It is already known that Coronavirus disease 2019 (COVID-19) may lead to various degrees and form... more It is already known that Coronavirus disease 2019 (COVID-19) may lead to various degrees and forms of lung parenchyma damage, but some cases take a strikingly severe course that is difficult to manage. We report the case of a 62-year old male, non-obese, non-smoker, and non-diabetic, who presented with fever, chills, and shortness of breath. The infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was diagnosed by real-time Polymerase Chain Reaction. Although the patient had been vaccinated with 2 doses of Pfizer-BioNTech COVID-19 vaccine 7 months earlier and had no risk factors for a severe outcome, serial computed tomography (CT) scan revealed lung involvement progressively extending from an initial 30% to 40% to almost 100% 2.5 months later. The spectrum of lung lesions included at first only ground-glass opacities and some tiny emphysema bullae, but later also bronchiectasis, pulmonary fibrosis, and large emphysema bullae as post-COVID-19 pulmonary sequela...
Introduction: Chronic kidney disease (CKD) induces changes in the myocardium known to influence m... more Introduction: Chronic kidney disease (CKD) induces changes in the myocardium known to influence morbidity and mortality, most severe in patients with end stage renal disease. Objectives: The working hypothesis was that in patients on chronic hemodialysis the prevalence of left ventricular diastolic dysfunction is correlated with the inflammatory, oxidative, metabolic, nutritional, and atherosclerotic status. Patients and Methods: An observational study was performed on 51 patients (age 59.76 ± 13.24 years) on hemodialysis treatment. Transthoracic cardiac ultrasound was conducted to evaluate LVDD. The burden of cardiac and arterial atherosclerosis was evaluated by cardiac ultrasound (aortic and mitral valve calcifications), vascular ultrasound (carotid and femoral atheroma plaques, common carotid intima-media thickness), and by abdominal radiography (aortic calcification score). Demographic and anthropometric parameters were determined. Blood samples were used to determine laboratory...
Clinical nutrition (Edinburgh, Scotland), Jan 6, 2017
Patients on hemodialysis suffer from high risk of premature death, which is largely attributed to... more Patients on hemodialysis suffer from high risk of premature death, which is largely attributed to cardiovascular disease, but interventions targeting traditional cardiovascular risk factors have made little or no difference. Long chain n-3 polyunsaturated fatty acids (n-3 PUFA) are putative candidates to reduce cardiovascular disease. Diets rich in n-3 PUFA are recommended in the general population, although their role in the hemodialysis setting is uncertain. We evaluated the association between the dietary intake of n-3 PUFA and mortality for hemodialysis patients. The DIET-HD study is a prospective cohort study (January 2014-June 2017) in 9757 adults treated with hemodialysis in Europe and South America. Dietary n-3 PUFA intake was measured at baseline using the GA2LEN Food Frequency Questionnaire. Adjusted Cox regression analyses clustered by country were conducted to evaluate the association of dietary n-3 PUFA intake with cardiovascular and all-cause mortality. During a median...
Upper extremity deep vein thrombosis (UEDVT) refers to thrombosis of the axillary and/or of the s... more Upper extremity deep vein thrombosis (UEDVT) refers to thrombosis of the axillary and/or of the subclavian veins of the thoracic aperture. Based on pathogenesis UEDVT is classified as primary and secondary. Primary UEDVT is a rare disorder represented by Paget-Schroetter syndrome (or effort-related thrombosis) and idiopathic UEDVT. Secondary UEDVT accounts for most cases and usually develops in patients with the presence of a central venous catheter, pacemakers, or cancer. Symptoms are usually present within the first 24 hours after the trigger episode, however partial venous occlusions may cause a slow down in diagnosis. Less than 50% of symptomatic patients have imaging evidence of an UEDVT. It has a significant morbidity because of pulmonary embolism and a high incidence of posthrombotic syndrome. Both conservative and surgery therapy (thrombectomy, systemic or catheter-directed thrombolytic therapy, balloon angioplasty followed by stenting) have value as options therapies.
univ. Assist. Andra-elena Balcangiu-stroescu1,2, md, phd, delia timofte1, md, phd, lecturer danie... more univ. Assist. Andra-elena Balcangiu-stroescu1,2, md, phd, delia timofte1, md, phd, lecturer daniela Balan2, md, phd, lecturer laura raducu3,4, md, phd, univ. Assist. maria daniela tanasescu5,6, md, phd, lecturer cristina-ileana cosconel7, md, phd, Assoc. prof. dorin ionescu5,6, md, phd 1Department of Dialysis, Emergency University Hospital, Bucharest, Romania 2Faculty of Dental Medicine, Discipline of Physiology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 3Department of Plastic and Reconstructive Surgery, “Prof. Dr. Agrippa Ionescu” Clinical Emergency Hospital, Bucharest, Romania 4Faculty of Medicine, Discipline of Plastic and Reconstructive Surgery, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 5Department of Nephrology, Emergency University Hospital Bucharest, Bucharest, Romania 6Faculty of Medicine, Department of Medical Semiology, Discipline of Internal Medicine I and Nephrology, “Carol Davila” University of Medicine and Pharm...
It is already known that Coronavirus disease 2019 (COVID-19) may lead to various degrees and form... more It is already known that Coronavirus disease 2019 (COVID-19) may lead to various degrees and forms of lung parenchyma damage, but some cases take a strikingly severe course that is difficult to manage. We report the case of a 62-year old male, non-obese, non-smoker, and non-diabetic, who presented with fever, chills, and shortness of breath. The infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was diagnosed by real-time Polymerase Chain Reaction. Although the patient had been vaccinated with 2 doses of Pfizer-BioNTech COVID-19 vaccine 7 months earlier and had no risk factors for a severe outcome, serial computed tomography (CT) scan revealed lung involvement progressively extending from an initial 30% to 40% to almost 100% 2.5 months later. The spectrum of lung lesions included at first only ground-glass opacities and some tiny emphysema bullae, but later also bronchiectasis, pulmonary fibrosis, and large emphysema bullae as post-COVID-19 pulmonary sequela...
Introduction: Chronic kidney disease (CKD) induces changes in the myocardium known to influence m... more Introduction: Chronic kidney disease (CKD) induces changes in the myocardium known to influence morbidity and mortality, most severe in patients with end stage renal disease. Objectives: The working hypothesis was that in patients on chronic hemodialysis the prevalence of left ventricular diastolic dysfunction is correlated with the inflammatory, oxidative, metabolic, nutritional, and atherosclerotic status. Patients and Methods: An observational study was performed on 51 patients (age 59.76 ± 13.24 years) on hemodialysis treatment. Transthoracic cardiac ultrasound was conducted to evaluate LVDD. The burden of cardiac and arterial atherosclerosis was evaluated by cardiac ultrasound (aortic and mitral valve calcifications), vascular ultrasound (carotid and femoral atheroma plaques, common carotid intima-media thickness), and by abdominal radiography (aortic calcification score). Demographic and anthropometric parameters were determined. Blood samples were used to determine laboratory...
Clinical nutrition (Edinburgh, Scotland), Jan 6, 2017
Patients on hemodialysis suffer from high risk of premature death, which is largely attributed to... more Patients on hemodialysis suffer from high risk of premature death, which is largely attributed to cardiovascular disease, but interventions targeting traditional cardiovascular risk factors have made little or no difference. Long chain n-3 polyunsaturated fatty acids (n-3 PUFA) are putative candidates to reduce cardiovascular disease. Diets rich in n-3 PUFA are recommended in the general population, although their role in the hemodialysis setting is uncertain. We evaluated the association between the dietary intake of n-3 PUFA and mortality for hemodialysis patients. The DIET-HD study is a prospective cohort study (January 2014-June 2017) in 9757 adults treated with hemodialysis in Europe and South America. Dietary n-3 PUFA intake was measured at baseline using the GA2LEN Food Frequency Questionnaire. Adjusted Cox regression analyses clustered by country were conducted to evaluate the association of dietary n-3 PUFA intake with cardiovascular and all-cause mortality. During a median...
Upper extremity deep vein thrombosis (UEDVT) refers to thrombosis of the axillary and/or of the s... more Upper extremity deep vein thrombosis (UEDVT) refers to thrombosis of the axillary and/or of the subclavian veins of the thoracic aperture. Based on pathogenesis UEDVT is classified as primary and secondary. Primary UEDVT is a rare disorder represented by Paget-Schroetter syndrome (or effort-related thrombosis) and idiopathic UEDVT. Secondary UEDVT accounts for most cases and usually develops in patients with the presence of a central venous catheter, pacemakers, or cancer. Symptoms are usually present within the first 24 hours after the trigger episode, however partial venous occlusions may cause a slow down in diagnosis. Less than 50% of symptomatic patients have imaging evidence of an UEDVT. It has a significant morbidity because of pulmonary embolism and a high incidence of posthrombotic syndrome. Both conservative and surgery therapy (thrombectomy, systemic or catheter-directed thrombolytic therapy, balloon angioplasty followed by stenting) have value as options therapies.
univ. Assist. Andra-elena Balcangiu-stroescu1,2, md, phd, delia timofte1, md, phd, lecturer danie... more univ. Assist. Andra-elena Balcangiu-stroescu1,2, md, phd, delia timofte1, md, phd, lecturer daniela Balan2, md, phd, lecturer laura raducu3,4, md, phd, univ. Assist. maria daniela tanasescu5,6, md, phd, lecturer cristina-ileana cosconel7, md, phd, Assoc. prof. dorin ionescu5,6, md, phd 1Department of Dialysis, Emergency University Hospital, Bucharest, Romania 2Faculty of Dental Medicine, Discipline of Physiology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 3Department of Plastic and Reconstructive Surgery, “Prof. Dr. Agrippa Ionescu” Clinical Emergency Hospital, Bucharest, Romania 4Faculty of Medicine, Discipline of Plastic and Reconstructive Surgery, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 5Department of Nephrology, Emergency University Hospital Bucharest, Bucharest, Romania 6Faculty of Medicine, Department of Medical Semiology, Discipline of Internal Medicine I and Nephrology, “Carol Davila” University of Medicine and Pharm...
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