Erik Teske is professor in companion animal oncology. His specialties are apart from oncology, clinical cytology and epidemiology. He is very much engaged in the organisation of veterinary specialisation, both nationally as well as internationally. He is employed by the Utrecht University (The Netherlands) and the University of Liege (Belgium).
Although scientific evidence is limited, clopidogrel is frequently used as prophylaxis for arteri... more Although scientific evidence is limited, clopidogrel is frequently used as prophylaxis for arterial thromboembolism in cats with hypertrophic cardiomyopathy (HCM). Evaluating effects of clopidogrel therapy in asymptomatic cats with HCM on (1) conventional whole blood aggregation (WBA), (2) alternative platelet aggregation assessed with tubes of the Plateletworks® assay and (3) standard coagulation parameters. Prospective, randomized, double-blind, placebo-controlled pilot study. Fourteen asymptomatic HCM cats were randomly allocated to receive placebo (n = 5) or clopidogrel (18.75 mg/cat q24h, n = 9) as part of a larger study. Aggregation responses (to 20 µM adenosine diphosphate (ADP) and 10 µg/ml collagen) in WBA and the Plateletworks® assay and standard coagulation parameters were evaluated at baseline and after seven days of therapy. Clopidogrel therapy significantly reduced aggregation responses to ADP and collagen in the Plateletworks® agonists tubes (ADP and collagen: P < ...
In this report two dogs with essential thrombocythaemia (ET) are described. Both dogs were presen... more In this report two dogs with essential thrombocythaemia (ET) are described. Both dogs were presented more or less at the same time with a combination of reduced exercise tolerance and pale mucous membranes without any report of blood loss. Moderate-to-severe, Coomb's-negative anaemia and thrombocytosis (> 1249 x 10'/l) were present. In addition, the peripheral blood smear revealed the presence of basophilia and large numbers of abnormally shaped megakaryocytes in the bone marrow of both dogs. Treatment with vincristine (0.7 mg/m2 once intravenously) and hydroxyurea (500 mg/m2 p.o. per day) was started. Because of insufficient response to treatment after 3 weeks, the dosage of hydroxyurea was increased in both dogs to 2000 mg/m2 p.o. per day. The dogs deteriorated further, however, and were euthanized at 6 weeks after the start of treatment. Blood examination revealed pancytopenia in both dogs, most likely due to the myelosuppressive effects of high-dose hydroxyurea. A sur...
In this prospective randomized double-blind clinical study the anti-tumour activity of liposome-e... more In this prospective randomized double-blind clinical study the anti-tumour activity of liposome-encapsulated muramyl tripeptide phosphatidylethanolamine (L-MTP-PE) was evaluated as an adjuvant immunotherapy in dogs with mammary tumours of the simple carcinoma type. Dogs were randomized after surgery to one of two treatment groups, in which they were treated with either L-MTP-PE (2 mg/m2 i.v.; Ciba Geigy Basel, Switzerland) twice weekly for eight weeks, or with empty liposomes according to the same protocol. The minimal follow-up period was one year. Thirteen dogs were entered in the L-MTP-PE group and fourteen dogs in the placebo control group. Only minor toxicities (fever and shivering during 10-24 hours) were seen in six dogs treated with L-MTP-PE, these being mainly of the smaller breeds. At the time of evaluation seven dogs were still disease free. In the other twenty dogs the disease-free period (DFP) was ended by local recurrences in 16 and by distant metastases in 4. The diff...
A classical combination of myasthenia gravis and a thymoma is reported for the first time in a ca... more A classical combination of myasthenia gravis and a thymoma is reported for the first time in a cat. The clinical symptoms, pathophysiological and histopathological characteristics are discussed.
The Bouvier des Flandres (BdF) dog is predisposed to develop prostate carcinoma (PCA). In humans,... more The Bouvier des Flandres (BdF) dog is predisposed to develop prostate carcinoma (PCA). In humans, ethnic groups with higher prevalence of PCA have higher serum androgens concentrations and shorter polyglutamine (CAG) repeat lengths in the androgen receptor (AR) gene. In dogs, shorter CAG-I lengths are associated with increased PCA risk. To compare serum androgens concentrations in the BdF with other breeds and to determine whether CAG repeats length and plasma androgens concentrations are correlated. Androgens were measured in 46 BdF and in 53 other dog breed. Length of CAG-I and CAG-III repeats were measured in 41 BdF and correlated with androgen levels. In the BdF group shorter CAG-I and longer CAG-III repeat lengths were associated with lower androgen concentrations. As the shorter CAG-I repeat is associated with an increased PCA risk, higher androgen concentrations may protect against the development and progression of PCA.
SummaryObjective: To evaluate the diagnostic value of cytology of endoscopically obtained biopsie... more SummaryObjective: To evaluate the diagnostic value of cytology of endoscopically obtained biopsies in cats presented for chronic gastrointestinal complaints with emphasis on the diagnosis of low-grade alimentary lymphoma (LGAL). Materials and methods: Data of endoscopically obtained duodenal biopsies from 137 cats were evaluated retrospectively. Cytology was performed using the squash smear technique with subsequent Diff Quick® staining. Pathological findings were categorized according to type and grade of the inflammatory infiltrate. Moreover, reports were reviewed with regard to diagnosis of LGAL. Histopathology reports were analysed correspondingly and compared to cytology results. Histopathological samples were further evaluated by immunohistochemistry (IHC) if a diagnosis of LGAL had been expressed. Results: Squash smear preparation of intestinal biopsies was adequate for cytological examination in > 97% of cases. Using histopathology as gold standard, with cytology, a sensi...
In dogs with primary hypoadrenocorticism, hypocortisolism and hypoaldosteronism usually are prese... more In dogs with primary hypoadrenocorticism, hypocortisolism and hypoaldosteronism usually are present, but these deficiencies also may occur in isolated forms. The diagnosis is commonly made by measuring plasma cortisol concentration before and after stimulation with ACTH, thereby ignoring aldosterone. In search of an alternative approach that would include assessment of glucocorticoid and mineralocorticoid production, 2 pairs of endocrine variables were measured: (1) plasma concentration of cortisol and ACTH, and (2) plasma aldosterone concentration and plasma renin activity. In addition, the cortisol-to-ACTH ratio (CAR) and the aldosterone-to-renin ratio (ARR) were calculated. Reference intervals were established in a population of 60 healthy dogs. In these dogs, CAR ranged from 1.1 to 26.1 and ARR ranged from 0.1 to 1.5. The variables were compared with those of 22 dogs with spontaneous primary hypoadrenocorticism. Plasma concentration of cortisol and ACTH in both groups of dogs overlapped, whereas CAR did not. Similarly, plasma aldosterone concentration and plasma renin activity overlapped, whereas ARR did not. These observations indicate that measurement of these endogenous variables (in one blood sample) allows the specific diagnoses of primary hypocortisolism and primary hypoaldosteronism.
Objective—To assess intra- and interobserver repeatability of ocular biometric measurements obtai... more Objective—To assess intra- and interobserver repeatability of ocular biometric measurements obtained by means of high-resolution B-mode ultrasonography in dogs. Animals—6 Beagles without ocular abnormalities. Procedures—B-mode ultrasonography was performed bilaterally with a 10.5-MHz broadband compact linear array transducer. All measurements were made on 2 different occasions by 2 observers. The Bland-Altman method was used to assess agreement between measurements obtained by the 2 observers and between the 2 sets of measurements obtained by each observer. Results—Intra- and interobserver repeatability was highest for larger measurements, such as depth of the eye and depth of the anterior chamber. When repeatability was examined, bias was significantly different from 0 for only a few measurements, but the percentage difference between observations was as high as 180% for some measurements. Conclusions and Clinical Relevance—Results suggest that most measurements of intraocular dist...
lKlinik und Poliklinik frir kleine Haustiere an deÍ Freien Universitàt Berlin und 2Department oÍ ... more lKlinik und Poliklinik frir kleine Haustiere an deÍ Freien Universitàt Berlin und 2Department oÍ Clinical Sciences of Companion Animals, University of Utrecht zusammenfassung In einer retncspektiven Studie (1995) wurden die Diagnosenvon 3987 zytologischen Pràpara-ten verschiedenet Herkunft beim Hund er-mittelt. Es haudelte sich hierbei sowohl um Punltate die der Abteilung Zytologie der Kleintierklinik der Universitàt ljtrecht von ex-ternen Praxen zugesandt wurden als auch um selbst durchgeÍiihrte Biopsien. Dabei wurden
SummaryObjective: The Feline Chronic Enteropathy Activity Index (FCEAI) has been established as a... more SummaryObjective: The Feline Chronic Enteropathy Activity Index (FCEAI) has been established as a quantitative index for disease activity in chronic enteropathies in cats. A definite diagnosis is aimed at histology with initial exclusion of extraintestinal causes by laboratory examinations, diagnostic imaging and endoscopy. The study aimed to examine diagnostic parameters and FCEAI in chronic gastroenteropathies. Materials and methods: A retrospective case review of 147 cats with chronic enteropathies was performed. In all patients, the FCEAI was established and endoscopy performed including biopsies and duodenal cytology. Histopathologic reports were reviewed for the diagnosis of lymphoma and architectural changes (epithelial integrity, villi/ gland atrophy, intestinal crypt atrophy, lymphangiectasia, epitheliotropism/infiltration of intraepithelial lymphocytes). A cytopathologic score (CS) and histopathologic score (HS) regarding lymphocytic intestinal infiltration were assigned. ...
Although scientific evidence is limited, clopidogrel is frequently used as prophylaxis for arteri... more Although scientific evidence is limited, clopidogrel is frequently used as prophylaxis for arterial thromboembolism in cats with hypertrophic cardiomyopathy (HCM). Evaluating effects of clopidogrel therapy in asymptomatic cats with HCM on (1) conventional whole blood aggregation (WBA), (2) alternative platelet aggregation assessed with tubes of the Plateletworks® assay and (3) standard coagulation parameters. Prospective, randomized, double-blind, placebo-controlled pilot study. Fourteen asymptomatic HCM cats were randomly allocated to receive placebo (n = 5) or clopidogrel (18.75 mg/cat q24h, n = 9) as part of a larger study. Aggregation responses (to 20 µM adenosine diphosphate (ADP) and 10 µg/ml collagen) in WBA and the Plateletworks® assay and standard coagulation parameters were evaluated at baseline and after seven days of therapy. Clopidogrel therapy significantly reduced aggregation responses to ADP and collagen in the Plateletworks® agonists tubes (ADP and collagen: P < ...
In this report two dogs with essential thrombocythaemia (ET) are described. Both dogs were presen... more In this report two dogs with essential thrombocythaemia (ET) are described. Both dogs were presented more or less at the same time with a combination of reduced exercise tolerance and pale mucous membranes without any report of blood loss. Moderate-to-severe, Coomb's-negative anaemia and thrombocytosis (> 1249 x 10'/l) were present. In addition, the peripheral blood smear revealed the presence of basophilia and large numbers of abnormally shaped megakaryocytes in the bone marrow of both dogs. Treatment with vincristine (0.7 mg/m2 once intravenously) and hydroxyurea (500 mg/m2 p.o. per day) was started. Because of insufficient response to treatment after 3 weeks, the dosage of hydroxyurea was increased in both dogs to 2000 mg/m2 p.o. per day. The dogs deteriorated further, however, and were euthanized at 6 weeks after the start of treatment. Blood examination revealed pancytopenia in both dogs, most likely due to the myelosuppressive effects of high-dose hydroxyurea. A sur...
In this prospective randomized double-blind clinical study the anti-tumour activity of liposome-e... more In this prospective randomized double-blind clinical study the anti-tumour activity of liposome-encapsulated muramyl tripeptide phosphatidylethanolamine (L-MTP-PE) was evaluated as an adjuvant immunotherapy in dogs with mammary tumours of the simple carcinoma type. Dogs were randomized after surgery to one of two treatment groups, in which they were treated with either L-MTP-PE (2 mg/m2 i.v.; Ciba Geigy Basel, Switzerland) twice weekly for eight weeks, or with empty liposomes according to the same protocol. The minimal follow-up period was one year. Thirteen dogs were entered in the L-MTP-PE group and fourteen dogs in the placebo control group. Only minor toxicities (fever and shivering during 10-24 hours) were seen in six dogs treated with L-MTP-PE, these being mainly of the smaller breeds. At the time of evaluation seven dogs were still disease free. In the other twenty dogs the disease-free period (DFP) was ended by local recurrences in 16 and by distant metastases in 4. The diff...
A classical combination of myasthenia gravis and a thymoma is reported for the first time in a ca... more A classical combination of myasthenia gravis and a thymoma is reported for the first time in a cat. The clinical symptoms, pathophysiological and histopathological characteristics are discussed.
The Bouvier des Flandres (BdF) dog is predisposed to develop prostate carcinoma (PCA). In humans,... more The Bouvier des Flandres (BdF) dog is predisposed to develop prostate carcinoma (PCA). In humans, ethnic groups with higher prevalence of PCA have higher serum androgens concentrations and shorter polyglutamine (CAG) repeat lengths in the androgen receptor (AR) gene. In dogs, shorter CAG-I lengths are associated with increased PCA risk. To compare serum androgens concentrations in the BdF with other breeds and to determine whether CAG repeats length and plasma androgens concentrations are correlated. Androgens were measured in 46 BdF and in 53 other dog breed. Length of CAG-I and CAG-III repeats were measured in 41 BdF and correlated with androgen levels. In the BdF group shorter CAG-I and longer CAG-III repeat lengths were associated with lower androgen concentrations. As the shorter CAG-I repeat is associated with an increased PCA risk, higher androgen concentrations may protect against the development and progression of PCA.
SummaryObjective: To evaluate the diagnostic value of cytology of endoscopically obtained biopsie... more SummaryObjective: To evaluate the diagnostic value of cytology of endoscopically obtained biopsies in cats presented for chronic gastrointestinal complaints with emphasis on the diagnosis of low-grade alimentary lymphoma (LGAL). Materials and methods: Data of endoscopically obtained duodenal biopsies from 137 cats were evaluated retrospectively. Cytology was performed using the squash smear technique with subsequent Diff Quick® staining. Pathological findings were categorized according to type and grade of the inflammatory infiltrate. Moreover, reports were reviewed with regard to diagnosis of LGAL. Histopathology reports were analysed correspondingly and compared to cytology results. Histopathological samples were further evaluated by immunohistochemistry (IHC) if a diagnosis of LGAL had been expressed. Results: Squash smear preparation of intestinal biopsies was adequate for cytological examination in > 97% of cases. Using histopathology as gold standard, with cytology, a sensi...
In dogs with primary hypoadrenocorticism, hypocortisolism and hypoaldosteronism usually are prese... more In dogs with primary hypoadrenocorticism, hypocortisolism and hypoaldosteronism usually are present, but these deficiencies also may occur in isolated forms. The diagnosis is commonly made by measuring plasma cortisol concentration before and after stimulation with ACTH, thereby ignoring aldosterone. In search of an alternative approach that would include assessment of glucocorticoid and mineralocorticoid production, 2 pairs of endocrine variables were measured: (1) plasma concentration of cortisol and ACTH, and (2) plasma aldosterone concentration and plasma renin activity. In addition, the cortisol-to-ACTH ratio (CAR) and the aldosterone-to-renin ratio (ARR) were calculated. Reference intervals were established in a population of 60 healthy dogs. In these dogs, CAR ranged from 1.1 to 26.1 and ARR ranged from 0.1 to 1.5. The variables were compared with those of 22 dogs with spontaneous primary hypoadrenocorticism. Plasma concentration of cortisol and ACTH in both groups of dogs overlapped, whereas CAR did not. Similarly, plasma aldosterone concentration and plasma renin activity overlapped, whereas ARR did not. These observations indicate that measurement of these endogenous variables (in one blood sample) allows the specific diagnoses of primary hypocortisolism and primary hypoaldosteronism.
Objective—To assess intra- and interobserver repeatability of ocular biometric measurements obtai... more Objective—To assess intra- and interobserver repeatability of ocular biometric measurements obtained by means of high-resolution B-mode ultrasonography in dogs. Animals—6 Beagles without ocular abnormalities. Procedures—B-mode ultrasonography was performed bilaterally with a 10.5-MHz broadband compact linear array transducer. All measurements were made on 2 different occasions by 2 observers. The Bland-Altman method was used to assess agreement between measurements obtained by the 2 observers and between the 2 sets of measurements obtained by each observer. Results—Intra- and interobserver repeatability was highest for larger measurements, such as depth of the eye and depth of the anterior chamber. When repeatability was examined, bias was significantly different from 0 for only a few measurements, but the percentage difference between observations was as high as 180% for some measurements. Conclusions and Clinical Relevance—Results suggest that most measurements of intraocular dist...
lKlinik und Poliklinik frir kleine Haustiere an deÍ Freien Universitàt Berlin und 2Department oÍ ... more lKlinik und Poliklinik frir kleine Haustiere an deÍ Freien Universitàt Berlin und 2Department oÍ Clinical Sciences of Companion Animals, University of Utrecht zusammenfassung In einer retncspektiven Studie (1995) wurden die Diagnosenvon 3987 zytologischen Pràpara-ten verschiedenet Herkunft beim Hund er-mittelt. Es haudelte sich hierbei sowohl um Punltate die der Abteilung Zytologie der Kleintierklinik der Universitàt ljtrecht von ex-ternen Praxen zugesandt wurden als auch um selbst durchgeÍiihrte Biopsien. Dabei wurden
SummaryObjective: The Feline Chronic Enteropathy Activity Index (FCEAI) has been established as a... more SummaryObjective: The Feline Chronic Enteropathy Activity Index (FCEAI) has been established as a quantitative index for disease activity in chronic enteropathies in cats. A definite diagnosis is aimed at histology with initial exclusion of extraintestinal causes by laboratory examinations, diagnostic imaging and endoscopy. The study aimed to examine diagnostic parameters and FCEAI in chronic gastroenteropathies. Materials and methods: A retrospective case review of 147 cats with chronic enteropathies was performed. In all patients, the FCEAI was established and endoscopy performed including biopsies and duodenal cytology. Histopathologic reports were reviewed for the diagnosis of lymphoma and architectural changes (epithelial integrity, villi/ gland atrophy, intestinal crypt atrophy, lymphangiectasia, epitheliotropism/infiltration of intraepithelial lymphocytes). A cytopathologic score (CS) and histopathologic score (HS) regarding lymphocytic intestinal infiltration were assigned. ...
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