A two-step protocol for the asymmetric synthesis of protected quaternary (E)-vinylglycines from s... more A two-step protocol for the asymmetric synthesis of protected quaternary (E)-vinylglycines from simple aldehydes is reported. The key step is a regiocontrolled deconjugative asymmetric alkylation of dehydroamino acids, giving the targets as single geometric isomers with high diastereoselectivity (92-96% de). The products can be converted to valuable quaternary beta-amino alcohols by chemoselective reduction. [reaction: see text].
A versatile approach for the enantioselective synthesis of functionalised beta-hydroxy N-acetylcy... more A versatile approach for the enantioselective synthesis of functionalised beta-hydroxy N-acetylcysteamine thiol esters has been developed which allows the facile incorporation of isotopic labels. It has been shown that a remarkable reversal of selectivity occurs in the titanium mediated aldol reaction of acyloxazolidinone using either (S)- or (R)-tert-butyldimethylsilyloxybutanal. The aldol products are valuable intermediates in the synthesis of 4-hydroxy-6-substituted delta-lactones.
[reaction: see text] A practical and general two-step synthesis of carbamate-protected (E)-vinylg... more [reaction: see text] A practical and general two-step synthesis of carbamate-protected (E)-vinylglycines from aliphatic aldehydes is reported. The key step involves the kinetic alpha-protonation of dianionic dienolates derived from dehydroamino acids.
A two-step protocol for the asymmetric synthesis of protected quaternary (E)-vinylglycines from s... more A two-step protocol for the asymmetric synthesis of protected quaternary (E)-vinylglycines from simple aldehydes is reported. The key step is a regiocontrolled deconjugative asymmetric alkylation of dehydroamino acids, giving the targets as single geometric isomers with high diastereoselectivity (92-96% de). The products can be converted to valuable quaternary beta-amino alcohols by chemoselective reduction. [reaction: see text].
A versatile approach for the enantioselective synthesis of functionalised beta-hydroxy N-acetylcy... more A versatile approach for the enantioselective synthesis of functionalised beta-hydroxy N-acetylcysteamine thiol esters has been developed which allows the facile incorporation of isotopic labels. It has been shown that a remarkable reversal of selectivity occurs in the titanium mediated aldol reaction of acyloxazolidinone using either (S)- or (R)-tert-butyldimethylsilyloxybutanal. The aldol products are valuable intermediates in the synthesis of 4-hydroxy-6-substituted delta-lactones.
Recovery of CO2 from gas mixtures is an important industrial objective in view of several aspects... more Recovery of CO2 from gas mixtures is an important industrial objective in view of several aspects such as natural gas reforming, biomedical applications and even global warming. Polyimides consisting of flexible polyethyleneoxide (PEO) segments and rigid polyimide segments have been reported in recent years for this application. They exhibit high CO2 permeability coefficients and relatively high CO2/N2 selectivity due to
The first total syntheses of the 14-membered ring macrodilactone colletotriene are described. Sta... more The first total syntheses of the 14-membered ring macrodilactone colletotriene are described. Starting from ethyl (R)-3-hydroxybutanoate, two synthetic strategies are compared which will enable the incorporation of deuterium at non-exchangeable sites for biosynthetic studies.
El proyecto de I+D DEGRICOL propone una solucion al problema de los residuos plasticos generados ... more El proyecto de I+D DEGRICOL propone una solucion al problema de los residuos plasticos generados en el sector de la agricultura y la horticultura. El proyecto, que ha sido promovido por asociaciones europeas del sector de los bioplasticos y la agricultura, ha desarrollado una formulacion competitiva, 100% biodegradable y basada en materiales de origen natural para la fabricacion de accesorios (macetas, tutores, etc.) empleados en invernaderos y campos de cultivos, con un periodo de vida util controlado, siendo materiales seguros para la salud en lo que se refiere al contacto con productos alimenticios durante su crecimiento. Los accesorios han sido obtenidos mediante las tecnicas comunes de procesado, como la extrusion de film y el moldeo por inyeccion, consiguiendo resultados similares a los productos hechos con plasticos convencionales no biodegradables
A two-step protocol for the asymmetric synthesis of protected quaternary (E)-vinylglycines from s... more A two-step protocol for the asymmetric synthesis of protected quaternary (E)-vinylglycines from simple aldehydes is reported. The key step is a regiocontrolled deconjugative asymmetric alkylation of dehydroamino acids, giving the targets as single geometric isomers with high diastereoselectivity (92-96% de). The products can be converted to valuable quaternary beta-amino alcohols by chemoselective reduction. [reaction: see text].
A versatile approach for the enantioselective synthesis of functionalised beta-hydroxy N-acetylcy... more A versatile approach for the enantioselective synthesis of functionalised beta-hydroxy N-acetylcysteamine thiol esters has been developed which allows the facile incorporation of isotopic labels. It has been shown that a remarkable reversal of selectivity occurs in the titanium mediated aldol reaction of acyloxazolidinone using either (S)- or (R)-tert-butyldimethylsilyloxybutanal. The aldol products are valuable intermediates in the synthesis of 4-hydroxy-6-substituted delta-lactones.
[reaction: see text] A practical and general two-step synthesis of carbamate-protected (E)-vinylg... more [reaction: see text] A practical and general two-step synthesis of carbamate-protected (E)-vinylglycines from aliphatic aldehydes is reported. The key step involves the kinetic alpha-protonation of dianionic dienolates derived from dehydroamino acids.
A two-step protocol for the asymmetric synthesis of protected quaternary (E)-vinylglycines from s... more A two-step protocol for the asymmetric synthesis of protected quaternary (E)-vinylglycines from simple aldehydes is reported. The key step is a regiocontrolled deconjugative asymmetric alkylation of dehydroamino acids, giving the targets as single geometric isomers with high diastereoselectivity (92-96% de). The products can be converted to valuable quaternary beta-amino alcohols by chemoselective reduction. [reaction: see text].
A versatile approach for the enantioselective synthesis of functionalised beta-hydroxy N-acetylcy... more A versatile approach for the enantioselective synthesis of functionalised beta-hydroxy N-acetylcysteamine thiol esters has been developed which allows the facile incorporation of isotopic labels. It has been shown that a remarkable reversal of selectivity occurs in the titanium mediated aldol reaction of acyloxazolidinone using either (S)- or (R)-tert-butyldimethylsilyloxybutanal. The aldol products are valuable intermediates in the synthesis of 4-hydroxy-6-substituted delta-lactones.
Recovery of CO2 from gas mixtures is an important industrial objective in view of several aspects... more Recovery of CO2 from gas mixtures is an important industrial objective in view of several aspects such as natural gas reforming, biomedical applications and even global warming. Polyimides consisting of flexible polyethyleneoxide (PEO) segments and rigid polyimide segments have been reported in recent years for this application. They exhibit high CO2 permeability coefficients and relatively high CO2/N2 selectivity due to
The first total syntheses of the 14-membered ring macrodilactone colletotriene are described. Sta... more The first total syntheses of the 14-membered ring macrodilactone colletotriene are described. Starting from ethyl (R)-3-hydroxybutanoate, two synthetic strategies are compared which will enable the incorporation of deuterium at non-exchangeable sites for biosynthetic studies.
El proyecto de I+D DEGRICOL propone una solucion al problema de los residuos plasticos generados ... more El proyecto de I+D DEGRICOL propone una solucion al problema de los residuos plasticos generados en el sector de la agricultura y la horticultura. El proyecto, que ha sido promovido por asociaciones europeas del sector de los bioplasticos y la agricultura, ha desarrollado una formulacion competitiva, 100% biodegradable y basada en materiales de origen natural para la fabricacion de accesorios (macetas, tutores, etc.) empleados en invernaderos y campos de cultivos, con un periodo de vida util controlado, siendo materiales seguros para la salud en lo que se refiere al contacto con productos alimenticios durante su crecimiento. Los accesorios han sido obtenidos mediante las tecnicas comunes de procesado, como la extrusion de film y el moldeo por inyeccion, consiguiendo resultados similares a los productos hechos con plasticos convencionales no biodegradables
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