Patients diagnosed with a psychotic disorder and their first-degree relatives display increased r... more Patients diagnosed with a psychotic disorder and their first-degree relatives display increased reactivity to stress. Although experience of psychosocial stress is associated both with ventromedial prefrontal and mesolimbic dopamine neurotransmission, the role of prefrontal dopamine transmission in the stress psychosis phenotype remains underresearched. The current study aimed at investigating stress-induced in vivo dopamine release in ventromedial prefrontal cortex (vmPFC) of individuals at familial risk for psychosis. first-degree relatives of patients with a psychotic disorder displayed attenuated dopamine stress neuromodulation in vmpfC, possibly reflecting reduced prefrontal regulation of stress-induced mesolimbic dopamine release.<br><b>see also</b>Lataster, J., Collip, D., Ceccarini, J., Hernaus, D., Haas, D., Booij, L., ... & Myin-Germeys, I. (2013). Familial liability to psychosis is associated with attenuated dopamine stress signaling in ventromedial pref...
The high-affinity D2/3 PET radioligand 18F-fallypride offers the possibility of measuring both st... more The high-affinity D2/3 PET radioligand 18F-fallypride offers the possibility of measuring both striatal and extrastriatal dopa-mine release during activation paradigms. When a single 18F-fallypride scanning protocol is used, task timing is critical to the ability to explore both striatal and extrastriatal dopamine release simultaneously. We evaluated the sensitivity and opti-mal timing of task administration for a single 18F-fallypride PET protocol and the linearized simplified reference region kinetic model in detecting both striatal and extrastriatal reward-induced dopamine release, using human and simulation studies.Methods: Ten healthy volunteers underwent a single-bolus 18F-fallypride PET protocol. A reward responsiveness learning task was initi-ated at 100 min after injection. PET data were analyzed using the linearized simplified reference region model, which accounts for time-dependent changes in 18F-fallypride displacement.
<b>see also</b>Lataster, J., Collip, D., Ceccarini, J., Haas, D., Booij, L., van Os, ... more <b>see also</b>Lataster, J., Collip, D., Ceccarini, J., Haas, D., Booij, L., van Os, J., ... &amp; Myin-Germeys, I. (2011). Psychosocial stress is associated with in vivo dopamine release in human ventromedial prefrontal cortex: a positron emission tomography study using [18F] fallypride. <i>Neuroimage</i>, <i>58</i>(4), 1081-1089.<br><br><b>DOI: 10.1016/j.neuroimage.2011.07.030</b><br><br>Rodent studies suggest that prefrontal dopamine neurotransmission plays an important role in the neural processing of psychosocial stress. Human studies investigating stress-induced changes in dopamine levels, however, have focused solely on striatal dopamine transmission. The aim of this study was to investigate in vivo dopamine release in the human prefrontal cortex in response to a psychosocial stress challenge, using the highly selective dopamine D₂/₃ PET radioligand [¹⁸F]fallypride in healthy subjects. Twelve healthy subjects (age (y): 39.8; SD=15.8) underwent a single dynamic Positron Emission Tomography (PET) scanning session after intravenous administration of 185.2 (SD=10.2) MBq [¹⁸F]fallypride. Psychosocial stress was initiated at 100 min postinjection. PET data were analyzed using the linearized simplified reference region model (LSRRM), which accounts for time-dependent changes in [¹⁸F]fallypride displacement. Voxel-based statistical maps, representing specific D₂/₃ binding changes, were computed to localize areas with increased ligand displacement after task initiation, reflecting dopamine release. The psychosocial stress challenge induced detectable amounts of dopamine release throughout the prefrontal cortex, with dopaminergic activity in bilateral ventromedial prefrontal cortex being associated with subjectively rated experiences of psychosocial stress. The novel finding that a mild psychosocial stress in humans induces increased levels of endogenous dopamine in the PFC indicates that the dynamics of the dopamine-related stress response cannot be interpreted by focusing on mesolimbic brain regions alone.<br>
Published online: August 1, 2013. 2013;54:1849-1850. J Nucl Med. Jenny Ceccarini, Michel Koole an... more Published online: August 1, 2013. 2013;54:1849-1850. J Nucl Med. Jenny Ceccarini, Michel Koole and Koen Van Laere Receptor Ligands 2/3 Reply: TaskVersus Amphetamine-Induced Displacement of High-Affinity D http://jnm.snmjournals.org/content/54/10/1849.2 This article and updated information are available at: http://jnm.snmjournals.org/site/subscriptions/online.xhtml Information about subscriptions to JNM can be found at: http://jnm.snmjournals.org/site/misc/permission.xhtml Information about reproducing figures, tables, or other portions of this article can be found online at:
Patients diagnosed with a psychotic disorder and their first-degree relatives display increased r... more Patients diagnosed with a psychotic disorder and their first-degree relatives display increased reactivity to stress. Although experience of psychosocial stress is associated both with ventromedial prefrontal and mesolimbic dopamine neurotransmission, the role of prefrontal dopamine transmission in the stress psychosis phenotype remains underresearched. The current study aimed at investigating stress-induced in vivo dopamine release in ventromedial prefrontal cortex (vmPFC) of individuals at familial risk for psychosis. first-degree relatives of patients with a psychotic disorder displayed attenuated dopamine stress neuromodulation in vmpfC, possibly reflecting reduced prefrontal regulation of stress-induced mesolimbic dopamine release.<br><b>see also</b>Lataster, J., Collip, D., Ceccarini, J., Hernaus, D., Haas, D., Booij, L., ... & Myin-Germeys, I. (2013). Familial liability to psychosis is associated with attenuated dopamine stress signaling in ventromedial pref...
The high-affinity D2/3 PET radioligand 18F-fallypride offers the possibility of measuring both st... more The high-affinity D2/3 PET radioligand 18F-fallypride offers the possibility of measuring both striatal and extrastriatal dopa-mine release during activation paradigms. When a single 18F-fallypride scanning protocol is used, task timing is critical to the ability to explore both striatal and extrastriatal dopamine release simultaneously. We evaluated the sensitivity and opti-mal timing of task administration for a single 18F-fallypride PET protocol and the linearized simplified reference region kinetic model in detecting both striatal and extrastriatal reward-induced dopamine release, using human and simulation studies.Methods: Ten healthy volunteers underwent a single-bolus 18F-fallypride PET protocol. A reward responsiveness learning task was initi-ated at 100 min after injection. PET data were analyzed using the linearized simplified reference region model, which accounts for time-dependent changes in 18F-fallypride displacement.
<b>see also</b>Lataster, J., Collip, D., Ceccarini, J., Haas, D., Booij, L., van Os, ... more <b>see also</b>Lataster, J., Collip, D., Ceccarini, J., Haas, D., Booij, L., van Os, J., ... &amp; Myin-Germeys, I. (2011). Psychosocial stress is associated with in vivo dopamine release in human ventromedial prefrontal cortex: a positron emission tomography study using [18F] fallypride. <i>Neuroimage</i>, <i>58</i>(4), 1081-1089.<br><br><b>DOI: 10.1016/j.neuroimage.2011.07.030</b><br><br>Rodent studies suggest that prefrontal dopamine neurotransmission plays an important role in the neural processing of psychosocial stress. Human studies investigating stress-induced changes in dopamine levels, however, have focused solely on striatal dopamine transmission. The aim of this study was to investigate in vivo dopamine release in the human prefrontal cortex in response to a psychosocial stress challenge, using the highly selective dopamine D₂/₃ PET radioligand [¹⁸F]fallypride in healthy subjects. Twelve healthy subjects (age (y): 39.8; SD=15.8) underwent a single dynamic Positron Emission Tomography (PET) scanning session after intravenous administration of 185.2 (SD=10.2) MBq [¹⁸F]fallypride. Psychosocial stress was initiated at 100 min postinjection. PET data were analyzed using the linearized simplified reference region model (LSRRM), which accounts for time-dependent changes in [¹⁸F]fallypride displacement. Voxel-based statistical maps, representing specific D₂/₃ binding changes, were computed to localize areas with increased ligand displacement after task initiation, reflecting dopamine release. The psychosocial stress challenge induced detectable amounts of dopamine release throughout the prefrontal cortex, with dopaminergic activity in bilateral ventromedial prefrontal cortex being associated with subjectively rated experiences of psychosocial stress. The novel finding that a mild psychosocial stress in humans induces increased levels of endogenous dopamine in the PFC indicates that the dynamics of the dopamine-related stress response cannot be interpreted by focusing on mesolimbic brain regions alone.<br>
Published online: August 1, 2013. 2013;54:1849-1850. J Nucl Med. Jenny Ceccarini, Michel Koole an... more Published online: August 1, 2013. 2013;54:1849-1850. J Nucl Med. Jenny Ceccarini, Michel Koole and Koen Van Laere Receptor Ligands 2/3 Reply: TaskVersus Amphetamine-Induced Displacement of High-Affinity D http://jnm.snmjournals.org/content/54/10/1849.2 This article and updated information are available at: http://jnm.snmjournals.org/site/subscriptions/online.xhtml Information about subscriptions to JNM can be found at: http://jnm.snmjournals.org/site/misc/permission.xhtml Information about reproducing figures, tables, or other portions of this article can be found online at:
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