Introduction: To date, little is known about the clinical features of pediatric COVID-19 patients... more Introduction: To date, little is known about the clinical features of pediatric COVID-19 patients admitted to intensive care units (ICUs). Objective: Herein, we aimed to describe the differences in demographic characteristics, laboratory findings, clinical presentations, and outcomes of Iranian pediatric COVID-19 patients admitted to ICU versus those in non-ICU settings. Methods: This multicenter investigation involved 15 general and pediatrics hospitals and included cases with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection based on positive real-time reverse transcription polymerase chain reaction (RT-PCR) admitted to these centers between March and May 2020, during the initial peak of the COVID-19 pandemic in Iran. Results: Overall, 166 patients were included, 61 (36.7%) of whom required ICU admission. The highest number of admitted cases to ICU were in the age group of 1–5 years old. Malignancy and heart diseases were the most frequent underlying...
Journal of Advances in Medical Education & Professionalism, 2019
Introduction: Clinical reasoning as a critical and high level of clinical competency should be ac... more Introduction: Clinical reasoning as a critical and high level of clinical competency should be acquired during medical education, and medical educators should attempt to assess this ability in medical students. Nowadays, there are several ways to evaluate medical students’ clinical reasoning ability in different countries worldwide. There are some well-known clinical reasoning tests such as Key Feature (KF), Clinical Reasoning Problem (CRP), Script Concordance Test (SCT), and Comprehensive Integrative Puzzle (CIP). Each of these tests has its advantages and disadvantages. In this study, we evaluated the reliability of combination of clinical reasoning tests SCT, KF, CIP, and CRP in one national exam and the correlation between the subtest scores of these tests together with the total score of the exam. Methods: In this cross sectional study, a total number of 339 high ranked medical students from 60 medical schools in Iran participated in a national exam named “Medical Olympiad”. Th...
Background: Acute opium intoxication is one of the most common causes of poisoning in children in... more Background: Acute opium intoxication is one of the most common causes of poisoning in children in Iran. Although most cases are accidental, traditional misuse of opium for symptomatic therapy of various childhood diseases also contributes to high rate of opium intoxication in Iran. Cases: Here, we report two cases of opium intoxication in infants resulted from transdermal application of opium on burned skin. To our knowledge this is the first case report of intoxication from transdermal misuse of opium. Conclusion: Health care providers should be aware about signs and symptoms of opium intoxication in children. Opium intoxication should be suspected in each child with history of a recent burn injury that presented with decreased level of consciousness.
Objective: Timely detection of serious bacterial infections or prediction of sepsis and death is ... more Objective: Timely detection of serious bacterial infections or prediction of sepsis and death is of paramount importance in neutropenic patients especially in oncology settings. The aim of this study was to determine a rapid and secure predictor of sepsis in severe neutropenic cancer children. Methods: In addition to blood culture, we have evaluated serum soluble CD14 on this role and measured it in 39 neutropenic episodes in Mahak pediatric oncology center from September 2012 to January 2013. Fifteen episodes had positive bacterial cultures and 18 had fever. The mean sCD14 values were compared in the presence or absence of fever, positive blood culture and other clinical conditions. Also, mean levels compared in different white cell counts and different four combination settings of fever and blood culture. Findings: It was statistically higher in febrile episodes, in the presence of oral mucositis, indwelling catheter infection, otitis media, and post toxic epidermal necrolysis sep...
Background: AmpC β-lactamase enzymes cause multi-drug resistance. Aim and Objectives: The purpose... more Background: AmpC β-lactamase enzymes cause multi-drug resistance. Aim and Objectives: The purpose of this study is detection of AmpC enzymes in the isolated strains of E. coli and K. pneumoniae in three educational hospitals in Hamadan (Iran). Materials and Methods: One hundred and forty strains of E. coli and K. pneumoniae were isolated from the hospitals in Hamadan from March to September 2015. To detection of phenotypic AmpC activity, the AmpC detection disks were used. To detect genes encoding for AmpC PCR method was used. Results: Sixty eight isolates (48.5%) were resistant to third generation cephalosporin and of these 61 (43.5%) isolates had MIC 3 8 μg/mL to cefoxitin. All 68 isolates were analyzed by AmpC detection disks, of which 10 (7.14%) isolates were AmpCβ-lactamase producers. By PCR method, 24 (35.2%) isolates had cit and 48 (70.5%) were positive for fox, 42 (61.7%) for ebc, 46 (67.6%) for mox genes. None of the dha and acc genes were identified. Conclusion: High resis...
Objective The purpose of this study is to propose an innovative method of knowledge transfer that... more Objective The purpose of this study is to propose an innovative method of knowledge transfer that aims to improve health literacy about pediatric infectious diseases prevention in families. Children have an appreciable role in this scheme. Methods This study is a before and after trial that has been conducted in Hamedan in 2009. After changing seven infectious disease topics into childish poems, we selected five kindergartens randomly and taught these poetries to the children. Teaching process held after a pretest containing 24 questions that examined 103 of parents about mentioned topics. The same post-test was given after 4 months of teaching process. Findings The mean of correct answers to the pretest was 59.22% comparable with 81.00% for post-test (P<0.00). Gender and knowledge degree could not change the results significantly. Assuming one's correct answers to the questions as his/her Knowledge Mark, the mean of this variable increased to 5.32 by this method. Conclusion ...
Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences, 2012
Sir Amblyopia is an acquired visual impairment that can be attributed to the effect of any struct... more Sir Amblyopia is an acquired visual impairment that can be attributed to the effect of any structural abnormality of eye during childhood.[1,2,3] The prevalence of amblyopia varies from 2% to 4% in general population. Since visual pathways evolve during the 5th and 6th years of life, visual reduction will remain for whole life if it is not detected and treated during early childhood;[4,5,6] whereas the treatment will be successful if the visual impairment is detected in this time. Therefore, all screening and preventive services should be provided during early childhood. Visual defects screening program and management of visual disorders are among the most important health services worldwide. In Iran, public health nurses in kindergartens and preschool centers conduct this program. In addition, Welfare Organization annually recalls all children aged 3-6 years for screening of visual disorders.[7] The purpose of the present study was to evaluate the accuracy of the screening tests us...
Dear Editor; We read with interest the Iranikhah et al's article entitled “Stool Antigen Test... more Dear Editor; We read with interest the Iranikhah et al's article entitled “Stool Antigen Tests for the Detection of Helicobacter Pylori in Children” in the second issue of 2013 of Iran J Pediatr [1]. The authors have well reported an interesting investigation about the detection of bacterial antigens in stool for diagnosis of Helicobacter pylori in children. Also they appropriately used endoscopy and biopsy as a gold standard test for validation of the H. pylori infection and statistical indices are calculated accordingly. In the study, sensitivity, specificity, positive and negative likelihood ratios for H. pylori stool antigen was reported to be 85%, 93%, 89.7%, and 90% respectively, while 89.7%, and 90% are not likelihood ratios, they are positive and negative predictive values. There are some notices which should be considered before using these indices. The studies which mean to evaluate diagnostic tests or methods (as above mentioned Iranikhah et al's article) usually ...
Objective(s): Pseudomonas aeruginosa and Acinetobacter baumannii resist antibiotics by different ... more Objective(s): Pseudomonas aeruginosa and Acinetobacter baumannii resist antibiotics by different intrinsic and acquired mechanisms. This study aims to define various carbapenem-resistant mechanisms of isolated P. aeruginosa and A. baumannii from nine different provinces of Iran. Materials and Methods: In this cross-sectional study, all carbapenem-resistant P. aeruginosa and A. baumannii samples from nine provinces of Iran on a one-year time horizon were gathered. Modified Hedge Test (MHT) and Carba NP-Test were applied to the identification of producing-carbapenemase strains. The most important carbapenemase genes recognized by PCR and gene overexpression of the efflux pump were surveyed by efflux pump inhibitors (EPIs) and confirmed by Real-Time PCR. Results: Twenty-one percent and 43.5% of P. aeruginosa and A. baumannii isolates were resistant to carbapenem, respectively. MHT and Carba-NP tests identified 21% and 11% carbapenemase-producing strains in these Gram-negative bacteria,...
Background: Many problems in the diagnosis of patients with suspected appendicitis have led to th... more Background: Many problems in the diagnosis of patients with suspected appendicitis have led to the design of clinical scoring systems. In children, diagnostics tools for appendicitis are more critical. Younger patients, diagnostic challenges become more. Practical scoring systems are useful without any particular material and necessitate novel ability. Objectives: However, in spite of the reported outstanding consequences, these scoring systems are not employed regularly. Methods: In this cross-sectional study performed from October 2016 to October 2017, ten provinces out of the 31 provinces in Iran were randomly selected. A total of 631 patients referring to the hospitals with the suspicion of acute appendicitis were assessed. Related variables such as age, sex, right lower quadrant (RLQ) pain, migration of pain to RLQ, nausea, and presence of vomiting, anorexia, tenderness in RLQ and guarding, presence of rebound tenderness, and degree of fever were taken from recorded files by pe...
Background: To date, less is known about the clinical features of COVID-19 pediatric patients adm... more Background: To date, less is known about the clinical features of COVID-19 pediatric patients admitting to ICUs. Herein, we aimed to describe the differences in demographic characteristics, laboratory findings, clinical presentations, and outcomes between COVID-19 pediatric patients admitting to ICU and non-ICU settings.Methods: This multicenter study involved 15 general and pediatrics hospitals on confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by positive real-time reverse transcription polymerase chain reaction (RT-PCR) between March 19 and May 31, 2020, during the initial peak of the COVID-19 pandemic in Iran.Results: Overall, 166 patients were included, of which 61 (36.7%) required ICU admission, especially in <5 years old age group. Malignancy and heart diseases were the most frequent underlying condition. There was significant decrease in platelet counts, PH, HCO3 and base excess as well as increases in creatinine, creatine phosphokinase an...
Objective: Methicillin resistant staphylococcus aureus (MRSA) is a frequent cause of infections i... more Objective: Methicillin resistant staphylococcus aureus (MRSA) is a frequent cause of infections in children. The purpose of this study was to determine the frequency of nasal colonization of S. aureus in children and detection of inducible clindamycin resistance (ICR) by disk approximation test (D‐test). Methods: This was a cross‐sectional study conducted in Hamedan from 2007 to 2008. 520 nasal swabs were obtained from children under 12 years of age at the time of admission and 287 swabs at the time of discharge. Antibiogram was performed by method of disk diffusion for oxacillin, erythromycin, clindamycin, cefazolin and vancomycin as well as D‐test. Chi‐square test was applied for statistical analysis. Findings: Out of 520 patients, 118 (22.3%) were colonized with S. aureus as community‐ acquired (CA‐S. aureus). Of 287 patients, 64 (22.3%) were colonized with isolates of S. aureus at discharge time. Of these 64 patients, 32 cases were colonized with hospital acquired (HA‐S. aureus)...
Introduction: Myiasis is a parasitic infestation of the body by fly larvae. The common hosts of t... more Introduction: Myiasis is a parasitic infestation of the body by fly larvae. The common hosts of this larva are the animals, but in some cases it can also affect the human, which is rarely reported in children and commonly found in tropical and developing countries. Case Presentation: This study, presents a case of cutaneous myiasis in an infant. A 11-month-old girl with popular lesion on buccal area, she does not response to the initial anti-bacterial therapies and progress the buccal cellulitis. Retrieval of three larvae from the lesion led to definitive diagnosis of Calliphora vicina (Diptera: Calliphoridae) larvae infestation and treatment by occlusive ointment, resulted in complete cure. Conclusions: The myiasis is an uncommon disease in Iran and physicians should be aware of this disease, especially if there are nonhealing lesions on exposed skin and worm-like protruding lesion.
Background : Pertussis is a highly communicable, vaccine-preventable respiratory disease; which m... more Background : Pertussis is a highly communicable, vaccine-preventable respiratory disease; which may circulate even in populations with high vaccination coverage. Although frequent, but it is often underestimated as a cause of prolonged cough illness in both children and adults. Without boosting, the protection of the childhood vaccination would be minimal after 10 years. The need for adult booster vaccination depends on the national epidemiology. Objectives: The aim of this study was to evaluate the seroepidemiological incidence of Pertussis in fresh college students in four majors. Patients and Methods: In a cross sectional multicenter study, blood samples were obtained from 1617 junior students of four universities. None had received Pertussis booster vaccine in the preceding 10 years. Serum immunoglobulin G (IgG) antibody for Pertussis toxin antigen was measured. Some social and demographic determinants including age, sex and number of family members were recorded. Results: The m...
1Department of Pediatrics, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, ... more 1Department of Pediatrics, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran 2Department of Pediatrics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IR Iran *Corresponding author: Iraj Sedighi, Department of Pediatrics, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran. Tel: +98-8112640081, Fax: +98-8112640016, E-mail: sedighi@umsha.ac.ir
Endocrine, Metabolic & Immune Disorders - Drug Targets
Background: Severe congenital neutropenia (SCN4) caused by mutations in glucose-6- phosphatase ca... more Background: Severe congenital neutropenia (SCN4) caused by mutations in glucose-6- phosphatase catalytic subunit 3 (G6PC3) is characterized by recurrent infections due to severe neutropenia, may be accompanied by other extra-hematopoietic manifestations; including structural heart defects, urogenital abnormalities, prominent superficial venous markings, growth retention, and inflammatory bowel diseases with rare incidence. The homozygous or compound heterozygous mutations of G6PC3 are responsible for most cases of autosomal recessive SCN4. Herein, we present two cases of SCN4 affected by novel mutations in the G6PC3, in addition to a summarized list of variants in G6PC3 gene that are reported as pathogenic and related to the SCN4 phenotype. Case presentation: Herein, we present two cases of SCN4; the first case was a three-months old boy with severe neutropenia and prior history of hospitalization due to umbilical separation, umbilical herniation, omphalitis, and pyelonephritis; and...
Introduction: To date, little is known about the clinical features of pediatric COVID-19 patients... more Introduction: To date, little is known about the clinical features of pediatric COVID-19 patients admitted to intensive care units (ICUs). Objective: Herein, we aimed to describe the differences in demographic characteristics, laboratory findings, clinical presentations, and outcomes of Iranian pediatric COVID-19 patients admitted to ICU versus those in non-ICU settings. Methods: This multicenter investigation involved 15 general and pediatrics hospitals and included cases with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection based on positive real-time reverse transcription polymerase chain reaction (RT-PCR) admitted to these centers between March and May 2020, during the initial peak of the COVID-19 pandemic in Iran. Results: Overall, 166 patients were included, 61 (36.7%) of whom required ICU admission. The highest number of admitted cases to ICU were in the age group of 1–5 years old. Malignancy and heart diseases were the most frequent underlying...
Journal of Advances in Medical Education & Professionalism, 2019
Introduction: Clinical reasoning as a critical and high level of clinical competency should be ac... more Introduction: Clinical reasoning as a critical and high level of clinical competency should be acquired during medical education, and medical educators should attempt to assess this ability in medical students. Nowadays, there are several ways to evaluate medical students’ clinical reasoning ability in different countries worldwide. There are some well-known clinical reasoning tests such as Key Feature (KF), Clinical Reasoning Problem (CRP), Script Concordance Test (SCT), and Comprehensive Integrative Puzzle (CIP). Each of these tests has its advantages and disadvantages. In this study, we evaluated the reliability of combination of clinical reasoning tests SCT, KF, CIP, and CRP in one national exam and the correlation between the subtest scores of these tests together with the total score of the exam. Methods: In this cross sectional study, a total number of 339 high ranked medical students from 60 medical schools in Iran participated in a national exam named “Medical Olympiad”. Th...
Background: Acute opium intoxication is one of the most common causes of poisoning in children in... more Background: Acute opium intoxication is one of the most common causes of poisoning in children in Iran. Although most cases are accidental, traditional misuse of opium for symptomatic therapy of various childhood diseases also contributes to high rate of opium intoxication in Iran. Cases: Here, we report two cases of opium intoxication in infants resulted from transdermal application of opium on burned skin. To our knowledge this is the first case report of intoxication from transdermal misuse of opium. Conclusion: Health care providers should be aware about signs and symptoms of opium intoxication in children. Opium intoxication should be suspected in each child with history of a recent burn injury that presented with decreased level of consciousness.
Objective: Timely detection of serious bacterial infections or prediction of sepsis and death is ... more Objective: Timely detection of serious bacterial infections or prediction of sepsis and death is of paramount importance in neutropenic patients especially in oncology settings. The aim of this study was to determine a rapid and secure predictor of sepsis in severe neutropenic cancer children. Methods: In addition to blood culture, we have evaluated serum soluble CD14 on this role and measured it in 39 neutropenic episodes in Mahak pediatric oncology center from September 2012 to January 2013. Fifteen episodes had positive bacterial cultures and 18 had fever. The mean sCD14 values were compared in the presence or absence of fever, positive blood culture and other clinical conditions. Also, mean levels compared in different white cell counts and different four combination settings of fever and blood culture. Findings: It was statistically higher in febrile episodes, in the presence of oral mucositis, indwelling catheter infection, otitis media, and post toxic epidermal necrolysis sep...
Background: AmpC β-lactamase enzymes cause multi-drug resistance. Aim and Objectives: The purpose... more Background: AmpC β-lactamase enzymes cause multi-drug resistance. Aim and Objectives: The purpose of this study is detection of AmpC enzymes in the isolated strains of E. coli and K. pneumoniae in three educational hospitals in Hamadan (Iran). Materials and Methods: One hundred and forty strains of E. coli and K. pneumoniae were isolated from the hospitals in Hamadan from March to September 2015. To detection of phenotypic AmpC activity, the AmpC detection disks were used. To detect genes encoding for AmpC PCR method was used. Results: Sixty eight isolates (48.5%) were resistant to third generation cephalosporin and of these 61 (43.5%) isolates had MIC 3 8 μg/mL to cefoxitin. All 68 isolates were analyzed by AmpC detection disks, of which 10 (7.14%) isolates were AmpCβ-lactamase producers. By PCR method, 24 (35.2%) isolates had cit and 48 (70.5%) were positive for fox, 42 (61.7%) for ebc, 46 (67.6%) for mox genes. None of the dha and acc genes were identified. Conclusion: High resis...
Objective The purpose of this study is to propose an innovative method of knowledge transfer that... more Objective The purpose of this study is to propose an innovative method of knowledge transfer that aims to improve health literacy about pediatric infectious diseases prevention in families. Children have an appreciable role in this scheme. Methods This study is a before and after trial that has been conducted in Hamedan in 2009. After changing seven infectious disease topics into childish poems, we selected five kindergartens randomly and taught these poetries to the children. Teaching process held after a pretest containing 24 questions that examined 103 of parents about mentioned topics. The same post-test was given after 4 months of teaching process. Findings The mean of correct answers to the pretest was 59.22% comparable with 81.00% for post-test (P<0.00). Gender and knowledge degree could not change the results significantly. Assuming one's correct answers to the questions as his/her Knowledge Mark, the mean of this variable increased to 5.32 by this method. Conclusion ...
Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences, 2012
Sir Amblyopia is an acquired visual impairment that can be attributed to the effect of any struct... more Sir Amblyopia is an acquired visual impairment that can be attributed to the effect of any structural abnormality of eye during childhood.[1,2,3] The prevalence of amblyopia varies from 2% to 4% in general population. Since visual pathways evolve during the 5th and 6th years of life, visual reduction will remain for whole life if it is not detected and treated during early childhood;[4,5,6] whereas the treatment will be successful if the visual impairment is detected in this time. Therefore, all screening and preventive services should be provided during early childhood. Visual defects screening program and management of visual disorders are among the most important health services worldwide. In Iran, public health nurses in kindergartens and preschool centers conduct this program. In addition, Welfare Organization annually recalls all children aged 3-6 years for screening of visual disorders.[7] The purpose of the present study was to evaluate the accuracy of the screening tests us...
Dear Editor; We read with interest the Iranikhah et al's article entitled “Stool Antigen Test... more Dear Editor; We read with interest the Iranikhah et al's article entitled “Stool Antigen Tests for the Detection of Helicobacter Pylori in Children” in the second issue of 2013 of Iran J Pediatr [1]. The authors have well reported an interesting investigation about the detection of bacterial antigens in stool for diagnosis of Helicobacter pylori in children. Also they appropriately used endoscopy and biopsy as a gold standard test for validation of the H. pylori infection and statistical indices are calculated accordingly. In the study, sensitivity, specificity, positive and negative likelihood ratios for H. pylori stool antigen was reported to be 85%, 93%, 89.7%, and 90% respectively, while 89.7%, and 90% are not likelihood ratios, they are positive and negative predictive values. There are some notices which should be considered before using these indices. The studies which mean to evaluate diagnostic tests or methods (as above mentioned Iranikhah et al's article) usually ...
Objective(s): Pseudomonas aeruginosa and Acinetobacter baumannii resist antibiotics by different ... more Objective(s): Pseudomonas aeruginosa and Acinetobacter baumannii resist antibiotics by different intrinsic and acquired mechanisms. This study aims to define various carbapenem-resistant mechanisms of isolated P. aeruginosa and A. baumannii from nine different provinces of Iran. Materials and Methods: In this cross-sectional study, all carbapenem-resistant P. aeruginosa and A. baumannii samples from nine provinces of Iran on a one-year time horizon were gathered. Modified Hedge Test (MHT) and Carba NP-Test were applied to the identification of producing-carbapenemase strains. The most important carbapenemase genes recognized by PCR and gene overexpression of the efflux pump were surveyed by efflux pump inhibitors (EPIs) and confirmed by Real-Time PCR. Results: Twenty-one percent and 43.5% of P. aeruginosa and A. baumannii isolates were resistant to carbapenem, respectively. MHT and Carba-NP tests identified 21% and 11% carbapenemase-producing strains in these Gram-negative bacteria,...
Background: Many problems in the diagnosis of patients with suspected appendicitis have led to th... more Background: Many problems in the diagnosis of patients with suspected appendicitis have led to the design of clinical scoring systems. In children, diagnostics tools for appendicitis are more critical. Younger patients, diagnostic challenges become more. Practical scoring systems are useful without any particular material and necessitate novel ability. Objectives: However, in spite of the reported outstanding consequences, these scoring systems are not employed regularly. Methods: In this cross-sectional study performed from October 2016 to October 2017, ten provinces out of the 31 provinces in Iran were randomly selected. A total of 631 patients referring to the hospitals with the suspicion of acute appendicitis were assessed. Related variables such as age, sex, right lower quadrant (RLQ) pain, migration of pain to RLQ, nausea, and presence of vomiting, anorexia, tenderness in RLQ and guarding, presence of rebound tenderness, and degree of fever were taken from recorded files by pe...
Background: To date, less is known about the clinical features of COVID-19 pediatric patients adm... more Background: To date, less is known about the clinical features of COVID-19 pediatric patients admitting to ICUs. Herein, we aimed to describe the differences in demographic characteristics, laboratory findings, clinical presentations, and outcomes between COVID-19 pediatric patients admitting to ICU and non-ICU settings.Methods: This multicenter study involved 15 general and pediatrics hospitals on confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by positive real-time reverse transcription polymerase chain reaction (RT-PCR) between March 19 and May 31, 2020, during the initial peak of the COVID-19 pandemic in Iran.Results: Overall, 166 patients were included, of which 61 (36.7%) required ICU admission, especially in <5 years old age group. Malignancy and heart diseases were the most frequent underlying condition. There was significant decrease in platelet counts, PH, HCO3 and base excess as well as increases in creatinine, creatine phosphokinase an...
Objective: Methicillin resistant staphylococcus aureus (MRSA) is a frequent cause of infections i... more Objective: Methicillin resistant staphylococcus aureus (MRSA) is a frequent cause of infections in children. The purpose of this study was to determine the frequency of nasal colonization of S. aureus in children and detection of inducible clindamycin resistance (ICR) by disk approximation test (D‐test). Methods: This was a cross‐sectional study conducted in Hamedan from 2007 to 2008. 520 nasal swabs were obtained from children under 12 years of age at the time of admission and 287 swabs at the time of discharge. Antibiogram was performed by method of disk diffusion for oxacillin, erythromycin, clindamycin, cefazolin and vancomycin as well as D‐test. Chi‐square test was applied for statistical analysis. Findings: Out of 520 patients, 118 (22.3%) were colonized with S. aureus as community‐ acquired (CA‐S. aureus). Of 287 patients, 64 (22.3%) were colonized with isolates of S. aureus at discharge time. Of these 64 patients, 32 cases were colonized with hospital acquired (HA‐S. aureus)...
Introduction: Myiasis is a parasitic infestation of the body by fly larvae. The common hosts of t... more Introduction: Myiasis is a parasitic infestation of the body by fly larvae. The common hosts of this larva are the animals, but in some cases it can also affect the human, which is rarely reported in children and commonly found in tropical and developing countries. Case Presentation: This study, presents a case of cutaneous myiasis in an infant. A 11-month-old girl with popular lesion on buccal area, she does not response to the initial anti-bacterial therapies and progress the buccal cellulitis. Retrieval of three larvae from the lesion led to definitive diagnosis of Calliphora vicina (Diptera: Calliphoridae) larvae infestation and treatment by occlusive ointment, resulted in complete cure. Conclusions: The myiasis is an uncommon disease in Iran and physicians should be aware of this disease, especially if there are nonhealing lesions on exposed skin and worm-like protruding lesion.
Background : Pertussis is a highly communicable, vaccine-preventable respiratory disease; which m... more Background : Pertussis is a highly communicable, vaccine-preventable respiratory disease; which may circulate even in populations with high vaccination coverage. Although frequent, but it is often underestimated as a cause of prolonged cough illness in both children and adults. Without boosting, the protection of the childhood vaccination would be minimal after 10 years. The need for adult booster vaccination depends on the national epidemiology. Objectives: The aim of this study was to evaluate the seroepidemiological incidence of Pertussis in fresh college students in four majors. Patients and Methods: In a cross sectional multicenter study, blood samples were obtained from 1617 junior students of four universities. None had received Pertussis booster vaccine in the preceding 10 years. Serum immunoglobulin G (IgG) antibody for Pertussis toxin antigen was measured. Some social and demographic determinants including age, sex and number of family members were recorded. Results: The m...
1Department of Pediatrics, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, ... more 1Department of Pediatrics, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran 2Department of Pediatrics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IR Iran *Corresponding author: Iraj Sedighi, Department of Pediatrics, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran. Tel: +98-8112640081, Fax: +98-8112640016, E-mail: sedighi@umsha.ac.ir
Endocrine, Metabolic & Immune Disorders - Drug Targets
Background: Severe congenital neutropenia (SCN4) caused by mutations in glucose-6- phosphatase ca... more Background: Severe congenital neutropenia (SCN4) caused by mutations in glucose-6- phosphatase catalytic subunit 3 (G6PC3) is characterized by recurrent infections due to severe neutropenia, may be accompanied by other extra-hematopoietic manifestations; including structural heart defects, urogenital abnormalities, prominent superficial venous markings, growth retention, and inflammatory bowel diseases with rare incidence. The homozygous or compound heterozygous mutations of G6PC3 are responsible for most cases of autosomal recessive SCN4. Herein, we present two cases of SCN4 affected by novel mutations in the G6PC3, in addition to a summarized list of variants in G6PC3 gene that are reported as pathogenic and related to the SCN4 phenotype. Case presentation: Herein, we present two cases of SCN4; the first case was a three-months old boy with severe neutropenia and prior history of hospitalization due to umbilical separation, umbilical herniation, omphalitis, and pyelonephritis; and...
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