Multiple sclerosis is a chronic, immune-mediated disease of the central nervous system that typic... more Multiple sclerosis is a chronic, immune-mediated disease of the central nervous system that typically strikes young adults. It is often associated with a wide range of functional deficits and progressive disability. Common symptoms of multiple sclerosis include vision problems, spasticity, weakness, ataxia, bladder and bowel dysfunctions, fatigue, pain syndromes, tremors, vertigo, cognitive impairment, and mood disorders. Multiple sclerosis has a major negative impact on patient health-related quality of life (HRQoL). Quality of life (QoL) is a multidimensional construct composed of functional, physical, emotional, social and spiritual well-being. Researches have reported that individuals with multiple sclerosis have lower QoL than non-diseased and diseased populations. The inclusion of HRQoL questionnaires in the patient follow-up is a relevant issue to optimize treatment, facilitate treatment decisions and improve adherence, as well as to reduce the inconveniences derived from medication such as side effects.
Multiple sclerosis (MS) is a chronic demyelinating neurologic disorder that mainly affects young ... more Multiple sclerosis (MS) is a chronic demyelinating neurologic disorder that mainly affects young individuals (aged 20 to 50 years). Approximately 85% of patients experience an initial course with relapses and remissions (relapsing-remitting multiple sclerosis). Guidelines for the management of MS should be focused on three main areas: (a) the diagnosis of MS; (b) treatment of relapses; and (c) long-term preventive treatment including clinical follow up, dose adjustment, drug switch, control of therapeutic efficacy, and disease progression. Diagnosis should be established according to clinical and paraclinical criteria. Discussion on therapeutic recommendations is focused on the disease-modifying agents in acute phases and drugs for long-term treatment and symptomatic treatment. Differential diagnoses must be taken into account on making the diagnosis of MS. Therefore, diagnosis of MS should be established on clinical and radiological diagnostic criteria, cerebrospinal fluid analysis and evoked potentials.
Background: Transcranial color-coded sonography (TCCS) is used for evaluation of the vertebrobasi... more Background: Transcranial color-coded sonography (TCCS) is used for evaluation of the vertebrobasilar (VB) system. In most indviduals the origin of the basilar artery (BA) can not be visualised due to unfavourable angle of the vertebral arteries (VA) junction or unfavourable angle of insonation. All three vessels can be rarely visualised at the same time. Three-dimensional ultrasound (3D US) enables reconstruction from transcranial power Doppler (PD) imaging of the VB system. Methods: We tried to display the 3D images of the intracranial parts of the VA and BA. Interactive 3D imaging software was integrated into an ultrasound platform (Aloka Prosound 5500). Data aquisition was performed using 2, 5 MHz sector transducer, freehanded in a fixed length of time (10 seconds), allowing PD sonography. The images were postprocessed (TomTec imaging system). 12 patients were investigated in order to visualise all three vessels at the time, and to calculate the angle between each pair of vessels...
Introduction: In our previous studies we showed that three-dimensional ultrasound (3D US) reconst... more Introduction: In our previous studies we showed that three-dimensional ultrasound (3D US) reconstuction of images from Transcranial color-coded sonography (TCCS) and power Doppler imaging is very usefull in evaluation of the vertebrobasilar (VB) system. In most indviduals the origin of the basilar artery (BA) can not be visualised due to unfavourable angle of the vertebral arteries (VA) junction or unfavourable angle of insonation. In such cases 3D US enables mathematically reconstruction of the VB junction. The aim of this study was to calculate the angle of VB junction by means of 3D US and applie it into the vector analisys of the VB junction hemodinamics. Patients and methods: We tried to display the 3D images of the intracranial parts of the VA and BA. Interactive 3D imaging software was integrated into an ultrasound platform (Aloka Prosound 5500). Data aquisition was performed using 2, 5 MHz sector transducer, freehanded in a fixed length of time (10 seconds), allowing Power D...
Spontana disekcija karotidne arterija može biti uzrok moždanog udara u mlađih osoba. Prikaz pacij... more Spontana disekcija karotidne arterija može biti uzrok moždanog udara u mlađih osoba. Prikaz pacijenta kod kojeg se nakon bolova u desnoj strani vrata javljaju koreaticne kretnje lijeve ruke.
Cerebrospinal fluid (CSF) is a promising clinical sample for identification of novel biomarkers f... more Cerebrospinal fluid (CSF) is a promising clinical sample for identification of novel biomarkers for various neurological disorders. Considering its direct contact with brain tissue, CSF represents a valuable source of brain-related and brain-specific proteins. Multiple sclerosis is an inflammatory, demyelinating neurological disease affecting the central nervous system and so far there are no diagnostic or prognostic disease specific biomarkers available in the clinic. The primary aim of the present study was to develop a targeted mass spectrometry assay for simultaneous quantification of 30 brain-related proteins in CSF and subsequently to demonstrate assay feasibility in neurological samples derived from multiple sclerosis patients. Our multiplex selected reaction monitoring assay had wide dynamic range (median fold range across peptides = 8.16x103), and high assay reproducibility (median across peptides CV=4%). Candidate biomarkers were quantified in CSF samples from neurological...
Multiple sclerosis is a chronic, immune-mediated disease of the central nervous system that typic... more Multiple sclerosis is a chronic, immune-mediated disease of the central nervous system that typically strikes young adults. It is often associated with a wide range of functional deficits and progressive disability. Common symptoms of multiple sclerosis include vision problems, spasticity, weakness, ataxia, bladder and bowel dysfunctions, fatigue, pain syndromes, tremors, vertigo, cognitive impairment, and mood disorders. Multiple sclerosis has a major negative impact on patient health-related quality of life (HRQoL). Quality of life (QoL) is a multidimensional construct composed of functional, physical, emotional, social and spiritual well-being. Researches have reported that individuals with multiple sclerosis have lower QoL than non-diseased and diseased populations. The inclusion of HRQoL questionnaires in the patient follow-up is a relevant issue to optimize treatment, facilitate treatment decisions and improve adherence, as well as to reduce the inconveniences derived from medication such as side effects.
Multiple sclerosis (MS) is a chronic demyelinating neurologic disorder that mainly affects young ... more Multiple sclerosis (MS) is a chronic demyelinating neurologic disorder that mainly affects young individuals (aged 20 to 50 years). Approximately 85% of patients experience an initial course with relapses and remissions (relapsing-remitting multiple sclerosis). Guidelines for the management of MS should be focused on three main areas: (a) the diagnosis of MS; (b) treatment of relapses; and (c) long-term preventive treatment including clinical follow up, dose adjustment, drug switch, control of therapeutic efficacy, and disease progression. Diagnosis should be established according to clinical and paraclinical criteria. Discussion on therapeutic recommendations is focused on the disease-modifying agents in acute phases and drugs for long-term treatment and symptomatic treatment. Differential diagnoses must be taken into account on making the diagnosis of MS. Therefore, diagnosis of MS should be established on clinical and radiological diagnostic criteria, cerebrospinal fluid analysis and evoked potentials.
Background: Transcranial color-coded sonography (TCCS) is used for evaluation of the vertebrobasi... more Background: Transcranial color-coded sonography (TCCS) is used for evaluation of the vertebrobasilar (VB) system. In most indviduals the origin of the basilar artery (BA) can not be visualised due to unfavourable angle of the vertebral arteries (VA) junction or unfavourable angle of insonation. All three vessels can be rarely visualised at the same time. Three-dimensional ultrasound (3D US) enables reconstruction from transcranial power Doppler (PD) imaging of the VB system. Methods: We tried to display the 3D images of the intracranial parts of the VA and BA. Interactive 3D imaging software was integrated into an ultrasound platform (Aloka Prosound 5500). Data aquisition was performed using 2, 5 MHz sector transducer, freehanded in a fixed length of time (10 seconds), allowing PD sonography. The images were postprocessed (TomTec imaging system). 12 patients were investigated in order to visualise all three vessels at the time, and to calculate the angle between each pair of vessels...
Introduction: In our previous studies we showed that three-dimensional ultrasound (3D US) reconst... more Introduction: In our previous studies we showed that three-dimensional ultrasound (3D US) reconstuction of images from Transcranial color-coded sonography (TCCS) and power Doppler imaging is very usefull in evaluation of the vertebrobasilar (VB) system. In most indviduals the origin of the basilar artery (BA) can not be visualised due to unfavourable angle of the vertebral arteries (VA) junction or unfavourable angle of insonation. In such cases 3D US enables mathematically reconstruction of the VB junction. The aim of this study was to calculate the angle of VB junction by means of 3D US and applie it into the vector analisys of the VB junction hemodinamics. Patients and methods: We tried to display the 3D images of the intracranial parts of the VA and BA. Interactive 3D imaging software was integrated into an ultrasound platform (Aloka Prosound 5500). Data aquisition was performed using 2, 5 MHz sector transducer, freehanded in a fixed length of time (10 seconds), allowing Power D...
Spontana disekcija karotidne arterija može biti uzrok moždanog udara u mlađih osoba. Prikaz pacij... more Spontana disekcija karotidne arterija može biti uzrok moždanog udara u mlađih osoba. Prikaz pacijenta kod kojeg se nakon bolova u desnoj strani vrata javljaju koreaticne kretnje lijeve ruke.
Cerebrospinal fluid (CSF) is a promising clinical sample for identification of novel biomarkers f... more Cerebrospinal fluid (CSF) is a promising clinical sample for identification of novel biomarkers for various neurological disorders. Considering its direct contact with brain tissue, CSF represents a valuable source of brain-related and brain-specific proteins. Multiple sclerosis is an inflammatory, demyelinating neurological disease affecting the central nervous system and so far there are no diagnostic or prognostic disease specific biomarkers available in the clinic. The primary aim of the present study was to develop a targeted mass spectrometry assay for simultaneous quantification of 30 brain-related proteins in CSF and subsequently to demonstrate assay feasibility in neurological samples derived from multiple sclerosis patients. Our multiplex selected reaction monitoring assay had wide dynamic range (median fold range across peptides = 8.16x103), and high assay reproducibility (median across peptides CV=4%). Candidate biomarkers were quantified in CSF samples from neurological...
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