Fototransistor merupakan salah satu komponen yang berfungsi sebagai detektor cahaya yang dapat me... more Fototransistor merupakan salah satu komponen yang berfungsi sebagai detektor cahaya yang dapat mengubah efek cahaya menjadi sinyal listrik. Air yang keruh akan menyebabkan intensitas cahaya yang masuk kedalamnya berkurang. Dengan demikian tingkat kekeruhan air dapat dideteksi dengan alat pengukur intensitas cahaya seperti fototransistor dan LED inframerah sebagai sumber cahaya. Sistem yang telah dirancang bangun terdiri dari mikrokontroler AT89S51 sebagai pemroses data dan ADC digunakan untuk mengkonversi sinyal analog ke digital. Alat ini digunakan sebagai sistem pengontrol dengan keluarannya berupa alarm. Tegangan acuan yang dipakai agar alarm berbunyi adalah 1,656 volt. Pengujian sistem dilakukan dengan mendeteksi perubahan tingkat kekeruhan air pada sampel air minum kemasan, air PDAM, air sungai dan air kopi. Hasil yang diperoleh adalah semakin tinggi tingkat kekeruhan air atau semakin keruh air, maka tegangan keluaran sensor juga semakin tinggi.
Molecular data from 8 SSR regions of Euterpe edulis species used for estimate the dispersal kerne... more Molecular data from 8 SSR regions of Euterpe edulis species used for estimate the dispersal kernel of the species.
Neste trabalho, temos por objetivo verificar como ocorre o fenomeno da referenciacao em producoes... more Neste trabalho, temos por objetivo verificar como ocorre o fenomeno da referenciacao em producoes textuais de discentes do 3o ano do ensino medio regular, escritas no genero discursivo artigo de opiniao. Utilizaremos a Linguistica Textual como aporte teorico acerca do processo da referenciacao. Selecionamos, para tal analise, quatro producoes textuais, as quais apresentam inadequacoes quanto ao emprego de referentes. Os resultados apontam para a necessidade de se trabalhar mais o conceito de referenciacao em sala de aula. PALAVRAS-CHAVE: Referenciacao. Artigo de opiniao. Linguistica textual.
Consideramos que as pesquisas sobre multimodalidade ganham cada vez mais espaço dentro dos estudo... more Consideramos que as pesquisas sobre multimodalidade ganham cada vez mais espaço dentro dos estudos linguísticos, de modo que os aspectos imagéticos são essenciais para a construção dos significados, na qual a imagem atua como elemento semiótico cada vez mais relevante. Neste artigo, analisamos as relações multimodais envolvidas na constituição dos sentidos veiculados pela construção e propagação de estereótipos femininos em edições do calendário Campari. Para isso, amostras de imagens de três edições do calendário de 2015, 2016 e 2017, são analisadas. Nas análises, focalizamos as relações multimodais utilizando os preceitos da Teoria da Multimodalidade (KRESS; VAN LEEUWEN, 2001; KRESS, 2010) e explorando as categorias da Gramática do Design Visual (KRESS; VAN LEEUWEN, 2006). Os resultados revelaram que as relações multimodais carregam uma representação feminina aparentemente menos estereotipada dentro da mídia, criando superficialmente a imagem de que há um desligamento de alguns ...
1009 Background: Genomically-informed cancer therapy linking therapeutics targeting the molecular... more 1009 Background: Genomically-informed cancer therapy linking therapeutics targeting the molecular alterations driving the malignancy has the potential to transform the care of patients with metastatic breast cancer (MBC). Methods: DNA was isolated from 4 FFPE sections cut at 10 microns from 177 consecutive MBC that had relapsed after surgery, conventional hormonal/chemo and anti-HER2 targeted therapies received by our CLIA lab (Foundation Medicine). DNA sequencing was performed for 3,320 exons of 182 cancer-related genes to average depth of 1017X. Actionable Genomic alterations (GA) were defined as those linked to targeted anti-cancer therapies approved or being evaluated in active registered clinical trials. Results: Genomic profiles were generated from 169/177 (95%) BCs identifying 565 GA, averaging 3.34 GAs per tumor (range 0 to 10). 152 (90%) tumors harbored an actionable alteration mean 1.88 per tumor (range 0 to 6). In 124 (73%) tumors, ≥1.0 actionable GA was detected that wou...
5591Background: IO holds promise for EA with mismatch repair (MMR) or MSI-H phenotype, while tria... more 5591Background: IO holds promise for EA with mismatch repair (MMR) or MSI-H phenotype, while trials of targeted agents matched by histology/single biomarkers have yet to meet clinical endpoints. We...
11519Background: Carcinoma of unknown primary (CUP) has a poor prognosis and accounts for diagnos... more 11519Background: Carcinoma of unknown primary (CUP) has a poor prognosis and accounts for diagnoses in > 30,000 patients annually in the United States. Current tissue of origin (TOO) methods use pr...
Background: The survival of mantle cell lymphoma (MCL) has improved (median OS now >5 years) d... more Background: The survival of mantle cell lymphoma (MCL) has improved (median OS now >5 years) due to the use of dose-intensive strategies in younger patients (pts) achieving a deeper and earlier response (including molecular CR) and the application of novel therapies in the relapsed/refractory setting, where patients are typically chemoresistant. However, given the median age at onset in the mid to late 60's, and the remaining variability in outcomes, additional strategies are needed. A number of prognostic factors have been reported in MCL including MIPI, Ki67 and blastoid variants among others, the latter being frequently associated with del 17p or p53 mutations and a particularly poor outcome. Recent studies have begun to describe the genomic landscape of MCL by whole-genome, whole-exome and targeted sequencing. However, comprehensive evaluation of genomic alterations relevant for MCL pathogenesis and that could be potentially informative for patient's prognosis and pat...
Background The implementation of chemoimmunotherapy (R-CHOP) has dramatically improved the outcom... more Background The implementation of chemoimmunotherapy (R-CHOP) has dramatically improved the outcome of B-cell NHL particularly DLBCL…
Background: AITL is a rare mature T-cell lymphoma with an aggressive clinical course. Accurate di... more Background: AITL is a rare mature T-cell lymphoma with an aggressive clinical course. Accurate diagnosis is confounded by low tumor content limiting molecular characterization, histologic resemblance to peripheral T-cell lymphoma (PTCL), and a scarcity of sensitive diagnostic tools for routine sample analysis. Also, to date, no confirmed standard of care exists; most patients receive combination chemotherapy, but this approach is largely ineffective. Several research studies report RhoAG17V as a genomic hallmark of AITL that often co-occurs with somatic mutations in epigenetic regulators (TET2, IDH2, or DNMT3A); however these findings have yet to be translated in the clinic. The detection of clinically-relevant genomic alterations in AITL has the potential to improve outcome for this patient population by identifying targeted therapeutic agents. CGP provides an opportunity to address these collective unmet needs; herein, we report on our experience using this methodology in AITL. Me...
RESUMO:No Maciço de Baturité, assim como em outras regiões do Nordeste brasileiro, a farinhada –... more RESUMO:No Maciço de Baturité, assim como em outras regiões do Nordeste brasileiro, a farinhada – produção artesanal de farinha de mandioca –, assume diversos sentidos para além da dimensão do alimento, pois trata-se de prática cultural de grande importância para região. A casa de farinha remete às memórias dos farinheiros, aos gostos e sabores, ao tempo em que havia um circuito de farinhadas em grande parte das comunidades rurais. Porém, em tempos de padronizações dos alimentos, muitas formas de produção tradicionais estão em transformação. Como passos iniciais desta pesquisa, foram feitas incursões exploratórias na região, através da cooperação de informantes chave atuantes no território. O desenvolvimento da mandiocultura em sistema de consórcio, garante às famílias, não só o consumo da produção, como também a comercialização, contribuindo, concomitantemente com a segurança alimentar e nutricional e desenvolvimento dos agricultores familiares. Apesar de várias casas de farinha te...
5602 Background: High risk HPV initiates neoplasia in cSCC and progression requires additional ge... more 5602 Background: High risk HPV initiates neoplasia in cSCC and progression requires additional genomic alterations (GA). Treatment of localized cSCC is effective but the response to systemic therapy for metastatic disease is inadequate. CGP of 99 advanced stage cSCC was undertaken to identify GA associated with targeted therapeutic options relevant to the systemic treatment of cSCC. Methods: DNA was extracted from 99 FFPE cSCC clinical specimens. Hybridization captured libraries of 236 (FoundationOne, n = 66) or 305 (FoundationOne, n = 33) genes, plus select introns frequently rearranged in cancer were sequenced to high ( > 450x), uniform coverage. HPV16 and HPV 18 viral sequences were detected, but other hrHPVs were not assayed. All classes of genomic alterations (base subs, small in/dels, rearrangements, and copy number alterations) were evaluated and reported. CRGA were defined as GA associated with on-label targeted therapies and targeted therapies in mechanism-driven clinical trials. Results: 99 samp...
Fototransistor merupakan salah satu komponen yang berfungsi sebagai detektor cahaya yang dapat me... more Fototransistor merupakan salah satu komponen yang berfungsi sebagai detektor cahaya yang dapat mengubah efek cahaya menjadi sinyal listrik. Air yang keruh akan menyebabkan intensitas cahaya yang masuk kedalamnya berkurang. Dengan demikian tingkat kekeruhan air dapat dideteksi dengan alat pengukur intensitas cahaya seperti fototransistor dan LED inframerah sebagai sumber cahaya. Sistem yang telah dirancang bangun terdiri dari mikrokontroler AT89S51 sebagai pemroses data dan ADC digunakan untuk mengkonversi sinyal analog ke digital. Alat ini digunakan sebagai sistem pengontrol dengan keluarannya berupa alarm. Tegangan acuan yang dipakai agar alarm berbunyi adalah 1,656 volt. Pengujian sistem dilakukan dengan mendeteksi perubahan tingkat kekeruhan air pada sampel air minum kemasan, air PDAM, air sungai dan air kopi. Hasil yang diperoleh adalah semakin tinggi tingkat kekeruhan air atau semakin keruh air, maka tegangan keluaran sensor juga semakin tinggi.
Molecular data from 8 SSR regions of Euterpe edulis species used for estimate the dispersal kerne... more Molecular data from 8 SSR regions of Euterpe edulis species used for estimate the dispersal kernel of the species.
Neste trabalho, temos por objetivo verificar como ocorre o fenomeno da referenciacao em producoes... more Neste trabalho, temos por objetivo verificar como ocorre o fenomeno da referenciacao em producoes textuais de discentes do 3o ano do ensino medio regular, escritas no genero discursivo artigo de opiniao. Utilizaremos a Linguistica Textual como aporte teorico acerca do processo da referenciacao. Selecionamos, para tal analise, quatro producoes textuais, as quais apresentam inadequacoes quanto ao emprego de referentes. Os resultados apontam para a necessidade de se trabalhar mais o conceito de referenciacao em sala de aula. PALAVRAS-CHAVE: Referenciacao. Artigo de opiniao. Linguistica textual.
Consideramos que as pesquisas sobre multimodalidade ganham cada vez mais espaço dentro dos estudo... more Consideramos que as pesquisas sobre multimodalidade ganham cada vez mais espaço dentro dos estudos linguísticos, de modo que os aspectos imagéticos são essenciais para a construção dos significados, na qual a imagem atua como elemento semiótico cada vez mais relevante. Neste artigo, analisamos as relações multimodais envolvidas na constituição dos sentidos veiculados pela construção e propagação de estereótipos femininos em edições do calendário Campari. Para isso, amostras de imagens de três edições do calendário de 2015, 2016 e 2017, são analisadas. Nas análises, focalizamos as relações multimodais utilizando os preceitos da Teoria da Multimodalidade (KRESS; VAN LEEUWEN, 2001; KRESS, 2010) e explorando as categorias da Gramática do Design Visual (KRESS; VAN LEEUWEN, 2006). Os resultados revelaram que as relações multimodais carregam uma representação feminina aparentemente menos estereotipada dentro da mídia, criando superficialmente a imagem de que há um desligamento de alguns ...
1009 Background: Genomically-informed cancer therapy linking therapeutics targeting the molecular... more 1009 Background: Genomically-informed cancer therapy linking therapeutics targeting the molecular alterations driving the malignancy has the potential to transform the care of patients with metastatic breast cancer (MBC). Methods: DNA was isolated from 4 FFPE sections cut at 10 microns from 177 consecutive MBC that had relapsed after surgery, conventional hormonal/chemo and anti-HER2 targeted therapies received by our CLIA lab (Foundation Medicine). DNA sequencing was performed for 3,320 exons of 182 cancer-related genes to average depth of 1017X. Actionable Genomic alterations (GA) were defined as those linked to targeted anti-cancer therapies approved or being evaluated in active registered clinical trials. Results: Genomic profiles were generated from 169/177 (95%) BCs identifying 565 GA, averaging 3.34 GAs per tumor (range 0 to 10). 152 (90%) tumors harbored an actionable alteration mean 1.88 per tumor (range 0 to 6). In 124 (73%) tumors, ≥1.0 actionable GA was detected that wou...
5591Background: IO holds promise for EA with mismatch repair (MMR) or MSI-H phenotype, while tria... more 5591Background: IO holds promise for EA with mismatch repair (MMR) or MSI-H phenotype, while trials of targeted agents matched by histology/single biomarkers have yet to meet clinical endpoints. We...
11519Background: Carcinoma of unknown primary (CUP) has a poor prognosis and accounts for diagnos... more 11519Background: Carcinoma of unknown primary (CUP) has a poor prognosis and accounts for diagnoses in > 30,000 patients annually in the United States. Current tissue of origin (TOO) methods use pr...
Background: The survival of mantle cell lymphoma (MCL) has improved (median OS now >5 years) d... more Background: The survival of mantle cell lymphoma (MCL) has improved (median OS now >5 years) due to the use of dose-intensive strategies in younger patients (pts) achieving a deeper and earlier response (including molecular CR) and the application of novel therapies in the relapsed/refractory setting, where patients are typically chemoresistant. However, given the median age at onset in the mid to late 60's, and the remaining variability in outcomes, additional strategies are needed. A number of prognostic factors have been reported in MCL including MIPI, Ki67 and blastoid variants among others, the latter being frequently associated with del 17p or p53 mutations and a particularly poor outcome. Recent studies have begun to describe the genomic landscape of MCL by whole-genome, whole-exome and targeted sequencing. However, comprehensive evaluation of genomic alterations relevant for MCL pathogenesis and that could be potentially informative for patient's prognosis and pat...
Background The implementation of chemoimmunotherapy (R-CHOP) has dramatically improved the outcom... more Background The implementation of chemoimmunotherapy (R-CHOP) has dramatically improved the outcome of B-cell NHL particularly DLBCL…
Background: AITL is a rare mature T-cell lymphoma with an aggressive clinical course. Accurate di... more Background: AITL is a rare mature T-cell lymphoma with an aggressive clinical course. Accurate diagnosis is confounded by low tumor content limiting molecular characterization, histologic resemblance to peripheral T-cell lymphoma (PTCL), and a scarcity of sensitive diagnostic tools for routine sample analysis. Also, to date, no confirmed standard of care exists; most patients receive combination chemotherapy, but this approach is largely ineffective. Several research studies report RhoAG17V as a genomic hallmark of AITL that often co-occurs with somatic mutations in epigenetic regulators (TET2, IDH2, or DNMT3A); however these findings have yet to be translated in the clinic. The detection of clinically-relevant genomic alterations in AITL has the potential to improve outcome for this patient population by identifying targeted therapeutic agents. CGP provides an opportunity to address these collective unmet needs; herein, we report on our experience using this methodology in AITL. Me...
RESUMO:No Maciço de Baturité, assim como em outras regiões do Nordeste brasileiro, a farinhada –... more RESUMO:No Maciço de Baturité, assim como em outras regiões do Nordeste brasileiro, a farinhada – produção artesanal de farinha de mandioca –, assume diversos sentidos para além da dimensão do alimento, pois trata-se de prática cultural de grande importância para região. A casa de farinha remete às memórias dos farinheiros, aos gostos e sabores, ao tempo em que havia um circuito de farinhadas em grande parte das comunidades rurais. Porém, em tempos de padronizações dos alimentos, muitas formas de produção tradicionais estão em transformação. Como passos iniciais desta pesquisa, foram feitas incursões exploratórias na região, através da cooperação de informantes chave atuantes no território. O desenvolvimento da mandiocultura em sistema de consórcio, garante às famílias, não só o consumo da produção, como também a comercialização, contribuindo, concomitantemente com a segurança alimentar e nutricional e desenvolvimento dos agricultores familiares. Apesar de várias casas de farinha te...
5602 Background: High risk HPV initiates neoplasia in cSCC and progression requires additional ge... more 5602 Background: High risk HPV initiates neoplasia in cSCC and progression requires additional genomic alterations (GA). Treatment of localized cSCC is effective but the response to systemic therapy for metastatic disease is inadequate. CGP of 99 advanced stage cSCC was undertaken to identify GA associated with targeted therapeutic options relevant to the systemic treatment of cSCC. Methods: DNA was extracted from 99 FFPE cSCC clinical specimens. Hybridization captured libraries of 236 (FoundationOne, n = 66) or 305 (FoundationOne, n = 33) genes, plus select introns frequently rearranged in cancer were sequenced to high ( > 450x), uniform coverage. HPV16 and HPV 18 viral sequences were detected, but other hrHPVs were not assayed. All classes of genomic alterations (base subs, small in/dels, rearrangements, and copy number alterations) were evaluated and reported. CRGA were defined as GA associated with on-label targeted therapies and targeted therapies in mechanism-driven clinical trials. Results: 99 samp...
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