Epileptic disorders : international epilepsy journal with videotape, 2016
Status epilepticus is a neurological emergency with significant morbidity and mortality. This stu... more Status epilepticus is a neurological emergency with significant morbidity and mortality. This study describes the clinical profile, treatment, and predictors of outcome of status epilepticus in a tertiary referral centre in a developing country and aims to highlight the similarities and differences from data available from the western world. A retrospective analysis of data of patients treated for status epilepticus was conducted from prospectively maintained records, between January 2000 and September 2010. The demographic data, clinical profile and investigations (including neuroimaging and EEG), aetiology, treatment, and outcomes were studied and compared with data available from the western world. The analysis included 108 events in 84 patients. A single episode of status epilepticus was treated in 72 patients (86%) and multiple status epilepticus events, ranging from two to six per patient, were managed in 12 patients (14%). Mean age was 24.1±20.3 years and 63% were males. The ...
To investigate the potential role of a simple insulin resistance index i.e. Homeostatic Model Ass... more To investigate the potential role of a simple insulin resistance index i.e. Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) in identifying insulin resistance in patients admitted with an acute coronary syndrome without diabetes mellitus and its effect on short term outcome on cardiovascular morbidity and mortality. Seventy non-diabetic patients with impaired fasting glucose admitted with a diagnosis of acute myocardial infarction and followed prospectively for a median of six months for outcomes. Admission fasting glucose and insulin concentrations were measured and from these values an Insulin Resistance index was calculated. During hospital course a high incidence of heart failure (11/;29 vs5/;41; p<0.05) and mortality (4/29 vs 1/41; p=0.152) was seen in patients with Index > 2 as compared to patients with Index <2, but mortality data failed to show any statistical significance because of small sample size. At six months patients with Index >2 had high incide...
Epileptic disorders : international epilepsy journal with videotape, 2011
Photoparoxysmal response (PPR) is commonly associated with idiopathic generalised epilepsies. Mos... more Photoparoxysmal response (PPR) is commonly associated with idiopathic generalised epilepsies. Most of the focal events induced by intermittent photic stimulation (IPS) are reported to be of occipital origin. Only six temporal lobe epilepsy patients have been reported in the literature with focal PPR at extraoccipital sites. We report a four-year-old girl with possible encephalitis who presented initially with epilepsia partialis continua of limbs on the right side. Interictally, she had left centro-parietal periodic lateralized epileptiform discharges (PLEDs). She responded to medical treatment and was free of seizures and motor and cognitive deficits at six months follow-up. Repeat EEG at follow-up showed left centro-parietal spikes accentuated by IPS. This is the first report of an extraoccipital, extratemporal focus showing PPR. The possible mechanism of PPR from this fronto-parietal epileptogenic focus is discussed.
To investigate the potential role of a simple insulin resistance index i.e. Homeostatic Model Ass... more To investigate the potential role of a simple insulin resistance index i.e. Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) in identifying insulin resistance in patients admitted with an acute coronary syndrome without diabetes mellitus and its effect on short term outcome on cardiovascular morbidity and mortality. Seventy non-diabetic patients with impaired fasting glucose admitted with a diagnosis of acute myocardial infarction and followed prospectively for a median of six months for outcomes. Admission fasting glucose and insulin concentrations were measured and from these values an Insulin Resistance index was calculated. During hospital course a high incidence of heart failure (11/;29 vs5/;41; p<0.05) and mortality (4/29 vs 1/41; p=0.152) was seen in patients with Index > 2 as compared to patients with Index <2, but mortality data failed to show any statistical significance because of small sample size. At six months patients with Index >2 had high incide...
Catatonia is associated with a variety of psychiatric and medical illnesses. Very little research... more Catatonia is associated with a variety of psychiatric and medical illnesses. Very little research is available on the syndrome and the exact neurobiological correlates are not known. Though various cortical and subcortical circuits are implicated in the pathogenesis, the role of cerebellum is unknown. We report an unusual presentation of herpes simplex encephalitis, clinically as catatonic stupor and radiologically as isolated symmetrical cerebellar involvement affecting the posterior cerebellum. We discuss the possible role of the cerebellum in producing a catatonic state. We describe the clinical presentation of catatonia in a 19-year-old woman with herpes simplex encephalitis. Her magnetic reasonance imaging showed features of viral cerebellitis involving the posterior cerebellum with hemorrhagic transformation. She lacked the classical frontotemporal involvement of herpes and recovered completely without physical or neuropsychological sequelae. She did not show signs associated with cerebellar disease at any point during the illness. This case provides compelling evidence for the possible role of the posterior cerebellum in the clinical presentation of catatonia. This is probably related to its role in controlling the nonmotor cerebral functions through corticocerebellar connections. Further studies of catatonic syndromes are needed to establish this association.
Epileptic disorders : international epilepsy journal with videotape, 2016
Status epilepticus is a neurological emergency with significant morbidity and mortality. This stu... more Status epilepticus is a neurological emergency with significant morbidity and mortality. This study describes the clinical profile, treatment, and predictors of outcome of status epilepticus in a tertiary referral centre in a developing country and aims to highlight the similarities and differences from data available from the western world. A retrospective analysis of data of patients treated for status epilepticus was conducted from prospectively maintained records, between January 2000 and September 2010. The demographic data, clinical profile and investigations (including neuroimaging and EEG), aetiology, treatment, and outcomes were studied and compared with data available from the western world. The analysis included 108 events in 84 patients. A single episode of status epilepticus was treated in 72 patients (86%) and multiple status epilepticus events, ranging from two to six per patient, were managed in 12 patients (14%). Mean age was 24.1±20.3 years and 63% were males. The ...
To investigate the potential role of a simple insulin resistance index i.e. Homeostatic Model Ass... more To investigate the potential role of a simple insulin resistance index i.e. Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) in identifying insulin resistance in patients admitted with an acute coronary syndrome without diabetes mellitus and its effect on short term outcome on cardiovascular morbidity and mortality. Seventy non-diabetic patients with impaired fasting glucose admitted with a diagnosis of acute myocardial infarction and followed prospectively for a median of six months for outcomes. Admission fasting glucose and insulin concentrations were measured and from these values an Insulin Resistance index was calculated. During hospital course a high incidence of heart failure (11/;29 vs5/;41; p<0.05) and mortality (4/29 vs 1/41; p=0.152) was seen in patients with Index > 2 as compared to patients with Index <2, but mortality data failed to show any statistical significance because of small sample size. At six months patients with Index >2 had high incide...
Epileptic disorders : international epilepsy journal with videotape, 2011
Photoparoxysmal response (PPR) is commonly associated with idiopathic generalised epilepsies. Mos... more Photoparoxysmal response (PPR) is commonly associated with idiopathic generalised epilepsies. Most of the focal events induced by intermittent photic stimulation (IPS) are reported to be of occipital origin. Only six temporal lobe epilepsy patients have been reported in the literature with focal PPR at extraoccipital sites. We report a four-year-old girl with possible encephalitis who presented initially with epilepsia partialis continua of limbs on the right side. Interictally, she had left centro-parietal periodic lateralized epileptiform discharges (PLEDs). She responded to medical treatment and was free of seizures and motor and cognitive deficits at six months follow-up. Repeat EEG at follow-up showed left centro-parietal spikes accentuated by IPS. This is the first report of an extraoccipital, extratemporal focus showing PPR. The possible mechanism of PPR from this fronto-parietal epileptogenic focus is discussed.
To investigate the potential role of a simple insulin resistance index i.e. Homeostatic Model Ass... more To investigate the potential role of a simple insulin resistance index i.e. Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) in identifying insulin resistance in patients admitted with an acute coronary syndrome without diabetes mellitus and its effect on short term outcome on cardiovascular morbidity and mortality. Seventy non-diabetic patients with impaired fasting glucose admitted with a diagnosis of acute myocardial infarction and followed prospectively for a median of six months for outcomes. Admission fasting glucose and insulin concentrations were measured and from these values an Insulin Resistance index was calculated. During hospital course a high incidence of heart failure (11/;29 vs5/;41; p<0.05) and mortality (4/29 vs 1/41; p=0.152) was seen in patients with Index > 2 as compared to patients with Index <2, but mortality data failed to show any statistical significance because of small sample size. At six months patients with Index >2 had high incide...
Catatonia is associated with a variety of psychiatric and medical illnesses. Very little research... more Catatonia is associated with a variety of psychiatric and medical illnesses. Very little research is available on the syndrome and the exact neurobiological correlates are not known. Though various cortical and subcortical circuits are implicated in the pathogenesis, the role of cerebellum is unknown. We report an unusual presentation of herpes simplex encephalitis, clinically as catatonic stupor and radiologically as isolated symmetrical cerebellar involvement affecting the posterior cerebellum. We discuss the possible role of the cerebellum in producing a catatonic state. We describe the clinical presentation of catatonia in a 19-year-old woman with herpes simplex encephalitis. Her magnetic reasonance imaging showed features of viral cerebellitis involving the posterior cerebellum with hemorrhagic transformation. She lacked the classical frontotemporal involvement of herpes and recovered completely without physical or neuropsychological sequelae. She did not show signs associated with cerebellar disease at any point during the illness. This case provides compelling evidence for the possible role of the posterior cerebellum in the clinical presentation of catatonia. This is probably related to its role in controlling the nonmotor cerebral functions through corticocerebellar connections. Further studies of catatonic syndromes are needed to establish this association.
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Papers by Haseeb Hassan