Patients with a history of previous knee surgeries, such as anterior cruciate ligament reconstruc... more Patients with a history of previous knee surgeries, such as anterior cruciate ligament reconstruction (ACLR) and high tibial osteotomy (HTO), often have a higher likelihood of requiring a subsequent total knee arthroplasty (TKA). However, there is relatively limited data, especially in the Asian population, on how previous knee surgery could affect the clinical outcomes of TKA. Therefore, this study aims to evaluate the impact of previous knee surgeries on the clinical outcomes of future TKA. We reviewed the prospectively-collected data of 303 patients who underwent TKA by a single surgeon from a total joint registry of a tertiary hospital over a period of 5 years. Those with a history of previous knee surgery were identified. The SF-36 Health Survey, Oxford Knee Score (OKS) and Knee Society Score (KSS) were used to evaluate clinical outcomes pre-operatively, at 6 months and 2 years. Previous knee surgery did not have a significant impact on the patients' pre-operative baseline ...
... Lim, Jason Yek Sen (2000) Penghasilan produk kering (teh roselle dan ready mix roselle powder... more ... Lim, Jason Yek Sen (2000) Penghasilan produk kering (teh roselle dan ready mix roselle powder) daripada kaliks roselle. ... Formulasi yang paling diterima dari segi warna, kemasaman, kekelatan dan kemanisan adalah 2g serbuk Roselle yang ditambah dengan 15g gula halus ...
Infections by malaria parasites can lead to very different clinical outcomes, ranging from mild s... more Infections by malaria parasites can lead to very different clinical outcomes, ranging from mild symptoms to death. Differences in the ability of the spleen to deal with the infected red blood cells (iRBCs) are linked to differences in virulence. Using virulent and avirulent strains of the rodent malaria parasite Plasmodium yoelii, we investigated how parasite virulence modulates overall spleen function. Following parasite invasion, a difference in parasite virulence was observed in association with different levels of spleen morphology and iRBC rigidity, both of which contributed to enhanced parasite clearance. Moreover, iRBC rigidity as modulated by the spleen was demonstrated to correlate with disease outcome and thus can be used as a robust indicator of virulence. The data indicate that alterations in the biomechanical properties of iRBCs are the result of the complex interaction between host and parasite. Furthermore, we confirmed that early spleen responses are a key factor in directing the clinical outcome of an infection. IMPORTANCE The spleen and its response to parasite infection are important in eliminating parasites in malaria. By comparing P. yoelii parasite lines with different disease outcomes in mice that had either intact spleens or had had their spleens removed, we showed that upon parasite infection, the spleen exhibits dramatic changes that can affect parasite clearance. The spleen itself directly impacts RBC deformability independently of parasite genetics. The data indicated that the changes in the biomechanical properties of malaria parasite-infected RBCs are the result of the complex interaction between host and parasite, and RBC deformability itself can serve as a novel predictor of clinical outcome. The results also suggest that early responses in the spleen are a key factor directing the clinical outcome of an infection.
Introduction Sara Ahmed (2004a) sets out the problematic that I wish to tackle in this paperö nam... more Introduction Sara Ahmed (2004a) sets out the problematic that I wish to tackle in this paperö namely, how an understanding of affect as an impersonal force, located in neither subject nor object, that might potentially repeat a racialised or ethnicised relation between bodies can ...
Evaluation of tumor heterogeneity based on texture parameters has recently attracted much interes... more Evaluation of tumor heterogeneity based on texture parameters has recently attracted much interest in the PET imaging community. However, the impact of reconstruction settings on texture parameters is unclear, especially relating to time-of-flight (TOF) and point-spread function (PSF) modeling. Their effects on 55 texture features (TF) and 6 features based on first-order statistics (FOS) were investigated. Standardized uptake value (SUV) measures were also evaluated as peak, maximum and mean SUV. This study retrospectively recruited twenty patients with lesions in the lung who underwent a whole-body (18)F-FDG PET/CT scan. The coefficient of variation (COV) of each feature across different reconstructions was calculated. Peak SUV, mean SUV, 18 TFs and 1 FOS were the most robust, with a COV less than 5%, whereas skewness, cluster shade and zone percentage were the least robust, with a COV greater than 20% with respect to reconstruction algorithms using default settings. Heterogeneity parameters had different sensitivities to iteration number. Among them, 24 parameters including peak and mean SUV exhibited variation with a COV less than 5%, 28 parameters including maximum SUV showed variation with a COV in the range of 5-10%. In addition, skewness, cluster shade and zone percentage were the most sensitive to iteration number. In terms of sensitivity to FWHM, 15 TF and 1 FOS had the best performance with a COV less than 5%, whereas peak and mean SUV had COV between 5% and 10%. Grid size had the largest impact on image features, which was demonstrated by only 11 features, including peak and mean SUV, having COV less than 10%. Different image features have different sensitivities to reconstruction settings. Iteration number and FWHM of the Gaussian filter have similar impact on the image features. Grid size has larger impact on the features than iteration number and FWHM. The features which exhibited large variation such as skewness in FOS, cluster shade and zone percentage should be used with caution. The entropy in FOS, difference entropy, inverse difference normalized, inverse difference moment normalized, low grey-level run emphasis, high grey-level run emphasis and low grey-level zone emphasis are the most robust features.
Patients with a history of previous knee surgeries, such as anterior cruciate ligament reconstruc... more Patients with a history of previous knee surgeries, such as anterior cruciate ligament reconstruction (ACLR) and high tibial osteotomy (HTO), often have a higher likelihood of requiring a subsequent total knee arthroplasty (TKA). However, there is relatively limited data, especially in the Asian population, on how previous knee surgery could affect the clinical outcomes of TKA. Therefore, this study aims to evaluate the impact of previous knee surgeries on the clinical outcomes of future TKA. We reviewed the prospectively-collected data of 303 patients who underwent TKA by a single surgeon from a total joint registry of a tertiary hospital over a period of 5 years. Those with a history of previous knee surgery were identified. The SF-36 Health Survey, Oxford Knee Score (OKS) and Knee Society Score (KSS) were used to evaluate clinical outcomes pre-operatively, at 6 months and 2 years. Previous knee surgery did not have a significant impact on the patients' pre-operative baseline ...
... Lim, Jason Yek Sen (2000) Penghasilan produk kering (teh roselle dan ready mix roselle powder... more ... Lim, Jason Yek Sen (2000) Penghasilan produk kering (teh roselle dan ready mix roselle powder) daripada kaliks roselle. ... Formulasi yang paling diterima dari segi warna, kemasaman, kekelatan dan kemanisan adalah 2g serbuk Roselle yang ditambah dengan 15g gula halus ...
Infections by malaria parasites can lead to very different clinical outcomes, ranging from mild s... more Infections by malaria parasites can lead to very different clinical outcomes, ranging from mild symptoms to death. Differences in the ability of the spleen to deal with the infected red blood cells (iRBCs) are linked to differences in virulence. Using virulent and avirulent strains of the rodent malaria parasite Plasmodium yoelii, we investigated how parasite virulence modulates overall spleen function. Following parasite invasion, a difference in parasite virulence was observed in association with different levels of spleen morphology and iRBC rigidity, both of which contributed to enhanced parasite clearance. Moreover, iRBC rigidity as modulated by the spleen was demonstrated to correlate with disease outcome and thus can be used as a robust indicator of virulence. The data indicate that alterations in the biomechanical properties of iRBCs are the result of the complex interaction between host and parasite. Furthermore, we confirmed that early spleen responses are a key factor in directing the clinical outcome of an infection. IMPORTANCE The spleen and its response to parasite infection are important in eliminating parasites in malaria. By comparing P. yoelii parasite lines with different disease outcomes in mice that had either intact spleens or had had their spleens removed, we showed that upon parasite infection, the spleen exhibits dramatic changes that can affect parasite clearance. The spleen itself directly impacts RBC deformability independently of parasite genetics. The data indicated that the changes in the biomechanical properties of malaria parasite-infected RBCs are the result of the complex interaction between host and parasite, and RBC deformability itself can serve as a novel predictor of clinical outcome. The results also suggest that early responses in the spleen are a key factor directing the clinical outcome of an infection.
Introduction Sara Ahmed (2004a) sets out the problematic that I wish to tackle in this paperö nam... more Introduction Sara Ahmed (2004a) sets out the problematic that I wish to tackle in this paperö namely, how an understanding of affect as an impersonal force, located in neither subject nor object, that might potentially repeat a racialised or ethnicised relation between bodies can ...
Evaluation of tumor heterogeneity based on texture parameters has recently attracted much interes... more Evaluation of tumor heterogeneity based on texture parameters has recently attracted much interest in the PET imaging community. However, the impact of reconstruction settings on texture parameters is unclear, especially relating to time-of-flight (TOF) and point-spread function (PSF) modeling. Their effects on 55 texture features (TF) and 6 features based on first-order statistics (FOS) were investigated. Standardized uptake value (SUV) measures were also evaluated as peak, maximum and mean SUV. This study retrospectively recruited twenty patients with lesions in the lung who underwent a whole-body (18)F-FDG PET/CT scan. The coefficient of variation (COV) of each feature across different reconstructions was calculated. Peak SUV, mean SUV, 18 TFs and 1 FOS were the most robust, with a COV less than 5%, whereas skewness, cluster shade and zone percentage were the least robust, with a COV greater than 20% with respect to reconstruction algorithms using default settings. Heterogeneity parameters had different sensitivities to iteration number. Among them, 24 parameters including peak and mean SUV exhibited variation with a COV less than 5%, 28 parameters including maximum SUV showed variation with a COV in the range of 5-10%. In addition, skewness, cluster shade and zone percentage were the most sensitive to iteration number. In terms of sensitivity to FWHM, 15 TF and 1 FOS had the best performance with a COV less than 5%, whereas peak and mean SUV had COV between 5% and 10%. Grid size had the largest impact on image features, which was demonstrated by only 11 features, including peak and mean SUV, having COV less than 10%. Different image features have different sensitivities to reconstruction settings. Iteration number and FWHM of the Gaussian filter have similar impact on the image features. Grid size has larger impact on the features than iteration number and FWHM. The features which exhibited large variation such as skewness in FOS, cluster shade and zone percentage should be used with caution. The entropy in FOS, difference entropy, inverse difference normalized, inverse difference moment normalized, low grey-level run emphasis, high grey-level run emphasis and low grey-level zone emphasis are the most robust features.
This article is about the contestation of two different forms of nationalism in Singapore during ... more This article is about the contestation of two different forms of nationalism in Singapore during and after two elections in 2011. Manufactured nationalism is topdown, state-defined and economically driven, concerned mainly about accumulation of national wealth through globalization that would eventually ‘trickle down’ to the masses. This view is promoted by the ruling People’s Action Party (PAP). The PAP projects Singapore as a state born out of the party’s triumph over colonialism, racial violence, and communist insurgency. Popular nationalism, on the other hand, is bottom-up and people driven, concerned about local issues concerning national identity, social cohesion, and an appreciation (or at least an understanding) of local heritage. Proponents of popular nationalism emphasize a common beginning (birth of independent Singapore on 9 August 1965), shared historical memories (local heritage), several elements of a common culture (such as the use of Singlish), and an association with a specific ‘homeland’ (born and raised in Singapore and, for males, the completion of conscription). They view Singapore as a nation-state with a unique and evolving identity destabilized by a liberal immigration policy. The elections generated considerable attention due to the gains by the opposition parties and the public airing of frustrations against the PAP government. These frustrations are strongly driven by the influx of new migrants, especially those classified as ‘foreign talent’ by the PAP government. In this article, I argue that popular nationalism has emerged in twenty-first century Singapore and examine the debates over the future of Singapore during and after the elections.
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