Artificial Cells, Blood Substitutes and Biotechnology, 1997
Scarce availability and risk of transmission of infections and diseases (HIV, hepatitis B, Chagas... more Scarce availability and risk of transmission of infections and diseases (HIV, hepatitis B, Chagas' disease) limit the use and benefits of homologous blood transfusions for surgical purposes. Recent trials of perfluorocarbon-based hemosubstitutes (PFC-HSs) in experimental cardiopulmonary bypass (CPB) have demonstrated their ability to improve brain oxygenation, as compared with conventional crystalloid priming solutions. The objective of the project described here is to test different formulations of PFC-HSs and optimize their formulation and dosage for use in CPB. The project includes: (1) study the feasibility of implementing a laboratory for small scale production of PFC-HSs; (2) evaluate the efficacy of use of PFC-HSs in an animal model of CPB; and (3) evaluate the safety of use of PFC-HSs in an animal model of hemorrhagic shock. Several in-house PFC-HSs and outside PFC-HSs are being evaluated. The current state of the project is: (1) the feasibility study has been completed and several PFCs, emulsifiers and surfactants are being tested; (2) and (3) the animal models have been implemented are being used to test in-house and outside PFC-HSs as priming solutions in CPB and reinfusion fluids in hemorrhagic shock respectively. Some preliminary results are presented.
Standard jackknife confidence intervals for a quantile Q y (β) are usually preferred to confidenc... more Standard jackknife confidence intervals for a quantile Q y (β) are usually preferred to confidence intervals based on analytical variance estimators due to their operational simplicity. However, the standard jackknife confidence intervals can give undesirable coverage probabilities for small samples sizes and large or small values of β. In this paper confidence intervals for a population quantile based on several existing estimators of a quantile are derived. These intervals are based on an approximation for the cumulative distribution function of a studentized quantile estimator. Confidence intervals are empirically evaluated by using real data and some applications are illustrated. Results derived from simulation studies show that proposed confidence intervals are narrower than confidence intervals based on the standard jackknife technique, which assumes normal approximation. Proposed confidence intervals also achieve coverage probabilities above to their nominal level. This study indicates that the proposed method can be an alternative to the asymptotic confidence intervals, which can be unknown in practice, and the standard jackknife confidence intervals, which can have poor coverage probabilities and give wider intervals.
Artificial Cells, Blood Substitutes and Biotechnology, 1997
Scarce availability and risk of transmission of infections and diseases (HIV, hepatitis B, Chagas... more Scarce availability and risk of transmission of infections and diseases (HIV, hepatitis B, Chagas' disease) limit the use and benefits of homologous blood transfusions for surgical purposes. Recent trials of perfluorocarbon-based hemosubstitutes (PFC-HSs) in experimental cardiopulmonary bypass (CPB) have demonstrated their ability to improve brain oxygenation, as compared with conventional crystalloid priming solutions. The objective of the project described here is to test different formulations of PFC-HSs and optimize their formulation and dosage for use in CPB. The project includes: (1) study the feasibility of implementing a laboratory for small scale production of PFC-HSs; (2) evaluate the efficacy of use of PFC-HSs in an animal model of CPB; and (3) evaluate the safety of use of PFC-HSs in an animal model of hemorrhagic shock. Several in-house PFC-HSs and outside PFC-HSs are being evaluated. The current state of the project is: (1) the feasibility study has been completed and several PFCs, emulsifiers and surfactants are being tested; (2) and (3) the animal models have been implemented are being used to test in-house and outside PFC-HSs as priming solutions in CPB and reinfusion fluids in hemorrhagic shock respectively. Some preliminary results are presented.
Standard jackknife confidence intervals for a quantile Q y (β) are usually preferred to confidenc... more Standard jackknife confidence intervals for a quantile Q y (β) are usually preferred to confidence intervals based on analytical variance estimators due to their operational simplicity. However, the standard jackknife confidence intervals can give undesirable coverage probabilities for small samples sizes and large or small values of β. In this paper confidence intervals for a population quantile based on several existing estimators of a quantile are derived. These intervals are based on an approximation for the cumulative distribution function of a studentized quantile estimator. Confidence intervals are empirically evaluated by using real data and some applications are illustrated. Results derived from simulation studies show that proposed confidence intervals are narrower than confidence intervals based on the standard jackknife technique, which assumes normal approximation. Proposed confidence intervals also achieve coverage probabilities above to their nominal level. This study indicates that the proposed method can be an alternative to the asymptotic confidence intervals, which can be unknown in practice, and the standard jackknife confidence intervals, which can have poor coverage probabilities and give wider intervals.
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Papers by Ismael Arcos