espanol?Que se entiende por ascetismo?; ?Que interpretamos por moralidad?; ?Que comprendemos por ... more espanol?Que se entiende por ascetismo?; ?Que interpretamos por moralidad?; ?Que comprendemos por sexualidad? Son prerrogativas filosoficas que se abordan a partir de una reflexion de pensadores de gran peso en occidente; esta articulacion filosofica se sostiene en las ideas de dos grandes hombres F. Nietzsche y A. Schopenhauer. EnglishWhat is meant by asceticism? What do we interpret for morality? What do we understand for sexuality? They are philosophical prerogatives addressed from reflections of heavyweight thinkers in the West; this philosophical joint is held in the ideas of two great men F. Nietzsche and A. Schopenhauer.
Asymmetric Weyl semimetals, which possess an inherently chiral structure, have different energies... more Asymmetric Weyl semimetals, which possess an inherently chiral structure, have different energies and dispersion relations for left- and right-handed fermions. They exhibit certain effects not found in symmetric Weyl semimetals, such as the quantized circular photogalvanic effect and the helical magnetic effect. In this work, we derive the conditions required for breaking chiral symmetry by applying an external field in symmetric Weyl semimetals. We explicitly demonstrate that in certain materials with the ${T}_{d}$ point group, magnetic fields along low symmetry directions break the symmetry between left- and right-handed fermions; the symmetry breaking can be tuned by changing the direction and magnitude of the magnetic field. In some cases, we find an imbalance between the number of type I left- and right-handed Weyl cones (which is compensated by the number of type II cones of each chirality).
The long triumph of asceticism. Resumen ?Que se entiende por ascetismo?; ?Que interpretamos por m... more The long triumph of asceticism. Resumen ?Que se entiende por ascetismo?; ?Que interpretamos por moralidad?; ?Que comprendemos por sexualidad? Son prerrogativas filosoficas que se abordan a partir de una reflexion de pensadores de gran peso en occidente; esta articulacion filosofica se sostiene en las ideas de dos grandes hombres F. Nietzsche y A. Schopenhauer. Palabras clave: Ascetismo, genealogia, moral, etica, metafisica, Schopenhauer. Abstract What is meant by asceticism? What do we interpret for morality? What do we understand for sexuality? They are philosophical prerogatives addressed from reflections of heavyweight thinkers in the West; this philosophical joint is held in the ideas of two great men F. Nietzsche and A. Schopenhauer. Key words: Asceticism, genealogy, morality, ethics, metaphysics, Schopenhauer.
INI1/hSNF5/SMARCB1/BAF47 is an HIV-specific integrase (IN)-binding protein that influences HIV-1 ... more INI1/hSNF5/SMARCB1/BAF47 is an HIV-specific integrase (IN)-binding protein that influences HIV-1 transcription and particle production. INI1 binds to SAP18 (Sin3a-associated protein, 18 kDa), and both INI1 and SAP18 are incorporated into HIV-1 virions. To determine the significance of INI1 and the INI1-SAP18 interaction during HIV-1 replication, we isolated a panel of SAP18-interaction-defective (SID)-INI1 mutants using a yeast reverse two-hybrid screen. The SID-INI1 mutants, which retained the ability to bind to IN, cMYC, and INI1 but were impaired for binding to SAP18, were tested for their effects on HIV-1 particle production. SID-INI1 dramatically reduced the intracellular Gag/Gag-Pol protein levels and, in addition, decreased viral particle production. The SID-INI1-mediated effects were less dramatic in trans complementation assays using IN deletion mutant viruses with Vpr-reverse transcriptase (RT)-IN. SID-INI1 did not inhibit long-terminal-repeat (LTR)-mediated transcription,...
En esta tesina se va a proponer un nuevo metodo de dimensionamiento mediante el cual se consigan ... more En esta tesina se va a proponer un nuevo metodo de dimensionamiento mediante el cual se consigan soluciones mas optimas atendiendo a criterios de ELS Fisuracion. Para ello, se va a usar como base el modelo empleado para dimensionamiento mediante pretensado parcial en elementos unidireccionales, que es el Diagrama de Magnel. Se va a modificar el comportamiento de las inecuaciones de Magnel, de manera que el Diagrama se convierta en una solucion de cuatro curvas en lugar de cuatro rectas. De esta manera, se tiene en cuenta la cantidad de armadura pasiva que se dispone en la losa, creando soluciones mas ajustadas para la armadura activa. Mediante este metodo, el valor de la fuerza de pretensado P para anclar la armadura activa se vera reducido, disminuyendo asi el area de pretensado necesaria para soportar las cargas en la losa, lo que dara lugar a una disminucion en el coste de la misma.
INI1/hSNF5 is an HIV-1 integrase (IN) binding protein specifically incorporated into virions. A t... more INI1/hSNF5 is an HIV-1 integrase (IN) binding protein specifically incorporated into virions. A truncated mutant of INI1 (S6, amino acids 183 to 294) harboring the minimal IN binding Rpt1 domain potently inhibits HIV-1 particle production in a transdominant manner. The inhibition requires interaction of S6 with IN within Gag-Pol. While INI1 is a nuclear protein and harbors a masked nuclear export signal (NES), the transdominant negative mutant S6 is cytoplasmic, due to the unmasking of NES. Here, we examined the effects of subcellular localization of S6 on HIV-1 inhibition and further investigated the stages of assembly that are affected. We found that targeting a nuclear localization signal-containing S6 variant [NLS-S6(Rpt1)] to the nucleoplasm (but not to the nucleolus) resulted in complete reversal of inhibition of particle production. Electron microscopy indicated that although no electron-dense particles at any stage of assembly were seen in cells expressing S6, virions were p...
Determining the wavefunction that describes the fractional quantum Hall state at $\nu$ = 5/2 rema... more Determining the wavefunction that describes the fractional quantum Hall state at $\nu$ = 5/2 remains an unresolved question. Two main candidates are the Pfaffian and anti-Pfaffian states. A major difference between the two is the chirality of their neutral Majorana ...
espanol?Que se entiende por ascetismo?; ?Que interpretamos por moralidad?; ?Que comprendemos por ... more espanol?Que se entiende por ascetismo?; ?Que interpretamos por moralidad?; ?Que comprendemos por sexualidad? Son prerrogativas filosoficas que se abordan a partir de una reflexion de pensadores de gran peso en occidente; esta articulacion filosofica se sostiene en las ideas de dos grandes hombres F. Nietzsche y A. Schopenhauer. EnglishWhat is meant by asceticism? What do we interpret for morality? What do we understand for sexuality? They are philosophical prerogatives addressed from reflections of heavyweight thinkers in the West; this philosophical joint is held in the ideas of two great men F. Nietzsche and A. Schopenhauer.
Asymmetric Weyl semimetals, which possess an inherently chiral structure, have different energies... more Asymmetric Weyl semimetals, which possess an inherently chiral structure, have different energies and dispersion relations for left- and right-handed fermions. They exhibit certain effects not found in symmetric Weyl semimetals, such as the quantized circular photogalvanic effect and the helical magnetic effect. In this work, we derive the conditions required for breaking chiral symmetry by applying an external field in symmetric Weyl semimetals. We explicitly demonstrate that in certain materials with the ${T}_{d}$ point group, magnetic fields along low symmetry directions break the symmetry between left- and right-handed fermions; the symmetry breaking can be tuned by changing the direction and magnitude of the magnetic field. In some cases, we find an imbalance between the number of type I left- and right-handed Weyl cones (which is compensated by the number of type II cones of each chirality).
The long triumph of asceticism. Resumen ?Que se entiende por ascetismo?; ?Que interpretamos por m... more The long triumph of asceticism. Resumen ?Que se entiende por ascetismo?; ?Que interpretamos por moralidad?; ?Que comprendemos por sexualidad? Son prerrogativas filosoficas que se abordan a partir de una reflexion de pensadores de gran peso en occidente; esta articulacion filosofica se sostiene en las ideas de dos grandes hombres F. Nietzsche y A. Schopenhauer. Palabras clave: Ascetismo, genealogia, moral, etica, metafisica, Schopenhauer. Abstract What is meant by asceticism? What do we interpret for morality? What do we understand for sexuality? They are philosophical prerogatives addressed from reflections of heavyweight thinkers in the West; this philosophical joint is held in the ideas of two great men F. Nietzsche and A. Schopenhauer. Key words: Asceticism, genealogy, morality, ethics, metaphysics, Schopenhauer.
INI1/hSNF5/SMARCB1/BAF47 is an HIV-specific integrase (IN)-binding protein that influences HIV-1 ... more INI1/hSNF5/SMARCB1/BAF47 is an HIV-specific integrase (IN)-binding protein that influences HIV-1 transcription and particle production. INI1 binds to SAP18 (Sin3a-associated protein, 18 kDa), and both INI1 and SAP18 are incorporated into HIV-1 virions. To determine the significance of INI1 and the INI1-SAP18 interaction during HIV-1 replication, we isolated a panel of SAP18-interaction-defective (SID)-INI1 mutants using a yeast reverse two-hybrid screen. The SID-INI1 mutants, which retained the ability to bind to IN, cMYC, and INI1 but were impaired for binding to SAP18, were tested for their effects on HIV-1 particle production. SID-INI1 dramatically reduced the intracellular Gag/Gag-Pol protein levels and, in addition, decreased viral particle production. The SID-INI1-mediated effects were less dramatic in trans complementation assays using IN deletion mutant viruses with Vpr-reverse transcriptase (RT)-IN. SID-INI1 did not inhibit long-terminal-repeat (LTR)-mediated transcription,...
En esta tesina se va a proponer un nuevo metodo de dimensionamiento mediante el cual se consigan ... more En esta tesina se va a proponer un nuevo metodo de dimensionamiento mediante el cual se consigan soluciones mas optimas atendiendo a criterios de ELS Fisuracion. Para ello, se va a usar como base el modelo empleado para dimensionamiento mediante pretensado parcial en elementos unidireccionales, que es el Diagrama de Magnel. Se va a modificar el comportamiento de las inecuaciones de Magnel, de manera que el Diagrama se convierta en una solucion de cuatro curvas en lugar de cuatro rectas. De esta manera, se tiene en cuenta la cantidad de armadura pasiva que se dispone en la losa, creando soluciones mas ajustadas para la armadura activa. Mediante este metodo, el valor de la fuerza de pretensado P para anclar la armadura activa se vera reducido, disminuyendo asi el area de pretensado necesaria para soportar las cargas en la losa, lo que dara lugar a una disminucion en el coste de la misma.
INI1/hSNF5 is an HIV-1 integrase (IN) binding protein specifically incorporated into virions. A t... more INI1/hSNF5 is an HIV-1 integrase (IN) binding protein specifically incorporated into virions. A truncated mutant of INI1 (S6, amino acids 183 to 294) harboring the minimal IN binding Rpt1 domain potently inhibits HIV-1 particle production in a transdominant manner. The inhibition requires interaction of S6 with IN within Gag-Pol. While INI1 is a nuclear protein and harbors a masked nuclear export signal (NES), the transdominant negative mutant S6 is cytoplasmic, due to the unmasking of NES. Here, we examined the effects of subcellular localization of S6 on HIV-1 inhibition and further investigated the stages of assembly that are affected. We found that targeting a nuclear localization signal-containing S6 variant [NLS-S6(Rpt1)] to the nucleoplasm (but not to the nucleolus) resulted in complete reversal of inhibition of particle production. Electron microscopy indicated that although no electron-dense particles at any stage of assembly were seen in cells expressing S6, virions were p...
Determining the wavefunction that describes the fractional quantum Hall state at $\nu$ = 5/2 rema... more Determining the wavefunction that describes the fractional quantum Hall state at $\nu$ = 5/2 remains an unresolved question. Two main candidates are the Pfaffian and anti-Pfaffian states. A major difference between the two is the chirality of their neutral Majorana ...
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