Aim: To investigate the association of discordance in patient- and physician-reported symptoms on... more Aim: To investigate the association of discordance in patient- and physician-reported symptoms on health-related quality of life (HRQoL) in hepatocellular carcinoma (HCC). Patients & methods: Data were drawn from a point-in-time survey of physicians and patients conducted in Germany, Italy and Spain (October 2018 – January 2019). Physicians and their consulting patients independently reported baseline characteristics, symptoms, treatment history and satisfaction, and HRQoL derived using the Functional Assessment of Cancer Therapy-Hepatobiliary (FACT-Hep) questionnaire. Results: Of 486 patients analysed, tiredness (73.3%, 73.7%), pain/aches (67.7%, 66.9%) and weight/appetite loss (54.3%, 53.7%) were the most common and concordant patient and physician-reported symptom domains, respectively. The symptom domains showing the largest discordance were reflux/indigestion (14.6%, 5.1%), neurological (11.9%, 5.6%), dermatological (9.3%, 6.2%) symptoms and jaundice (4.7%, 10.3%). Reduced HRQo...
can be used to calculate Massachusetts hospital standar-dised mortality ratios and can be further... more can be used to calculate Massachusetts hospital standar-dised mortality ratios and can be further adapted for other state-wide data-sets. Design: We used binary logistic regression models to pre-dict the probability of death and to calculate the hospital standardised mortality ratios. Independent variables were patient sociodemographic characteristics (such as age, gender) and healthcare details (such as admission source). Statistical performance was evaluated using c statistics, Brier score and the Hosmer–Lemeshow test. Setting: Massachusetts hospitals providing care to patients over financial years 2005/6 to 2007/8. Patients: 1,073,122 patients admitted to Massachusetts hospitals corresponding to 36 hospital standardised mortality ratio diagnosis groups that account for 80 % of
Background & AimsLimited data on treatment of elderly patients with hepatocellular carcinoma (HCC... more Background & AimsLimited data on treatment of elderly patients with hepatocellular carcinoma (HCC) increase the unmet need. REACH and REACH‐2 were global phase III studies of ramucirumab in patients with HCC after prior sorafenib, where patients with alpha‐fetoprotein (AFP) ≥400 ng/mL showed an overall ssurvival (OS) benefit for ramucirumab. These post‐hoc analyses examined efficacy and safety of ramucirumab in patients with HCC and baseline AFP ≥ 400 ng/mL by three prespecified age subgroups (<65, ≥65 to <75 and ≥75 years).MethodsIndividual patient data were pooled from REACH (baseline AFP ≥400 ng/mL) and REACH‐2. Kaplan‐Meier and Cox proportional hazards regression methods (stratified by study) assessed OS, progression‐free survival (PFS), time to progression (TTP) and patient‐reported outcomes (Functional Hepatobiliary System Index‐8 [FHSI‐8] score).ResultsA total of 542 patients (<65 years: n = 302; ≥65 to <75 years: n = 160; ≥75 years: n = 80) showed similar baselin...
Current medical research and opinion, Jan 12, 2016
To estimate health utility values, explore predictors of utility values, and estimate the quality... more To estimate health utility values, explore predictors of utility values, and estimate the quality-adjusted life years (QALYs) gained by treatment in multicentric Castleman's disease (MCD). The SF-36 was administered to 79 patients enrolled in a randomized, double-blind, placebo-controlled, multi-national study to determine the safety and efficacy of siltuximab plus best supportive care (BSC) compared with BSC, in subjects with symptomatic MCD. Utility (SF-6D) scores were derived from the SF-36. Sensitivity analyses using utilities obtained by mapping the SF-36 to the EQ-5D were also conducted. Repeated measures, mixed effects models were conducted to estimate effects of treatment, responder status and ≥ Grade 3 adverse events (AEs) on changes in utility values over time, controlling for baseline utility value. Additionally, differential QALY gain was assessed in the trial using multiple regression. Patients on siltuximab and those who experienced a complete or partial response h...
Second International Conference on e-Social Science. National Centre for e-Social Science, Jun 30, 2006
▪ Algorithmically, GWR can be reduced to two functions▪ one to calculate the weights▪ the other t... more ▪ Algorithmically, GWR can be reduced to two functions▪ one to calculate the weights▪ the other to fit the regression▪ d is one of n subsets of the core dataset D. Weights are calculated using function 1 concurrently applied to each of the n subsets. The data, now including weights, are passed to function 2 (a weighted regression fit), concurrently applied to each of the n subsets to give an outcome, z. The results are then pooled for a final assessment.
INTRODUCTION In early 1990, local people in Tau-Yuan County, Taiwan, noted surface radioactivity ... more INTRODUCTION In early 1990, local people in Tau-Yuan County, Taiwan, noted surface radioactivity in Ta-han River valley. The contaminated area was said to be within 1 km from an outlet drainage from the government-owned Institute of Nuclear Energy Researches (INER). It was reported that accidents with spent nuclear fuel had occurred in the Institute in late 80’s (1). About 6 years after the accident, the contamination in he valley was contained and part of the soil from contaminated area replaced. In order to make a more comprehensive evaluation of the contaminated area, we conducted a systematic sampling and tried to characterize Cs distribution in 1999.
Risk of bias assessment, study characteristics, sensitivity analyses, subgroup results and Bayesi... more Risk of bias assessment, study characteristics, sensitivity analyses, subgroup results and Bayesian code. (DOCX 3820 kb)
International variations in life expectancy: A spatio-temporal analysis Article in Tijdschrift vo... more International variations in life expectancy: A spatio-temporal analysis Article in Tijdschrift voor Economische en Sociale Geografie · February 2010
All in-text references underlined in blue are linked to publications on ResearchGate, letting you... more All in-text references underlined in blue are linked to publications on ResearchGate, letting you access and read them immediately.
After saying that “The most frequently tested hypotheses of life-course SEP and health were the a... more After saying that “The most frequently tested hypotheses of life-course SEP and health were the accumulation of risk, sensitive (or critical) periods, and social mobility.”, we further elaborate that “The accumulation risk model focuses on the total cumulative exposure to SEP throughout a life course, whereas the sensitive or critical period entails the SEP of a certain period in a life course having stronger effects than those of other periods. The social mobility model describes the trajectories of SEP that people are involved in through their life span and is often defined as inter-generational movements of social position from family of origin to adulthood. The pattern of social mobility were found to be significantly associated with health in later life. The health of people who remained stable in an advantaged position is likely to be better when compared to that of those who moved upward from a disadvantaged to an advantaged position. The health of who remained in the disadva...
Aim: To investigate the association of discordance in patient- and physician-reported symptoms on... more Aim: To investigate the association of discordance in patient- and physician-reported symptoms on health-related quality of life (HRQoL) in hepatocellular carcinoma (HCC). Patients & methods: Data were drawn from a point-in-time survey of physicians and patients conducted in Germany, Italy and Spain (October 2018 – January 2019). Physicians and their consulting patients independently reported baseline characteristics, symptoms, treatment history and satisfaction, and HRQoL derived using the Functional Assessment of Cancer Therapy-Hepatobiliary (FACT-Hep) questionnaire. Results: Of 486 patients analysed, tiredness (73.3%, 73.7%), pain/aches (67.7%, 66.9%) and weight/appetite loss (54.3%, 53.7%) were the most common and concordant patient and physician-reported symptom domains, respectively. The symptom domains showing the largest discordance were reflux/indigestion (14.6%, 5.1%), neurological (11.9%, 5.6%), dermatological (9.3%, 6.2%) symptoms and jaundice (4.7%, 10.3%). Reduced HRQo...
can be used to calculate Massachusetts hospital standar-dised mortality ratios and can be further... more can be used to calculate Massachusetts hospital standar-dised mortality ratios and can be further adapted for other state-wide data-sets. Design: We used binary logistic regression models to pre-dict the probability of death and to calculate the hospital standardised mortality ratios. Independent variables were patient sociodemographic characteristics (such as age, gender) and healthcare details (such as admission source). Statistical performance was evaluated using c statistics, Brier score and the Hosmer–Lemeshow test. Setting: Massachusetts hospitals providing care to patients over financial years 2005/6 to 2007/8. Patients: 1,073,122 patients admitted to Massachusetts hospitals corresponding to 36 hospital standardised mortality ratio diagnosis groups that account for 80 % of
Background & AimsLimited data on treatment of elderly patients with hepatocellular carcinoma (HCC... more Background & AimsLimited data on treatment of elderly patients with hepatocellular carcinoma (HCC) increase the unmet need. REACH and REACH‐2 were global phase III studies of ramucirumab in patients with HCC after prior sorafenib, where patients with alpha‐fetoprotein (AFP) ≥400 ng/mL showed an overall ssurvival (OS) benefit for ramucirumab. These post‐hoc analyses examined efficacy and safety of ramucirumab in patients with HCC and baseline AFP ≥ 400 ng/mL by three prespecified age subgroups (<65, ≥65 to <75 and ≥75 years).MethodsIndividual patient data were pooled from REACH (baseline AFP ≥400 ng/mL) and REACH‐2. Kaplan‐Meier and Cox proportional hazards regression methods (stratified by study) assessed OS, progression‐free survival (PFS), time to progression (TTP) and patient‐reported outcomes (Functional Hepatobiliary System Index‐8 [FHSI‐8] score).ResultsA total of 542 patients (<65 years: n = 302; ≥65 to <75 years: n = 160; ≥75 years: n = 80) showed similar baselin...
Current medical research and opinion, Jan 12, 2016
To estimate health utility values, explore predictors of utility values, and estimate the quality... more To estimate health utility values, explore predictors of utility values, and estimate the quality-adjusted life years (QALYs) gained by treatment in multicentric Castleman's disease (MCD). The SF-36 was administered to 79 patients enrolled in a randomized, double-blind, placebo-controlled, multi-national study to determine the safety and efficacy of siltuximab plus best supportive care (BSC) compared with BSC, in subjects with symptomatic MCD. Utility (SF-6D) scores were derived from the SF-36. Sensitivity analyses using utilities obtained by mapping the SF-36 to the EQ-5D were also conducted. Repeated measures, mixed effects models were conducted to estimate effects of treatment, responder status and ≥ Grade 3 adverse events (AEs) on changes in utility values over time, controlling for baseline utility value. Additionally, differential QALY gain was assessed in the trial using multiple regression. Patients on siltuximab and those who experienced a complete or partial response h...
Second International Conference on e-Social Science. National Centre for e-Social Science, Jun 30, 2006
▪ Algorithmically, GWR can be reduced to two functions▪ one to calculate the weights▪ the other t... more ▪ Algorithmically, GWR can be reduced to two functions▪ one to calculate the weights▪ the other to fit the regression▪ d is one of n subsets of the core dataset D. Weights are calculated using function 1 concurrently applied to each of the n subsets. The data, now including weights, are passed to function 2 (a weighted regression fit), concurrently applied to each of the n subsets to give an outcome, z. The results are then pooled for a final assessment.
INTRODUCTION In early 1990, local people in Tau-Yuan County, Taiwan, noted surface radioactivity ... more INTRODUCTION In early 1990, local people in Tau-Yuan County, Taiwan, noted surface radioactivity in Ta-han River valley. The contaminated area was said to be within 1 km from an outlet drainage from the government-owned Institute of Nuclear Energy Researches (INER). It was reported that accidents with spent nuclear fuel had occurred in the Institute in late 80’s (1). About 6 years after the accident, the contamination in he valley was contained and part of the soil from contaminated area replaced. In order to make a more comprehensive evaluation of the contaminated area, we conducted a systematic sampling and tried to characterize Cs distribution in 1999.
Risk of bias assessment, study characteristics, sensitivity analyses, subgroup results and Bayesi... more Risk of bias assessment, study characteristics, sensitivity analyses, subgroup results and Bayesian code. (DOCX 3820 kb)
International variations in life expectancy: A spatio-temporal analysis Article in Tijdschrift vo... more International variations in life expectancy: A spatio-temporal analysis Article in Tijdschrift voor Economische en Sociale Geografie · February 2010
All in-text references underlined in blue are linked to publications on ResearchGate, letting you... more All in-text references underlined in blue are linked to publications on ResearchGate, letting you access and read them immediately.
After saying that “The most frequently tested hypotheses of life-course SEP and health were the a... more After saying that “The most frequently tested hypotheses of life-course SEP and health were the accumulation of risk, sensitive (or critical) periods, and social mobility.”, we further elaborate that “The accumulation risk model focuses on the total cumulative exposure to SEP throughout a life course, whereas the sensitive or critical period entails the SEP of a certain period in a life course having stronger effects than those of other periods. The social mobility model describes the trajectories of SEP that people are involved in through their life span and is often defined as inter-generational movements of social position from family of origin to adulthood. The pattern of social mobility were found to be significantly associated with health in later life. The health of people who remained stable in an advantaged position is likely to be better when compared to that of those who moved upward from a disadvantaged to an advantaged position. The health of who remained in the disadva...
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