International Journal of High Dilution Research - ISSN 1982-6206, 2021
As part of a rigorous investigation into the effects of Gelsemium sempervirens on laboratory mice... more As part of a rigorous investigation into the effects of Gelsemium sempervirens on laboratory mice, we performed two complete series of experiments and published three scientific papers. A recent commentary has, however, called into question the reproducibility and validity of these findings. In this article we discuss the major issues raised by this critique within the framework of methodological aspects and the interpretation of results of high-dilution and homeopathic research. The charge of non-reproducibility is shown to be unfounded, because a same homeopathic medicine displayed the same direction of effects in two well-validated models (light-dark and open-field), albeit with nonlinear patterns. The double-blind protocols and statistics by means of ANOVA were performed appropriately and the difference between dilutions of Gelsemium (5cH, 7cH, 9cH and 30cH with variations according to model) and placebo was statistically highly significant. Our investigations brought to light s...
The aim of the study was to investigate the association between oculonasal symptoms on exposure t... more The aim of the study was to investigate the association between oculonasal symptoms on exposure to different allergens and actual sensitization. Results showed that oculonasal symptoms on exposure to different allergens are reliable in identifying subjects sensitized to pollen and pets, but not to mite. These questions, however, do not allow to reliably exclude the presence of sensitization
International Journal of Environmental Research and Public Health, 2021
Background: The coronavirus disease 2019 (COVID-19) pandemic had a devastating impact on nursing ... more Background: The coronavirus disease 2019 (COVID-19) pandemic had a devastating impact on nursing homes/long-term care facilities. This study examined the relationship between geography, size, design, organizational characteristics, and implementation of infection prevention and control (IPC) measures and the extent of COVID-19 outbreaks in nursing homes in the Autonomous Province of Trento (Italy) during the time frame of March-May 2020. Methods: The analysis included 57 nursing homes (5145 beds). The association between median cumulative incidence of COVID-19 cases among residents and characteristics of nursing homes was assessed by Mann–Whitney U test, Kruskal–Wallis test or Spearman rho. To evaluate the potential confounding of geographical area, a 2-level random intercept logistic model was fitted, with level 1 units (patients in nursing homes) nested into level 2 units (nursing homes), and “being a COVID-19 case” as the dependent variable. Results: Median cumulative incidence w...
"In this paper we review and present methods and models, based on the ma... more "In this paper we review and present methods and models, based on the maximum likelihood approach, for the study of the pattern of variability of a set of standardized mortality ratios. These methods can be useful in analyzing and mapping standardized mortality risks for very rare causes of death." The geographical scope is worldwide. (SUMMARY IN ITA)
Scientific literature recommends nurses to use the Geriatric Depression Scale (GDS) in the assess... more Scientific literature recommends nurses to use the Geriatric Depression Scale (GDS) in the assessment of symptoms of depression among elderly with no cognitive deficits. The first purpose of this observational study was to determine the prevalence of depressive symptoms and the related antidepressant therapy in a sample of institutionalized elderly people administering the 30 questions GDS (GDS 30). The second aim was to estimate the time to complete the test. The survey is a cross-sectional multicenter study. 115 cognitively intact elderly residents in 5 retirement houses in the province of Vicenza (Italy) were administered the 30 items GDS by nursing staff: 80 females with a median age of 83 years (Inter Quartile Range RIQ: 80-85) and 35 males with a median age of 79 years (RIQ: 73-85). The prevalence of depression was 46% (95% Confidence Interval: 37-55%). The difference in depression between males and females was not significant (p=0.646). The median of the total answering time ...
International Journal of High Dilution Research - ISSN 1982-6206, 2021
As part of a rigorous investigation into the effects of Gelsemium sempervirens on laboratory mice... more As part of a rigorous investigation into the effects of Gelsemium sempervirens on laboratory mice, we performed two complete series of experiments and published three scientific papers. A recent commentary has, however, called into question the reproducibility and validity of these findings. In this article we discuss the major issues raised by this critique within the framework of methodological aspects and the interpretation of results of high-dilution and homeopathic research. The charge of non-reproducibility is shown to be unfounded, because a same homeopathic medicine displayed the same direction of effects in two well-validated models (light-dark and open-field), albeit with nonlinear patterns. The double-blind protocols and statistics by means of ANOVA were performed appropriately and the difference between dilutions of Gelsemium (5cH, 7cH, 9cH and 30cH with variations according to model) and placebo was statistically highly significant. Our investigations brought to light s...
The aim of the study was to investigate the association between oculonasal symptoms on exposure t... more The aim of the study was to investigate the association between oculonasal symptoms on exposure to different allergens and actual sensitization. Results showed that oculonasal symptoms on exposure to different allergens are reliable in identifying subjects sensitized to pollen and pets, but not to mite. These questions, however, do not allow to reliably exclude the presence of sensitization
International Journal of Environmental Research and Public Health, 2021
Background: The coronavirus disease 2019 (COVID-19) pandemic had a devastating impact on nursing ... more Background: The coronavirus disease 2019 (COVID-19) pandemic had a devastating impact on nursing homes/long-term care facilities. This study examined the relationship between geography, size, design, organizational characteristics, and implementation of infection prevention and control (IPC) measures and the extent of COVID-19 outbreaks in nursing homes in the Autonomous Province of Trento (Italy) during the time frame of March-May 2020. Methods: The analysis included 57 nursing homes (5145 beds). The association between median cumulative incidence of COVID-19 cases among residents and characteristics of nursing homes was assessed by Mann–Whitney U test, Kruskal–Wallis test or Spearman rho. To evaluate the potential confounding of geographical area, a 2-level random intercept logistic model was fitted, with level 1 units (patients in nursing homes) nested into level 2 units (nursing homes), and “being a COVID-19 case” as the dependent variable. Results: Median cumulative incidence w...
"In this paper we review and present methods and models, based on the ma... more "In this paper we review and present methods and models, based on the maximum likelihood approach, for the study of the pattern of variability of a set of standardized mortality ratios. These methods can be useful in analyzing and mapping standardized mortality risks for very rare causes of death." The geographical scope is worldwide. (SUMMARY IN ITA)
Scientific literature recommends nurses to use the Geriatric Depression Scale (GDS) in the assess... more Scientific literature recommends nurses to use the Geriatric Depression Scale (GDS) in the assessment of symptoms of depression among elderly with no cognitive deficits. The first purpose of this observational study was to determine the prevalence of depressive symptoms and the related antidepressant therapy in a sample of institutionalized elderly people administering the 30 questions GDS (GDS 30). The second aim was to estimate the time to complete the test. The survey is a cross-sectional multicenter study. 115 cognitively intact elderly residents in 5 retirement houses in the province of Vicenza (Italy) were administered the 30 items GDS by nursing staff: 80 females with a median age of 83 years (Inter Quartile Range RIQ: 80-85) and 35 males with a median age of 79 years (RIQ: 73-85). The prevalence of depression was 46% (95% Confidence Interval: 37-55%). The difference in depression between males and females was not significant (p=0.646). The median of the total answering time ...
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Papers by E. Zanolin