Molecular iodine catalysed benzylic sp3 C–H bond amination has been developed for the synthesis o... more Molecular iodine catalysed benzylic sp3 C–H bond amination has been developed for the synthesis of quinazolines from 2-aminobenzaldehydes and 2-aminobenzophenones with benzylamines. The use of oxygen as a green oxidant combined with the transition-metal-, additive- and solvent-free conditions makes the methodology economical and greener. The lack of aqueous work up also enhances the efficiency of this protocol. A series of 2-arylquinazolines was synthesised in good to excellent yields by using the developed protocol. 2-Aminobenzyl alcohols could also be employed to prepare the corresponding quinazoline derivatives.
Herein, an efficient, atom economic and external oxidant free approach has been disclosed for the... more Herein, an efficient, atom economic and external oxidant free approach has been disclosed for the synthesis of isoquinolines. Azines were employed for annulation reactions with alkynes via sequential C-H/N-N bond...
A green and sustainable methodology for the synthesis of isoquinolines using Ru(ii)/PEG-400 as ho... more A green and sustainable methodology for the synthesis of isoquinolines using Ru(ii)/PEG-400 as homogeneous recyclable catalytic system and N-tosylhydrazone, a rarely explored directing group has been reported.
In this work, N-Cbz hydrazone has been employed as a rarely explored directing group for the synt... more In this work, N-Cbz hydrazone has been employed as a rarely explored directing group for the synthesis of isoquinolines by annulation with internal alkynes via C–H/N–N activation using Ru catalyst. Additive as well as external oxidant-free rapid protocol has been established for the synthesis of isoquinolines using microwave strategy. Use of non-volatile and biodegradable PEG as a green solvent with lower catalyst loading makes the proposed protocol environmentally benign. Further, higher functional group tolerance and wide substrate scope has been observed under the stated methodology with higher yields.
Molecular iodine catalysed benzylic sp3 C–H bond amination has been developed for the synthesis o... more Molecular iodine catalysed benzylic sp3 C–H bond amination has been developed for the synthesis of quinazolines from 2-aminobenzaldehydes and 2-aminobenzophenones with benzylamines. The use of oxygen as a green oxidant combined with the transition-metal-, additive- and solvent-free conditions makes the methodology economical and greener. The lack of aqueous work up also enhances the efficiency of this protocol. A series of 2-arylquinazolines was synthesised in good to excellent yields by using the developed protocol. 2-Aminobenzyl alcohols could also be employed to prepare the corresponding quinazoline derivatives.
Herein, an efficient, atom economic and external oxidant free approach has been disclosed for the... more Herein, an efficient, atom economic and external oxidant free approach has been disclosed for the synthesis of isoquinolines. Azines were employed for annulation reactions with alkynes via sequential C-H/N-N bond...
A green and sustainable methodology for the synthesis of isoquinolines using Ru(ii)/PEG-400 as ho... more A green and sustainable methodology for the synthesis of isoquinolines using Ru(ii)/PEG-400 as homogeneous recyclable catalytic system and N-tosylhydrazone, a rarely explored directing group has been reported.
In this work, N-Cbz hydrazone has been employed as a rarely explored directing group for the synt... more In this work, N-Cbz hydrazone has been employed as a rarely explored directing group for the synthesis of isoquinolines by annulation with internal alkynes via C–H/N–N activation using Ru catalyst. Additive as well as external oxidant-free rapid protocol has been established for the synthesis of isoquinolines using microwave strategy. Use of non-volatile and biodegradable PEG as a green solvent with lower catalyst loading makes the proposed protocol environmentally benign. Further, higher functional group tolerance and wide substrate scope has been observed under the stated methodology with higher yields.
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