The present invention is a process wherein sulfide production by bacteria is efficiently turned o... more The present invention is a process wherein sulfide production by bacteria is efficiently turned on and off, using pH adjustment. The adjustment of pH impacts sulfide production by bacteria by altering the relative amounts of H.sub.2 S and HS-- in solution and thereby control the inhibition of the bacterial metabolism that produces sulfide. This process can be used to make
Tank 241-T-102 (hereafter referred to as T-102) is a 530,000 gallon single-shell waste tank locat... more Tank 241-T-102 (hereafter referred to as T-102) is a 530,000 gallon single-shell waste tank located in the 200 West T Tank farm at the Hanford Site. In 1993, two cores were taken from this tank and analysis of the cores was conducted by Battelle`s 325-A Laboratory. Characterization of the waste in this tank was conducted to support Hanford Federal Facility
A system and a process for producing selected isotopic daughter products from parent materials ch... more A system and a process for producing selected isotopic daughter products from parent materials characterized by the steps of loading the parent material upon a sorbent having a functional group configured to selectively bind the parent material under designated conditions, generating the selected isotopic daughter products, and eluting said selected isotopic daughter products from the sorbent. In one embodiment, the process also includes the step of passing an eluent formed by the elution step through a second sorbent material that is configured to remove a preselected material from said eluent. In some applications a passage of the material through a third sorbent material after passage through the second sorbent material is also performed.
The present invention is a process wherein sulfide production by bacteria is efficiently turned o... more The present invention is a process wherein sulfide production by bacteria is efficiently turned on and off, using pH adjustment. The adjustment of pH impacts sulfide production by bacteria by altering the relative amounts of H.sub.2 S and HS-- in solution and thereby control the inhibition of the bacterial metabolism that produces sulfide. This process can be used to make
Biomedical Sensing, Imaging, and Tracking Technologies I, 1996
The goal of our work is two fold: (1) to develop a portable rapid laser based breath analyzer for... more The goal of our work is two fold: (1) to develop a portable rapid laser based breath analyzer for monitoring metabolic processes, and (2) predict these metabolic processes through physiologically based pharmacokinetic (PBPK) modeling. Small infrared active molecules such as ammonia, carbon monoxide, carbon dioxide, methane and ethane are present in exhaled breath and can be readily detected by laser absorption spectroscopy. In addition, many of the stable isotopomers of these molecules can be accurately detected, making it possible to follow specific metabolic processes. Potential areas of applications for this technology include the diagnosis of certain pathologies (e.g. Helicobacter Pylori infection), detection of trauma due to either physical or chemical causes and monitoring nutrient uptake (i.e., malnutrition). In order to understand the origin and elucidate the metabolic processes associated with these small molecules, we are employing physiologically based pharmacokinetic (PBPK) models. A PBPK model is founded on known physiological processes (i.e., blood flow rates, tissue volumes, breathing rate, etc.), chemical-specific processes (i.e., tissue solubility coefficients, molecular weight, chemical density, etc.), and on metabolic processes (tissue site and rate of metabolic biotransformation). Since many of these processes are well understood, a PBPK model can be developed and validated against the more readily available experimental animal data, and then by extrapolating the parameters to apply to man, the model can predict chemical behavior in humans.
One of the concerns expressed by the External Flowsheet Review Team (EFRT) is about the potential... more One of the concerns expressed by the External Flowsheet Review Team (EFRT) is about the potential for pipe plugging at the Waste Treatment and Immobilization Plant (WTP). Per the review's executive summary, Piping that transports slurries will plug unless it is properly designed ...
Prepared for the US Department of Energy under Contract DE-AC05-76RL01830 ... AP Poloski F Nigl H... more Prepared for the US Department of Energy under Contract DE-AC05-76RL01830 ... AP Poloski F Nigl HE Adkins MJ Minette J Abrefah JJ Toth AM Casella JM Tingey RE Hohimer ST Yokuda ... AP Poloski F Nigl HE Adkins MJ Minette J Abrefah JJ Toth AM Casella JM Tingey RE ...
This document records the data quality objectives (DQO) process applied to the Ferrocyanide Safet... more This document records the data quality objectives (DQO) process applied to the Ferrocyanide Safety Issue at the Hanford Site. Specifically, the major recommendations and findings from this Ferrocyanide DQO process are presented. The decision logic diagrams and decision error tolerances also are provided. The document includes the DQO sample-size formulas for determining specific tank sampling requirements, and many of the
The present invention is a process wherein sulfide production by bacteria is efficiently turned o... more The present invention is a process wherein sulfide production by bacteria is efficiently turned on and off, using pH adjustment. The adjustment of pH impacts sulfide production by bacteria by altering the relative amounts of H.sub.2 S and HS-- in solution and thereby control the inhibition of the bacterial metabolism that produces sulfide. This process can be used to make
Tank 241-T-102 (hereafter referred to as T-102) is a 530,000 gallon single-shell waste tank locat... more Tank 241-T-102 (hereafter referred to as T-102) is a 530,000 gallon single-shell waste tank located in the 200 West T Tank farm at the Hanford Site. In 1993, two cores were taken from this tank and analysis of the cores was conducted by Battelle`s 325-A Laboratory. Characterization of the waste in this tank was conducted to support Hanford Federal Facility
A system and a process for producing selected isotopic daughter products from parent materials ch... more A system and a process for producing selected isotopic daughter products from parent materials characterized by the steps of loading the parent material upon a sorbent having a functional group configured to selectively bind the parent material under designated conditions, generating the selected isotopic daughter products, and eluting said selected isotopic daughter products from the sorbent. In one embodiment, the process also includes the step of passing an eluent formed by the elution step through a second sorbent material that is configured to remove a preselected material from said eluent. In some applications a passage of the material through a third sorbent material after passage through the second sorbent material is also performed.
The present invention is a process wherein sulfide production by bacteria is efficiently turned o... more The present invention is a process wherein sulfide production by bacteria is efficiently turned on and off, using pH adjustment. The adjustment of pH impacts sulfide production by bacteria by altering the relative amounts of H.sub.2 S and HS-- in solution and thereby control the inhibition of the bacterial metabolism that produces sulfide. This process can be used to make
Biomedical Sensing, Imaging, and Tracking Technologies I, 1996
The goal of our work is two fold: (1) to develop a portable rapid laser based breath analyzer for... more The goal of our work is two fold: (1) to develop a portable rapid laser based breath analyzer for monitoring metabolic processes, and (2) predict these metabolic processes through physiologically based pharmacokinetic (PBPK) modeling. Small infrared active molecules such as ammonia, carbon monoxide, carbon dioxide, methane and ethane are present in exhaled breath and can be readily detected by laser absorption spectroscopy. In addition, many of the stable isotopomers of these molecules can be accurately detected, making it possible to follow specific metabolic processes. Potential areas of applications for this technology include the diagnosis of certain pathologies (e.g. Helicobacter Pylori infection), detection of trauma due to either physical or chemical causes and monitoring nutrient uptake (i.e., malnutrition). In order to understand the origin and elucidate the metabolic processes associated with these small molecules, we are employing physiologically based pharmacokinetic (PBPK) models. A PBPK model is founded on known physiological processes (i.e., blood flow rates, tissue volumes, breathing rate, etc.), chemical-specific processes (i.e., tissue solubility coefficients, molecular weight, chemical density, etc.), and on metabolic processes (tissue site and rate of metabolic biotransformation). Since many of these processes are well understood, a PBPK model can be developed and validated against the more readily available experimental animal data, and then by extrapolating the parameters to apply to man, the model can predict chemical behavior in humans.
One of the concerns expressed by the External Flowsheet Review Team (EFRT) is about the potential... more One of the concerns expressed by the External Flowsheet Review Team (EFRT) is about the potential for pipe plugging at the Waste Treatment and Immobilization Plant (WTP). Per the review's executive summary, Piping that transports slurries will plug unless it is properly designed ...
Prepared for the US Department of Energy under Contract DE-AC05-76RL01830 ... AP Poloski F Nigl H... more Prepared for the US Department of Energy under Contract DE-AC05-76RL01830 ... AP Poloski F Nigl HE Adkins MJ Minette J Abrefah JJ Toth AM Casella JM Tingey RE Hohimer ST Yokuda ... AP Poloski F Nigl HE Adkins MJ Minette J Abrefah JJ Toth AM Casella JM Tingey RE ...
This document records the data quality objectives (DQO) process applied to the Ferrocyanide Safet... more This document records the data quality objectives (DQO) process applied to the Ferrocyanide Safety Issue at the Hanford Site. Specifically, the major recommendations and findings from this Ferrocyanide DQO process are presented. The decision logic diagrams and decision error tolerances also are provided. The document includes the DQO sample-size formulas for determining specific tank sampling requirements, and many of the
Uploads
Papers by James Toth