A workshop on implementation strategies for the introduction of the RTS,S/AS01 (RTS,S) malaria va... more A workshop on implementation strategies for the introduction of the RTS,S/AS01 (RTS,S) malaria vaccine in countries with areas of highly seasonal transmission, was held as a hybrid meeting in Dakar, Senegal, and online, 23–25 January 2023. Delegates from Expanded Programmes on Immunization (EPI) and National Malaria Control Programmes (NMCPs) from 13 African countries, and representatives from key stakeholders participated. RTS,S is the first malaria vaccine to be recommended by the World Health Organization (WHO). The recommendation followed pilot implementation of the vaccine in Ghana, Kenya and Malawi, which showed that introduction of the vaccine was highly effective at scale, and was associated with a 30% reduction in hospital admissions with severe malaria in age groups eligible to have received the vaccine and no evidence of the safety signals that had been observed in the phase 3 trial. Clinical trials in Mali and Burkina Faso, showed that in children receiving Seasonal Mala...
ABSTRACT Phytochemical investigation of the leaves of Phragmanthera capitata collected on Cassia ... more ABSTRACT Phytochemical investigation of the leaves of Phragmanthera capitata collected on Cassia spectabilis tree led to the isolation of two natural lactones, rel-(1R,5S,7S)-7-[2-(4-hydroxyphenyl)ethyl]-2,6-dioxabicyclo[3.3.1]nonan-3-one (1) and 4-{2-[rel-(1R,3R,5S)-7-oxo-2,6-dioxabicyclo[3.3.1]non-3-yl]ethyl}phenyl 3,4,5-trihydroxybenzoate (2) together with the known compounds betulinic acid (3), dodoneine (4), quercetin 3-O-α-l-rhamnopyranoside (5), quercetin 3-O-α-l-arabinofuranoside (6), quercetin (7), betulin (8), lupeol (9), and sitosterol (10). Their structures were established by means of modern spectroscopic techniques, and the relative configuration of compound 1 was confirmed by X-ray analysis. Compounds 1 and 2 were tested in vitro for their antiplasmodial activity against the Plasmodium falciparum chloroquine sensitive-strains NF54 and 3D7. Compound 2 exhibited good antiplasmodial activity against both strains with IC50 of 2.4 and 4.9 μm, respectively, while compound 1 was inactive.
Journal of fungi (Basel, Switzerland), Jan 12, 2018
There is continuing need for new and improved drugs to tackle malaria, which remains a major publ... more There is continuing need for new and improved drugs to tackle malaria, which remains a major public health problem, especially in tropical and subtropical regions of the world. Natural products represent credible sources of new antiplasmodial agents for antimalarial drug development. Endophytes that widely colonize healthy tissues of plants have been shown to synthesize a great variety of secondary metabolites that might possess antiplasmodial benefits. The present study was carried out to evaluate the antiplasmodial potential of extracts from endophytic fungi isolated from against a chloroquine-resistant strain of ). Sixty-one fungal isolates with infection frequency of 67.77% were obtained from the bark of . Twelve selected isolates were classified into six different genera including , , , , and . Extracts from the 12 isolates were tested against , and nine showed good activity (IC < 10 μg·mL) with three fungi including (IC = 0.44 μg·mL), (IC = 0.2 μg&mid...
A workshop on implementation strategies for the introduction of the RTS,S/AS01 (RTS,S) malaria va... more A workshop on implementation strategies for the introduction of the RTS,S/AS01 (RTS,S) malaria vaccine in countries with areas of highly seasonal transmission, was held as a hybrid meeting in Dakar, Senegal, and online, 23–25 January 2023. Delegates from Expanded Programmes on Immunization (EPI) and National Malaria Control Programmes (NMCPs) from 13 African countries, and representatives from key stakeholders participated. RTS,S is the first malaria vaccine to be recommended by the World Health Organization (WHO). The recommendation followed pilot implementation of the vaccine in Ghana, Kenya and Malawi, which showed that introduction of the vaccine was highly effective at scale, and was associated with a 30% reduction in hospital admissions with severe malaria in age groups eligible to have received the vaccine and no evidence of the safety signals that had been observed in the phase 3 trial. Clinical trials in Mali and Burkina Faso, showed that in children receiving Seasonal Mala...
ABSTRACT Phytochemical investigation of the leaves of Phragmanthera capitata collected on Cassia ... more ABSTRACT Phytochemical investigation of the leaves of Phragmanthera capitata collected on Cassia spectabilis tree led to the isolation of two natural lactones, rel-(1R,5S,7S)-7-[2-(4-hydroxyphenyl)ethyl]-2,6-dioxabicyclo[3.3.1]nonan-3-one (1) and 4-{2-[rel-(1R,3R,5S)-7-oxo-2,6-dioxabicyclo[3.3.1]non-3-yl]ethyl}phenyl 3,4,5-trihydroxybenzoate (2) together with the known compounds betulinic acid (3), dodoneine (4), quercetin 3-O-α-l-rhamnopyranoside (5), quercetin 3-O-α-l-arabinofuranoside (6), quercetin (7), betulin (8), lupeol (9), and sitosterol (10). Their structures were established by means of modern spectroscopic techniques, and the relative configuration of compound 1 was confirmed by X-ray analysis. Compounds 1 and 2 were tested in vitro for their antiplasmodial activity against the Plasmodium falciparum chloroquine sensitive-strains NF54 and 3D7. Compound 2 exhibited good antiplasmodial activity against both strains with IC50 of 2.4 and 4.9 μm, respectively, while compound 1 was inactive.
Journal of fungi (Basel, Switzerland), Jan 12, 2018
There is continuing need for new and improved drugs to tackle malaria, which remains a major publ... more There is continuing need for new and improved drugs to tackle malaria, which remains a major public health problem, especially in tropical and subtropical regions of the world. Natural products represent credible sources of new antiplasmodial agents for antimalarial drug development. Endophytes that widely colonize healthy tissues of plants have been shown to synthesize a great variety of secondary metabolites that might possess antiplasmodial benefits. The present study was carried out to evaluate the antiplasmodial potential of extracts from endophytic fungi isolated from against a chloroquine-resistant strain of ). Sixty-one fungal isolates with infection frequency of 67.77% were obtained from the bark of . Twelve selected isolates were classified into six different genera including , , , , and . Extracts from the 12 isolates were tested against , and nine showed good activity (IC < 10 μg·mL) with three fungi including (IC = 0.44 μg·mL), (IC = 0.2 μg&mid...
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Papers by Joel Ateba