties, i.e., greater lipophilicity, high molecular weight resulting in poor aqueous solubility. It was reported that more than 40% of the drugs discovered belong to the Biopharmaceutics Classification System Class II and IV drugs, i.e., have low aqueous solubility, poor dissolution, and low bioavailability. Thus, it can be stated that drug solubility and bioavailability enhancement approaches are the important challenges in facing the pharmaceutical scientists. In this chapter, we have discussed many methods to uplift the drug solubility which includes pH modification, crystal structure manipulation which includes polymorphs, salt formation, cocrystal, complexation, crystal structure disruption (amorphization), supersaturated solutions, prodrug strategies, size reduction, and excipient-based solubilization which includes cosolvency, polymer as excipient, surfactant as excipient, lipid, and cyclodextrin. Overall, this chapter provides the summary of the strategies which may be used to report the challenges of low solubility during drug discovery.
The patient presented with recurrent epigastric pain and recent onset jaundice, with laboratory f... more The patient presented with recurrent epigastric pain and recent onset jaundice, with laboratory findings showing anemia (10.5 g/dL) and increased bilirubin levels (3.40 mg/dL).
Abstract The systemic absorption of a drug from its site of application is one of the major consi... more Abstract The systemic absorption of a drug from its site of application is one of the major considerations for the successful drug product design. Absorption site plays a crucial role in the success of drug delivery as well as its therapeutic effect at the anticipated site. Numerous diffusion pathways (viz, facilitated and carrier-mediated transportation) help drug molecules to get absorbed into the systemic circulation. However, the physiology of the human cell membrane usually prevents the entry of such drug molecules and acts as a barrier in their absorption process. Physiological barriers have been categorized into two part, i.e., mucosal and nonmucosal barriers. On the other hand, first pass metabolism, disease conditions, and food habits of the patient are also responsible for the difference in the absorption pattern of drugs. Therefore, it is always challenging for the formulation scientists to overcome these physiological constraints and develop a versatile drug formulation that can suit all cadre of patients. At the time of dosage form development, a scientist has to consider all the physicochemical, physiological, and pharmaceutical factors to come up with a clinically successful product. This chapter focuses on various physiological constraints that pose major barriers during the absorption of drugs in the body. This chapter also expounds on strategies that can be employed to overcome such barriers by modifying product characteristics such as mucoadhesive property, solubilization, enhancement of permeation, and uptake facilitator.
An amendment to this paper has been published and can be accessed via a link at the top of the pa... more An amendment to this paper has been published and can be accessed via a link at the top of the paper.
A 34-year-old multipara presented 72 hours postpartum with acute right-sided abdominal pain. The ... more A 34-year-old multipara presented 72 hours postpartum with acute right-sided abdominal pain. The investigation revealed mild leucocytosis with positive D-dimer and elevated C reactive protein. Abdominal ultrasound and abdominopelvic CT demonstrated an enlarged right ovarian vein with endoluminal thrombus, representing postpartum ovarian vein thrombosis. The patient became asymptomatic 48 hours after starting broad-spectrum antibiotic treatment and anticoagulant therapy. She completed the treatment in ambulatory regimen and control abdominopelvic CT imaging was performed and revealed a duplicated right ovarian vein and a small residual subacute thrombus in the lumen of the distal right ovarian vein. The patient remained asymptomatic in the clinical follow-up.
In this study, a lauroyl grafted hydrophobic glycolipid derivative of alginate has been successfu... more In this study, a lauroyl grafted hydrophobic glycolipid derivative of alginate has been successfully synthesized and characterized. This glycolipid has been incorporated into Psyllium husk gel-alginate composite films and compared with the films containing only Psyllim husk gel and Psyllim husk gel-alginate for its mechanical and physicochemical properties. Additionally, the composite film has also been evaluated for protein adsorption and antimicrobial property to verify its utility in biomedical applications. The results showed that the composite films have enhanced physicochemical and mechanical properties. The film produced better swelling characteristic and lower protein adsorption property indicating the usefulness of the film in wound care dressing, particularly for low suppurating wounds. Incorporation of the synthesised glycolipid derivative also imparts antimicrobial activity to the composite film. Therefore, the developed film is capable of sustaining the microbial contam...
Multifunctional Nanocarriers for Contemporary Healthcare Applications
Nanocomposites are a class of materials in which one or more phases with nanoscale dimensions are... more Nanocomposites are a class of materials in which one or more phases with nanoscale dimensions are embedded in a metal, ceramic, or polymer matrix. The properties of nanocomposites depend on matrix, loading, degree of dispersion, size, shape, and orientation of the nanoscale phase and interaction between the matrix and the nanoscale phase. Nanocomposites are generally prepared using direct melt intercalation. The formation of nanocomposite is ascertained by XRD pattern, FTIR spectra, electron microscopy, and thermal analysis like DSC and TGA. Nanocomposites have properties of nanoparticles, multifunctional capabilities, chemical functionalization, huge interphase zone. Novel nanomaterials offer a new chemotherapeutic route for cancer treatment by combining cell imaging and hyperthermia in a synergistic way. In spite of toxicity and safety concerns, multifunctional nanocomposite still interest the researchers because of emergence of versatile properties, better understanding of diseas...
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