T helper 17 (Th17) cells have a prominent role in autoimmune diseases. In contrast, the nature of... more T helper 17 (Th17) cells have a prominent role in autoimmune diseases. In contrast, the nature of these cells in cancer is controversial, with either pro- or antitumorigenic activities depending on various cancer settings. Chronic lymphocytic leukemia (CLL), a B-cell malignancy, is characterized by an imbalance in T-cell immune responses that contributes to disease progression and increased mortality. Many clinical reports indicate an increase in Th17 cells and/or interleukin 17 serum cytokine levels in patients with CLL compared with healthy individuals, which correlates with various prognostic markers and significant changes in the tumor microenvironment. The exact mechanisms by which Th17 cells might contribute to CLL progression remain poorly investigated. In this review, we provide an updated presentation of the clinical information related to the significance of Th17 cells in CLL and their interaction with the complex leukemic microenvironment, including various mediators, imm...
Presentation given by Dr Wesam Gamal at the workshop on EM field interaction with biological tiss... more Presentation given by Dr Wesam Gamal at the workshop on EM field interaction with biological tissues for cancer and regenerative medicine held in Bangor, UK on July 13th 2018. The presentation is entitled "Dielectric characterization of brain cancer cell lines..."
Urologic Oncology: Seminars and Original Investigations, 2011
We report on the feasibility and outcomes of the N-shaped pouch with an afferent tubular isoperis... more We report on the feasibility and outcomes of the N-shaped pouch with an afferent tubular isoperistaltic segment as a new technique for creating a capacious, low pressure bladder substitute following radical cystectomy. Between April 2000 and April 2006, 42 patients (36 male, 6 female) with invasive bladder cancer were considered good candidates for orthotopic urinary diversion. All had radical cystectomy with bilateral pelvic lymphadenectomy and orthotopic bladder substitution by an ileal low pressure reservoir (N-shaped) with an afferent isoperistaltic tubular segment. Of the 42 patients, 36 (86%) had squamous cell carcinoma; 6 had transitional cell carcinoma. None of the patients had positive lymph nodes after pathologic examination of the specimen. The patients were available for a median follow-up period of 24.8 months. Follow-up included clinical and radiographic studies to determine functional and oncological outcomes. Eleven patients (26.2%) had early complications during the period ≤ 3 months following surgery. Seven of these patients had complications such as wound infection, prolonged ileus, persistent urinary leakage, and deep venous thrombosis that were treated conservatively. One female patient developed a pouch-vaginal fistula that required repair. The remaining 3 patients had oncologic failures, 1 of which was isolated urethral recurrence. Late complications occurred in 15 patients (35.7%). These included pouch stones, outflow obstruction, mucus retention, and adhesive bowel obstruction. Daytime and night-time continence was achieved in 92% and 80% of the patients, respectively, and ureteroileal stricture was observed in 5%. The upper tracts remained unchanged or improved in nearly 95% of the patients. Ileal orthotopic bladder substitution (N-shaped) with an afferent ileal tubular segment offers good functional results with good preservation of the renal units. It is considered a safe and technically feasible surgical procedure.
Open Access Macedonian Journal of Medical Sciences, 2022
BACKGROUND: Color mismatch between tooth structure and restoration is a common reason for restora... more BACKGROUND: Color mismatch between tooth structure and restoration is a common reason for restoration replacement. This is due, in part, to the diverse chemical structure of both substrates, which display a different staining potential resulting in a significant color mismatch. AIM: The aim of the study was to evaluates the color change of single shade resin composite and compare it to fibrous-filled resin composite (FRc) after storage in coloring beverages. METHODS: Trapezoidal Class V cavities were prepared on the buccal and lingual surfaces of 30 premolars. Cavities on the buccal surface were restored with Omnichroma (ON) and palatal surface with FRc. Specimens were stored on water, tea, and coffee solutions for 24 h and 72 h. The color change was measured after each immersion time and statistically analyzed using three-way analysis of variance (ANOVA) (α = 0.05). RESULTS: Three-way ANOVA showed that different materials had a significant effect on both ΔL and Δa (p < 0.001). F...
A continuum mixture theory with microstructure is developed for guided wave propagation in bilami... more A continuum mixture theory with microstructure is developed for guided wave propagation in bilaminated periodic composites of piezoelectric materials. The theory leads to the simple governing coupled equations for the actual composites which retain the integrity of the propagation process in each constituent but allow them to coexist under analytically derived interaction parameters. As a consequence of the analysis, effective
T helper 17 (Th17) cells have a prominent role in autoimmune diseases. In contrast, the nature of... more T helper 17 (Th17) cells have a prominent role in autoimmune diseases. In contrast, the nature of these cells in cancer is controversial, with either pro- or antitumorigenic activities depending on various cancer settings. Chronic lymphocytic leukemia (CLL), a B-cell malignancy, is characterized by an imbalance in T-cell immune responses that contributes to disease progression and increased mortality. Many clinical reports indicate an increase in Th17 cells and/or interleukin 17 serum cytokine levels in patients with CLL compared with healthy individuals, which correlates with various prognostic markers and significant changes in the tumor microenvironment. The exact mechanisms by which Th17 cells might contribute to CLL progression remain poorly investigated. In this review, we provide an updated presentation of the clinical information related to the significance of Th17 cells in CLL and their interaction with the complex leukemic microenvironment, including various mediators, imm...
Presentation given by Dr Wesam Gamal at the workshop on EM field interaction with biological tiss... more Presentation given by Dr Wesam Gamal at the workshop on EM field interaction with biological tissues for cancer and regenerative medicine held in Bangor, UK on July 13th 2018. The presentation is entitled "Dielectric characterization of brain cancer cell lines..."
Urologic Oncology: Seminars and Original Investigations, 2011
We report on the feasibility and outcomes of the N-shaped pouch with an afferent tubular isoperis... more We report on the feasibility and outcomes of the N-shaped pouch with an afferent tubular isoperistaltic segment as a new technique for creating a capacious, low pressure bladder substitute following radical cystectomy. Between April 2000 and April 2006, 42 patients (36 male, 6 female) with invasive bladder cancer were considered good candidates for orthotopic urinary diversion. All had radical cystectomy with bilateral pelvic lymphadenectomy and orthotopic bladder substitution by an ileal low pressure reservoir (N-shaped) with an afferent isoperistaltic tubular segment. Of the 42 patients, 36 (86%) had squamous cell carcinoma; 6 had transitional cell carcinoma. None of the patients had positive lymph nodes after pathologic examination of the specimen. The patients were available for a median follow-up period of 24.8 months. Follow-up included clinical and radiographic studies to determine functional and oncological outcomes. Eleven patients (26.2%) had early complications during the period ≤ 3 months following surgery. Seven of these patients had complications such as wound infection, prolonged ileus, persistent urinary leakage, and deep venous thrombosis that were treated conservatively. One female patient developed a pouch-vaginal fistula that required repair. The remaining 3 patients had oncologic failures, 1 of which was isolated urethral recurrence. Late complications occurred in 15 patients (35.7%). These included pouch stones, outflow obstruction, mucus retention, and adhesive bowel obstruction. Daytime and night-time continence was achieved in 92% and 80% of the patients, respectively, and ureteroileal stricture was observed in 5%. The upper tracts remained unchanged or improved in nearly 95% of the patients. Ileal orthotopic bladder substitution (N-shaped) with an afferent ileal tubular segment offers good functional results with good preservation of the renal units. It is considered a safe and technically feasible surgical procedure.
Open Access Macedonian Journal of Medical Sciences, 2022
BACKGROUND: Color mismatch between tooth structure and restoration is a common reason for restora... more BACKGROUND: Color mismatch between tooth structure and restoration is a common reason for restoration replacement. This is due, in part, to the diverse chemical structure of both substrates, which display a different staining potential resulting in a significant color mismatch. AIM: The aim of the study was to evaluates the color change of single shade resin composite and compare it to fibrous-filled resin composite (FRc) after storage in coloring beverages. METHODS: Trapezoidal Class V cavities were prepared on the buccal and lingual surfaces of 30 premolars. Cavities on the buccal surface were restored with Omnichroma (ON) and palatal surface with FRc. Specimens were stored on water, tea, and coffee solutions for 24 h and 72 h. The color change was measured after each immersion time and statistically analyzed using three-way analysis of variance (ANOVA) (α = 0.05). RESULTS: Three-way ANOVA showed that different materials had a significant effect on both ΔL and Δa (p < 0.001). F...
A continuum mixture theory with microstructure is developed for guided wave propagation in bilami... more A continuum mixture theory with microstructure is developed for guided wave propagation in bilaminated periodic composites of piezoelectric materials. The theory leads to the simple governing coupled equations for the actual composites which retain the integrity of the propagation process in each constituent but allow them to coexist under analytically derived interaction parameters. As a consequence of the analysis, effective
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Papers by Wael Gamal