The successful integration of hot-melt extrusion (HME) and fused deposition modelling (FDM) depen... more The successful integration of hot-melt extrusion (HME) and fused deposition modelling (FDM) depends on a better understanding of the impact of environmental conditions on the printability of formulations, since they significantly affect the properties of the raw materials, whose control is crucial to enable three-dimensional printing (3DP). Hence, the objective of this work was to investigate the correlation between the environmental settings and the properties of paroxetine (PRX)-loaded filaments, previously produced by HME, which affect printability by FDM. The influence of different drying methods of the physical mixtures (PMs) and HME-filaments (FILs) on the quality and printability of these products was also assessed. The printability of FILs was evaluated in terms of the water content, and the mechanical and thermal properties of the products. Stability studies and physicochemical, thermal, and in vitro dissolution tests were carried out on the 3D-printed tablets. Stability st...
The preparation of amorphous and co-amorphous systems (CAMs) effectively addresses the solubility... more The preparation of amorphous and co-amorphous systems (CAMs) effectively addresses the solubility and bioavailability issues of poorly water-soluble chemical entities. However, stress conditions imposed during common pharmaceutical processing (e.g., tableting) may cause the recrystallization of the systems, warranting close stability monitoring throughout production. This work aimed at assessing the water and heat stability of amorphous olanzapine (OLZ) and OLZ-CAMs when subject to wet granulation and pelletization. Starting materials and products were characterized using calorimetry, diffractometry and spectroscopy, and their performance behavior was evaluated by dissolution testing. The results indicated that amorphous OLZ was reconverted back to a crystalline state after exposure to water and heat; conversely, OLZ-CAMs stabilized with saccharin (SAC), a sulfonic acid, did not show any significant loss of the amorphous content, confirming the higher stability of OLZ in the CAM. Be...
of the poster presented at the 3rd European Conference on Pharmaceutics. 25-26 march 2019, Bologn... more of the poster presented at the 3rd European Conference on Pharmaceutics. 25-26 march 2019, Bologne, ItalyN/
of the communication presented at the Controlled Release Society Virtual Annual Meeting, 29 June-... more of the communication presented at the Controlled Release Society Virtual Annual Meeting, 29 June-2 July 2020N/
of the poster presented at the 3rd European Conference on Pharmaceutics. 25-26 March 2019, Bologn... more of the poster presented at the 3rd European Conference on Pharmaceutics. 25-26 March 2019, Bologne, ItalyN/
Poster presented at the 2nd International Congress of CiiEM: Translational Research and Innovatio... more Poster presented at the 2nd International Congress of CiiEM: Translational Research and Innovation in Human and Health Sciences. Egas Moniz, Caparica, Portugal, 11-13 June 2017N/
Poster presented at the AAPS Annual Meeting and Exposition (American Association of Pharmaceutica... more Poster presented at the AAPS Annual Meeting and Exposition (American Association of Pharmaceutical Scientists). October 25-29, 2015, Orlando (FL), USA"Purpose: Investigation of the potential of casein micellar formulations as drug vehicles in pediatrics."Fundação para a Ciência e a Tecnologia (PTDC/DTP-FTO/1057/2012
Poster presented at the 2nd International Congress of CiiEM: “Translational Research and Innovati... more Poster presented at the 2nd International Congress of CiiEM: “Translational Research and Innovation in Human and Health Sciences”. Egas Moniz, Caparica, Portugal, 11-13 June 2017N/
Poster presented at the PSWC2020 Virtual (7th FIP Pharmaceutical Sciences World Congress), 4-6 Oc... more Poster presented at the PSWC2020 Virtual (7th FIP Pharmaceutical Sciences World Congress), 4-6 October 2020N/
Poster presented at 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Tech... more Poster presented at 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology. 19-22 Março 2018, Granada, EspanhaN/
A drug’s bioavailability, i.e., the extent to and rate at which it enters the systemic circulatio... more A drug’s bioavailability, i.e., the extent to and rate at which it enters the systemic circulation, thus accessing the site of action, is largely determined by the properties of the drug [...]
of the poster presented at the 4th International Congress of CiiEM - "Health, Well-being and... more of the poster presented at the 4th International Congress of CiiEM - "Health, Well-being and Ageing in the XXI Century." 2-5 June 2019, Campus Egas Moniz, Monte de Caparica, PortugalN/
The successful integration of hot-melt extrusion (HME) and fused deposition modelling (FDM) depen... more The successful integration of hot-melt extrusion (HME) and fused deposition modelling (FDM) depends on a better understanding of the impact of environmental conditions on the printability of formulations, since they significantly affect the properties of the raw materials, whose control is crucial to enable three-dimensional printing (3DP). Hence, the objective of this work was to investigate the correlation between the environmental settings and the properties of paroxetine (PRX)-loaded filaments, previously produced by HME, which affect printability by FDM. The influence of different drying methods of the physical mixtures (PMs) and HME-filaments (FILs) on the quality and printability of these products was also assessed. The printability of FILs was evaluated in terms of the water content, and the mechanical and thermal properties of the products. Stability studies and physicochemical, thermal, and in vitro dissolution tests were carried out on the 3D-printed tablets. Stability st...
The preparation of amorphous and co-amorphous systems (CAMs) effectively addresses the solubility... more The preparation of amorphous and co-amorphous systems (CAMs) effectively addresses the solubility and bioavailability issues of poorly water-soluble chemical entities. However, stress conditions imposed during common pharmaceutical processing (e.g., tableting) may cause the recrystallization of the systems, warranting close stability monitoring throughout production. This work aimed at assessing the water and heat stability of amorphous olanzapine (OLZ) and OLZ-CAMs when subject to wet granulation and pelletization. Starting materials and products were characterized using calorimetry, diffractometry and spectroscopy, and their performance behavior was evaluated by dissolution testing. The results indicated that amorphous OLZ was reconverted back to a crystalline state after exposure to water and heat; conversely, OLZ-CAMs stabilized with saccharin (SAC), a sulfonic acid, did not show any significant loss of the amorphous content, confirming the higher stability of OLZ in the CAM. Be...
of the poster presented at the 3rd European Conference on Pharmaceutics. 25-26 march 2019, Bologn... more of the poster presented at the 3rd European Conference on Pharmaceutics. 25-26 march 2019, Bologne, ItalyN/
of the communication presented at the Controlled Release Society Virtual Annual Meeting, 29 June-... more of the communication presented at the Controlled Release Society Virtual Annual Meeting, 29 June-2 July 2020N/
of the poster presented at the 3rd European Conference on Pharmaceutics. 25-26 March 2019, Bologn... more of the poster presented at the 3rd European Conference on Pharmaceutics. 25-26 March 2019, Bologne, ItalyN/
Poster presented at the 2nd International Congress of CiiEM: Translational Research and Innovatio... more Poster presented at the 2nd International Congress of CiiEM: Translational Research and Innovation in Human and Health Sciences. Egas Moniz, Caparica, Portugal, 11-13 June 2017N/
Poster presented at the AAPS Annual Meeting and Exposition (American Association of Pharmaceutica... more Poster presented at the AAPS Annual Meeting and Exposition (American Association of Pharmaceutical Scientists). October 25-29, 2015, Orlando (FL), USA"Purpose: Investigation of the potential of casein micellar formulations as drug vehicles in pediatrics."Fundação para a Ciência e a Tecnologia (PTDC/DTP-FTO/1057/2012
Poster presented at the 2nd International Congress of CiiEM: “Translational Research and Innovati... more Poster presented at the 2nd International Congress of CiiEM: “Translational Research and Innovation in Human and Health Sciences”. Egas Moniz, Caparica, Portugal, 11-13 June 2017N/
Poster presented at the PSWC2020 Virtual (7th FIP Pharmaceutical Sciences World Congress), 4-6 Oc... more Poster presented at the PSWC2020 Virtual (7th FIP Pharmaceutical Sciences World Congress), 4-6 October 2020N/
Poster presented at 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Tech... more Poster presented at 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology. 19-22 Março 2018, Granada, EspanhaN/
A drug’s bioavailability, i.e., the extent to and rate at which it enters the systemic circulatio... more A drug’s bioavailability, i.e., the extent to and rate at which it enters the systemic circulation, thus accessing the site of action, is largely determined by the properties of the drug [...]
of the poster presented at the 4th International Congress of CiiEM - "Health, Well-being and... more of the poster presented at the 4th International Congress of CiiEM - "Health, Well-being and Ageing in the XXI Century." 2-5 June 2019, Campus Egas Moniz, Monte de Caparica, PortugalN/
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Papers by Ana Isabel Fernandes