International Journal of Geriatric Psychiatry, 2021
Dementia remains a clinical diagnosis with a degree of subjective assessment and potential for in... more Dementia remains a clinical diagnosis with a degree of subjective assessment and potential for interrater disagreement. We described interrater agreement of clinical dementia diagnosis for various diagnostic criteria.
Standard methods for the meta-analysis of diagnostic tests without a gold standard are limited to... more Standard methods for the meta-analysis of diagnostic tests without a gold standard are limited to dichotomous data. Multivariate probit models are used to analyze correlated binary data, and can be extended to multivariate ordered probit models to model polytomous (i.e. non-binary) data. Within the context of an imperfect gold standard, they have previously been used for the analysis of dichotomous and polytomous diagnostic tests in a single study, and for the meta-analysis of dichotomous tests. In this paper, we developed a hierarchical, latent class multivariate probit model for the meta-analysis of polytomous and dichotomous diagnostic tests without a gold standard. The model can accommodate a hierarchical partial pooling model on the conditional within-study correlations, which allow us to obtain summary estimates of joint test accuracy. Dichotomous tests use probit regression likelihoods and polytomous tests use ordinal probit regression likelihoods. We fitted the models using ...
Purpose of Review Type 2 diabetes (T2DM) presents a growing global health and economic burden. De... more Purpose of Review Type 2 diabetes (T2DM) presents a growing global health and economic burden. Dental settings have been employed to identify individuals who may be at high risk of diabetes, who exhibit non-diabetic hyperglycaemia (NDH – also termed “prediabetes”) and who already unknowingly have the condition, through the use of targeted risk-assessments. This review aims to synthesize the existing literature supporting dental teams’ identification of individuals at an increased risk of or suffering from undiagnosed NDH or T2DM in dental specialist care settings. Recent Findings Electronic databases were searched for studies reporting the identification of NDH and or T2DM, in specialist care dental settings. Screening of returned articles and data extraction were completed by two independent reviewers (RJ, ZY). A descriptive synthesis of the included articles was undertaken. Due to heterogeneity of the literature, a meta-analysis could not be performed. The search yielded 52 eligib...
Standard methods for the meta-analysis of medical tests without a gold standard are limited to di... more Standard methods for the meta-analysis of medical tests without a gold standard are limited to dichotomous data. Multivariate probit models are used to analyze correlated binary data, and can be extended to multivariate ordered probit models to model ordinal data. Within the context of an imperfect gold standard, they have previously been used for the analysis of dichotomous and ordinal tests in a single study, and for the meta-analysis of dichotomous tests. In this paper, we developed a hierarchical, latent class multivariate probit model for the simultaneous meta-analysis of ordinal and dichotomous tests without assuming a gold standard. The model can accommodate a hierarchical partial pooling model on the conditional within-study correlations, enabling one to obtain summary estimates of joint test accuracy. Dichotomous tests use probit regression likelihoods and ordinal tests use ordered probit regression likelihoods. We fitted the models using Stan, which uses a state-of-the-art...
International Journal of Geriatric Psychiatry, 2021
Dementia remains a clinical diagnosis with a degree of subjective assessment and potential for in... more Dementia remains a clinical diagnosis with a degree of subjective assessment and potential for interrater disagreement. We described interrater agreement of clinical dementia diagnosis for various diagnostic criteria.
Standard methods for the meta-analysis of diagnostic tests without a gold standard are limited to... more Standard methods for the meta-analysis of diagnostic tests without a gold standard are limited to dichotomous data. Multivariate probit models are used to analyze correlated binary data, and can be extended to multivariate ordered probit models to model polytomous (i.e. non-binary) data. Within the context of an imperfect gold standard, they have previously been used for the analysis of dichotomous and polytomous diagnostic tests in a single study, and for the meta-analysis of dichotomous tests. In this paper, we developed a hierarchical, latent class multivariate probit model for the meta-analysis of polytomous and dichotomous diagnostic tests without a gold standard. The model can accommodate a hierarchical partial pooling model on the conditional within-study correlations, which allow us to obtain summary estimates of joint test accuracy. Dichotomous tests use probit regression likelihoods and polytomous tests use ordinal probit regression likelihoods. We fitted the models using ...
Purpose of Review Type 2 diabetes (T2DM) presents a growing global health and economic burden. De... more Purpose of Review Type 2 diabetes (T2DM) presents a growing global health and economic burden. Dental settings have been employed to identify individuals who may be at high risk of diabetes, who exhibit non-diabetic hyperglycaemia (NDH – also termed “prediabetes”) and who already unknowingly have the condition, through the use of targeted risk-assessments. This review aims to synthesize the existing literature supporting dental teams’ identification of individuals at an increased risk of or suffering from undiagnosed NDH or T2DM in dental specialist care settings. Recent Findings Electronic databases were searched for studies reporting the identification of NDH and or T2DM, in specialist care dental settings. Screening of returned articles and data extraction were completed by two independent reviewers (RJ, ZY). A descriptive synthesis of the included articles was undertaken. Due to heterogeneity of the literature, a meta-analysis could not be performed. The search yielded 52 eligib...
Standard methods for the meta-analysis of medical tests without a gold standard are limited to di... more Standard methods for the meta-analysis of medical tests without a gold standard are limited to dichotomous data. Multivariate probit models are used to analyze correlated binary data, and can be extended to multivariate ordered probit models to model ordinal data. Within the context of an imperfect gold standard, they have previously been used for the analysis of dichotomous and ordinal tests in a single study, and for the meta-analysis of dichotomous tests. In this paper, we developed a hierarchical, latent class multivariate probit model for the simultaneous meta-analysis of ordinal and dichotomous tests without assuming a gold standard. The model can accommodate a hierarchical partial pooling model on the conditional within-study correlations, enabling one to obtain summary estimates of joint test accuracy. Dichotomous tests use probit regression likelihoods and ordinal tests use ordered probit regression likelihoods. We fitted the models using Stan, which uses a state-of-the-art...
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Papers by Enzo Cerullo