The Center for New York City Neighborhoods (CNYCN) was created in 2008 to coordinate and expand s... more The Center for New York City Neighborhoods (CNYCN) was created in 2008 to coordinate and expand services to New York City residents at risk of losing their home to foreclosure. Through comprehensive citywide programming that includes legal services, housing counseling, community outreach and education. CNYCN is proposing to create a call center that will be organized as a first line
Glycoprotein H/glycoprotein L (gH/gL) complexes of herpesviruses are required for fusion of infec... more Glycoprotein H/glycoprotein L (gH/gL) complexes of herpesviruses are required for fusion of infecting virions with host cell membranes. In human cyto- megalovirus (HCMV), neutralizing monoclonal anti- bodies (MAb) specific for gH inhibit the transfer of a fluorescent probe to the host cell from labelled virus particles. In similar fashion, in the present study, neutralizing gH-specific MAb inhibited HCMV- induced fusion-from-without
Antimicrobial Resistance and Infection Control, 2015
Extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae are often susceptible in vitro ... more Extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae are often susceptible in vitro to β-lactam/β-lactamase inhibitor (BLBLI) combination antibiotics, but their use has been limited by concerns of clinical inefficacy. We aimed to compare outcomes between patients treated with BLBLIs and carbapenems for bloodstream infection (BSI) caused by cefotaxime non-susceptible (likely ESBL- or AmpC β-lactamase-producing) Escherichia coli and Klebsiella pneumoniae. All adult patients with a BSI caused by cefotaxime non-susceptible E. coli or K. pneumoniae were included from May 2012-May 2013. We compared outcomes between patients who had definitive monotherapy with a carbapenem to those who had definitive monotherapy with a BLBLI. There were 92 BSIs that fulfilled the microbiological inclusion criteria. 79 (85.9%) were caused by E. coli and 13 (14.1%) by K. pneumoniae. Four out of 23 (17.4%) patients treated with carbapenem monotherapy and 2 out of 24 (8.3%) patients treated with BLBLI monotherapy died (adjusted HR for survival 0.91, 95% CI 0.13 to 6.28; p = 0.92). The time to resolution of systemic inflammatory response syndrome (SIRS) criteria did not vary between the treatment groups (adjusted HR 0.91, 95% CI 0.32 to 2.59; p = 0.97). The length of hospital admission post-positive blood culture was slightly longer in patients treated with BLBLIs (median duration 15 vs. 11 days), although this was not significant (adjusted HR 0.62; 95% CI 0.27 to 1.42; p = 0.26). There were no significant differences in subsequent isolation of carbapenem resistant organisms (4.3% vs. 4.2%, p = 1.0), C. difficile infection (13.0% vs. 8.3%, p = 0.67) or relapsed BSI (0% vs. 2%, p = 0.23). BLBLIs appear to have a similar efficacy to carbapenems in the treatment of cefotaxime-resistant E. coli and K. pneumoniae bloodstream infections. Directed therapy with a BLBLI, when susceptibility is proven, may represent an appropriate carbapenem-sparing option.
Elevated B-type natriuretic peptide (BNP) regulates cGMP-phosphodiesterase activity. Its elevatio... more Elevated B-type natriuretic peptide (BNP) regulates cGMP-phosphodiesterase activity. Its elevation is regarded as an early compensatory response to cardiac failure where it can facilitate sympathovagal balance and cardiorenal homeostasis. However, recent reports suggest a paradoxical proadrenergic action of BNP. Because phosphodiesterase activity is altered in cardiovascular disease, we tested the hypothesis that BNP might lose its efficacy by minimizing the action of cGMP on downstream pathways coupled to neurotransmission. BNP decreased norepinephrine release from atrial preparations in response to field stimulation and also significantly reduced the heart rate responses to sympathetic nerve stimulation in vitro. Using electrophysiological recording and fluorescence imaging, BNP also reduced the depolarization evoked calcium current and intracellular calcium transient in isolated cardiac sympathetic neurons. Pharmacological manipulations suggested that the reduction in the calcium...
Background: Patients with BSIs caused by gram-negative organisms have a high rate of mortality. O... more Background: Patients with BSIs caused by gram-negative organisms have a high rate of mortality. Our objectives were to identify the predictors of mortality associated with gram-negative BSIs in ICUs. Methods: A multicenter, retrospective cohort study between 2005 and 2007 was performed, including 808 patients with BSIs due to Enterobacteriaceae. Results: 265 (32.8%) patients were identified as having BSI with onset in the ICU. The BSIs were caused by E. coli (n = 90), Klebsiella spp. (n = 107) or Enterobacter spp. (n = 68). The overall 28-day mortality rate was 30.1% (80 of 265). In multivariate analysis, significant predictors of mortality were APACHE Π severity score > 25 at the time of infection (OR 10.7 [CI 4.5 - 25.7], P < 0.001) and need for vasopressor use (OR 4.2 [2.2 - 8.0], P < 0.001). In multivariate analysis of patients with the highest quartile of Apache Π scores, male sex (OR 4.82 [CI 1.15 - 20.29], P = 0.03) and vasopressor use (OR 4.07 [CI 1.1 - 15.1], P = 0...
Background: Extended-spectrum beta-lactamases (ESBLs) commonly found in Enterobacteriaceae have b... more Background: Extended-spectrum beta-lactamases (ESBLs) commonly found in Enterobacteriaceae have been of TEM and SHV types in the United States. However, detection of CTX-M-type ESBLs is increasingly reported. Methods: Bacteremic isolates of Escherichia coli and Klebsiella pneumoniae were collected at three tertiary medical centers in Northeastern United States (Pennsylvania, New York, and Massachusetts) between 2005 and 2007. ESBL producing isolates were identified by standard phenotypic methods and characterized by PCR and sequencing. Results: A total of 855 bacteremic isolates were available for study. Sixty-four isolates (7.5%; 47 K. pneumoniae and 17 E. coli) produced ESBLs. The ESBL types observed in K. pneumoniae were SHV (85%), KPC (19%), and CTX-M (2%). Specific SHV types included SHV-2a, 5, 7, 12, 30 and 31. All KPC-positive isolates were from the New York site and produced either KPC-2 or 3. In E. coli, CTX-M was the most common (41%), followed by SHV (35%) and TEM (6%). C...
Antimicrobial agents and chemotherapy, Jan 13, 2015
The novel extended-spectrum β-lactamase (ESBL), PME-1, was first described in 2010 from a Pseudom... more The novel extended-spectrum β-lactamase (ESBL), PME-1, was first described in 2010 from a Pseudomonas aeruginosa strain obtained from multiple clinical specimens from a single patient admitted to University of Pittsburgh Medical Center in 2008.….
... SU Gerbersdorf (*) Institute of Hydraulic Engineering, University of Stuttgart, Pfaffenwaldri... more ... SU Gerbersdorf (*) Institute of Hydraulic Engineering, University of Stuttgart, Pfaffenwaldring 61, 70569 Stuttgart, Germany e-mail: Sabine.Gerbersdorf@iws.uni-stuttgart.de J Soils Sediments (2009) 9:640652 DOI 10.1007/s11368-009-0142-5 Page 2. Keywords CSM . ...
Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand gated ion channels whi... more Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand gated ion channels which are widely distributed in the human brain. Multiple subtypes of these receptors exist, each with individual pharmacological and functional profiles. They mediate the effects of nicotine, a widely used drug of abuse, are involved in a number of physiological and behavioural processes and are additionally implicated in a number of pathological conditions such as Alzheimer's disease, Parkinson's disease and schizophrenia. The nAChRs have a pentameric structure composed of five membrane spanning subunits, of which nine different types have thus far been identified and cloned. The multiple subunits identified provide the basis for the heterogeneity of structure and function observed in the nAChR subtypes and are responsible for the individual characteristics of each. A substantial amount of information on human nAChR structure and function has come from studies on neuroblastoma cel...
Page 1. Eur. J. Phycol. (2002), 37: 485492. # 2002 British Phycological Society DOI: 10.1017\S09... more Page 1. Eur. J. Phycol. (2002), 37: 485492. # 2002 British Phycological Society DOI: 10.1017\S0967026202003888 Printed in the United Kingdom 485 Determination of microphytobenthic biomass using pulse-amplitude modulated minimum fluorescence ...
The Center for New York City Neighborhoods (CNYCN) was created in 2008 to coordinate and expand s... more The Center for New York City Neighborhoods (CNYCN) was created in 2008 to coordinate and expand services to New York City residents at risk of losing their home to foreclosure. Through comprehensive citywide programming that includes legal services, housing counseling, community outreach and education. CNYCN is proposing to create a call center that will be organized as a first line
Glycoprotein H/glycoprotein L (gH/gL) complexes of herpesviruses are required for fusion of infec... more Glycoprotein H/glycoprotein L (gH/gL) complexes of herpesviruses are required for fusion of infecting virions with host cell membranes. In human cyto- megalovirus (HCMV), neutralizing monoclonal anti- bodies (MAb) specific for gH inhibit the transfer of a fluorescent probe to the host cell from labelled virus particles. In similar fashion, in the present study, neutralizing gH-specific MAb inhibited HCMV- induced fusion-from-without
Antimicrobial Resistance and Infection Control, 2015
Extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae are often susceptible in vitro ... more Extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae are often susceptible in vitro to β-lactam/β-lactamase inhibitor (BLBLI) combination antibiotics, but their use has been limited by concerns of clinical inefficacy. We aimed to compare outcomes between patients treated with BLBLIs and carbapenems for bloodstream infection (BSI) caused by cefotaxime non-susceptible (likely ESBL- or AmpC β-lactamase-producing) Escherichia coli and Klebsiella pneumoniae. All adult patients with a BSI caused by cefotaxime non-susceptible E. coli or K. pneumoniae were included from May 2012-May 2013. We compared outcomes between patients who had definitive monotherapy with a carbapenem to those who had definitive monotherapy with a BLBLI. There were 92 BSIs that fulfilled the microbiological inclusion criteria. 79 (85.9%) were caused by E. coli and 13 (14.1%) by K. pneumoniae. Four out of 23 (17.4%) patients treated with carbapenem monotherapy and 2 out of 24 (8.3%) patients treated with BLBLI monotherapy died (adjusted HR for survival 0.91, 95% CI 0.13 to 6.28; p = 0.92). The time to resolution of systemic inflammatory response syndrome (SIRS) criteria did not vary between the treatment groups (adjusted HR 0.91, 95% CI 0.32 to 2.59; p = 0.97). The length of hospital admission post-positive blood culture was slightly longer in patients treated with BLBLIs (median duration 15 vs. 11 days), although this was not significant (adjusted HR 0.62; 95% CI 0.27 to 1.42; p = 0.26). There were no significant differences in subsequent isolation of carbapenem resistant organisms (4.3% vs. 4.2%, p = 1.0), C. difficile infection (13.0% vs. 8.3%, p = 0.67) or relapsed BSI (0% vs. 2%, p = 0.23). BLBLIs appear to have a similar efficacy to carbapenems in the treatment of cefotaxime-resistant E. coli and K. pneumoniae bloodstream infections. Directed therapy with a BLBLI, when susceptibility is proven, may represent an appropriate carbapenem-sparing option.
Elevated B-type natriuretic peptide (BNP) regulates cGMP-phosphodiesterase activity. Its elevatio... more Elevated B-type natriuretic peptide (BNP) regulates cGMP-phosphodiesterase activity. Its elevation is regarded as an early compensatory response to cardiac failure where it can facilitate sympathovagal balance and cardiorenal homeostasis. However, recent reports suggest a paradoxical proadrenergic action of BNP. Because phosphodiesterase activity is altered in cardiovascular disease, we tested the hypothesis that BNP might lose its efficacy by minimizing the action of cGMP on downstream pathways coupled to neurotransmission. BNP decreased norepinephrine release from atrial preparations in response to field stimulation and also significantly reduced the heart rate responses to sympathetic nerve stimulation in vitro. Using electrophysiological recording and fluorescence imaging, BNP also reduced the depolarization evoked calcium current and intracellular calcium transient in isolated cardiac sympathetic neurons. Pharmacological manipulations suggested that the reduction in the calcium...
Background: Patients with BSIs caused by gram-negative organisms have a high rate of mortality. O... more Background: Patients with BSIs caused by gram-negative organisms have a high rate of mortality. Our objectives were to identify the predictors of mortality associated with gram-negative BSIs in ICUs. Methods: A multicenter, retrospective cohort study between 2005 and 2007 was performed, including 808 patients with BSIs due to Enterobacteriaceae. Results: 265 (32.8%) patients were identified as having BSI with onset in the ICU. The BSIs were caused by E. coli (n = 90), Klebsiella spp. (n = 107) or Enterobacter spp. (n = 68). The overall 28-day mortality rate was 30.1% (80 of 265). In multivariate analysis, significant predictors of mortality were APACHE Π severity score > 25 at the time of infection (OR 10.7 [CI 4.5 - 25.7], P < 0.001) and need for vasopressor use (OR 4.2 [2.2 - 8.0], P < 0.001). In multivariate analysis of patients with the highest quartile of Apache Π scores, male sex (OR 4.82 [CI 1.15 - 20.29], P = 0.03) and vasopressor use (OR 4.07 [CI 1.1 - 15.1], P = 0...
Background: Extended-spectrum beta-lactamases (ESBLs) commonly found in Enterobacteriaceae have b... more Background: Extended-spectrum beta-lactamases (ESBLs) commonly found in Enterobacteriaceae have been of TEM and SHV types in the United States. However, detection of CTX-M-type ESBLs is increasingly reported. Methods: Bacteremic isolates of Escherichia coli and Klebsiella pneumoniae were collected at three tertiary medical centers in Northeastern United States (Pennsylvania, New York, and Massachusetts) between 2005 and 2007. ESBL producing isolates were identified by standard phenotypic methods and characterized by PCR and sequencing. Results: A total of 855 bacteremic isolates were available for study. Sixty-four isolates (7.5%; 47 K. pneumoniae and 17 E. coli) produced ESBLs. The ESBL types observed in K. pneumoniae were SHV (85%), KPC (19%), and CTX-M (2%). Specific SHV types included SHV-2a, 5, 7, 12, 30 and 31. All KPC-positive isolates were from the New York site and produced either KPC-2 or 3. In E. coli, CTX-M was the most common (41%), followed by SHV (35%) and TEM (6%). C...
Antimicrobial agents and chemotherapy, Jan 13, 2015
The novel extended-spectrum β-lactamase (ESBL), PME-1, was first described in 2010 from a Pseudom... more The novel extended-spectrum β-lactamase (ESBL), PME-1, was first described in 2010 from a Pseudomonas aeruginosa strain obtained from multiple clinical specimens from a single patient admitted to University of Pittsburgh Medical Center in 2008.….
... SU Gerbersdorf (*) Institute of Hydraulic Engineering, University of Stuttgart, Pfaffenwaldri... more ... SU Gerbersdorf (*) Institute of Hydraulic Engineering, University of Stuttgart, Pfaffenwaldring 61, 70569 Stuttgart, Germany e-mail: Sabine.Gerbersdorf@iws.uni-stuttgart.de J Soils Sediments (2009) 9:640652 DOI 10.1007/s11368-009-0142-5 Page 2. Keywords CSM . ...
Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand gated ion channels whi... more Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand gated ion channels which are widely distributed in the human brain. Multiple subtypes of these receptors exist, each with individual pharmacological and functional profiles. They mediate the effects of nicotine, a widely used drug of abuse, are involved in a number of physiological and behavioural processes and are additionally implicated in a number of pathological conditions such as Alzheimer's disease, Parkinson's disease and schizophrenia. The nAChRs have a pentameric structure composed of five membrane spanning subunits, of which nine different types have thus far been identified and cloned. The multiple subunits identified provide the basis for the heterogeneity of structure and function observed in the nAChR subtypes and are responsible for the individual characteristics of each. A substantial amount of information on human nAChR structure and function has come from studies on neuroblastoma cel...
Page 1. Eur. J. Phycol. (2002), 37: 485492. # 2002 British Phycological Society DOI: 10.1017\S09... more Page 1. Eur. J. Phycol. (2002), 37: 485492. # 2002 British Phycological Society DOI: 10.1017\S0967026202003888 Printed in the United Kingdom 485 Determination of microphytobenthic biomass using pulse-amplitude modulated minimum fluorescence ...
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