L. Moura e Silva + , P. Simões + , J. Gabriel e Silva + ... J. Boavida * , P. Monteiro * , J. Reb... more L. Moura e Silva + , P. Simões + , J. Gabriel e Silva + ... J. Boavida * , P. Monteiro * , J. Rebhan * , C. Renato * , L. Almeida * , N. Sthoer * ... +Dep. de Engenharia Informática, Universidade de Coimbra, Pólo II, 3030 Coimbra, Portugal * Siemens SA, BU.NET, Rua Irmãos ...
Cerebrovascular and cardiovascular diseases are the leading causes of death and disability worldw... more Cerebrovascular and cardiovascular diseases are the leading causes of death and disability worldwide. They are complex disorders resulting from the interplay of genetic and environmental factors, and may share several susceptibility genes. Several recent studies have implicated variants of the Kalirin (KALRN) gene with susceptibility to cardiovascular and metabolic phenotypes, but no studies have yet been performed in stroke patients. KALRN is involved, among others, in the inhibition of inducible nitric oxide synthase, in the regulation of ischemic signal transduction, and in neuronal morphogenesis, plasticity, and stability. The goal of the present study was to determine whether SNPs in the KALRN region on 3q13, which includes the Ropporin gene (ROPN1), predispose to ischemic stroke (IS) in a cohort of Portuguese patients and controls. We genotyped 34 tagging SNPs in the KALRN and ROPN1 chromosomal region on 565 IS patients and 517 unrelated controls, and performed genotype imputation for 405 markers on chromosome 3. We tested the single-marker association of these SNPs with IS. One SNP (rs4499545) in the ROPN1–KALRN intergenic region and two SNPs in KALRN (rs17286604 and rs11712619) showed significant (P SNPs also showed an association at P P 2009). These studies suggest that variants in the KALRN gene region constitute risk factors for stroke and that KALRN may represent a common risk factor for vascular diseases.
In this study we present and discuss a case of a patient in which a Kirschner wire was used for f... more In this study we present and discuss a case of a patient in which a Kirschner wire was used for fixation of a fractured zygomatic bone. The Kirschner wire was not removed after four weeks as recommended in the literature but only after behaving as foreign body.
L. Moura e Silva + , P. Simões + , J. Gabriel e Silva + ... J. Boavida * , P. Monteiro * , J. Reb... more L. Moura e Silva + , P. Simões + , J. Gabriel e Silva + ... J. Boavida * , P. Monteiro * , J. Rebhan * , C. Renato * , L. Almeida * , N. Sthoer * ... +Dep. de Engenharia Informática, Universidade de Coimbra, Pólo II, 3030 Coimbra, Portugal * Siemens SA, BU.NET, Rua Irmãos ...
Cerebrovascular and cardiovascular diseases are the leading causes of death and disability worldw... more Cerebrovascular and cardiovascular diseases are the leading causes of death and disability worldwide. They are complex disorders resulting from the interplay of genetic and environmental factors, and may share several susceptibility genes. Several recent studies have implicated variants of the Kalirin (KALRN) gene with susceptibility to cardiovascular and metabolic phenotypes, but no studies have yet been performed in stroke patients. KALRN is involved, among others, in the inhibition of inducible nitric oxide synthase, in the regulation of ischemic signal transduction, and in neuronal morphogenesis, plasticity, and stability. The goal of the present study was to determine whether SNPs in the KALRN region on 3q13, which includes the Ropporin gene (ROPN1), predispose to ischemic stroke (IS) in a cohort of Portuguese patients and controls. We genotyped 34 tagging SNPs in the KALRN and ROPN1 chromosomal region on 565 IS patients and 517 unrelated controls, and performed genotype imputation for 405 markers on chromosome 3. We tested the single-marker association of these SNPs with IS. One SNP (rs4499545) in the ROPN1–KALRN intergenic region and two SNPs in KALRN (rs17286604 and rs11712619) showed significant (P SNPs also showed an association at P P 2009). These studies suggest that variants in the KALRN gene region constitute risk factors for stroke and that KALRN may represent a common risk factor for vascular diseases.
In this study we present and discuss a case of a patient in which a Kirschner wire was used for f... more In this study we present and discuss a case of a patient in which a Kirschner wire was used for fixation of a fractured zygomatic bone. The Kirschner wire was not removed after four weeks as recommended in the literature but only after behaving as foreign body.
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