Renal cell carcinoma (RCC) is the third most common genitourinary cancer accounting for approxima... more Renal cell carcinoma (RCC) is the third most common genitourinary cancer accounting for approximately 180,000 deaths worldwide in 2020. Although over two-thirds of patients initially present localized disease, up to 50% of them may progress to metastatic disease. Adjuvant therapy aims to reduce the recurrence risk and improve outcomes in several types of cancers but is currently an unmet need in RCC. The results achieved with tyrosine kinase inhibitors in metastatic RCC led to the evaluation of these target therapies in an early setting with conflicting results for disease-free survival and no overall survival (OS) benefit. Likewise, the results of immune checkpoint inhibitors (ICIs) in an adjuvant setting are conflicting. Available data did not show an improvement in OS with ICIs in the early phase, although a positive trend for pembrolizumab has been recorded, receiving the Food and Drug Administration’s approval in this setting. However, the disappointing results of several ICIs ...
Complete duplication of the bladder, urethra, vaginal and clitoris is an extremely rare congenita... more Complete duplication of the bladder, urethra, vaginal and clitoris is an extremely rare congenital anomaly that is usually diagnosed at pediatric age. We report an unusual case of a complete bladder, vaginal, clitoris and urethra duplication occurred in an old female patient (81 years old). This case highlighted the fact that an anatomical anomaly should be considered in all patients with persistent urinary tract problems, especially in old women, due to patients’ reluctance to consult physicians for this kind of problem. (Urologia 2009; 76: 258-9)
Study design, materials and methods Between 1993 and 2006 bladder replacement with a sigmoid colo... more Study design, materials and methods Between 1993 and 2006 bladder replacement with a sigmoid colonic segment was performed on 122 patients, 106 men (86.9%) and 16 (13.1%) women, mean age 63.2 (range 42-77 median 64.12 ±7.65). Mean follow up was 48.2 months (range 4-158, median 38.4 ± 58.3). 96 patients (86 M, 10 F) underwent urodynamic evaluation. Functional data were stratified into four groups (A,B,C,D) based on follow up. 6 months (96 pts–group A), 2 years (52 pts–group B), 5 years (44 pts group C) and 10 years (11 pts–group D) after surgery evaluations were performed by means of: 3 day detailed micturition time chart, uroflowmetry, pressure-flow study and urethral pressure profile. We have considered continent day-time and night-time all patients who didn’t use pads and referred themselves as completely dry.
This study aimed at evaluating the distibution in prostate tissue of fosfomycin trometamol before... more This study aimed at evaluating the distibution in prostate tissue of fosfomycin trometamol before prostate biopsy in order to assess the better timing of drug administratio
Objectives: The incidence of prostate cancer in renal transplant recipients (RTRs) is increasing,... more Objectives: The incidence of prostate cancer in renal transplant recipients (RTRs) is increasing, but few data are available in the literature. In this study, we reviewed the 25-year experience in the management of prostate cancer after kidney transplantation at the Florence Transplant Centre.Methods: We retrospectively reviewed the data from 617 RTR male patients who underwent renal transplantation at our institute between July 1996 and September 2016. Data regarding demographics, renal transplantation, prostate cancer and immunosuppressive treatment were analyzed. The probability of death was estimated by using the Kaplan-Meier method and differences between patients' groups were assessed by the log-rank test.Results: From July 1991 to September 2016, 617 kidney transplantations of male patients were performed at our institute. Among these, 20 patients were subsequently diagnosed with prostate cancer accounting for a cumulative incidence of 3.24%. After a median follow-up of 5...
Objectives: We evaluated the efficacy of sutureless laparoscopic partial nephrectomy (LPN), using... more Objectives: We evaluated the efficacy of sutureless laparoscopic partial nephrectomy (LPN), using a fibrin gel in order to minimize renal ischemia time and preserve kidney function. Materials and Methods: Nineteen patients (mean age 58.3 ± 7.1) undergoing sutureless LPN using a fbrin gel were compared with a control group consisting of 21 patients (mean age 57.9 ± 7.5) subjected to LPN with standard suturing. Intraand post-operative data for the two groups were compared. The following parameters were recorded: patient demographics, Charlson Comorbidity Index, tumor characteristics according to the RENAL score, warm ischemia and operative times, estimated blood loss, mean hospital stay, post-operative complications referring to the Clavien-Dindo classification, renal function parameters pathologic and follow-up data. The main outcome measure was renal ischemia time and maintenance of kidney function. Results: Median warm ischemia time was 13 minutes (range 11-19) in the group treated...
Renal cell carcinoma (RCC) is the third most common genitourinary cancer accounting for approxima... more Renal cell carcinoma (RCC) is the third most common genitourinary cancer accounting for approximately 180,000 deaths worldwide in 2020. Although over two-thirds of patients initially present localized disease, up to 50% of them may progress to metastatic disease. Adjuvant therapy aims to reduce the recurrence risk and improve outcomes in several types of cancers but is currently an unmet need in RCC. The results achieved with tyrosine kinase inhibitors in metastatic RCC led to the evaluation of these target therapies in an early setting with conflicting results for disease-free survival and no overall survival (OS) benefit. Likewise, the results of immune checkpoint inhibitors (ICIs) in an adjuvant setting are conflicting. Available data did not show an improvement in OS with ICIs in the early phase, although a positive trend for pembrolizumab has been recorded, receiving the Food and Drug Administration’s approval in this setting. However, the disappointing results of several ICIs ...
Complete duplication of the bladder, urethra, vaginal and clitoris is an extremely rare congenita... more Complete duplication of the bladder, urethra, vaginal and clitoris is an extremely rare congenital anomaly that is usually diagnosed at pediatric age. We report an unusual case of a complete bladder, vaginal, clitoris and urethra duplication occurred in an old female patient (81 years old). This case highlighted the fact that an anatomical anomaly should be considered in all patients with persistent urinary tract problems, especially in old women, due to patients’ reluctance to consult physicians for this kind of problem. (Urologia 2009; 76: 258-9)
Study design, materials and methods Between 1993 and 2006 bladder replacement with a sigmoid colo... more Study design, materials and methods Between 1993 and 2006 bladder replacement with a sigmoid colonic segment was performed on 122 patients, 106 men (86.9%) and 16 (13.1%) women, mean age 63.2 (range 42-77 median 64.12 ±7.65). Mean follow up was 48.2 months (range 4-158, median 38.4 ± 58.3). 96 patients (86 M, 10 F) underwent urodynamic evaluation. Functional data were stratified into four groups (A,B,C,D) based on follow up. 6 months (96 pts–group A), 2 years (52 pts–group B), 5 years (44 pts group C) and 10 years (11 pts–group D) after surgery evaluations were performed by means of: 3 day detailed micturition time chart, uroflowmetry, pressure-flow study and urethral pressure profile. We have considered continent day-time and night-time all patients who didn’t use pads and referred themselves as completely dry.
This study aimed at evaluating the distibution in prostate tissue of fosfomycin trometamol before... more This study aimed at evaluating the distibution in prostate tissue of fosfomycin trometamol before prostate biopsy in order to assess the better timing of drug administratio
Objectives: The incidence of prostate cancer in renal transplant recipients (RTRs) is increasing,... more Objectives: The incidence of prostate cancer in renal transplant recipients (RTRs) is increasing, but few data are available in the literature. In this study, we reviewed the 25-year experience in the management of prostate cancer after kidney transplantation at the Florence Transplant Centre.Methods: We retrospectively reviewed the data from 617 RTR male patients who underwent renal transplantation at our institute between July 1996 and September 2016. Data regarding demographics, renal transplantation, prostate cancer and immunosuppressive treatment were analyzed. The probability of death was estimated by using the Kaplan-Meier method and differences between patients' groups were assessed by the log-rank test.Results: From July 1991 to September 2016, 617 kidney transplantations of male patients were performed at our institute. Among these, 20 patients were subsequently diagnosed with prostate cancer accounting for a cumulative incidence of 3.24%. After a median follow-up of 5...
Objectives: We evaluated the efficacy of sutureless laparoscopic partial nephrectomy (LPN), using... more Objectives: We evaluated the efficacy of sutureless laparoscopic partial nephrectomy (LPN), using a fibrin gel in order to minimize renal ischemia time and preserve kidney function. Materials and Methods: Nineteen patients (mean age 58.3 ± 7.1) undergoing sutureless LPN using a fbrin gel were compared with a control group consisting of 21 patients (mean age 57.9 ± 7.5) subjected to LPN with standard suturing. Intraand post-operative data for the two groups were compared. The following parameters were recorded: patient demographics, Charlson Comorbidity Index, tumor characteristics according to the RENAL score, warm ischemia and operative times, estimated blood loss, mean hospital stay, post-operative complications referring to the Clavien-Dindo classification, renal function parameters pathologic and follow-up data. The main outcome measure was renal ischemia time and maintenance of kidney function. Results: Median warm ischemia time was 13 minutes (range 11-19) in the group treated...
Uploads