Aims. Lactate threshold (LT), a measure of exercise capacity, is the highest oxygen uptake during... more Aims. Lactate threshold (LT), a measure of exercise capacity, is the highest oxygen uptake during exercise without developing lactic acidosis. The Gold standard method for determining LT is to measure blood lactate concentration. It is reported that in exercise Saliva lactate can be measured non-invasively in lieu of blood lactate. Methods. This study was designed to determine whether measurement of Saliva lactate can be used as an alternative for blood lactate in the chemically injured. For this purpose, 17 patients were ...
One of the mains fights at the leather and footwear productive chain refers to the tributary poli... more One of the mains fights at the leather and footwear productive chain refers to the tributary policy on the exports of wet blue leather. In one hand, there are the Centre of the Tanagers Industries from Brazil (CICB) and the national makers of shoes and artifacts of leather that want the taxation. On the other hand, there are the Agriculture National Confederation (CNA) and the tanagers of wet blue that don’t want it. After a decision of the federal government, the extinction of the taxation from January of 2007 was established. This paper had like objective discusses the exportations of brazilian leather and any obstacles to the competitiveness of the chain and thus creates fundamentals for policies about this question. The numbers of exports of leather as in value as in quantities and the rate of exchange between 1999 and 2005 were used. Along this period, there is an improvement of exports of crust and finished leathers, as in value as in quantities, but this occurred, in true, di...
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015
Chronic obstructive pulmonary disease (COPD) is a heterogeneous and progressive inflammatory cond... more Chronic obstructive pulmonary disease (COPD) is a heterogeneous and progressive inflammatory condition that has been linked to the dysregulation of many metabolic pathways including lipid biosynthesis. How lipid metabolism could affect disease progression in smokers with COPD remains unclear. We cross-examined the transcriptomics, proteomics, metabolomics, and phenomics data available on the public domain to elucidate the mechanisms by which lipid metabolism is perturbed in COPD. We reconstructed a sputum lipid COPD (SpLiCO) signaling network utilizing active/inactive, and functional/dysfunctional lipid-mediated signaling pathways to explore how lipid-metabolism could promote COPD pathogenesis in smokers. SpLiCO was further utilized to investigate signal amplifiers, distributers, propagators, feed-forward and/or -back loops that link COPD disease severity and hypoxia to disruption in the metabolism of sphingolipids, fatty acids and energy. Also, hypergraph analysis and calculations for dependency of molecules identified several important nodes in the network with modular regulatory and signal distribution activities. Our systems-based analyses indicate that arachidonic acid is a critical and early signal distributer that is upregulated by the sphingolipid signaling pathway in COPD, while hypoxia plays a critical role in the elevated dependency to glucose as a major energy source. Integration of SpLiCo and clinical data shows a strong association between hypoxia and the upregulation of sphingolipids in smokers with emphysema, vascular disease, hypertension and those with increased risk of lung cancer.
Plasma proteomic profile of sulfur mustard exposed lung diseases patients using 2-dimensional gel... more Plasma proteomic profile of sulfur mustard exposed lung diseases patients using 2-dimensional gel electrophoresis
Background: Neurotransmitter release is an essential link in cell communication of the nervous sy... more Background: Neurotransmitter release is an essential link in cell communication of the nervous system. Many investigations have focused on gamma amino butyric acid (GABA)-ergic neurotransmission, because it has been implicated in the pathophysiology of several central nervous system disorders. To bypass complications related to homo-and heterosynaptic modulation and to avoid indirect interpretations of data, we herein describe a simple approach for direct measurement of GABA release.
Patients with diabetes mellitus (DM), experience significant morbidity and mortality from microva... more Patients with diabetes mellitus (DM), experience significant morbidity and mortality from microvascular retinopathy, nephropathy and neuropathy. Hyperglycemia can induce diabetic complications through multiple pathways. Activation of protein kinase C (PKC) by hyperglycemia is one of the pathways which causes diabetic complications. Effect of nifedipine (a calcium channel blocker), and polymyxine B sulphate (a Protein kinase C inhibitor) was studied in adult male Sprague- dawley rats, who was made diabetic with streptozotocin. PKC activity was determined in tissues and serum enzymes and metabolite level was measured in all controls, diabetic and drug treated animals. The results showed that, levels of the, urea (two –fold), creatinine (60%), triglyceride (two-fold) and liver alanine transaminase (ALT) activity (two-fold), were significantly increased in diabetic group. In nifedipine, treated diabetic group, although urea and creatinine level was increased, but liver enzymes were not ...
Accumulation of the amyloid protein (Aβ) in the brain is an important step in the pathogenesis of... more Accumulation of the amyloid protein (Aβ) in the brain is an important step in the pathogenesis of Alzheimer's disease. However, the mechanism by which Aβ exerts its neurotoxic effect is largely unknown. It has been suggested that the peptide can bind to the α7 nicotinic ...
Objective: The aim of present study was to determine the maximum oxygen uptake (VO 2 max) and max... more Objective: The aim of present study was to determine the maximum oxygen uptake (VO 2 max) and maximum heart rate (HR max) in chemically injured patients who had normal functional tests but suffer from exertional dyspenea, and to compare the data with predicted values. Materials and Methods: VO 2 max and HR max were measured in 19 chemically injured patients underwent the exercise test and then compared with predicted values. Results: Data showed that measured VO 2 max and HR max were significantly lower than ...
Iranian Journal of Pharmaceutical Research, Nov 20, 2010
Diethyl p-nitrophenyl phosphate (paraoxon) is the active toxic metabolite of parathion. Some evid... more Diethyl p-nitrophenyl phosphate (paraoxon) is the active toxic metabolite of parathion. Some evidences indicate that OPs affect the GABA system via noncholinergic mechanisms. The purpose of this study was to investigate the effects of paraoxon on K+-evoked [3H]-GABA release from cerebellar synaptosomes. Adult male rats (200±30 g; 3-4 months old) were sacrificed by decapitation and the cerebellum was removed immediately and homogenized. Homogenate was centrifuged twice at 1000× g for 5 min (all in 0-4? C). ...
Abstract: Renal ischemia-reperfusion (IR) injury is a common problem in kidney transplantation. T... more Abstract: Renal ischemia-reperfusion (IR) injury is a common problem in kidney transplantation. There is increasing evidence about the role of the reactive oxygen species (ROS) in these injuries and endogenous antioxidants seem to have an important role in decreasing the renal tissue injury. The aim of this study was to investigate the effects of kidney IR on renal antioxidant enzymes activity such as catalase and superoxide dismutase (SOD) and renal glutathione (GSH) levels. The level of malondialdehyde (MDA), an end ...
Aims. Lactate threshold (LT), a measure of exercise capacity, is the highest oxygen uptake during... more Aims. Lactate threshold (LT), a measure of exercise capacity, is the highest oxygen uptake during exercise without developing lactic acidosis. The Gold standard method for determining LT is to measure blood lactate concentration. It is reported that in exercise Saliva lactate can be measured non-invasively in lieu of blood lactate. Methods. This study was designed to determine whether measurement of Saliva lactate can be used as an alternative for blood lactate in the chemically injured. For this purpose, 17 patients were ...
One of the mains fights at the leather and footwear productive chain refers to the tributary poli... more One of the mains fights at the leather and footwear productive chain refers to the tributary policy on the exports of wet blue leather. In one hand, there are the Centre of the Tanagers Industries from Brazil (CICB) and the national makers of shoes and artifacts of leather that want the taxation. On the other hand, there are the Agriculture National Confederation (CNA) and the tanagers of wet blue that don’t want it. After a decision of the federal government, the extinction of the taxation from January of 2007 was established. This paper had like objective discusses the exportations of brazilian leather and any obstacles to the competitiveness of the chain and thus creates fundamentals for policies about this question. The numbers of exports of leather as in value as in quantities and the rate of exchange between 1999 and 2005 were used. Along this period, there is an improvement of exports of crust and finished leathers, as in value as in quantities, but this occurred, in true, di...
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015
Chronic obstructive pulmonary disease (COPD) is a heterogeneous and progressive inflammatory cond... more Chronic obstructive pulmonary disease (COPD) is a heterogeneous and progressive inflammatory condition that has been linked to the dysregulation of many metabolic pathways including lipid biosynthesis. How lipid metabolism could affect disease progression in smokers with COPD remains unclear. We cross-examined the transcriptomics, proteomics, metabolomics, and phenomics data available on the public domain to elucidate the mechanisms by which lipid metabolism is perturbed in COPD. We reconstructed a sputum lipid COPD (SpLiCO) signaling network utilizing active/inactive, and functional/dysfunctional lipid-mediated signaling pathways to explore how lipid-metabolism could promote COPD pathogenesis in smokers. SpLiCO was further utilized to investigate signal amplifiers, distributers, propagators, feed-forward and/or -back loops that link COPD disease severity and hypoxia to disruption in the metabolism of sphingolipids, fatty acids and energy. Also, hypergraph analysis and calculations for dependency of molecules identified several important nodes in the network with modular regulatory and signal distribution activities. Our systems-based analyses indicate that arachidonic acid is a critical and early signal distributer that is upregulated by the sphingolipid signaling pathway in COPD, while hypoxia plays a critical role in the elevated dependency to glucose as a major energy source. Integration of SpLiCo and clinical data shows a strong association between hypoxia and the upregulation of sphingolipids in smokers with emphysema, vascular disease, hypertension and those with increased risk of lung cancer.
Plasma proteomic profile of sulfur mustard exposed lung diseases patients using 2-dimensional gel... more Plasma proteomic profile of sulfur mustard exposed lung diseases patients using 2-dimensional gel electrophoresis
Background: Neurotransmitter release is an essential link in cell communication of the nervous sy... more Background: Neurotransmitter release is an essential link in cell communication of the nervous system. Many investigations have focused on gamma amino butyric acid (GABA)-ergic neurotransmission, because it has been implicated in the pathophysiology of several central nervous system disorders. To bypass complications related to homo-and heterosynaptic modulation and to avoid indirect interpretations of data, we herein describe a simple approach for direct measurement of GABA release.
Patients with diabetes mellitus (DM), experience significant morbidity and mortality from microva... more Patients with diabetes mellitus (DM), experience significant morbidity and mortality from microvascular retinopathy, nephropathy and neuropathy. Hyperglycemia can induce diabetic complications through multiple pathways. Activation of protein kinase C (PKC) by hyperglycemia is one of the pathways which causes diabetic complications. Effect of nifedipine (a calcium channel blocker), and polymyxine B sulphate (a Protein kinase C inhibitor) was studied in adult male Sprague- dawley rats, who was made diabetic with streptozotocin. PKC activity was determined in tissues and serum enzymes and metabolite level was measured in all controls, diabetic and drug treated animals. The results showed that, levels of the, urea (two –fold), creatinine (60%), triglyceride (two-fold) and liver alanine transaminase (ALT) activity (two-fold), were significantly increased in diabetic group. In nifedipine, treated diabetic group, although urea and creatinine level was increased, but liver enzymes were not ...
Accumulation of the amyloid protein (Aβ) in the brain is an important step in the pathogenesis of... more Accumulation of the amyloid protein (Aβ) in the brain is an important step in the pathogenesis of Alzheimer's disease. However, the mechanism by which Aβ exerts its neurotoxic effect is largely unknown. It has been suggested that the peptide can bind to the α7 nicotinic ...
Objective: The aim of present study was to determine the maximum oxygen uptake (VO 2 max) and max... more Objective: The aim of present study was to determine the maximum oxygen uptake (VO 2 max) and maximum heart rate (HR max) in chemically injured patients who had normal functional tests but suffer from exertional dyspenea, and to compare the data with predicted values. Materials and Methods: VO 2 max and HR max were measured in 19 chemically injured patients underwent the exercise test and then compared with predicted values. Results: Data showed that measured VO 2 max and HR max were significantly lower than ...
Iranian Journal of Pharmaceutical Research, Nov 20, 2010
Diethyl p-nitrophenyl phosphate (paraoxon) is the active toxic metabolite of parathion. Some evid... more Diethyl p-nitrophenyl phosphate (paraoxon) is the active toxic metabolite of parathion. Some evidences indicate that OPs affect the GABA system via noncholinergic mechanisms. The purpose of this study was to investigate the effects of paraoxon on K+-evoked [3H]-GABA release from cerebellar synaptosomes. Adult male rats (200±30 g; 3-4 months old) were sacrificed by decapitation and the cerebellum was removed immediately and homogenized. Homogenate was centrifuged twice at 1000× g for 5 min (all in 0-4? C). ...
Abstract: Renal ischemia-reperfusion (IR) injury is a common problem in kidney transplantation. T... more Abstract: Renal ischemia-reperfusion (IR) injury is a common problem in kidney transplantation. There is increasing evidence about the role of the reactive oxygen species (ROS) in these injuries and endogenous antioxidants seem to have an important role in decreasing the renal tissue injury. The aim of this study was to investigate the effects of kidney IR on renal antioxidant enzymes activity such as catalase and superoxide dismutase (SOD) and renal glutathione (GSH) levels. The level of malondialdehyde (MDA), an end ...
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