Cardiovascular disease (CVD) and cancer are the first and second leading causes of death worldwid... more Cardiovascular disease (CVD) and cancer are the first and second leading causes of death worldwide, respectively. Epidemiological evidence has demonstrated that the incidence of cancer is elevated in patients with CVD and vice versa. However, these conditions are usually regarded as separate events despite the presence of shared risk factors between both conditions, such as metabolic abnormalities and lifestyle. Cohort studies suggested that controlling for CVD risk factors may have an impact on cancer incidence. Therefore, it could be concluded that interventions that improve CVD and cancer shared risk factors may potentially be effective in preventing and treating both diseases. The ketogenic diet (KD), a low-carbohydrate and high-fat diet, has been widely prescribed in weight loss programs for metabolic abnormalities. Furthermore, recent research has investigated the effects of KD on the treatment of numerous diseases, including CVD and cancer, due to its role in promoting ketoly...
Background There are many studies on high-sensitivity C-reactive protein (hs-CRP) association wit... more Background There are many studies on high-sensitivity C-reactive protein (hs-CRP) association with cardiovascular disease (CVD); however, just a few studies investigated whether the low-density lipoprotein cholesterol (LDL-C) could participate in hs-CRP prognostic strength. This study aimed to determine the alliance of hs-CRP and LDL-C in different concentrations in occurrence cardiovascular events in the Isfahan Cohort Study (ICS). Methods 3277 participants aged 35 and above were included in the current analysis. We evaluated the association of elevated hs-CRP levels (≥ 3 mg/dL) and CVD events including myocardial infarction, ischemic heart disease, stroke, CVD, CVD mortality, and all-cause mortality in those with LDL-C ≥ or < 130 mg/dL Cox frailty models was used to determine possible interactions. Results In both crude and fully adjusted models, there was no significant interaction between LDL-C and hs-CRP levels with the incidence of MI, stroke, CVD mortality, and all-cause d...
Nutrition, Metabolism and Cardiovascular Diseases, 2021
AIMS With an increase in the number of published prospective cohort studies, we sought to summari... more AIMS With an increase in the number of published prospective cohort studies, we sought to summarize the relationship between dairy products consumption and the risk of hypertension (HTN). DATA SYNTHESIS We searched PubMed, Web of Science, Embase, Science direct, and Scopus. Pooled RRs and 95% CIs were calculated using a random effects model. The certainty of the evidence was assessed by Grading of Recommendations Assessment, Development and Evaluation (GRADE). Sixteen studies were included in the current meta-analysis. We found an inverse association between total dairy products (RR = 0.90; 95% CI: 0.87, 0.94; n = 16), low-fat dairy products (RR = 0.86; 95% CI: 0.77, 0.96; n = 8), milk (RR = 0.94; 95% CI: 0.90, 0.99; n = 11), and fermented dairy (RR = 0.95; 95% CI: 0.91, 0.99; n = 8) consumption and the risk of HTN. However, in subgroup analysis, despite a significant association for total dairy products in women, Americans, longer and larger studies, and self-reported HTN, no associations were found in males, Europeans, or Asians, and studies which followed participants for <10 years or had <3000 participants or measured HTN. Dose-response analysis revealed a non-linear association between total dairy products and milk consumption and the risk of HTN, but a linear association for low-fat dairy products. CONCLUSIONS Higher dairy products consumption was associated with reduced risk of HTN. This association was dependent on sex, geographical region of study, and the stage of HTN. However, the certainty of the evidence was graded either as low or very low.
Context Several epidemiological studies have investigated the association between a vegetarian di... more Context Several epidemiological studies have investigated the association between a vegetarian diet and risk of depression, but because of inconsistency between studies, the exact association remains unclear. Objective In this systematic review and meta-analysis, the relationship between vegetarian diets and risk of depression in observational studies was evaluated. Data sources The Medline, Embase, Scopus, ISI Web of Science, and Cochrane Library databases were searched from inception through September 1, 2020. Study selection Observational studies were included that examined mean levels of depression and risk for depression in vegetarians compared with nonvegetarians. Data extraction Pooled effect sizes were estimated using the random-effects model and were reported as standardized mean differences or odds ratios (ORs) with their corresponding 95%CIs. Heterogeneity was tested using the I2 statistic. Results Combining 9 effect sizes in this meta-analysis illustrated that adherence ...
مقدمه: رژیم غذایی غنی از روغن زیتون به عنوان یک منبع اسیدهای چرب تک غیر اشباع، از طریق کاهش شاخص... more مقدمه: رژیم غذایی غنی از روغن زیتون به عنوان یک منبع اسیدهای چرب تک غیر اشباع، از طریق کاهش شاخصهای لیپیدی پلاسما در کاهش بیماریهای قلبی- عروقی نقش دارد. هدف از انجام این مطالعه بررسی اثر رژیم غذایی غنی از روغن زیتون بر سطح پلاسمایی شاخصهای قند و لیپید پلاسما در زنان دارای اضافه وزن میباشد. روشها: این مطالعه به صورت یک کارآزمایی بالینی متقاطع طراحی شد که درآن 20 زن سالم دارای اضافه وزن در محدوده سنی 50-20 سال و محدوده 29/9-25 = BMI، با روش تخصیص تصادفی به دو گروه تقسیم شدند. یک گروه رژیم غذایی معمولی محدود از انرژی (51 درصد کربوهیدرات، 15 درصد پروتئین، 34 درصد چربی کل، 16 درصد SFA، 8 درصد MUFA و 10 درصد PUFA) وگروه دیگر رژیم محدود از انرژی و غنی از روغن زیتون (ترکیب درشت مغذیها شبیه رژیم معمولی ولی با 8 درصد SFA، 16 درصد MUFA و 10 درصد PUFA) دریافت کردند. طول مدت مداخله در هر فاز 6 هفته و بین دو فاز نیز 2 هفته wash-out بود. سطوح پلاسمایی قند، کلسترول، تری گلیسیرید، LDL و HDL در حالت ناشتا در ابتدا و انتهای هر دو فاز اندازهگیری شد. تغییرات شاخصهای ذکر شده در طول هر فاز مطالعه...
Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences, 2020
Background: Although increasing salt intake is associated with greater odds of obesity, little is... more Background: Although increasing salt intake is associated with greater odds of obesity, little is known about its relationship with body fat. We investigated the relation of urinary sodium (UNa) with obesity indices, including Clínica Universidad de Navarra–Body Adiposity Estimator (CUN-BAE), a body shape index (ABSI), body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR). Materials and Methods: A total of 508 free-living adults aged ≥ 19 years were selected through stratified multistage random method as a representative of general population from central parts of Iran and were included in this cross-sectional study. Dietary sodium intake was measured using 24-h UNa (24-UNa) excretion. Weight, height, and WC were measured using standard protocols and calibrated equipment and used to measure obesity indicators, including BMI, WHtR, ABSI, and CUN-BAE. Adjusted univariate multiple logistic regression was used to assess the risk of having greater obesity meas...
مقدمه : گرلين ( Ghrelin ) تنها هورمون شناخته شده مؤثر در افزايش اشتها در انسان میباشد و ممكن است... more مقدمه : گرلين ( Ghrelin ) تنها هورمون شناخته شده مؤثر در افزايش اشتها در انسان میباشد و ممكن است به عنوان عامل مؤثری در افزايش اشتها و دريافت غذا پس از كاهش وزن عمل كند. كشف راهحلهايي براي كاهش گرلين و كاهش اشتها جهت حفظ كاهش وزن مورد نياز است. آگاهي در مورد رابطه بين ورزش و اشتها هم براي ورزشكاران و هم براي افرادي كه علاقهمند به حفظ وزن مناسب هستند، اهميت دارد. هدف از اين مقاله مروري، بررسي شواهد موجود در مورد رابطه بين گرلين و عوامل مربوط به شيوه زندگي و همچنين ارایه پيشنهادهايي براي كنترل وزن بود. روشها: مطالعه حاضر، يك مطالعه مروري بود. با استفاده از بانكهاي اطلاعاتي و موتورهاي جستجوي علمي مانند PubMed و Elsevier و كليد واژههای ورزش، اشتها، گرلين، چاقي و كنترل وزن مقالات با طرحهاي كارآزمايي باليني انتخاب شدند. بازه زماني مقالات مورد استفاده از سال 2000 تا سال 2012 ميلادي بود. يافتهها: مطالعات نشان دادند، ورزشهاي طولاني مدت باعث افزايش جزیي در دريافت انرژي ميشود كه شايد به علت تغيير در ميزان هورمونهاي تنظيم كننده اشتها باشد. شواهد موجود نشان ميدهد كه ورزشهاي شديد ب...
The increasing prevalence rate of breast cancer among Asian-American women shows the more signifi... more The increasing prevalence rate of breast cancer among Asian-American women shows the more significant role of lifestyle factors in etiology than genetic factors. The search engine PubMed was used for searching related paper by “breast cancer”, “soy”, “isoflavones”, “phytoestrogen” as the key words. We selected papers which published during 1990 to 2012. Various experimental studies reported the protective role of soy protein and soy isoflavone for breast cancer. However, some studies showed that soy isoflavone induces cell proliferation in vitro and interacts with tamoxifen effects. Indeed, epidemiological studies showed conflict findings. The rate soy is consumed by Asian has protective effect on breast cancer. Soy consumption should provide 20-50 mg of isoflavones per day to protect against breast cancer. Soy consumption during childhood had more beneficiary effects rather than adolescent and adulthood, and during adolescent is more favorable than adulthood Key words : Soy, Breast...
PurposeThe associations between legume consumption and cardiovascular events (CVEs) have extensiv... more PurposeThe associations between legume consumption and cardiovascular events (CVEs) have extensively been studied. However, there are few studies that considered longitudinal association between legume consumption (with repeated measurements across time) and CVEs in low-income countries where legume consumption is lower than the Western countries. The authors aimed to investigate the long-term longitudinal relationship between soybean, non-soybean and overall legume consumption and CVEs using repeated measures of legumes and time-varying confounders in a cohort study of the general population.Design/methodology/approachThe current study was performed within the framework of the Isfahan cohort study among 5,432 healthy participants. The participants were followed-up for fatal and non-fatal myocardial infarction, unstable angina, fatal and non-fatal stroke and sudden cardiac death for 13 years. Dietary intake was evaluated using a validated food frequency questionnaire in 2001, 2007 a...
Primary hyperparathyroidism (PHPT) is associated with increased risk of cardiovascular morbidity ... more Primary hyperparathyroidism (PHPT) is associated with increased risk of cardiovascular morbidity and mortality. We aim to determine whether parathyroidectomy (PTX) can change cardiometabolic risk factors including serum lipids, glycemic parameters, systolic and diastolic blood pressure, C reactive protein (CRP), and body mass index (BMI). MEDLINE, Web of Science, Scopus, and Google Scholar were searched for relevant articles published till June 2020. Fixed-effect or random-effects models were used to estimate the weighted mean difference (WMD) and 95% CI for outcomes where applicable. In total, 34 studies were eligible to be included in the current meta-analysis. Our results indicated no favorable change in serum triglyceride (n = 13, WMD = −0.06, 95% CI: −0.15, 0.03 mmol/L), total cholesterol (n = 15, WMD = 0.01, 95% CI: −0.14, 0.16 mmol/L), LDL-C (n = 10, WMD = −0.01, 95% CI: −0.17, 0.19 mmol/L), HDL-C (n = 10, WMD = 0.03, 95% CI: −0.001, 0.06 mmol/L), and CRP (n = 5, WMD = 0.82, 95% CI: −0.01, 1.64 mg/L) after PTX in PHPT patients. However, glucose (n = 24, WMD = −0.16, 95% CI: −0.26, −0.06 mmol/L), serum insulin (n = 12, WMD = −1.11, 95% CI: −1.73, −0.49 µIU/mL), systolic (n = 17, WMD = −10.14, 95% CI: −12.27, −8.01 mmHg), and diastolic (n = 16, WMD = −5.21, 95% CI: −7.0, −3.43 mmHg) blood pressures were decreased after PTX, whilst a significant increase was observed in BMI (n = 13, WMD = 0.35, 95% CI: 0.19, 0.51 kg/m2). PTX could improve glycemic parameters and blood pressure, without any significant change in serum lipoproteins and CRP.
International Journal for Vitamin and Nutrition Research, 2019
. Objectives: Diabetic nephropathy may adversely influence on sleep duration. The quality of diet... more . Objectives: Diabetic nephropathy may adversely influence on sleep duration. The quality of diet may also be affected by both sleep duration and diabetes nephropathy. Therefore, lower diet quality in short sleepers-diabetic nephropathy patients might be related to higher metabolic abnormalities. In the present study, we investigated if sleep duration is related to diet quality indices and biochemical markers in diabetic nephropathy patients. Method: This cross-sectional study was conducted among 237 diabetic nephropathy patients, randomly selected from patients attending in the Alzahra University Hospital, Isfahan, Iran. Usual dietary intake was assessed using validated food frequency questionnaire. Diet quality indices (including diet diversity score, dietary energy density, mean adequacy ratio, and nutrient adequacy ratio) were calculated based on standard definitions. Sleep duration was estimated using self-reported nocturnal hours of sleep. Results: Short sleepers (5–6 h) had higher blood urea nitrogen and creatinine compared with those who slept more than 7.5 h (20.26 + 0.23 mg/dl vs. 17.61 + 0.30 mg/dl, P &amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.0001, and 1.98 + 0.27 mg/dl vs. 1.90 + 0.24 mg/dl, P = 0.03, respectively). Serum triglyceride levels were positively correlated with sleep duration (P = 0.02). Diet quality indices were not significantly associated with sleep duration. Conclusion: Higher sleep duration is significantly related to lower kidney-related biomarkers in diabetic nephropathy patients. Diet quality indices were not associated with sleep duration in diabetic nephropathy patients. More longitudinal studies are required to evaluate the associations of sleep duration, diet quality and biochemical markers in diabetic nephropathy patients.
Frequently reported poor dietary habits of young adults increase their risk of metabolic syndrome... more Frequently reported poor dietary habits of young adults increase their risk of metabolic syndrome (MetS). Excess adiposity is the most established predictor of MetS, and numerous anthropometric measures have been proposed as proxy indicators of adiposity. We aimed to assess prevalence of MetS in young adult population and to make comparison between weight- and shape-oriented measures of adiposity to identify the best index in association with measured body fat and as a risk predictor for MetS. Healthy males and females aged 18–25 years from the Northwest of England were recruited using convenience sampling (n=550). As part of the assessment of the overall health of young adults, the biochemical variables and adiposity measures BMI, waist circumference (WC), waist-to-height ratio (WHtR), waist-to-hip ratio (WHR), new BMI, Body Adiposity Index (BAI), Clinica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE), and A Body Shape Index (ABSI) were assessed. Linear regression analys...
Journal of the American College of Nutrition, 2017
ABSTRACT Objective: Our objective was to perform a systematic review and meta-analysis on randomi... more ABSTRACT Objective: Our objective was to perform a systematic review and meta-analysis on randomized controlled trials (RCTs) assessing the effect of green tea on serum adiponectin concentration. Method: We searched PubMed, ISI Web of Science, Scopus, and the Google Scholar databases up to November 2016. RCTs conducted among human adults studied the effects of green tea and green tea extract on serum adiponectin concentrations as an outcome variable was included. The weighted mean differences and standard deviations (SD) of change in serum adiponectin levels were calculated. The random effects model was used for deriving a summary of mean estimates with their corresponding SDs. The protocol was registered with PROSPERO (No. CRD42017057716). Result: Fourteen RCTs were eligible to be included in the systematic review and the meta-analysis. Our analysis showed that green tea did not significantly affect adiponectin concentrations in comparison with placebo (weighted mean difference = −0.02 µg/ml, 95% confidence interval [CI], −0.41, 0.38; p = 0.936). There was a substantial heterogeneity between studies (I2 = 91.7%; p < 0.0001). Subgroup analyses based on sex, type of intervention, continent, and body mass index (BMI) could not explain the sources of heterogeneity. Metaregression analyses revealed that the dose and duration of green tea ingestion did not have any effect on adiponectin concentrations. Conclusion: Green tea could not change the circulatory adiponectin levels. The dose and duration of green tea could not change the result. RCTs with longer follow-up periods and higher doses are needed to replicate our results.
Cardiovascular disease (CVD) and cancer are the first and second leading causes of death worldwid... more Cardiovascular disease (CVD) and cancer are the first and second leading causes of death worldwide, respectively. Epidemiological evidence has demonstrated that the incidence of cancer is elevated in patients with CVD and vice versa. However, these conditions are usually regarded as separate events despite the presence of shared risk factors between both conditions, such as metabolic abnormalities and lifestyle. Cohort studies suggested that controlling for CVD risk factors may have an impact on cancer incidence. Therefore, it could be concluded that interventions that improve CVD and cancer shared risk factors may potentially be effective in preventing and treating both diseases. The ketogenic diet (KD), a low-carbohydrate and high-fat diet, has been widely prescribed in weight loss programs for metabolic abnormalities. Furthermore, recent research has investigated the effects of KD on the treatment of numerous diseases, including CVD and cancer, due to its role in promoting ketoly...
Background There are many studies on high-sensitivity C-reactive protein (hs-CRP) association wit... more Background There are many studies on high-sensitivity C-reactive protein (hs-CRP) association with cardiovascular disease (CVD); however, just a few studies investigated whether the low-density lipoprotein cholesterol (LDL-C) could participate in hs-CRP prognostic strength. This study aimed to determine the alliance of hs-CRP and LDL-C in different concentrations in occurrence cardiovascular events in the Isfahan Cohort Study (ICS). Methods 3277 participants aged 35 and above were included in the current analysis. We evaluated the association of elevated hs-CRP levels (≥ 3 mg/dL) and CVD events including myocardial infarction, ischemic heart disease, stroke, CVD, CVD mortality, and all-cause mortality in those with LDL-C ≥ or < 130 mg/dL Cox frailty models was used to determine possible interactions. Results In both crude and fully adjusted models, there was no significant interaction between LDL-C and hs-CRP levels with the incidence of MI, stroke, CVD mortality, and all-cause d...
Nutrition, Metabolism and Cardiovascular Diseases, 2021
AIMS With an increase in the number of published prospective cohort studies, we sought to summari... more AIMS With an increase in the number of published prospective cohort studies, we sought to summarize the relationship between dairy products consumption and the risk of hypertension (HTN). DATA SYNTHESIS We searched PubMed, Web of Science, Embase, Science direct, and Scopus. Pooled RRs and 95% CIs were calculated using a random effects model. The certainty of the evidence was assessed by Grading of Recommendations Assessment, Development and Evaluation (GRADE). Sixteen studies were included in the current meta-analysis. We found an inverse association between total dairy products (RR = 0.90; 95% CI: 0.87, 0.94; n = 16), low-fat dairy products (RR = 0.86; 95% CI: 0.77, 0.96; n = 8), milk (RR = 0.94; 95% CI: 0.90, 0.99; n = 11), and fermented dairy (RR = 0.95; 95% CI: 0.91, 0.99; n = 8) consumption and the risk of HTN. However, in subgroup analysis, despite a significant association for total dairy products in women, Americans, longer and larger studies, and self-reported HTN, no associations were found in males, Europeans, or Asians, and studies which followed participants for <10 years or had <3000 participants or measured HTN. Dose-response analysis revealed a non-linear association between total dairy products and milk consumption and the risk of HTN, but a linear association for low-fat dairy products. CONCLUSIONS Higher dairy products consumption was associated with reduced risk of HTN. This association was dependent on sex, geographical region of study, and the stage of HTN. However, the certainty of the evidence was graded either as low or very low.
Context Several epidemiological studies have investigated the association between a vegetarian di... more Context Several epidemiological studies have investigated the association between a vegetarian diet and risk of depression, but because of inconsistency between studies, the exact association remains unclear. Objective In this systematic review and meta-analysis, the relationship between vegetarian diets and risk of depression in observational studies was evaluated. Data sources The Medline, Embase, Scopus, ISI Web of Science, and Cochrane Library databases were searched from inception through September 1, 2020. Study selection Observational studies were included that examined mean levels of depression and risk for depression in vegetarians compared with nonvegetarians. Data extraction Pooled effect sizes were estimated using the random-effects model and were reported as standardized mean differences or odds ratios (ORs) with their corresponding 95%CIs. Heterogeneity was tested using the I2 statistic. Results Combining 9 effect sizes in this meta-analysis illustrated that adherence ...
مقدمه: رژیم غذایی غنی از روغن زیتون به عنوان یک منبع اسیدهای چرب تک غیر اشباع، از طریق کاهش شاخص... more مقدمه: رژیم غذایی غنی از روغن زیتون به عنوان یک منبع اسیدهای چرب تک غیر اشباع، از طریق کاهش شاخصهای لیپیدی پلاسما در کاهش بیماریهای قلبی- عروقی نقش دارد. هدف از انجام این مطالعه بررسی اثر رژیم غذایی غنی از روغن زیتون بر سطح پلاسمایی شاخصهای قند و لیپید پلاسما در زنان دارای اضافه وزن میباشد. روشها: این مطالعه به صورت یک کارآزمایی بالینی متقاطع طراحی شد که درآن 20 زن سالم دارای اضافه وزن در محدوده سنی 50-20 سال و محدوده 29/9-25 = BMI، با روش تخصیص تصادفی به دو گروه تقسیم شدند. یک گروه رژیم غذایی معمولی محدود از انرژی (51 درصد کربوهیدرات، 15 درصد پروتئین، 34 درصد چربی کل، 16 درصد SFA، 8 درصد MUFA و 10 درصد PUFA) وگروه دیگر رژیم محدود از انرژی و غنی از روغن زیتون (ترکیب درشت مغذیها شبیه رژیم معمولی ولی با 8 درصد SFA، 16 درصد MUFA و 10 درصد PUFA) دریافت کردند. طول مدت مداخله در هر فاز 6 هفته و بین دو فاز نیز 2 هفته wash-out بود. سطوح پلاسمایی قند، کلسترول، تری گلیسیرید، LDL و HDL در حالت ناشتا در ابتدا و انتهای هر دو فاز اندازهگیری شد. تغییرات شاخصهای ذکر شده در طول هر فاز مطالعه...
Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences, 2020
Background: Although increasing salt intake is associated with greater odds of obesity, little is... more Background: Although increasing salt intake is associated with greater odds of obesity, little is known about its relationship with body fat. We investigated the relation of urinary sodium (UNa) with obesity indices, including Clínica Universidad de Navarra–Body Adiposity Estimator (CUN-BAE), a body shape index (ABSI), body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR). Materials and Methods: A total of 508 free-living adults aged ≥ 19 years were selected through stratified multistage random method as a representative of general population from central parts of Iran and were included in this cross-sectional study. Dietary sodium intake was measured using 24-h UNa (24-UNa) excretion. Weight, height, and WC were measured using standard protocols and calibrated equipment and used to measure obesity indicators, including BMI, WHtR, ABSI, and CUN-BAE. Adjusted univariate multiple logistic regression was used to assess the risk of having greater obesity meas...
مقدمه : گرلين ( Ghrelin ) تنها هورمون شناخته شده مؤثر در افزايش اشتها در انسان میباشد و ممكن است... more مقدمه : گرلين ( Ghrelin ) تنها هورمون شناخته شده مؤثر در افزايش اشتها در انسان میباشد و ممكن است به عنوان عامل مؤثری در افزايش اشتها و دريافت غذا پس از كاهش وزن عمل كند. كشف راهحلهايي براي كاهش گرلين و كاهش اشتها جهت حفظ كاهش وزن مورد نياز است. آگاهي در مورد رابطه بين ورزش و اشتها هم براي ورزشكاران و هم براي افرادي كه علاقهمند به حفظ وزن مناسب هستند، اهميت دارد. هدف از اين مقاله مروري، بررسي شواهد موجود در مورد رابطه بين گرلين و عوامل مربوط به شيوه زندگي و همچنين ارایه پيشنهادهايي براي كنترل وزن بود. روشها: مطالعه حاضر، يك مطالعه مروري بود. با استفاده از بانكهاي اطلاعاتي و موتورهاي جستجوي علمي مانند PubMed و Elsevier و كليد واژههای ورزش، اشتها، گرلين، چاقي و كنترل وزن مقالات با طرحهاي كارآزمايي باليني انتخاب شدند. بازه زماني مقالات مورد استفاده از سال 2000 تا سال 2012 ميلادي بود. يافتهها: مطالعات نشان دادند، ورزشهاي طولاني مدت باعث افزايش جزیي در دريافت انرژي ميشود كه شايد به علت تغيير در ميزان هورمونهاي تنظيم كننده اشتها باشد. شواهد موجود نشان ميدهد كه ورزشهاي شديد ب...
The increasing prevalence rate of breast cancer among Asian-American women shows the more signifi... more The increasing prevalence rate of breast cancer among Asian-American women shows the more significant role of lifestyle factors in etiology than genetic factors. The search engine PubMed was used for searching related paper by “breast cancer”, “soy”, “isoflavones”, “phytoestrogen” as the key words. We selected papers which published during 1990 to 2012. Various experimental studies reported the protective role of soy protein and soy isoflavone for breast cancer. However, some studies showed that soy isoflavone induces cell proliferation in vitro and interacts with tamoxifen effects. Indeed, epidemiological studies showed conflict findings. The rate soy is consumed by Asian has protective effect on breast cancer. Soy consumption should provide 20-50 mg of isoflavones per day to protect against breast cancer. Soy consumption during childhood had more beneficiary effects rather than adolescent and adulthood, and during adolescent is more favorable than adulthood Key words : Soy, Breast...
PurposeThe associations between legume consumption and cardiovascular events (CVEs) have extensiv... more PurposeThe associations between legume consumption and cardiovascular events (CVEs) have extensively been studied. However, there are few studies that considered longitudinal association between legume consumption (with repeated measurements across time) and CVEs in low-income countries where legume consumption is lower than the Western countries. The authors aimed to investigate the long-term longitudinal relationship between soybean, non-soybean and overall legume consumption and CVEs using repeated measures of legumes and time-varying confounders in a cohort study of the general population.Design/methodology/approachThe current study was performed within the framework of the Isfahan cohort study among 5,432 healthy participants. The participants were followed-up for fatal and non-fatal myocardial infarction, unstable angina, fatal and non-fatal stroke and sudden cardiac death for 13 years. Dietary intake was evaluated using a validated food frequency questionnaire in 2001, 2007 a...
Primary hyperparathyroidism (PHPT) is associated with increased risk of cardiovascular morbidity ... more Primary hyperparathyroidism (PHPT) is associated with increased risk of cardiovascular morbidity and mortality. We aim to determine whether parathyroidectomy (PTX) can change cardiometabolic risk factors including serum lipids, glycemic parameters, systolic and diastolic blood pressure, C reactive protein (CRP), and body mass index (BMI). MEDLINE, Web of Science, Scopus, and Google Scholar were searched for relevant articles published till June 2020. Fixed-effect or random-effects models were used to estimate the weighted mean difference (WMD) and 95% CI for outcomes where applicable. In total, 34 studies were eligible to be included in the current meta-analysis. Our results indicated no favorable change in serum triglyceride (n = 13, WMD = −0.06, 95% CI: −0.15, 0.03 mmol/L), total cholesterol (n = 15, WMD = 0.01, 95% CI: −0.14, 0.16 mmol/L), LDL-C (n = 10, WMD = −0.01, 95% CI: −0.17, 0.19 mmol/L), HDL-C (n = 10, WMD = 0.03, 95% CI: −0.001, 0.06 mmol/L), and CRP (n = 5, WMD = 0.82, 95% CI: −0.01, 1.64 mg/L) after PTX in PHPT patients. However, glucose (n = 24, WMD = −0.16, 95% CI: −0.26, −0.06 mmol/L), serum insulin (n = 12, WMD = −1.11, 95% CI: −1.73, −0.49 µIU/mL), systolic (n = 17, WMD = −10.14, 95% CI: −12.27, −8.01 mmHg), and diastolic (n = 16, WMD = −5.21, 95% CI: −7.0, −3.43 mmHg) blood pressures were decreased after PTX, whilst a significant increase was observed in BMI (n = 13, WMD = 0.35, 95% CI: 0.19, 0.51 kg/m2). PTX could improve glycemic parameters and blood pressure, without any significant change in serum lipoproteins and CRP.
International Journal for Vitamin and Nutrition Research, 2019
. Objectives: Diabetic nephropathy may adversely influence on sleep duration. The quality of diet... more . Objectives: Diabetic nephropathy may adversely influence on sleep duration. The quality of diet may also be affected by both sleep duration and diabetes nephropathy. Therefore, lower diet quality in short sleepers-diabetic nephropathy patients might be related to higher metabolic abnormalities. In the present study, we investigated if sleep duration is related to diet quality indices and biochemical markers in diabetic nephropathy patients. Method: This cross-sectional study was conducted among 237 diabetic nephropathy patients, randomly selected from patients attending in the Alzahra University Hospital, Isfahan, Iran. Usual dietary intake was assessed using validated food frequency questionnaire. Diet quality indices (including diet diversity score, dietary energy density, mean adequacy ratio, and nutrient adequacy ratio) were calculated based on standard definitions. Sleep duration was estimated using self-reported nocturnal hours of sleep. Results: Short sleepers (5–6 h) had higher blood urea nitrogen and creatinine compared with those who slept more than 7.5 h (20.26 + 0.23 mg/dl vs. 17.61 + 0.30 mg/dl, P &amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.0001, and 1.98 + 0.27 mg/dl vs. 1.90 + 0.24 mg/dl, P = 0.03, respectively). Serum triglyceride levels were positively correlated with sleep duration (P = 0.02). Diet quality indices were not significantly associated with sleep duration. Conclusion: Higher sleep duration is significantly related to lower kidney-related biomarkers in diabetic nephropathy patients. Diet quality indices were not associated with sleep duration in diabetic nephropathy patients. More longitudinal studies are required to evaluate the associations of sleep duration, diet quality and biochemical markers in diabetic nephropathy patients.
Frequently reported poor dietary habits of young adults increase their risk of metabolic syndrome... more Frequently reported poor dietary habits of young adults increase their risk of metabolic syndrome (MetS). Excess adiposity is the most established predictor of MetS, and numerous anthropometric measures have been proposed as proxy indicators of adiposity. We aimed to assess prevalence of MetS in young adult population and to make comparison between weight- and shape-oriented measures of adiposity to identify the best index in association with measured body fat and as a risk predictor for MetS. Healthy males and females aged 18–25 years from the Northwest of England were recruited using convenience sampling (n=550). As part of the assessment of the overall health of young adults, the biochemical variables and adiposity measures BMI, waist circumference (WC), waist-to-height ratio (WHtR), waist-to-hip ratio (WHR), new BMI, Body Adiposity Index (BAI), Clinica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE), and A Body Shape Index (ABSI) were assessed. Linear regression analys...
Journal of the American College of Nutrition, 2017
ABSTRACT Objective: Our objective was to perform a systematic review and meta-analysis on randomi... more ABSTRACT Objective: Our objective was to perform a systematic review and meta-analysis on randomized controlled trials (RCTs) assessing the effect of green tea on serum adiponectin concentration. Method: We searched PubMed, ISI Web of Science, Scopus, and the Google Scholar databases up to November 2016. RCTs conducted among human adults studied the effects of green tea and green tea extract on serum adiponectin concentrations as an outcome variable was included. The weighted mean differences and standard deviations (SD) of change in serum adiponectin levels were calculated. The random effects model was used for deriving a summary of mean estimates with their corresponding SDs. The protocol was registered with PROSPERO (No. CRD42017057716). Result: Fourteen RCTs were eligible to be included in the systematic review and the meta-analysis. Our analysis showed that green tea did not significantly affect adiponectin concentrations in comparison with placebo (weighted mean difference = −0.02 µg/ml, 95% confidence interval [CI], −0.41, 0.38; p = 0.936). There was a substantial heterogeneity between studies (I2 = 91.7%; p < 0.0001). Subgroup analyses based on sex, type of intervention, continent, and body mass index (BMI) could not explain the sources of heterogeneity. Metaregression analyses revealed that the dose and duration of green tea ingestion did not have any effect on adiponectin concentrations. Conclusion: Green tea could not change the circulatory adiponectin levels. The dose and duration of green tea could not change the result. RCTs with longer follow-up periods and higher doses are needed to replicate our results.
Uploads
Papers by Fahimeh Haghighatdoost