International Journal of Innovative Research in Medical Science, 2020
Marinacci anastomosis, also known as Ulnar-Median anastomosis, is an anastomosis in which the bra... more Marinacci anastomosis, also known as Ulnar-Median anastomosis, is an anastomosis in which the branch anastomotic originates proximally in the ulnar nerve and unites distally with the median nerve. A purpose of this study was to determine the incidence and the characteristics of Marinacci anastomosis in the Bosnian population. The 60 anterior forearms of fresh frozen adult cadavers were dissected in the Department of Pathology, University Clinical Centre Tuzla and the morgue of Tuzla during a time period of two years. The Marinacci anastomosis was evidenced in one male forearm in the right side behind the ulnar artery, following an transversal course of 5.2 cm until its connection with the median nerve in only one branch. The incidence of Marinacci anastomosis was 1.67%. Since this anastomosis can expalin some cases where injuries in the forearm nerves are not reflected in the hand muscles, it is important to study. Our study contributes to a limited research on the Marinacci anast...
Breast cancer is the most common cancer among women. In Bosnia and Herzegovina, accurate data on ... more Breast cancer is the most common cancer among women. In Bosnia and Herzegovina, accurate data on the status of breast cancer are lacking due to the absence of a central registry. Multiple international guidelines imply that institutions that monitor breast cancer patients should have optimal therapeutic options for treatment. In addition, there have been several international consensus guidelines written on the management of breast cancer. Application of consensus guidelines have previously been demonstrated to have a positive influence on breast cancer care. The importance of specialty breast centers has previously been reported. As part of the 2021 Bosnian-Hercegovinian American Academy of Arts and Sciences (BHAAAS) conference in Mostar, a round table of multidisciplinary specialists from Bosnia and Herzegovina and the diaspora was held. All were either members of BHAAAS or regularly participate in collaborative projects. The focus of the consortium was to write the first multid...
Background: Invasive ductal cancer (IDC) represents about 75% of all breast malignancies. There a... more Background: Invasive ductal cancer (IDC) represents about 75% of all breast malignancies. There are many breast cancer prognostic factors, but the ones that have the most impact on the survival rates in advanced breast cancer are tumor size and regional lymph node involvement. Axillary lymph node dissection (ALND) has particularly important and undoubtful role in current surgical options for breast cancer treatment. With the introduction of sentinel lymph node biopsy (SLNB) for breast cancer patients it was possible to identify those to whom regional spread of the disease did not occur at the time of surgery, and thus spare them an unnecessary ALND procedure. Objective: To determine the rate of sentinel lymph node (SLN) detection using only methylene blue dye as a mapping agent, as well as to correlate the number of positive SLNs with the number of positive non-sentinel lymph nodes (non-SLNs). Methods: The study represents a prospective study that included 50 female patients with hi...
The role of Epstein Barr virus (EBV) in the onset of Hodgkin's lymphoma has been a subject of... more The role of Epstein Barr virus (EBV) in the onset of Hodgkin's lymphoma has been a subject of ongoing research. However, confirmation of EBV oncogenic involvement was not possible due to the small number of neoplastic cells characteristic for this type of tumor. Presence of EBV infection in neoplastic and non-neoplastic cells was analyzed in 81 cases of Hodgkin's lymphoma. In neoplastic cells, using an immunohistochemical method, latent membrane protein 1 (LMP1) was found in 33,3% of cases, while in situ hybridization results demonstrated the presence of EBER RNA in 48,1% of the cases. EBER RNA was found in non-neoplastic lymphocytes in 38,3% of cases. EBV is most frequently associated with Hodgkin's lymphoma in the first and seventh decade of life, specifically the nodular sclerosis subtype. No apparent difference was observed in the association of Hodgkin's lymphoma with EBV between genders, or in relation to clinical stage of the disease and average age of the pat...
In about 70% of cases, ovarian carcinoma has been diagnosed at an advanced stage. Invasion and me... more In about 70% of cases, ovarian carcinoma has been diagnosed at an advanced stage. Invasion and metastasis of solid tumors request protease activity resulting in basal membrane destruction and surrounding matrix. In that process, urokinase plasminogen activator (uPA) and its receptor, urokinase plasminogen activator receptor (suPAR) play a key role, that via plasmin activation lead to basal membrane and matrix degradation in surrounding of the tumor, enable to its invasion and metastasis. Determination of serum concentration of those tumor markers can be useful in preoperative as well as in postoperative period. Their serum concentrations in ovarian cancer patients may help in good monitoring of remission or progression during chemotherapy treatment. In late 1950s and eariy 1960s, when it was found out that malignant ovarian tumors were chemosensitive, their chemotherapy treatment has begun. In the beginning it was used only mono-therapy, and by discovering new cytostatics it was rep...
The exact incidence and mortality rate in Bosnia and Herzegovina are unknown as there are no Nati... more The exact incidence and mortality rate in Bosnia and Herzegovina are unknown as there are no National Cancer Register. The available data are mostly based on the estimation from neighboring countries. Therefore, the aim of this study was to present the preliminary but more accurate estimates of cervical cancer incidence and mortality rates in Bosnia and Herzegovina. The data on cervical cancer cases in Bosnia and Herzegovina were collected from different sources and varies depending on the size of the city or region. To calculate the crude rates for the period from 2000 to 2008, we used the Bosnian and Herzegovinian population census for 1991. Thus, the crude incidence rate in Sarajevo region is more equable (app. 30.4/100,000 women-year), while in Tuzla Canton it varied from 18.5 in 2005 to 4.8/100,000 in 2000. In Tuzla Canton, in the period 1993-2006, 27.1% of all women with cervical cancer were younger than 30. However, the exact crude incidence in Bosnia and Herzegovina could be...
Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina, 2011
To determinate the difference of abundance of CD4+, CD8+ and CD56+ bronchoalveolar fluid's ly... more To determinate the difference of abundance of CD4+, CD8+ and CD56+ bronchoalveolar fluid's lymphocytes and their subpopulations between non- and small cell lung cancer. Also, the differences of abundance of examined lymphocytes were compared between main clinical stages of lung cancer. Mini-bronchoalveolar lavate was taken from lungs of 55 patients with cancer. After laboratory processing and adding CD3, CD4, CD8, CD27, CD28 and CD56 antibody, the material was analysed by flow cytometer. Results of Mini-BAL for non- and small cell lung cancer were compared, as well as the different clinical stages of the disease. Immature and regulatory forms of lymphocytes are more activated, while mature and activated forms are less activated in small cell lung cancer compared to non small type. With an increase of the clinical stage of disease, immunological reaction of T lymphocytes is better expressed because of increasing of abundance of immature and regulatory forms of different subpopula...
Disclosures Abstract: Background: Cancer patients in developing and low income countries have lim... more Disclosures Abstract: Background: Cancer patients in developing and low income countries have limited access to target therapies. Many patients with gastrointestinal stromal tumors (GIST) have had to wait for extended period of time to receive imatinib mesylate (067 months), the standard treatment for patients with advanced/metastatic disease. Some patients never received the target therapy. We set to evaluate if delayed therapy had deleterious effects on patient outcome. Methods: We examined the relationship between delayed imatinib therapy and treatment outcome for 145 patients with GIST in period from June 2005 to December 2015 treated in three university clinical centers in Bosnia and Herzegovina. Since 58% of patients waited > 1 month for therapy, we stratified them into following groups: immediate therapy (range 05 months wait; median 0.5 month, n = 63), > 6 month wait (median wait 9 months, n = 17), never received imatinib (median wait 21 months, n = 25) and imatinib not indicated (low recurrence risk, n = 40). Results: At
Introduction: Benign and malignant tumors can arise from each of the eyelid layers. Our aim was t... more Introduction: Benign and malignant tumors can arise from each of the eyelid layers. Our aim was to investigate the frequency and distribution of the eyelid tumors in tertiary health institution in Tuzla Region in Bosnia and Herzegovina. Methods: We analyzed medical records for all the patients treated for eyelid malignancies in University Clinical Center Tuzla, from January 2012 to December 2016. Demographic, clinical and pathological data were collected and analyzed. Results: A total of 89 patients were treated during the 5 year period. Forty seven of the patients were male (52 %) and 42 (48 %) were female. Patient age ranged from 11 to 92 years, with the mean age of 66.6 years. The most common eyelid malignancy was basal cell carcinoma (80.95%), followed by squamous cell carcinoma (14.29%), merkel cell carcinoma (3.17%) and melanoma (1.59%). Conclusion: The annual incidence of eyelid tumors in Tuzla region is about 3.73/100 000 population. Majority of the mal...
International Journal of Innovative Research in Medical Science, 2020
Marinacci anastomosis, also known as Ulnar-Median anastomosis, is an anastomosis in which the bra... more Marinacci anastomosis, also known as Ulnar-Median anastomosis, is an anastomosis in which the branch anastomotic originates proximally in the ulnar nerve and unites distally with the median nerve. A purpose of this study was to determine the incidence and the characteristics of Marinacci anastomosis in the Bosnian population. The 60 anterior forearms of fresh frozen adult cadavers were dissected in the Department of Pathology, University Clinical Centre Tuzla and the morgue of Tuzla during a time period of two years. The Marinacci anastomosis was evidenced in one male forearm in the right side behind the ulnar artery, following an transversal course of 5.2 cm until its connection with the median nerve in only one branch. The incidence of Marinacci anastomosis was 1.67%. Since this anastomosis can expalin some cases where injuries in the forearm nerves are not reflected in the hand muscles, it is important to study. Our study contributes to a limited research on the Marinacci anast...
Breast cancer is the most common cancer among women. In Bosnia and Herzegovina, accurate data on ... more Breast cancer is the most common cancer among women. In Bosnia and Herzegovina, accurate data on the status of breast cancer are lacking due to the absence of a central registry. Multiple international guidelines imply that institutions that monitor breast cancer patients should have optimal therapeutic options for treatment. In addition, there have been several international consensus guidelines written on the management of breast cancer. Application of consensus guidelines have previously been demonstrated to have a positive influence on breast cancer care. The importance of specialty breast centers has previously been reported. As part of the 2021 Bosnian-Hercegovinian American Academy of Arts and Sciences (BHAAAS) conference in Mostar, a round table of multidisciplinary specialists from Bosnia and Herzegovina and the diaspora was held. All were either members of BHAAAS or regularly participate in collaborative projects. The focus of the consortium was to write the first multid...
Background: Invasive ductal cancer (IDC) represents about 75% of all breast malignancies. There a... more Background: Invasive ductal cancer (IDC) represents about 75% of all breast malignancies. There are many breast cancer prognostic factors, but the ones that have the most impact on the survival rates in advanced breast cancer are tumor size and regional lymph node involvement. Axillary lymph node dissection (ALND) has particularly important and undoubtful role in current surgical options for breast cancer treatment. With the introduction of sentinel lymph node biopsy (SLNB) for breast cancer patients it was possible to identify those to whom regional spread of the disease did not occur at the time of surgery, and thus spare them an unnecessary ALND procedure. Objective: To determine the rate of sentinel lymph node (SLN) detection using only methylene blue dye as a mapping agent, as well as to correlate the number of positive SLNs with the number of positive non-sentinel lymph nodes (non-SLNs). Methods: The study represents a prospective study that included 50 female patients with hi...
The role of Epstein Barr virus (EBV) in the onset of Hodgkin's lymphoma has been a subject of... more The role of Epstein Barr virus (EBV) in the onset of Hodgkin's lymphoma has been a subject of ongoing research. However, confirmation of EBV oncogenic involvement was not possible due to the small number of neoplastic cells characteristic for this type of tumor. Presence of EBV infection in neoplastic and non-neoplastic cells was analyzed in 81 cases of Hodgkin's lymphoma. In neoplastic cells, using an immunohistochemical method, latent membrane protein 1 (LMP1) was found in 33,3% of cases, while in situ hybridization results demonstrated the presence of EBER RNA in 48,1% of the cases. EBER RNA was found in non-neoplastic lymphocytes in 38,3% of cases. EBV is most frequently associated with Hodgkin's lymphoma in the first and seventh decade of life, specifically the nodular sclerosis subtype. No apparent difference was observed in the association of Hodgkin's lymphoma with EBV between genders, or in relation to clinical stage of the disease and average age of the pat...
In about 70% of cases, ovarian carcinoma has been diagnosed at an advanced stage. Invasion and me... more In about 70% of cases, ovarian carcinoma has been diagnosed at an advanced stage. Invasion and metastasis of solid tumors request protease activity resulting in basal membrane destruction and surrounding matrix. In that process, urokinase plasminogen activator (uPA) and its receptor, urokinase plasminogen activator receptor (suPAR) play a key role, that via plasmin activation lead to basal membrane and matrix degradation in surrounding of the tumor, enable to its invasion and metastasis. Determination of serum concentration of those tumor markers can be useful in preoperative as well as in postoperative period. Their serum concentrations in ovarian cancer patients may help in good monitoring of remission or progression during chemotherapy treatment. In late 1950s and eariy 1960s, when it was found out that malignant ovarian tumors were chemosensitive, their chemotherapy treatment has begun. In the beginning it was used only mono-therapy, and by discovering new cytostatics it was rep...
The exact incidence and mortality rate in Bosnia and Herzegovina are unknown as there are no Nati... more The exact incidence and mortality rate in Bosnia and Herzegovina are unknown as there are no National Cancer Register. The available data are mostly based on the estimation from neighboring countries. Therefore, the aim of this study was to present the preliminary but more accurate estimates of cervical cancer incidence and mortality rates in Bosnia and Herzegovina. The data on cervical cancer cases in Bosnia and Herzegovina were collected from different sources and varies depending on the size of the city or region. To calculate the crude rates for the period from 2000 to 2008, we used the Bosnian and Herzegovinian population census for 1991. Thus, the crude incidence rate in Sarajevo region is more equable (app. 30.4/100,000 women-year), while in Tuzla Canton it varied from 18.5 in 2005 to 4.8/100,000 in 2000. In Tuzla Canton, in the period 1993-2006, 27.1% of all women with cervical cancer were younger than 30. However, the exact crude incidence in Bosnia and Herzegovina could be...
Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina, 2011
To determinate the difference of abundance of CD4+, CD8+ and CD56+ bronchoalveolar fluid's ly... more To determinate the difference of abundance of CD4+, CD8+ and CD56+ bronchoalveolar fluid's lymphocytes and their subpopulations between non- and small cell lung cancer. Also, the differences of abundance of examined lymphocytes were compared between main clinical stages of lung cancer. Mini-bronchoalveolar lavate was taken from lungs of 55 patients with cancer. After laboratory processing and adding CD3, CD4, CD8, CD27, CD28 and CD56 antibody, the material was analysed by flow cytometer. Results of Mini-BAL for non- and small cell lung cancer were compared, as well as the different clinical stages of the disease. Immature and regulatory forms of lymphocytes are more activated, while mature and activated forms are less activated in small cell lung cancer compared to non small type. With an increase of the clinical stage of disease, immunological reaction of T lymphocytes is better expressed because of increasing of abundance of immature and regulatory forms of different subpopula...
Disclosures Abstract: Background: Cancer patients in developing and low income countries have lim... more Disclosures Abstract: Background: Cancer patients in developing and low income countries have limited access to target therapies. Many patients with gastrointestinal stromal tumors (GIST) have had to wait for extended period of time to receive imatinib mesylate (067 months), the standard treatment for patients with advanced/metastatic disease. Some patients never received the target therapy. We set to evaluate if delayed therapy had deleterious effects on patient outcome. Methods: We examined the relationship between delayed imatinib therapy and treatment outcome for 145 patients with GIST in period from June 2005 to December 2015 treated in three university clinical centers in Bosnia and Herzegovina. Since 58% of patients waited > 1 month for therapy, we stratified them into following groups: immediate therapy (range 05 months wait; median 0.5 month, n = 63), > 6 month wait (median wait 9 months, n = 17), never received imatinib (median wait 21 months, n = 25) and imatinib not indicated (low recurrence risk, n = 40). Results: At
Introduction: Benign and malignant tumors can arise from each of the eyelid layers. Our aim was t... more Introduction: Benign and malignant tumors can arise from each of the eyelid layers. Our aim was to investigate the frequency and distribution of the eyelid tumors in tertiary health institution in Tuzla Region in Bosnia and Herzegovina. Methods: We analyzed medical records for all the patients treated for eyelid malignancies in University Clinical Center Tuzla, from January 2012 to December 2016. Demographic, clinical and pathological data were collected and analyzed. Results: A total of 89 patients were treated during the 5 year period. Forty seven of the patients were male (52 %) and 42 (48 %) were female. Patient age ranged from 11 to 92 years, with the mean age of 66.6 years. The most common eyelid malignancy was basal cell carcinoma (80.95%), followed by squamous cell carcinoma (14.29%), merkel cell carcinoma (3.17%) and melanoma (1.59%). Conclusion: The annual incidence of eyelid tumors in Tuzla region is about 3.73/100 000 population. Majority of the mal...
Uploads