CNS & neurological disorders drug targets, Jan 20, 2017
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and Huntin... more Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and Huntington's disease, represent worldwide a major health problem with great financial impact. They are multifactorial diseases, hallmarked by similar pathogenesis that covers conditions such as oxidative stress, formation of free radicals, abnormal protein dynamics (degradation and aggregation), mitochondrial dysfunction, lipid peroxidation and cellular death or senescence. Flavonols are polyphenolic compounds, widely distributed in the plant kingdom and found in high concentrations in vegetables, fruits and teas. Their neuroprotective effects are mainly related to their antioxidant, anti-proliferative and anti-inflammatory properties. It was this paper's intention to contribute with an evidence analysis of recent studies approaching neuroprotective effects of flavonols and the potential to conduct human clinical studies.This paper was based on a literature search of PubMed and Scielo...
Objetivo: Avaliar o colágeno tipo III na anastomose colocólica por invaginação terminoterminal co... more Objetivo: Avaliar o colágeno tipo III na anastomose colocólica por invaginação terminoterminal comparado com a sutura manual contínua em plano único em cães. Métodos: Foram randomizados 60 cães e distribuídos em dois grupos de 30. No grupo controle, os animais foram submetidos à anastomose colocólica terminoterminal com sutura em plano único; e no grupo estudo fizeram-se anastomose por invaginação e suturas cardinais. No fim os animais foram submetidos à eutanásia (10 de cada grupo no sétimo dia do pós-operatório [DPO7] e 20 em DPO21) e o segmento anastomosado foi recuperado para estudos histológicos e imuno-histoquímicos. Os achados foram analisados com o teste t de Student. Resultados: No colágeno tipo III entre os grupos controle e estudo não houve diferença estatística com p = 0,2166 e p = 0,2712, respectivamente. No grupo estudo houve diferença significativa com predomínio do colágeno tipo III no sétimo DPO com um p = 0,003. Não ocorreram óbitos antes da eutanásia. Conclusão: N...
This review was based on a literature search of PubMed and Scielo databases using the keywords &a... more This review was based on a literature search of PubMed and Scielo databases using the keywords "quercetin, rutin, isoquercitrin, isoquercitin (IQ), quercetin-3-glucoside, bioavailability, flavonols and favonoids, and cancer" and combinations of all the words. We collected relevant scientific publications from 1990 to 2015 about the absorption, bioavailability, chemoprevention activity, and treatment effects as well as the underlying anticancer mechanisms of isoquercitin. Flavonoids are a group of polyphenolic compounds widely distributed throughout the plant kingdom. The subclass of flavonols receives special attention owing to their health benefits. The main components of this class are quercetin, rutin, and IQ, which is a flavonoid and although mostly found as a glycoside, is an aglycone (lacks a glycoside side chain). This compound presents similar therapeutic profiles to quercetin but with superior bioavailability, resulting in increased efficacy compared to the aglycone form. IQ has therapeutic applications owing to its wide range of pharmacological effects including antioxidant, antiproliferative, anti-inflammatory, anti-hypertensive, and anti-diabetic. The protective effects of IQ in cancer may be due to actions on lipid peroxidation. In addition, the antitumor effect of IQ and its underlying mechanism are related to interactions with Wnt signaling pathway, mixed-lineage protein kinase 3, mitogen-activated protein kinase, apoptotic pathways, as well proinflammatory protein signaling. This review contributed to clarifying the mechanisms of absorption, metabolism, and actions of IQ and isoquercitrin in cancer.
CNS & neurological disorders drug targets, Jan 20, 2017
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and Huntin... more Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and Huntington's disease, represent worldwide a major health problem with great financial impact. They are multifactorial diseases, hallmarked by similar pathogenesis that covers conditions such as oxidative stress, formation of free radicals, abnormal protein dynamics (degradation and aggregation), mitochondrial dysfunction, lipid peroxidation and cellular death or senescence. Flavonols are polyphenolic compounds, widely distributed in the plant kingdom and found in high concentrations in vegetables, fruits and teas. Their neuroprotective effects are mainly related to their antioxidant, anti-proliferative and anti-inflammatory properties. It was this paper's intention to contribute with an evidence analysis of recent studies approaching neuroprotective effects of flavonols and the potential to conduct human clinical studies.This paper was based on a literature search of PubMed and Scielo...
Objetivo: Avaliar o colágeno tipo III na anastomose colocólica por invaginação terminoterminal co... more Objetivo: Avaliar o colágeno tipo III na anastomose colocólica por invaginação terminoterminal comparado com a sutura manual contínua em plano único em cães. Métodos: Foram randomizados 60 cães e distribuídos em dois grupos de 30. No grupo controle, os animais foram submetidos à anastomose colocólica terminoterminal com sutura em plano único; e no grupo estudo fizeram-se anastomose por invaginação e suturas cardinais. No fim os animais foram submetidos à eutanásia (10 de cada grupo no sétimo dia do pós-operatório [DPO7] e 20 em DPO21) e o segmento anastomosado foi recuperado para estudos histológicos e imuno-histoquímicos. Os achados foram analisados com o teste t de Student. Resultados: No colágeno tipo III entre os grupos controle e estudo não houve diferença estatística com p = 0,2166 e p = 0,2712, respectivamente. No grupo estudo houve diferença significativa com predomínio do colágeno tipo III no sétimo DPO com um p = 0,003. Não ocorreram óbitos antes da eutanásia. Conclusão: N...
This review was based on a literature search of PubMed and Scielo databases using the keywords &a... more This review was based on a literature search of PubMed and Scielo databases using the keywords "quercetin, rutin, isoquercitrin, isoquercitin (IQ), quercetin-3-glucoside, bioavailability, flavonols and favonoids, and cancer" and combinations of all the words. We collected relevant scientific publications from 1990 to 2015 about the absorption, bioavailability, chemoprevention activity, and treatment effects as well as the underlying anticancer mechanisms of isoquercitin. Flavonoids are a group of polyphenolic compounds widely distributed throughout the plant kingdom. The subclass of flavonols receives special attention owing to their health benefits. The main components of this class are quercetin, rutin, and IQ, which is a flavonoid and although mostly found as a glycoside, is an aglycone (lacks a glycoside side chain). This compound presents similar therapeutic profiles to quercetin but with superior bioavailability, resulting in increased efficacy compared to the aglycone form. IQ has therapeutic applications owing to its wide range of pharmacological effects including antioxidant, antiproliferative, anti-inflammatory, anti-hypertensive, and anti-diabetic. The protective effects of IQ in cancer may be due to actions on lipid peroxidation. In addition, the antitumor effect of IQ and its underlying mechanism are related to interactions with Wnt signaling pathway, mixed-lineage protein kinase 3, mitogen-activated protein kinase, apoptotic pathways, as well proinflammatory protein signaling. This review contributed to clarifying the mechanisms of absorption, metabolism, and actions of IQ and isoquercitrin in cancer.
Uploads
Papers by Guilherme Orfali