Introduction: the study of the frequency of diseases, including those affecting the maxillofacial... more Introduction: the study of the frequency of diseases, including those affecting the maxillofacial region, is of fundamental importance to clinicians, epidemiologists and managers to formulate a profile of the most prevalent health problems and needs of a particular region. Such epidemiological studies reveal the prevalence of many diseases and particularize the distribution of these characteristics depending on the region or location being analyzed. Objective: the present study aimed to assess the frequency of oral lesions diagnosed in a dental clinic in the city of Montes Claros MG, Brazil. Methods : a descriptive study was conducted in patients assisted at Department of Oral Diagnosis at Universidades Norte de las Unidas Mine, Funorte / SOEBRAS, Brazil from February 2010 to July 2012. Patients were characterized by: socio-demographic characteristics; systemic conditions; physical examination; habits and addictions; characterization of oral lesions, procedures performed and the most frequent histopathologic diagnoses. Data were analyzed descriptively using SPSS version 17.0. Results: the study included 125 patients. Most patients were female (58.4%) aged 40 to 59 years (42.4 %), 88.2 % had no extra-oral lesions, the most prevalent occurrence of lesions was in lips (24.8 %) and 36.6 % were diagnosed with non-neoplastic proliferative. Conclusion: the more diagnosed and frequent oral pathologies were non-neoplastic proliferative processes.
As celulas T Regulatorias (Treg) representam uma subpopulacao de linfocitos T CD4+ que desempenha... more As celulas T Regulatorias (Treg) representam uma subpopulacao de linfocitos T CD4+ que desempenham importante papel na regulacao e supressao da resposta imune. O objetivo deste trabalho foi investigar a expressao das celulas Treg atraves dos seus marcadores CD4, CD25, CTLA-4 e Foxp3 utilizando a tecnica de imunoistoquimica em amostras de carcinoma de celulas escamosas de cavidade bucal (CECB) e carcinoma de celulas escamosas de labio (CCEL). A relacao dos marcadores das celulas Treg com os dados de sobrevida tambem foi avaliada. Foi observado um maior percentual de celulas CD4+ (p=0.019) e Foxp3+ (p=0.04) em amostras de CECB quando comparadas com CCEL. CECB mostrou um menor percentual de celulas CTLA-4+ que CCEL (p<0.0001). Alem disso, a relacao entre CD4/Foxp3, CD4/CD25 e CD4/CTLA-4 foi significativamente maior no CECB, indicando um maior numero de celulas Treg no CECB. O teste log-rank mostrou que pacientes com altas contagens de CD4; CD4/Foxp3; CD4/CD25 e CD4/CTLA-4 tiveram me...
ABSTRACT RESUMEN El cáncer bucal a nivel mundial se considera uno de los más incidentes en cabeza... more ABSTRACT RESUMEN El cáncer bucal a nivel mundial se considera uno de los más incidentes en cabeza y cuello, y la lengua, la ubicación topográfica bucal más frecuente. Los principales factores de riesgo son: tabaquismo, alcoholismo, herencia y una higiene bucal inadecuada. Se reporta el caso de un hombre de 64 años de edad con hábitos tóxicos de tabaquismo y alcoholismo, y además deficiente higiene bucal. El paciente sufre enfermedad de Alzheimer y desarrolló en la lengua un carcinoma escamocelular con adenopatías cervicales metastásicas. El diagnóstico fue confirmado histopatológicamente. Se realizó glosectomía total y posterior radioterapia cervical. Se motivó a los familiares a mejorar la higiene bucal del paciente y actualmente se encuentra bajo control médico. Aunque no se puede asegurar que la aparición y desarrollo del cáncer bucal en este paciente fue debido al padecimiento de Alzheimer o a los demás factores de riesgo, si se contempló la posibilidad de convertirse este padecimiento neurológico en un factor predisponente para esta enfermedad. Palabras clave: cáncer bucal, cáncer de lengua, enfermedad de Alzheimer.
Introduction: Bisphosphonates are analogous to endogenous pyrophosphates and present high affinit... more Introduction: Bisphosphonates are analogous to endogenous pyrophosphates and present high affinity with mineralized tissues, acting on sites with large bone formation and resorption. Bisphosphonates are used for the treatment of osteoporosis, osteogenesis imperfecta, fibrous dysplasia, Paget’s disease, multiple myeloma and bone metastases form various types of malignant neoplasias.However, several complications from their use have been described, especially osteonecrosis of gnathic bones. This disorder may be similar to those found in other pathologies, like osteoradionecrosis and osteomyelite. objectives: The aims of this literature review were to identify the possible involved mechanisms in the etiopatogenesis, the clinical manifestations, as well as protocols of prevention, diagnosis and treatment for osteonecrosis of gnathic bones. Revision of Literature: It was reported that osteonecrosis caused by bisphosphonates is more often in patients with multiple myeloma and breast cance...
El cancer bucal a nivel mundial se considera uno de los mas incidentes en cabeza y cuello, y la l... more El cancer bucal a nivel mundial se considera uno de los mas incidentes en cabeza y cuello, y la lengua, la ubicacion topografica bucal mas frecuente. Los principales factores de riesgo son: tabaquismo, alcoholismo, herencia y una higiene bucal inadecuada. Se reporta el caso de un hombre de 64 anos de edad con habitos toxicos de tabaquismo y alcoholismo, y ademas deficiente higiene bucal. El paciente sufre enfermedad de Alzheimer y desarrollo en la lengua un carcinoma escamocelular con adenopatias cervicales metastasicas. El diagnostico fue confirmado histopatologicamente. Se realizo glosectomia total y posterior radioterapia cervical. Se motivo a los familiares a mejorar la higiene bucal del paciente y actualmente se encuentra bajo control medico. Aunque no se puede asegurar que la aparicion y desarrollo del cancer bucal en este paciente fue debido al padecimiento de Alzheimer o a los demas factores de riesgo, si se contemplo la posibilidad de convertirse este padecimiento neurologi...
Hiperplasia epitelial multifocal ou doenca de Heck e proliferacao localizada de epitelio escamoso... more Hiperplasia epitelial multifocal ou doenca de Heck e proliferacao localizada de epitelio escamoso oral, benigna, que afeta a mucosa oral de criancas e adultos jovens de diversas regioes do mundo e em diferentes grupos etnicos, como indigenas e esquimos. Sao indolores em sua maioria, localizando-se principalmente nas mucosas jugal, labial, lingual, gengival. Tem sido associada aos tipos 13 e 32 do papilomavirus humano (HPV). Paciente TES, sexo feminino, 6 anos de idade, leucoderma, compareceu a clinica de Diagnostico Bucal do curso de Odontologia dasFaculdades Unidas do Norte de Minas acompanhada pela mae, que descreveu presenca de carocos indolores na bochecha da filha. O exame intrabucal revelou nodulos em mucosa jugal esquerda e direita, alem de lingua e mucosa labial. Os nodulos apresentavam consistencia macia, agrupados, de forma arredondada, sesseis, com algumas lesoes exibindo superficie papilar, coloracao semelhante a mucosa, exceto em algumas areas mais esbranquicadas. As le...
T Regulatory (Treg) cells represent a T CD4 lymphocytes subpopulation that displays important rol... more T Regulatory (Treg) cells represent a T CD4 lymphocytes subpopulation that displays important roles in the regulation and suppression of immune responses. We investigated the expression of Treg cell markers CD4, CD25, CTLA-4 and FoxP3 by immunohistochemistry in samples of oral cavity squamous cell carcinoma (OCSCC) and lip squamous cell carcinoma (LSCC). The relationship of Treg markers with survival data was also evaluated. We observed a higher percentual of CD4 (P=0.019) and FoxP3 (P=0.040) positive cells in OCSCC samples when compared with LSCC. OCSCC showed lower percentual of CTLA4 cells than LSCC (P<0.0001). Moreover, CD4/FoxP3, CD4/CD25 and CD4/CTLA-4 ratio was significantly greater in OCSCC, indicating higher numbers of Treg cell phenotype in OCSCC. A log-rank test showed that patients with high counts of CD4; CD4/FoxP3, CD4/CD25 and CD4/CTLA-4 showed a decrease of survival in relation to patients with low cell counts (P<0.05). In line with this findings, samples with ...
Resumo: Objetivo e Metodologia: O objetivo deste estudo foi realizar um levantamento das lesoes d... more Resumo: Objetivo e Metodologia: O objetivo deste estudo foi realizar um levantamento das lesoes de mucosa diagnosticadas pelo laboratorio de patologia bucal, do curso de Odontologia das Faculdades Unidas do Norte de Minas Gerais (Funorte), no periodo de 2005 a 2008. Simultaneamente, foi estabelecido o perfil epidemiologico dos individuos que procuraram o servico da clinica de diagnostico bucal, da mesma faculdade, no periodo descrito, e que foram submetidos a biopsia e/ou citologia esfoliativa. Resultados: Os resultados mostraram uma diversidade de lesoes de mucosa bucal, sendo as mais frequentes: a hiperplasia fibrosa (17,85%), a leucoplasia (9,85%), o nevo (6,77%), a mucocele (5,85%) e o cisto periapical (5,54%). Quanto ao genero, o perfil epidemiologico mostrou um maior percentual de individuos do sexo feminino (57,85%), com maior frequencia na 4a decada de vida (12,62%). Conclusao: A diversidade de lesoes bucais observada reforca a importância do conhecimento da epidemiologia de...
Introduction: the study of the frequency of diseases, including those affecting the maxillofacial... more Introduction: the study of the frequency of diseases, including those affecting the maxillofacial region, is of fundamental importance to clinicians, epidemiologists and managers to formulate a profile of the most prevalent health problems and needs of a particular region. Such epidemiological studies reveal the prevalence of many diseases and particularize the distribution of these characteristics depending on the region or location being analyzed. Objective: the present study aimed to assess the frequency of oral lesions diagnosed in a dental clinic in the city of Montes Claros MG, Brazil. Methods : a descriptive study was conducted in patients assisted at Department of Oral Diagnosis at Universidades Norte de las Unidas Mine, Funorte / SOEBRAS, Brazil from February 2010 to July 2012. Patients were characterized by: socio-demographic characteristics; systemic conditions; physical examination; habits and addictions; characterization of oral lesions, procedures performed and the mos...
Objetivo Propõe-se identificar a prevalência dos hábitos tabagistas e etilistas entre pacientes d... more Objetivo Propõe-se identificar a prevalência dos hábitos tabagistas e etilistas entre pacientes diagnosticados com lesões bucais, assim como possíveis fatores associados. Material e método Estudo analítico, de caráter retrospectivo, entre pacientes assistidos por clínica odontológica universitária na área de Diagnóstico Bucal. Foram analisados os prontuários odontológicos e laudos histopatológicos dos pacientes que realizaram o procedimento de biópsia entre fevereiro de 2010 e julho de 2012. As variáveis dependentes – hábitos nocivos à saúde – foram construídas pelas informações referentes aos hábitos tabagistas e etilistas então atuais ou passados. Utilizou-se o software SPSS 19.0. Foram conduzidas análises descritivas e univariada pelo teste qui-quadrado de Pearson (p≤0,05). A normalidade da amostra foi investigada pelo teste Kolmogorov-Smirnov e Shapiro-Wilk (p<0,05). Resultado Dos 125 pacientes atendidos no período de avaliação, 110 foram incluídos. A presença de hábitos taba...
Tumor-infiltrating lymphocytes (TILs) are a heterogeneous cell family which plays an important ro... more Tumor-infiltrating lymphocytes (TILs) are a heterogeneous cell family which plays an important role in tumor-associated immune response. Of these, T regulatory (Treg) cells have also been shown to inhibit anti-tumor response. We aimed to evaluate the expression of T regulatory cell markers (CD4, CD25, CTLA-4 and FoxP3) in samples of oral cavity squamous cell carcinoma (OCSCC) and lip SCC (LSCC) by immunohistochemistry. The relationship of Treg markers with survival data and the proliferative index were also evaluated. We observed similar numbers of CD4-, CD25- and FoxP3(+) cells in OCSCC and LSCC. On the other hand, numbers of CTLA-4(+) cells were significantly lower in OCSCC than in LSCC. OCSCC samples with high numbers of CD4 exhibited a high proliferative index, while samples with high CTLA-4 counts demonstrated a low tumoral proliferative index. A log-rank test showed that patients with OCSCC that presented high counts of CD4 showed a significantly decreased survival compared wi...
Introduction: the study of the frequency of diseases, including those affecting the maxillofacial... more Introduction: the study of the frequency of diseases, including those affecting the maxillofacial region, is of fundamental importance to clinicians, epidemiologists and managers to formulate a profile of the most prevalent health problems and needs of a particular region. Such epidemiological studies reveal the prevalence of many diseases and particularize the distribution of these characteristics depending on the region or location being analyzed. Objective: the present study aimed to assess the frequency of oral lesions diagnosed in a dental clinic in the city of Montes Claros MG, Brazil. Methods : a descriptive study was conducted in patients assisted at Department of Oral Diagnosis at Universidades Norte de las Unidas Mine, Funorte / SOEBRAS, Brazil from February 2010 to July 2012. Patients were characterized by: socio-demographic characteristics; systemic conditions; physical examination; habits and addictions; characterization of oral lesions, procedures performed and the most frequent histopathologic diagnoses. Data were analyzed descriptively using SPSS version 17.0. Results: the study included 125 patients. Most patients were female (58.4%) aged 40 to 59 years (42.4 %), 88.2 % had no extra-oral lesions, the most prevalent occurrence of lesions was in lips (24.8 %) and 36.6 % were diagnosed with non-neoplastic proliferative. Conclusion: the more diagnosed and frequent oral pathologies were non-neoplastic proliferative processes.
As celulas T Regulatorias (Treg) representam uma subpopulacao de linfocitos T CD4+ que desempenha... more As celulas T Regulatorias (Treg) representam uma subpopulacao de linfocitos T CD4+ que desempenham importante papel na regulacao e supressao da resposta imune. O objetivo deste trabalho foi investigar a expressao das celulas Treg atraves dos seus marcadores CD4, CD25, CTLA-4 e Foxp3 utilizando a tecnica de imunoistoquimica em amostras de carcinoma de celulas escamosas de cavidade bucal (CECB) e carcinoma de celulas escamosas de labio (CCEL). A relacao dos marcadores das celulas Treg com os dados de sobrevida tambem foi avaliada. Foi observado um maior percentual de celulas CD4+ (p=0.019) e Foxp3+ (p=0.04) em amostras de CECB quando comparadas com CCEL. CECB mostrou um menor percentual de celulas CTLA-4+ que CCEL (p<0.0001). Alem disso, a relacao entre CD4/Foxp3, CD4/CD25 e CD4/CTLA-4 foi significativamente maior no CECB, indicando um maior numero de celulas Treg no CECB. O teste log-rank mostrou que pacientes com altas contagens de CD4; CD4/Foxp3; CD4/CD25 e CD4/CTLA-4 tiveram me...
ABSTRACT RESUMEN El cáncer bucal a nivel mundial se considera uno de los más incidentes en cabeza... more ABSTRACT RESUMEN El cáncer bucal a nivel mundial se considera uno de los más incidentes en cabeza y cuello, y la lengua, la ubicación topográfica bucal más frecuente. Los principales factores de riesgo son: tabaquismo, alcoholismo, herencia y una higiene bucal inadecuada. Se reporta el caso de un hombre de 64 años de edad con hábitos tóxicos de tabaquismo y alcoholismo, y además deficiente higiene bucal. El paciente sufre enfermedad de Alzheimer y desarrolló en la lengua un carcinoma escamocelular con adenopatías cervicales metastásicas. El diagnóstico fue confirmado histopatológicamente. Se realizó glosectomía total y posterior radioterapia cervical. Se motivó a los familiares a mejorar la higiene bucal del paciente y actualmente se encuentra bajo control médico. Aunque no se puede asegurar que la aparición y desarrollo del cáncer bucal en este paciente fue debido al padecimiento de Alzheimer o a los demás factores de riesgo, si se contempló la posibilidad de convertirse este padecimiento neurológico en un factor predisponente para esta enfermedad. Palabras clave: cáncer bucal, cáncer de lengua, enfermedad de Alzheimer.
Introduction: Bisphosphonates are analogous to endogenous pyrophosphates and present high affinit... more Introduction: Bisphosphonates are analogous to endogenous pyrophosphates and present high affinity with mineralized tissues, acting on sites with large bone formation and resorption. Bisphosphonates are used for the treatment of osteoporosis, osteogenesis imperfecta, fibrous dysplasia, Paget’s disease, multiple myeloma and bone metastases form various types of malignant neoplasias.However, several complications from their use have been described, especially osteonecrosis of gnathic bones. This disorder may be similar to those found in other pathologies, like osteoradionecrosis and osteomyelite. objectives: The aims of this literature review were to identify the possible involved mechanisms in the etiopatogenesis, the clinical manifestations, as well as protocols of prevention, diagnosis and treatment for osteonecrosis of gnathic bones. Revision of Literature: It was reported that osteonecrosis caused by bisphosphonates is more often in patients with multiple myeloma and breast cance...
El cancer bucal a nivel mundial se considera uno de los mas incidentes en cabeza y cuello, y la l... more El cancer bucal a nivel mundial se considera uno de los mas incidentes en cabeza y cuello, y la lengua, la ubicacion topografica bucal mas frecuente. Los principales factores de riesgo son: tabaquismo, alcoholismo, herencia y una higiene bucal inadecuada. Se reporta el caso de un hombre de 64 anos de edad con habitos toxicos de tabaquismo y alcoholismo, y ademas deficiente higiene bucal. El paciente sufre enfermedad de Alzheimer y desarrollo en la lengua un carcinoma escamocelular con adenopatias cervicales metastasicas. El diagnostico fue confirmado histopatologicamente. Se realizo glosectomia total y posterior radioterapia cervical. Se motivo a los familiares a mejorar la higiene bucal del paciente y actualmente se encuentra bajo control medico. Aunque no se puede asegurar que la aparicion y desarrollo del cancer bucal en este paciente fue debido al padecimiento de Alzheimer o a los demas factores de riesgo, si se contemplo la posibilidad de convertirse este padecimiento neurologi...
Hiperplasia epitelial multifocal ou doenca de Heck e proliferacao localizada de epitelio escamoso... more Hiperplasia epitelial multifocal ou doenca de Heck e proliferacao localizada de epitelio escamoso oral, benigna, que afeta a mucosa oral de criancas e adultos jovens de diversas regioes do mundo e em diferentes grupos etnicos, como indigenas e esquimos. Sao indolores em sua maioria, localizando-se principalmente nas mucosas jugal, labial, lingual, gengival. Tem sido associada aos tipos 13 e 32 do papilomavirus humano (HPV). Paciente TES, sexo feminino, 6 anos de idade, leucoderma, compareceu a clinica de Diagnostico Bucal do curso de Odontologia dasFaculdades Unidas do Norte de Minas acompanhada pela mae, que descreveu presenca de carocos indolores na bochecha da filha. O exame intrabucal revelou nodulos em mucosa jugal esquerda e direita, alem de lingua e mucosa labial. Os nodulos apresentavam consistencia macia, agrupados, de forma arredondada, sesseis, com algumas lesoes exibindo superficie papilar, coloracao semelhante a mucosa, exceto em algumas areas mais esbranquicadas. As le...
T Regulatory (Treg) cells represent a T CD4 lymphocytes subpopulation that displays important rol... more T Regulatory (Treg) cells represent a T CD4 lymphocytes subpopulation that displays important roles in the regulation and suppression of immune responses. We investigated the expression of Treg cell markers CD4, CD25, CTLA-4 and FoxP3 by immunohistochemistry in samples of oral cavity squamous cell carcinoma (OCSCC) and lip squamous cell carcinoma (LSCC). The relationship of Treg markers with survival data was also evaluated. We observed a higher percentual of CD4 (P=0.019) and FoxP3 (P=0.040) positive cells in OCSCC samples when compared with LSCC. OCSCC showed lower percentual of CTLA4 cells than LSCC (P<0.0001). Moreover, CD4/FoxP3, CD4/CD25 and CD4/CTLA-4 ratio was significantly greater in OCSCC, indicating higher numbers of Treg cell phenotype in OCSCC. A log-rank test showed that patients with high counts of CD4; CD4/FoxP3, CD4/CD25 and CD4/CTLA-4 showed a decrease of survival in relation to patients with low cell counts (P<0.05). In line with this findings, samples with ...
Resumo: Objetivo e Metodologia: O objetivo deste estudo foi realizar um levantamento das lesoes d... more Resumo: Objetivo e Metodologia: O objetivo deste estudo foi realizar um levantamento das lesoes de mucosa diagnosticadas pelo laboratorio de patologia bucal, do curso de Odontologia das Faculdades Unidas do Norte de Minas Gerais (Funorte), no periodo de 2005 a 2008. Simultaneamente, foi estabelecido o perfil epidemiologico dos individuos que procuraram o servico da clinica de diagnostico bucal, da mesma faculdade, no periodo descrito, e que foram submetidos a biopsia e/ou citologia esfoliativa. Resultados: Os resultados mostraram uma diversidade de lesoes de mucosa bucal, sendo as mais frequentes: a hiperplasia fibrosa (17,85%), a leucoplasia (9,85%), o nevo (6,77%), a mucocele (5,85%) e o cisto periapical (5,54%). Quanto ao genero, o perfil epidemiologico mostrou um maior percentual de individuos do sexo feminino (57,85%), com maior frequencia na 4a decada de vida (12,62%). Conclusao: A diversidade de lesoes bucais observada reforca a importância do conhecimento da epidemiologia de...
Introduction: the study of the frequency of diseases, including those affecting the maxillofacial... more Introduction: the study of the frequency of diseases, including those affecting the maxillofacial region, is of fundamental importance to clinicians, epidemiologists and managers to formulate a profile of the most prevalent health problems and needs of a particular region. Such epidemiological studies reveal the prevalence of many diseases and particularize the distribution of these characteristics depending on the region or location being analyzed. Objective: the present study aimed to assess the frequency of oral lesions diagnosed in a dental clinic in the city of Montes Claros MG, Brazil. Methods : a descriptive study was conducted in patients assisted at Department of Oral Diagnosis at Universidades Norte de las Unidas Mine, Funorte / SOEBRAS, Brazil from February 2010 to July 2012. Patients were characterized by: socio-demographic characteristics; systemic conditions; physical examination; habits and addictions; characterization of oral lesions, procedures performed and the mos...
Objetivo Propõe-se identificar a prevalência dos hábitos tabagistas e etilistas entre pacientes d... more Objetivo Propõe-se identificar a prevalência dos hábitos tabagistas e etilistas entre pacientes diagnosticados com lesões bucais, assim como possíveis fatores associados. Material e método Estudo analítico, de caráter retrospectivo, entre pacientes assistidos por clínica odontológica universitária na área de Diagnóstico Bucal. Foram analisados os prontuários odontológicos e laudos histopatológicos dos pacientes que realizaram o procedimento de biópsia entre fevereiro de 2010 e julho de 2012. As variáveis dependentes – hábitos nocivos à saúde – foram construídas pelas informações referentes aos hábitos tabagistas e etilistas então atuais ou passados. Utilizou-se o software SPSS 19.0. Foram conduzidas análises descritivas e univariada pelo teste qui-quadrado de Pearson (p≤0,05). A normalidade da amostra foi investigada pelo teste Kolmogorov-Smirnov e Shapiro-Wilk (p<0,05). Resultado Dos 125 pacientes atendidos no período de avaliação, 110 foram incluídos. A presença de hábitos taba...
Tumor-infiltrating lymphocytes (TILs) are a heterogeneous cell family which plays an important ro... more Tumor-infiltrating lymphocytes (TILs) are a heterogeneous cell family which plays an important role in tumor-associated immune response. Of these, T regulatory (Treg) cells have also been shown to inhibit anti-tumor response. We aimed to evaluate the expression of T regulatory cell markers (CD4, CD25, CTLA-4 and FoxP3) in samples of oral cavity squamous cell carcinoma (OCSCC) and lip SCC (LSCC) by immunohistochemistry. The relationship of Treg markers with survival data and the proliferative index were also evaluated. We observed similar numbers of CD4-, CD25- and FoxP3(+) cells in OCSCC and LSCC. On the other hand, numbers of CTLA-4(+) cells were significantly lower in OCSCC than in LSCC. OCSCC samples with high numbers of CD4 exhibited a high proliferative index, while samples with high CTLA-4 counts demonstrated a low tumoral proliferative index. A log-rank test showed that patients with OCSCC that presented high counts of CD4 showed a significantly decreased survival compared wi...
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