SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2013 Checklist: Recom... more SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents for the Operative hysteroscopy versus vacuum aspiration for incomplete spontaneous abortion (HY-PER) trial. (PDF 129Â kb)
Informed consent for the Operative hysteroscopy versus vacuum aspiration for incomplete spontaneo... more Informed consent for the Operative hysteroscopy versus vacuum aspiration for incomplete spontaneous abortion (HY-PER) trial. (PDF 285Â kb)
Follow up questionnaire of the Operative hysteroscopy versus vacuum aspiration for incomplete spo... more Follow up questionnaire of the Operative hysteroscopy versus vacuum aspiration for incomplete spontaneous abortion (HY-PER) trial. (PDF 231Â kb)
Items from the World Health Organization Trial Registration Data Set for the Operative hysterosco... more Items from the World Health Organization Trial Registration Data Set for the Operative hysteroscopy versus vacuum aspiration for incomplete spontaneous abortion (HY-PER) trial. (DOC 45Â kb)
En comparaison avec une population non obese (IMC 30). En particulier, il existe une relation lin... more En comparaison avec une population non obese (IMC 30). En particulier, il existe une relation lineaire entre le taux de cesarienne et le poids maternel. Bien qu'il existe aussi une relation lineaire entre l'IMC matemel et le risque de macrosomie fœtale, les donnees de la litterature sont contradictoires concernant le taux de dystocie des epaules certaines etudes retrouvant des taux augmentes dans une population d'obeses, d'autres non. Enfin, le taux d'hemorragie du post-partum et surtout les taux d'infections puerperales et de complications thromboemboliques sont plus eleves chez les obeses, quelle que soit la voie d'accouchement.
BackgroundSafety data about rilpivirine use during pregnancy remain scarce, and rilpivirine plasm... more BackgroundSafety data about rilpivirine use during pregnancy remain scarce, and rilpivirine plasma concentrations are reduced during second/third trimesters, with a potential risk of viral breakthroughs. Thus, French guidelines recommend switching to rilpivirine-free combinations (RFCs) during pregnancy.ObjectivesTo describe the characteristics of women initiating pregnancy while on rilpivirine and to compare the outcomes for virologically suppressed subjects continuing rilpivirine until delivery versus switching to an RFC.MethodsIn the ANRS-EPF French Perinatal cohort, we included women on rilpivirine at conception in 2010–18. Pregnancy outcomes were compared between patients continuing versus interrupting rilpivirine. In women with documented viral suppression (<50 copies/mL) before 14 weeks of gestation (WG) while on rilpivirine, we compared the probability of viral rebound (≥50 copies/mL) during pregnancy between subjects continuing rilpivirine versus those switching to RFC.R...
Journal de gynécologie, obstétrique et biologie de la reproduction, 2014
Pregnancy before 15 years old remains a troublesome issue for medical teams which are not used to... more Pregnancy before 15 years old remains a troublesome issue for medical teams which are not used to working with adolescents. The aim of this work is to study the outcome of the pregnancies among very young adolescents, the psycho-social context, the medical management, the professionals involved in it and the follow-up after pregnancy. Retrospective analysis from four cases, in the university hospital of Rennes, during the year 2011. All the pregnancies were terminated, half of them on a psychological indication. Three adolescents showed evidence of major psychological distress and two of them had a history of sexual abuse. The medical care was heterogeneous, from the first meet until the follow-up after pregnancy, including the medical abortion. A multidisciplinary teamwork was found in three of the four cases. Pregnancy before the age of 15 years old is a rare event and often ends with a medical abortion. The medical management of those vulnerable adolescents is complex and require...
International journal of cancer. Journal international du cancer, Jan 15, 2011
Epithelial ovarian cancer (EOC) usually spreads into the peritoneal cavity, thereby providing an ... more Epithelial ovarian cancer (EOC) usually spreads into the peritoneal cavity, thereby providing an opportunity for intraperitoneal adoptive immunotherapy with Vγ9Vδ2 T lymphocytes, a T cell subpopulation endowed with high lytic properties against tumor cells. However, previous studies have reported that Vγ9Vδ2 T cells fail to expand from peripheral blood mononuclear cells in one-third of patients with cancer. Here, from a cohort of 37 patients with EOC, a multiple correspondence analysis identified three populations, one of which was not suitable for Vγ9Vδ2 T-cell adoptive therapy. Interestingly, the ineligible patients were identified based on the frequency of Vγ9Vδ2 T cells in their peripheral blood and the patients' age. The average time to tumor recurrence was also found to be significantly different between the three populations, suggesting that the innate immune response is involved in EOC prognosis. A dramatic decrease in the lytic properties of Vγ9Vδ2 T cells occurred fol...
SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2013 Checklist: Recom... more SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents for the Operative hysteroscopy versus vacuum aspiration for incomplete spontaneous abortion (HY-PER) trial. (PDF 129Â kb)
Informed consent for the Operative hysteroscopy versus vacuum aspiration for incomplete spontaneo... more Informed consent for the Operative hysteroscopy versus vacuum aspiration for incomplete spontaneous abortion (HY-PER) trial. (PDF 285Â kb)
Follow up questionnaire of the Operative hysteroscopy versus vacuum aspiration for incomplete spo... more Follow up questionnaire of the Operative hysteroscopy versus vacuum aspiration for incomplete spontaneous abortion (HY-PER) trial. (PDF 231Â kb)
Items from the World Health Organization Trial Registration Data Set for the Operative hysterosco... more Items from the World Health Organization Trial Registration Data Set for the Operative hysteroscopy versus vacuum aspiration for incomplete spontaneous abortion (HY-PER) trial. (DOC 45Â kb)
En comparaison avec une population non obese (IMC 30). En particulier, il existe une relation lin... more En comparaison avec une population non obese (IMC 30). En particulier, il existe une relation lineaire entre le taux de cesarienne et le poids maternel. Bien qu'il existe aussi une relation lineaire entre l'IMC matemel et le risque de macrosomie fœtale, les donnees de la litterature sont contradictoires concernant le taux de dystocie des epaules certaines etudes retrouvant des taux augmentes dans une population d'obeses, d'autres non. Enfin, le taux d'hemorragie du post-partum et surtout les taux d'infections puerperales et de complications thromboemboliques sont plus eleves chez les obeses, quelle que soit la voie d'accouchement.
BackgroundSafety data about rilpivirine use during pregnancy remain scarce, and rilpivirine plasm... more BackgroundSafety data about rilpivirine use during pregnancy remain scarce, and rilpivirine plasma concentrations are reduced during second/third trimesters, with a potential risk of viral breakthroughs. Thus, French guidelines recommend switching to rilpivirine-free combinations (RFCs) during pregnancy.ObjectivesTo describe the characteristics of women initiating pregnancy while on rilpivirine and to compare the outcomes for virologically suppressed subjects continuing rilpivirine until delivery versus switching to an RFC.MethodsIn the ANRS-EPF French Perinatal cohort, we included women on rilpivirine at conception in 2010–18. Pregnancy outcomes were compared between patients continuing versus interrupting rilpivirine. In women with documented viral suppression (<50 copies/mL) before 14 weeks of gestation (WG) while on rilpivirine, we compared the probability of viral rebound (≥50 copies/mL) during pregnancy between subjects continuing rilpivirine versus those switching to RFC.R...
Journal de gynécologie, obstétrique et biologie de la reproduction, 2014
Pregnancy before 15 years old remains a troublesome issue for medical teams which are not used to... more Pregnancy before 15 years old remains a troublesome issue for medical teams which are not used to working with adolescents. The aim of this work is to study the outcome of the pregnancies among very young adolescents, the psycho-social context, the medical management, the professionals involved in it and the follow-up after pregnancy. Retrospective analysis from four cases, in the university hospital of Rennes, during the year 2011. All the pregnancies were terminated, half of them on a psychological indication. Three adolescents showed evidence of major psychological distress and two of them had a history of sexual abuse. The medical care was heterogeneous, from the first meet until the follow-up after pregnancy, including the medical abortion. A multidisciplinary teamwork was found in three of the four cases. Pregnancy before the age of 15 years old is a rare event and often ends with a medical abortion. The medical management of those vulnerable adolescents is complex and require...
International journal of cancer. Journal international du cancer, Jan 15, 2011
Epithelial ovarian cancer (EOC) usually spreads into the peritoneal cavity, thereby providing an ... more Epithelial ovarian cancer (EOC) usually spreads into the peritoneal cavity, thereby providing an opportunity for intraperitoneal adoptive immunotherapy with Vγ9Vδ2 T lymphocytes, a T cell subpopulation endowed with high lytic properties against tumor cells. However, previous studies have reported that Vγ9Vδ2 T cells fail to expand from peripheral blood mononuclear cells in one-third of patients with cancer. Here, from a cohort of 37 patients with EOC, a multiple correspondence analysis identified three populations, one of which was not suitable for Vγ9Vδ2 T-cell adoptive therapy. Interestingly, the ineligible patients were identified based on the frequency of Vγ9Vδ2 T cells in their peripheral blood and the patients' age. The average time to tumor recurrence was also found to be significantly different between the three populations, suggesting that the innate immune response is involved in EOC prognosis. A dramatic decrease in the lytic properties of Vγ9Vδ2 T cells occurred fol...
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